Morgagni-Stewart-Morel Syndrome Research Articles

Neuropsychological Profile of Internal Frontal Hyperostosis

AbstractBackgroundIn 1765 Giovanni Morgagni described internal frontal hyperostosis syndrome (IFH), obesity and hirsutism. Stevart (1928) and Morel (1930) added the presence of neurological and neuropsychiatric involvement, constituting the definition of Morgagni‐Stewart‐Morel Syndrome (MSM). There are cases of HFI with absence of the rest of symptoms.MethodClinical, neuropsychological and neuropsychiatric evaluation of 5 patients treated for cognitive and behavioral impairment in whom neuroimaging neuroimaging showed internal frontal hyperostosis, apparently of sufficient entity to be associated with frontal lobe compression. Independent evaluation of the rest of the clinical and and family history that could indicate the presence of the constellation of constitutive symptoms of MSM.ResultThe neuropsychological battery showed as fundamental findings: depressive mood, attentional deficit, deterioration of working and recent memory, loss of concentration. No productive psychotic symptoms. Difficulty in complex tasks or complex skills. Anhedonia. No obsessive or compulsive symptomatology, nor anxiety as a predominant symptom. Irritability and irascibility. Mnesic process of inactive profile, difficulty in the change of mnesic strategy or language, or inhibition of irrelevant stimuli, problems with calculation, reasoning, sequencing or mental organization. Reduced verbal and non‐verbal fluency and disordered self‐regulation. Attention was drawn to the discordance between the significant functional impairment of the patients and the relatively preserved performance on neurocognitive battery.ConclusionThe presence of psychiatric and neurocognitive symptomatology associated with HFI has a characteristic profile, a varied constellation of deficits attributable to frontal lobe dysfunction, but should be actively investigated, because of its difficult until it significantly affects the patient’s performance.

Pronounced hyperostosis frontalis interna and co‐occurring lesions in the skull base suggestive of a pituitary tumor in a woman from medieval Germany

AbstractHyperostosis frontalis interna (HFI) is an osseous overgrowth characterized by symmetrical, irregular bone apposition on the internal table of the frontal bone, which preferentially occurs in females. In 1719, Morgagni described the condition as one sign of a triad comprising HFI, hirsutism, and obesity (Morgagni's syndrome). The etiopathogenesis of HFI is largely unresolved, but the condition is frequently associated with metabolic, endocrine, and neuropsychiatric disorders. In archaeological cases, which rely solely on dry bone diagnosis, the cause of HFI generally remains unknown, as is also the case regarding accompanying signs and symptoms. Here, we report a case of pronounced HFI in the skeleton of an old‐adult woman from medieval Hildesheim dating to the 8th to 11th century CE. In addition to HFI, the cranium exhibits resorptive lesions of the sella turcica with dehiscence of the roof of the sphenoid sinus. The co‐occurrence of these lesions suggests an underlying common cause for them. On the basis of differential diagnosis, we consider a functioning pituitary neuroendocrine tumor (PitNET) as the most likely common cause for the two conditions.

Depression revealing Morgagni-Stewart-Morel syndrome

Morgagni Stewart Morel (MSM) syndrome is defined as the presence of hyperostosis frontalis interna, variably associated with metabolic, endocrine, and neuropsychiatric disorders. In the literature, the majority of reported cases presented with depression, without any studies focusing on the nature of the link between the two types of disorder. In fact, depression raises the question of whether it is related to this syndrome or to aging, since the prevalence of the MSM syndrome increases with age. In this work, we report a clinical case to discuss the relationship between MSM syndrome and depression in a 67-year-old woman who presented with depression and imagery consistent with MSM syndrome.

Morgagni-Steawart-Morel syndrome: Case report

Hyperostosis frontalis interna (HOFI) is characterized by the benign growth of the inner plate of the frontal bone. It is most common in older women. Etiology is unknown. Morgagni-Stewart-Morel syndrome(MSM) is characterized by HOFI, obesity, hirsutism and mental illnesses but these associations are mostly based only on case reports. MSM syndrome is misunderstood and less reported pathology. The clinical presentation is not well defined andits finding is usually coincidental. The patient may present variable symptomatology. The idea that we should keep in mind is that HOFI representthe main pattern of MSM. Thus, it is highly importantto specify the presence and degree of HOFI in radiological reports.

Morgagni–Stewart–Morel syndrome: A new case

Introduction: Morgagni–Stewart–Morel (MSM) syndrome is defined as the presence of hyperostosis frontalis interna (HFI) associated with metabolic, endocrine, and neuropsychiatric disorders. Here, we present an MSM syndrome case involving a woman with symptoms of depression and infertility. Case Report: A 38-year-old woman admitted for inaugural diabetic ketosis and she reported a history of severe frontal headache of which she had suffered for several years associated to depression, obesity, and infertility. Axial cranial computed tomography (CT) scan showed bilateral thickening of the inner table of the frontal bone. Her endocrine dysfunctions and neuropsychiatric symptoms are interpreted as components of Morgagni–Stewart–Morel syndrome and may correlate with the severity of the frontal hyperostosis and the cortical atrophy. Conclusion: We describe a case of MSM syndrome, presenting many of the clinical features described in the literature. The exact etiology of HFI and MSM syndrome remains unclear; the most interesting theories relate to estrogen dysfunction, obesity and leptin dysfunction, and genetics.

Morgagni Stewart morel syndrome - Additional features

A case of Morgagni Stewart Morel syndrome with progressive depression in frontal bone, headache, transient monoparesis, obesity; imbalance, neuropsychiatric symptoms and recurrent disc prolapse with absent right radial pulse is discussed. This syndrome was first mentioned 235 years back, but till now exact pathology is not known. Balance assessment using dynamic posturography was done, which revealed abnormal vestibular function. To our knowledge this is the first case examined for Dynamic Posturography.

Morgagni's syndrome

Morgagni's Syndrome is a polyglandular endocrine syndrome, occurring almost exclusively in the female sex. It is characterized of the classical triad: internal frontal hyperostosis, obesity, virillism, and often accompanied by an old-age type of diabetes. In itself the hyperostosis is of little significance, but sometimes it is a valuable sign of a disorder of the carbohydrate metabolism. In many cases the syndrome is almost symptomless, in other cases senile neuro-psychiatric symptoms and ailments of old age dominate the clinical picture. The internal frontal hyperostosis has no closer relation to other more or less diffuse thickenings of the skull.

The etiology of hyperostosis cranii (metabolic craniopathy); a clinical study.

1. The clinical features of hyperostosis cranii are briefly reviewed. In large series of cases the syndrome has been found to occur almost entirely in females. 2. In recent studies of dystrophia myotonica, it is apparent that hyperostosis cranii is one of the variable features of the disorder. This disease occurs equally among males and females and the hyperostosis cranii also is distributed equally among males and females. 3. Hyperostosis cranii also occurs in patients with Morgagni's syndrome, with acromegaly, and as "senile hyperostosis." 4. The etiology of hyperostosis is still a matter for speculation. More recent studies have focused attention on the endocrine system, and it seems probable, in view of the sex distribution in dystrophia myotonica, that the key to the problem may be found in this disorder. 5. In dystrophia myotonica the characteristic skull changes are hyperostosis cranii, a small pituitary fossa, excessive sinus formation and prognathism. These are acromegaloid changes. Gonadal atrophy is a common feature and endocrine study suggests that the endocrine defect is primarily a failure of the androgenic function of the adrenals and the testes. 6. In rodents and in humans ablation of the gonads leads to overactivity of gonadotrophic cells and, at times, of somatotrophic cells. Sometimes pituitary tumours develop. 7. Acromegaloid features may occur in eunuchs, and it is likely that the acromegaloid changes in dystrophia myotonica are of the same order from overactivity of growth hormone. 8. In animals excess of growth hormone produces thickening of the skull. 9. In dystrophia myotonica, acromegaly, and Morgagni's syndrome, it is suggested that hyperostosis cranii is an expression of unrestrained activity of growth hormone.

Hyperostosis Cranii

HomeRadiologyVol. 65, No. 2 PreviousNext Announcements and Book ReviewsBook ReviewsHyperostosis CraniiPublished Online:Aug 1 1955https://doi.org/10.1148/65.2.285bMoreSectionsPDF ToolsImage ViewerAdd to favoritesCiteTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinked In AbstractStewart - Morel Syndrome; Metabolic Craniopathy; Morgagni's Syndrome; Stewart-Morel-Moore Syndrome (Ritvo); Le Syndrome de Morgagni-Morel. By Sherwood Moore, M.D., Professor Emeritus of Radiology, Washington University School of Medicine; Former Director of the Edward Mal-linckrodt Institute of Radiology, St. Louis, Mo. A volume of 226 pages, with 107 illustrations and 7 tables. Published by Charles C Thomas, Springfield, I11. Price $10.50.Prof. Sherwood Moore has prepared an excellent monograph on a subject, hyperostosis cranii, which he has been studying for many years and to which he has made significant contributions. It is unfortunate that the etiology of this condition remains obscure.Four types of hyperostosis make up the author's classification: hyperostosis frontalis interna, hyperostosis calvariae diffusa, nebula frontalis, and hyperostosis frontoparietalis. All phases of the condition are covered, including the roentgen diagnosis, the dimensions of the skull as determined roentgenologically, the clinical aspects, pathology, treatment, social and economic aspects, and even paleopathology. A statistical analysis of comparative measurements of normal and hyperostotic skulls is of special interest. An excellent historical review is appended, and there is a voluminous bibliography. This is a valuable and complete study which will be welcomed by radiologists and clinicians who are interested in further study of this condition and its possible etiology.Article HistoryPublished in print: Aug 1955 FiguresReferencesRelatedDetailsRecommended Articles RSNA Education Exhibits RSNA Case Collection Vol. 65, No. 2 Metrics Altmetric Score PDF download

Concurrence of Morgagni's syndrome, schizophrenia and adenomatous goiter in monozygotic twins.

SummaryClinical and histopathological data are presented on monozygotic twin sisters concordant as to schizophrenia, Morgagni's syndrome, and adenomatous goiter. The association of the three traits may have been coincidental, but apparently had a common denominator. The genetic theory of Morgagni's syndrome (pointing to autosomal dominance with irregular penetrance and especially low manifestation in the male) is discussed.

Hyperostosis frontalis interna; two contrasting cases.

It is assumed that the reader is familiar with the salient features of hyperostosis frontalis interna; therefore, discussion of the condition and its accompanying symptom complex will be omitted. A full description can be found in Henschen's classic monograph, Morgagni's Syndrome. The two case histories briefly given here are interesting because of their unusual courses, and the variation of development of the hyperostosis. REPORT OF CASES Case 1.— The first patient was admitted to the Barnes Hospital in March, 1928. She was a thin, white, 22-year-old married woman, complaining chiefly of a severe headache. On examination a doubtful nystagmus and a slight bilateral increase of the patellar reflexes were observed. Lumbar puncture disclosed no abnormalities. The late Prof. Sidney Schwab suggested the diagnosis of toxic irritation of the nervous system (frequently the symptoms associated with hyperostosis frontalis interna resemble those of mild chronic intoxication). A diagnosis of encephalitis was made,

Morgagni's Syndrome and Brain Tumors

Morgagni's Syndrome and Brain Tumors

Morgagni's Syndrome.

Morgagni's Syndrome.

Failing vision caused by a bony spike compressing the optic nerve within the optic canal, report of two cases associated with Morgagni's syndrome benefited by operation.

Failing vision caused by a bony spike compressing the optic nerve within the optic canal, report of two cases associated with Morgagni's syndrome benefited by operation.

FolkeHenschen: Morgagni's Syndrome

Acta Medica ScandinavicaVolume 136, Issue 3 p. 238-239 FolkeHenschen: Morgagni's Syndrome Jan Mellgren, Jan MellgrenSearch for more papers by this author Jan Mellgren, Jan MellgrenSearch for more papers by this author First published: January/December 1950 https://doi.org/10.1111/j.0954-6820.1950.tb09635.xAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume136, Issue3January/December 1950Pages 238-239 RelatedInformation

Morgagni's Syndrome

Morgagni's Syndrome

METABOLIC CRANIOPATHY: HYPEROSTOSIS FRONTALIS INTERNA

Excerpt The entity generally referred to ashyperostosis frontalis interna, the Morgagni syndrome, or the Stewart-Morel syndrome, and recently renamed metabolic craniopathy by Moore43is not new to m...

Morgagni's Syndrome: A Clinical and Pathological Study

In recent years attention has been drawn afresh to a group of cases in which there is a hyperostosis of the flat bones of the skull, associated with various mental changes and signs of endocrinological disturbances. In 1761 Morgagni mentioned the existence of hyperostosis of the inner table of the skull, and referred to its association with virilism and obesity. Morgagni's brilliant observation was neglected until recently, when it was proposed to name the condition Morgagni's syndrome. F. Morel (1931) published his monograph on frontal hyperostosis of the skull, and expressed the opinion that hyperostosis frontalis interna is a well-defined disease. He suggested that the proliferation of bone is provoked by adhesions between the dura and the inner table of the skull. As characteristics of the syndrome he described obesity, polyphagia, polydipsia, disturbance of sleep, weakness of muscles, loss of sight, headaches, and sometimes epileptic fits. In his opinion a pituitary disturbance is the primary cause of the disease. Shortly before Morel, R. M. Stewart (1928) described cases of insanity with localized calvarial hyperostosis. He found sclerosis of the anterior lobe of the pituitary, which he considered was the responsible cause. Schiff and Trelles (1931) suggested that there might be a relationship with Dercum's disease. Dressier (1927) and Greig (1928) dealt with the pathology of the bony changes. Greig suggests that a disturbance of the calcium and phosphorus metabolism is the causative agent. Critchley (1931), dealing with the neurology of old age, emphasized the importance of hyperostosis frontalis interna. A very extensive series of skulls taken from the average hospital population was investigated by Sherwood Moore (1936), 6,650 in all. In his case material there was 1.4 per cent. of hyperostosis. He tried to classify hyperostosis into four forms.