In this study, we present a new cryptosystem named Deoxyribose Nucleic Acid (DNA) secret writing with the Laplace transform of the Mittag-Leffler function. The method is proper for encrypting large files. In this technique, we consider the original message as binary sequence. These binary streams corresponding to the plain text is transformed to DNA bases by utilizing DNA encoding, then the DNA codes are transformed to positive integers. We apply the Laplace transform to these numbers which are coefficients of the expansion of the Mittag-Leffler function. To provide multi-stage protection, the outcome coefficients are transformed to binary sequences and other level of encryption with cumulative XOR is applied and equivalent MSBs obtained at every iteration are utilized for building cipher text. Decryption is implemented in the opposite way. We employ monobit test, correlation analysis for measuring the reliability of encryption, and Python programming language to obtain secret message, the plain text, and computations of statistical tests.
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