You have accessJournal of UrologyInfertility: Therapy (MP31)1 Sep 2021MP31-18 ONLINE MALE INFERTILITY SUPPLEMENTS: A GROWING MARKET WITHOUT GROWING EVIDENCE Igor Inoyatov, Spencer Mossack, Michael Hung, Varun Talanki, James Rail, David Schulsinger, and Yefim Sheynkin Igor InoyatovIgor Inoyatov More articles by this author , Spencer MossackSpencer Mossack More articles by this author , Michael HungMichael Hung More articles by this author , Varun TalankiVarun Talanki More articles by this author , James RailJames Rail More articles by this author , David SchulsingerDavid Schulsinger More articles by this author , and Yefim SheynkinYefim Sheynkin More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002035.18AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: The current American Urological Association guidelines state no clear recommendation can be made for the treatment of male infertility using antioxidants. While many supplements have been shown in small, low quality studies to improve semen parameters, few, if any have been shown to actually improve natural conception rates or live birth rates. We aim to examine the current online market for male infertility supplements and evaluate the clinical evidence of their ingredients. METHODS: Amazon, Google Shopping and Walmart search engines were queried for currently available male infertility supplements. Customer reviews, supplement costs, claims and ingredient information were collected. The active ingredients were then compared with known supplements included in randomized controlled trials (RCTs) for subfertile men RESULTS: A total of 243 products were reviewed across the 3 online marketplaces and 30 distinct supplements were analyzed containing a total of 73 ingredients. We found that 70% of the products claimed to improve sperm motility, 63% claimed to increase sperm count, and 12% claimed to increase the chance of conceiving. The average 30 day cost per product was $35.10 and 4 products made “money back guarantees.” At least half the products contained Zinc (57%), Folic Acid (53%), L-Carnitine (50%) and Selenium (50%). The most reviewed product accumulated 1214 reviews with an average rating of 4.48/5 stars. Of the 73 ingredients reviewed, 58.9% of them have never been studied in human clinical trials on male infertility. In total, 12 of the 15 most common ingredients were cited in human clinical trials. Only 2/15 (13%) ingredients (Vitamin E and Zinc) have been shown to improve conception rates while 6/15 (40%) ingredients have been shown to increase semen parameters. CONCLUSIONS: The online market for male infertility supplements is saturated with products claiming to improve semen parameters and the chance of conceiving. While comparatively less expensive than artificial reproductive technology (ART), many include ingredients that have either not been found to have the advertised effect or have never been tested in human trials. Patients should be warned of the large number of male infertility products on the market that have little to no evidence of improving fertility, and may increase the burden of cost on patients who may eventually require ART. Source of Funding: N.A. © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e562-e562 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Igor Inoyatov More articles by this author Spencer Mossack More articles by this author Michael Hung More articles by this author Varun Talanki More articles by this author James Rail More articles by this author David Schulsinger More articles by this author Yefim Sheynkin More articles by this author Expand All Advertisement Loading ...