Ethylene Molecules Research Articles

A self-assembly capsule-like solvation structure electrolyte for lithium metal batteries

The localized high-concentration electrolyte can be achieved by diluting a high-concentration electrolyte with an anti-solvent, which inherits the original solvation structural characteristics and reduces harmful interfacial reactions, resulting in an electrolyte with unique functions suitable for lithium metal batteries. Here, we design a localized high-concentration electrolyte with a capsule-like solvation structure and non-flammable properties to obtain stable-cycle and safe lithium metal batteries. The weak coordination and dipole-dipole interactions of fluorinated ether molecules promote the self-assembly of capsule-like solvated sheaths, encapsulating cations/anions and polar solvent molecules within the solvation sheath, which improves the oxidative stability of the electrolyte system and promotes the reduction of anions. A high-quality solid electrolyte layer was derived at the electrode interfaces, leading to rapid Li+ transport and dendrite-free lithium deposition. Consequently, a Coulombic efficiency of 99.7% is achieved, and the assembled Li||NCM811 battery exhibits a long cycle life of more than 400 cycles at 0.5C with a capacity retention of 83%. This work provides a promising approach for developing non-flammable electrolytes suitable for high-voltage lithium metal batteries.

Ethane Triggered Gate‐Opening in a Flexible−Robust Metal−Organic Framework for Ultra‐high Purity Ethylene Purification

Priority recognition separation of inert and larger ethane molecules from high‐concentration ethylene mixtures instead of traditional thermodynamic or size sieving strategy is a fundamental challenge. Herein, we report the ethane triggered gate‐opening in the flexible‐robust metal−organic framework Zn(ad)(min), the 3‐methylisonicotinic acid ligand can spin as a flexible gate when adsorbing the cross‐section well‐matched ethane molecule, thus achieving the unprecedent ethane adsorption capacity (62.6 cm3 g‐1) and ethane/ethylene uptake ratio (3.34) under low‐pressure region (0.1 bar and 298 K). The ethane‐induced structural transition behavior is uncovered by a collaboration of single‐crystal X‐ray diffraction, in‐situ variable pressure X‐ray diffraction and theoretical calculations, elucidating the synergetic mechanism of cross‐section matching and multiple supramolecular interactions within the tailor‐made pore channels. Dynamic breakthrough experiments revealed the outstanding separation performance of Zn(ad)(min) in the production of ultra‐high purity ethylene (> 99.995%) with a productivity of up to 39.2 L/kg under ambient conditions.

Ethane Triggered Gate-Opening in a Flexible-Robust Metal-Organic Framework for Ultra-high Purity Ethylene Purification.

Priority recognition separation of inert and larger ethane molecules from high-concentration ethylene mixtures instead of traditional thermodynamic or size sieving strategy is a fundamental challenge. Herein, we report the ethane triggered gate-opening in the flexible-robust metal-organic framework Zn(ad)(min), the 3-methylisonicotinic acid ligand can spin as a flexible gate when adsorbing the cross-section well-matched ethane molecule, thus achieving the unprecedent ethane adsorption capacity (62.6cm3 g-1) and ethane/ethylene uptake ratio (3.34) under low-pressure region (0.1 bar and 298 K). The ethane-induced structural transition behavior is uncovered by a collaboration of single-crystal X-ray diffraction, in-situ variable pressure X-ray diffraction and theoretical calculations, elucidating the synergetic mechanism of cross-section matching and multiple supramolecular interactions within the tailor-made pore channels. Dynamic breakthrough experiments revealed the outstanding separation performance of Zn(ad)(min) in the production of ultra-high purity ethylene (> 99.995%) with a productivity of up to 39.2 L/kg under ambient conditions.

Curcuma longa rhizome extract: a potential antibiofilm agent against antibiotic-resistant foodborne pathogens

The traditional medicinal value of Curcuma longa (turmeric) and its potential relevance in modern healthcare suggests that traditional remedies and natural products can provide valuable solutions to contemporary challenges, such as combating biofilms and antibiotic-resistant pathogens, potentially offering new strategies for addressing health and safety issues in the fields of food and medicine. This study assessed the antibiofilm and antibacterial characterization of Curcuma longa rhizome extract against antibiotic-resistant foodborne pathogens. Gas Chromatography-Mass Spectrometry (GC-MS) and Fourier-transform infrared (FTIR) analysis were determined to check for the compounds, functional groups, and constituents of the plant extract. In-vitro antibiofilm and antibacterial bioassay of the extract were determined using standard bacteriological procedures. Potential mechanisms of the plant extract were also studied using standard biological methods. The important chemical constituents from the GC-MS extract of C. longa are arturmerone, cinnamyl angelate, tumerone, γ-atlantone, atlantone, α-atlantone, γ-atlantone and curlone. The FTIR analysis of the extract comprises alkyl halides, bromoalkanes, alkanes, ethylene molecules, arenes, amines, alcohols, sulfones, carboxylic acids and their derivatives, aromatic compounds, and phenols. The MIC of C. longa crude extract ranges from ethanol extract (0.03125 − 0.5 mg/mL) and acetone extract (0.0625 − 0.5 mg/mL). The MBC range is as follows: ethanol extract (0.125 − 1 mg/mL), acetone extract (0.125 − 1 mg/mL). The time-kill kinetics showed significant cell reduction with time. The bacterial isolates’ nucleic acids and protein leakage were consistent with increased extract concentration and time. There was a reduction in the biofilm cell on the shrimp surface and EPS with increased concentration and time. C. longa exerted significant anti-biofilm activity by removing existing biofilms, disrupting cell connections, and decreasing cells in biofilms. These findings can aid food protection from microbial contamination and prevent biofilms-related infections.

Photoreactions of the C2H4-SO2 Complex in a Low-Temperature Matrix Investigated by Infrared Spectroscopy and Density Functional Theory Calculations.

Ethylene and sulfur dioxide molecules were co-deposited on a CsI window at cryogenic temperature, and the photoproducts upon UV irradiation were observed using Fourier transform infrared (FTIR) spectroscopy. The products were found to be UV wavelength-dependent; at shorter wavelengths (λ = 266 nm) one strong peak was observed while more than three peaks were identified at longer UV wavelengths (λ = 300 nm). Spectral features changed seamlessly along with UV wavelength. Density functional theory (DFT) calculations were carried out for potential products, and spectral matches between observations and calculations seemed satisfactory, assuming a cyclic molecule (oxathietane 2-oxide) as the main photoproduct at longer UV wavelengths. On the other hand, the spectra of photoproducts at shorter UV wavelengths were reproduced by assuming the decomposition products of an intermediate, from the supplementary experiments using deuterated samples. Plausible photoreaction schemes were presented to account for the observed photoproducts.

Crystallization Control to Prepare Uniform CsPbI2Br Thin Films for High-Efficiency Perovskite Solar Cells.

All-inorganic perovskite solar cells (PSCs) face challenges related to film inhomogeneity, which arises from nonideal crystallization. This issue significantly impedes the advancement of all-inorganic PSCs. In this study, we observed that during the crystallization process of CsPbI2Br, the Br-rich intermediate phase is often preferentially deposited, leading to an uneven distribution in the out-of-plane direction of the perovskite film. To address this issue, crown ether molecules (dibenzo-18-crown-6) were introduced into the perovskite precursor solution. The complexation of crown ether with Cs cations and Br anions optimizes the crystallization sequence of the perovskite, ensuring that the intermediate phase closely conforms to the standard stoichiometric ratio. This adjustment significantly mitigates the problem of uneven halogen ion distribution along the out-of-plane direction. Furthermore, the crown ether thermally decomposes during the high-temperature annealing process, thereby not affecting the composition of the final perovskite film. Following crown ether treatment, the efficiency of the PSCs reached 14.08%, and the unpackaged devices maintained 80% of their initial efficiency after 1000 h of exposure to light in an atmospheric environment.

Crystal structure of [Ni(OH2)6]Cl2·(18-crown-6)2·2H2O

The crystal structure of the title compound, hexaaquanickel(II) dichloride–1,4,7,10,13,16-hexaoxacyclooctadecane–water (1/2/2), [Ni(H2O)6]Cl2·2C12H24O6·2H2O, is reported. The asymmetric unit contains half of the Ni(OH2)6 moiety with a formula of C12H32ClNi0.50O10 at 105 K and triclinic (P 1) symmetry. The [Ni(OH2)6]2+ cation has close to ideal octahedral geometry with O—Ni—O bond angles that are within 3° of idealized values. The supramolecular structure includes hydrogen bonding between the water ligands, 18-crown-6 molecules, Cl− anions, and co-crystallized water solvent. Two crown ether molecules flank the [Ni(OH2)6]2+ molecule at the axial positions in a sandwich-like structure. The relatively symmetric hydrogen-bonding network is enabled by small Cl− counter-ions and likely influences the more idealized octahedral geometry of [Ni(OH2)6]2+.

Computational Study on the Inhibition Mechanisms of the Ziegler-Natta Catalyst in the Propylene Polymerization Process: Part 1 Effects of Acetylene and Methylacetylene

Acetylene and methylacetylene are impurities commonly found in the raw materials used for the production of polymers such as polypropylene and polyethylene. Experimental evidence indicates that both acetylene and methylacetylene can decrease the productivity of the Ziegler-Natta catalyst and alter the properties of the resulting polymer. However, there is still a lack of understanding regarding the mechanisms through which these substances affect this process. Therefore, elucidating these mechanisms is crucial to develop effective solutions to this problem. In this study, the inhibition mechanisms of the Ziegler-Natta catalyst by acetylene and methylacetylene are presented and compared with the incorporation of the first propylene monomer (chain initiation) to elucidate experimental effects. The Density Functional Theory (DFT) method was used, along with the B3LYP-D3 functional and the 6-311++G(d,p) basis set. The recorded adsorption energies were −11.10, −13.99, and −0.31 kcal mol−1, while the activation energies were 1.53, 2.83, and 28.36 kcal mol−1 for acetylene, methylacetylene, and propylene, respectively. The determined rate constants were 4.68 × 1011, 5.29 × 1011, and 2.3 × 10−8 M−1 s−1 for acetylene, methylacetylene, and propylene, respectively. Based on these values, it is concluded that inhibition reactions are more feasible than propylene insertion only if an ethylene molecule has not been previously adsorbed, as such an event reinforces propylene adsorption.

Efficient sorbent/catalyst composites for CO2-mediated oxidative dehydrogenation of ethane via isothermal integrated CO2 capture and utilization

The isothermal integrated CO2 capture and utilization to produce ethylene (ICCU-ODHE) performances of dual functional materials (DFM) were improved by doping five transition metal elements (Fe, Co, Ni, Cu, Zn). The results show that the DFM doped with Zn exhibits excellent ICCU-ODHE performance with an ethylene yield of 35.1 %. The results based on in-situ XPS and DFT calculation show that the doping transition metal elements can reduce the energy barriers for activating ethane and CO2. It is mainly because doping transition metal elements with strong electronegativity can increase the coordinative unsaturated Cr3+ ions to adsorb more ethane molecules, meanwhile, the doping also reduces the charge density of Cr3+ and generates additional unfilled electron orbitals facilitating charge transfer to improve the CO2 and ethane activation. However, the decrease in charge density can increase the difficulty of ethylene desorption and reduce the ethylene selectivity. In addition, the cyclic regeneration experiment shows that the ICCU-ODHE performance of DFM can decrease with the increase of cycles, however, significant performance restoration is achievable after regeneration in the air at 650 °C, attributed to the limited graphitization of coke deposition on the DFM.

Gas-Phase Studies of NMR Shielding and Indirect Spin-Spin Coupling in 13C-Enriched Ethane and Ethylene.

13C and 1H NMR spectra were observed as the function of density in 1,2-13C-enriched ethane and ethylene for the pure gaseous compounds and their binary mixtures with xenon and carbon dioxide gases as the solvents. All the chemical shifts and indirect spin-spin couplings were linearly dependent on the solvent density. The appropriate NMR parameters (σ and nJ) in isolated 13C2H6 and 13C2H4 molecules and the coefficients responsible for the binary molecular interactions were determined and compared with previous similar measurements and selected calculated shielding data. The newly obtained 13C shielding values in the isolated ethane and ethylene molecules suggest visible secondary isotope effects due to the additional carbon-13 atom. All the investigated shielding parameters depend on intermolecular interactions, and the dependence of 13C shielding is much more marked. In contrast, the indirect spin-spin couplings in 13C2H6 and 13C2H4 molecules are almost independent of solvent molecules. Their nJ values determined in liquids over sixty years ago are generally consistent with the same nJ parameters in isolated 13C2H6 and 13C2H4 molecules.

In Situ Ligand-Transformation-Assisted Assembly of a Polyoxometalate and Silver-Phosphine Oxide Cluster for Colorimetric Detection of Phenol Contaminants.

In situ ligand transformation strategies represent an efficient pathway for constructing function-oriented polyoxometalate (POM)-based crystalline materials. Herein, three POM-based hybrid networks were synthesized through in situ transformation of the phosphine ligand, formulated as [Ag(dppeo)6][H2PMo12O40]·5H2O (1), [Ag(dedpo)]4[SiW12O40]·6H2O (2), and [Ag(dppeo)]3[PW12O40]·3H2O (3) (dedpo = (2-(diphenylphosphaneyl)ethyl)diphenylphosphine oxide; dppeo = ethane-1,2-diylbis(diphenylphosphine oxide)). During the synthesis of these compounds, the 1,2-diphenylphosphine ethane molecule underwent in situ oxidation, transforming into dppeo and dedpo ligands, respectively. Compound 1 features a supramolecular architecture assembled from [Ag(dppeo)3]+/[Ag2(dppeo)6]2+ cationic clusters with disordered Ag centers and protonated [H2PMo12O40]- anions. Compound 2 presents a 3-D POM-supported metal-organic framework consisting of binuclear [Ag(dedpo)]22+ units, {-dedpo-Ag-dedpo-} chains, and [SiW12O40]4- polyoxoanions. Compound 3 displays a 2-D layered structure formed by {-dppeo-Ag3-dppeo-} chains and [PW12O40]3- clusters. Pronounced argentophilic interactions are observed in compounds 1 and 3. The three compounds demonstrate satisfactory heterogeneous catalytic activity in the colorimetric detection reactions toward phenol pollutants with detection limits of 1.73, 1.92, and 4.6 μM, respectively. Additionally, compounds 1-3 show high anti-interference capabilities and high sensitivity in differentiating phenol from its halogenated derivatives. This work presents some guidance for designing specific function-oriented POM-based materials via an in situ ligand transformation strategy.

Trichloroethylene and tetrachloroethylene adsorption studies on α-antimony phosphorous nanosheets – A first-principles study

In recent days, monolayer materials have been pioneering research to detect different kinds of toxic pollutants in the air atmosphere. In this work, we utilised alpha-phase antimony phosphorous (α-SbP) as a sensing substrate to detect the chlorinated ethylene molecules such as trichloroethylene (TCE) and tetrachloroethylene (PCE). Initially, the structural stability including the dynamical firmness of α-SbP is validated by cohesive energy and phonon band spectrum. Furthermore, the electronic characteristic of pristine α-SbP is investigated by band structure and projected density of states (PDOS) maps. The calculated energy gap of α-SbP is observed to be 1.162 eV which validates the semiconductor behaviour. Importantly, the interaction behavior of TCE and PCE on α-SbP is explored with regard to Mulliken charge analysis, adsorption energy, and relative band gap changes. The adsorption-energy values are recorded within the physisorption scope (−0.027 eV to −0.593 eV). Thus, the proposed α-SbP is a good candidate for the detection of TCE and PCE in the air atmosphere.

Crystal structure of (1,4,7,10,13,16-hexa-oxa-cycloocta-decane-κ6 O)potassium-μ-oxalato-tri-phenylstannate(IV), the first reported 18-crown-6-stabilized potassium salt of tri-phenyl-oxalatostannate.

The title complex, (1,4,7,10,13,16-hexa-oxa-cyclo-octa-decane-1κ6 O)(μ-oxalato-1κ2 O 1,O 2:2κ2 O 1',O 2')triphenyl-2κ3 C-potassium(I)tin(IV), [KSn(C6H5)3(C2O4)(C12H24O6)] or K[18-Crown-6][(C6H5)3SnO4C2], was synthesized. The complex consists of a potassium cation coordinated to the six oxygen atoms of a crown ether mol-ecule and the two oxygen atoms of the oxalatotri-phenyl-stannate anion. It crystallizes in the monoclinic crystal system within the space group P21. The tin atom is coordinated by one chelating oxalate ligand and three phenyl groups, forming a cis-trigonal-bipyramidal geometry around the tin atom. The cations and anions form ion pairs, linked through carbonyl coordination to the potassium atoms. The crystal structure features C-H⋯O hydrogen bonds between the oxygen atoms of the oxalate group and the hydrogen atoms of the phenyl groups, resulting in an infinite chain structure extending along a-axis direction. The primary inter-chain inter-actions are van der Waals forces.

The Halogen Bond to Ethers - Prototypic Molecules and Experimental Electron Density.

Halogen bonds to dialkyl ether molecules have remained largely unexplored. We here address the synthesis and the structural chemistry of the first halogen-bonded noncyclic alkyl ethers, combining 1,4-diiodotetrafluorobenzene and the prototypic or commonly used ethers dimethyl ether, tetrahydrofuran, and methyl-tert-butyl ether as halogen acceptors. Two different structural motifs based on moderately strong halogen bonds were obtained: Discrete trimolecular aggregates are formed, and unexpected halogen-bonded supramolecular chain adducts feature oxygen-bifurcated halogen bonds with 1:1 donor:acceptor ratio. Both structure types may be selectively obtained even for the same ether by adjusting the stoichiometry in the crystallization experiments. The geometric features of the etheric oxygen center were found to be flexible, in contrast to the almost linear geometry about the halogen donor atom. A high-resolution X-ray diffraction experiment on the extended adduct of dimethyl ether allowed us to study the electronic details of the acceptor-bifurcated I···O···I halogen bonds. The electron density in the bond critical points and derived properties such as the Laplacian indicate essentially electrostatic interactions and explain the geometrical flexibility of ethers in halogen bonds. Our studies demonstrate the great versatility of ethers as halogen bond acceptors, that can occur in many geometrical arrangements and whose contribution to nature's structural designs should not be underestimated.

Theoretical analysis of H/D isotope effect on the binding of a positron to acetaldehyde molecule

Theoretical analysis of H/D isotope effect on the binding of a positron to acetaldehyde molecule

Multipocket Cage Enables the Binding of High-Order Bulky and Drug Guests Uncovered by MS Methodology.

Achieving high guest loading and multiguest-binding capacity holds crucial significance for advancement in separation, catalysis, and drug delivery with synthetic receptors; however, it remains a challenging bottleneck in characterization of high-stoichiometry guest-binding events. Herein, we describe a large-sized coordination cage (MOC-70-Zn8Pd6) possessing 12 peripheral pockets capable of accommodating multiple guests and a high-resolution electrospray ionization mass spectrometry (HR-ESI-MS)-based method to understand the solution host-guest chemistry. A diverse range of bulky guests, varying from drug molecules to rigid fullerenes as well as flexible host molecules of crown ethers and calixarenes, could be loaded into open pockets with high capacities. Notably, these hollow cage pockets provide multisites to capture different guests, showing heteroguest coloading behavior to capture binary, ternary, or even quaternary guests. Moreover, a pair of commercially applied drugs for the combination therapy of chronic lymphocytic leukemia (CLL) has been tested, highlighting its potential in multidrug delivery for combined treatment.

ETHYLENE CONVERSION IN A BARRIER DISCHARGE: EXPERIMENT AND MODELING

The selective conversion of ethylene and its mixtures with argon and air in a barrier discharge has been studied. Plasma chemical transformation proceeds without the formation of polymer-like substances or products of deep oxidation to oxygen-containing compounds and various saturated and unsaturated hydrocarbons. Synthesis is carried out on a set-up with a gas-liquid reactor in the presence of water, which ensures the elimination of formed substances from the discharge area and prevents repeated exposure to barrier discharge plasma. The treatment of ethylene in a barrier discharge leads to the formation of saturated and unsaturated hydrocarbons C1–C5+ with a predominance of compounds with four carbon atoms in the molecule, the total content of which in the reaction products reaches 58.4 wt.%. The addition of argon to ethylene does not significantly affect the set and content of substances in the reaction products, an increase in ethylene conversion is observed, the maximum value of which reaches 58.9 wt.%. The treatment of a mixture of ethylene with air additives leads to the formation of hydroxyl and carboxyl compounds with a total content of ~29 wt.% in the products, and saturated and unsaturated hydrocarbons C1–C4 with a predominant acetylene content up to ~47 wt.%. The conversion of ethylene in one pass of the reaction mixture through the reactor under these conditions is 12.8 wt.%. When evaluating the energy losses of barrier discharge electrons in electron-molecular interactions during the conversion of ethylene, it was found that 78% of the energy of barrier discharge electrons is spent mainly on excitation of the electronic states of ethylene molecules, and argon additives can increase it to 86%. In the case of conversion of ethylene mixtures with air additives, it is shown that only ~14% of the discharge energy is spent on the excitation of the electronic states of the ethylene molecule, and the main amount (65%) is spent on the excitation of various different states of nitrogen molecules. The data obtained were used to develop a model of the chemical kinetics of ethylene conversion in a barrier discharge. The proposed model contains more than 280 reactions and is in good agreement with experimental data. As a result of the simulation, new data were obtained on the behavior of an ethylene molecule in a barrier discharge plasma with an average electron energy of 4-5 eV. The results obtained will be useful in the development of modern ethylene processing methods focused on the technological simplicity and compactness of the chemical process that meets the principles of "green chemistry" and low carbon footprint in the environment. For citation: Ryabov A.Yu., Kydryashov S.V. Ethylene conversion in a barrier discharge: experiment and modeling. ChemChemTech [Izv. Vyssh. Uchebn. Zaved. Khim. Khim. Tekhnol.]. 2024. V. 67. N 8. P. 6-14. DOI: 10.6060/ivkkt.20246708.12t.

Superior sodiophilicity and molecule crowding of crown ether boost the electrochemical performance of all-climate sodium-ion batteries

Sodium-ion batteries (SIBs) as one of the promising alternatives to lithium-ion batteries have achieved remarkable progress in the past. However, the all-climate performance is still very challenging for SIBs. Herein, 15-Crown-5 (15-C-5) is screened as an electrolyte additive from a number of ether molecules theoretically. The good sodiophilicity, high molecule rigidity, and bulky size enable it to reshape the solvation sheath and promote the anion engagement in the solvated structures by molecule crowding. This change also enhances Na-ion transfer, inhibits side reactions, and leads to a thin and robust solid-electrolyte interphase. Furthermore, the electrochemical stability and operating temperature windows of the electrolyte are extended. These profits improve the electrochemical performance of SIBs in all climates, much better than the case without 15-C-5. This improvement is also adopted to μ-Sn, μ-Bi, hard carbon, and MoS2. This work opens a door to prioritize the potential molecules in theory for advanced electrolytes.

A new photoionization-induced substitution reaction chemical ionization time-of-flight mass spectrometry for highly sensitive detection of trace exhaled ethylene

Highly sensitive and rapid detection of ethylene, the smallest alkene of great significance in human physiological metabolism remains a great challenge. In this study, we developed a new photoionization-induced substitution reaction chemical ionization time-of-flight mass spectrometry (PSCI-TOFMS) for trace exhaled ethylene detection. An intriguing ionization phenomenon involving a substitution reaction between the CH2Br2+ reactant ion and ethylene molecule was discovered and studied for the first time. The formation of readily identifiable [CH2Br·C2H4]+ product ion greatly enhanced the ionization efficiency of ethylene, which led to approximately 800-fold improvement of signal intensity over that in single photon ionization mode. The CH2Br2+ reactant ion intensity and ion-molecule reaction time were optimized, and a Nafion tube was employed to eliminate the influence of humidity on the ionization of ethylene. Consequently, a limit of detection (LOD) as low as 0.1 ppbv for ethylene was attained within 30 s at 100 % relative humidity. The application of PSCI-TOFMS on the rapid detection of trace amounts of exhaled ethylene from healthy smoker and non-smoker volunteers demonstrated the satisfactory performance and potential of this system for trace ethylene measurement in clinical diagnosis, atmospheric measurement, and process monitoring.

Medicinal chemistry perspective on the structure-activity relationship of stilbene derivatives.

Stilbenes are a small family of polyphenolic secondary metabolites produced in a variety of closely related plant species. These compounds function as phytoalexins, aiding plant defense against phytopathogens and plants' adaptation to abiotic environmental factors. Structurally, some important phenolic compounds have a 14-carbon skeleton and usually have two isomeric forms, Z and E. Stilbenes contain two benzene rings linked by a molecule of ethanol or ethylene. Some derivatives of natural (poly)phenolic stilbenes such as resveratrol, pterostilbene, and combretastatin A-4 have shown various biological activities, such as anti-microbial, anti-cancer, and anti-inflammatory properties as well as protection against heart disease, Alzheimer's disease, and diabetes. Among stilbenes, resveratrol is certainly the most popular and extensively studied for its health properties. In recent years, an increasing number of stilbene compounds have been investigated for their bioactivity. This review focuses on the assessment of synthetic stilbene derivatives in terms of their biological activities and structure-activity relationship. The goal of this study is to consider the structural changes and different substitutions on phenyl rings that can improve the desired medicinal effects of stilbene-based compounds beyond the usual standards and subsequently discover biological activities by identifying effective alternatives of the evaluated compounds.