Recently, semi-precast composite (SPC) columns have been newly developed using steel angles and internal molds. Although the manufacturability, constructability, and seismic performance of SPC columns have been proven to meet design requirements, their structural responses under fire conditions (or fire resistance) have not yet been reasonably examined. Thus, in the present study, an experimental study was conducted for five full-scale SPC columns under standard fire conditions. The test parameters included the joint detail, axial load ratio, thickness of the precast section, and slenderness ratio. The test results show that the fire resistance rating was relatively low due to the high moisture contents and relatively high axial load ratio, and concrete spalling controlled the fire resistance of the columns. The concrete spalling was affected by the concrete moisture contents and permeability, the consequent moisture clog phenomenon, the relatively high axial load ratio, and the longitudinal weak planes between the concrete cover and confined concrete created by longitudinal and transverse bars. Addressing these effects, a finite element analysis (FEA) model was developed for SPC columns using ABAQUS. Although there were some discrepancies between the test and analysis results, the FEA model gave a conservative prediction, which is reasonable for design purpose considering the complexity of nonlinear thermal-stress analysis.