ABSTRACT In the present work, coefficient of volume expansion is estimated using ultrasonic velocity and density of 8CB, 8CB + 0.5% ZnO, 8CB + 2.0% ZnO and 8CB + 5.0% ZnO mixtures in the temperature range of 283.15K–318.15K. The coefficient of volume expansion is used to evaluate numerous thermo-acoustic parameters viz; Moelwyn-Hughes parameter (C 1 ), Beyer’s nonlinear parameter (B/A), reduced volume (V*), reduced bulk modulus (B*), isochoric acoustical parameter (Δ), fractional free volume (f), repulsive exponent (n), isobaric (Γ), isochoric (Γ′′), and isothermal (Γ′) Gruneisen parameters, Anderson-Gruneisen parameter (δ) and Sharma’s constant (S 0 ). Present study reveals that Sharma constant can be treated as molecular constant for 8CB and ZnO dispersed 8CB mixtures. A relationship between Δ≅B* +0.1 and C 1 ≅δ +1 has been established for all the samples under investigation. The effect of increase of ZnO NPs concentration on the intermolecular interactions has been explained in terms of temperature variation of thermo-acoustical parameters.