Modulation Characteristics Research Articles

Complex Reflectivity Modulation Characteristics at Visible Wavelength Using Liquid Crystal on a Metasurface Device

Active metasurface device capable of complex modulation in the visible light range is demonstrated. To realize complex modulation, a liquid crystal (LC) of twisted nematic mode on a plasmonic antenna metasurface, where resonance wavelength is sensitive to its geometry and nearby optical environment, is integrated. For the LC process on the metasurface, the alignment characteristics of the material exposed to the LC on the metasurface are first identified and the polyimide alignment layer is omitted. The LC works in twisted nematic mode to enhance complex modulation characteristics. The complex reflectivity coefficient is measured while varying the voltage applied to both the antenna and metal electrode in the visible light region. Complex reflectivity into a doughnut shape with a small voltage variation of 3.1 V on the antenna electrode and 2.5 V on the metal electrode is successfully modulated. The largest complex modulation is achieved at a wavelength of 660 nm, with phase and reflectivity amplitude modulations of 0–2π radian in a doughnut shape and 0.3 and 0.6, respectively. So far true holographic experience is limited by high‐order overlapping and twin images. Through this approach, a technical method is suggested for overcoming such obstacles and accomplishing advanced holographic display.

Atomic orbitals modulated dual functional bimetallic phosphides derived from MOF on MOF structure for boosting high efficient overall water splitting

The electronic modulation characteristics of efficient metal phosphide electrocatalysts can be utilized to tune the performance of oxygen evolution reaction (OER). However, improving the overall water splitting performance remains a challenging task. By building metal organic framework (MOF) on MOF heterostructures, an efficient strategy for controlling the electrical structure of MOFs was presented in this study. ZIF-67 was in-situ synthesized on MIL-88 (Fe) using a two-step self-assembly method, followed by low-temperature phosphorization to ultimately synthesize FeP-CoP3 bimetallic phosphides. By combining atomic orbital theory and theoretical calculations (density functional theory), the results reveal the successful modulation of electronic orbitals in FeP-CoP3 bimetallic phosphides, which are synthesized from MOF on MOF structure. The synergistic impact of the metal center Co species and the phase conjugation of both kinds of MOFs are responsible for this regulatory phenomenon. Therefore, the catalyst demonstrates excellent properties, demonstrating HER 81 mV (η10) in a 1.0 mol L−1 KOH solution and OER 239 mV (η50) low overpotentials. The FeP-CoP3 linked dual electrode alkaline batteries, which are bifunctional electrocatalysts, have a good electrocatalytic ability and may last for 50 h. They require just 1.49 V (η50) for total water breakdown. Through this technique, the electrical structure of electrocatalysts may be altered to increase catalytic activity.

Multifunctional electrically switchable metalens

Here, we propose three all-solid-state, electrically switchable, transmissive, and multifunctional metalens arrays comprising tunable metal-oxide material BaTiO3 (BTO) nanopillars with different structural parameters. To produce the required phase profile for each metalens, the rectangular nanopillars, as the unit cell of the BTO structure, are developed to support arbitrary combinations of two independent phase shifts (0−2π) with bias voltage states of 0 V and 60 V, at first. Second, the structure parameters of different functional metalens arrays are generated efficiently and accurately based on the dual-phase modulation characteristics of a single structure. Finally, we use the finite-difference time-domain method to simulate the three kinds of switchable metalenses. The results show that the three metalenses can realize the function of adjustable focus position, switchable beam focusing and beam deflection, and switchable beam focusing and beam splitting.

Single-pulse Emissions of PSRs J1611–0114 and J1617+1123

In this paper, the emissions from two pulsars, PSRs J1611−0114 and J1617+1123, were investigated using the Five-hundred-meter Aperture Spherical radio Telescope operating at a central frequency of 1250 MHz. The average pulse profile of PSR J1611−0114 shows two components, the first of which is relatively weak in intensity. The two-dimensional pulse stack exhibits an obvious nulling phenomenon, with an estimated nulling fraction of 40.1% ± 5.4%. The durations of the nulls and bursts are consistent with power-law distributions, and no periodic nulling phenomenon is found. The results from PSR J1617+1123 demonstrate that the average pulse profile is composed of four components. The peak intensity of the fourth component varies significantly, causing an unstable integrated profile. In addition, the modulation characteristics of J1611−0114 and J1617+1123 were studied by analyzing the modulation index, longitude resolved fluctuation spectrum and two-dimensional fluctuation spectrum using the software PSRSALSA. It was found that the two pulsars exhibit intensity modulation. In particular, J1611−0114 displays even–odd modulation, with the modulation period of approximately two pulses. The modulation period of J1617+1123 is relatively broad. There is an obvious subpulse drift phenomenon, and the value of P 2 is ∼0.125c/P 0, corresponding to 12 pulse longitude bins, and the drift rate (P 2/P 3) is about 0.29.

Whistle or squeal? Distinguish and evaluate two typical abnormal sounds of collaborative robots

The whistle and squeal are two typical abnormal sounds among the radiated noise of running collaborative robots, indicating potential faults and causing discomfort through auditory perception. This study investigated whether psychoacoustic parameters for sound quality could distinguish the whistle and squeal and evaluate their discomfort. A total of 20 abnormal sound stimuli, including 6 whistles and 14 squeals, were obtained from various collaborative robots. The cepstrum characteristics and sound quality metrics (i.e., roughness, sharpness, fluctuation strength and tonality) of all stimuli were analyzed by controlling the equal loudness. Twenty-four participants rated the 'discomfort of abnormal sound in the stimuli' on an 11-point scale. The results show that the modulation frequencies of the fundamental frequency of the whistles were 2.9 Hz to 5.5 Hz, whereas the squeals had no obvious modulation characteristics. The modulation frequencies of the fundamental frequency were highly correlated (with a correlation coefficient of 0.89) to the discomfort responses for whistles, whereas tonality was significantly correlated (with a correlation coefficient of 0.82) to the discomfort responses for squeals. The linear models using single dependent variables of modulation frequency in cepstrum and tonality had determination coefficients of 0.77 and 0.66, respectively, in evaluating the discomfort of whistles and squeals.

Triple plasmon induced transparency based on multilayer graphene metamaterials

In this study, a novel multilayer terahertz metamaterial with four graphene sub-structures is designed to achieve dynamically tunable triple plasmon-induced transparency (PIT) due to interference among bright-bright modes. Coupled mode theory (CMT) and finite-difference time-domain (FDTD) simulations show a high degree of consistency in their results. Interestingly, enhanced transmission dips are observed when various graphene structures couple with the two longitudinal graphene strips at the bottom layer. Based on the dynamic modulation characteristics of graphene, the metamaterial demonstrates seven-band optical switching capabilities, achieving modulation depths (MD) of 94.6%, 88.1%, 90.8%, 90.8%, 90.4%, 86.6%, and 87.5%. Additionally, the proposed graphene metamaterial also shows excellent slow-light effects, with a group index reaching up to 1034. This proposed terahertz metamaterial holds significant theoretical implications for the development of dynamically integrated terahertz optoelectronic devices.

Sidelobes and sideband minimization in time-modulated array antenna based on chaotic exchange nonlinear dandelion optimization algorithm

Time-modulated array antenna (TMAA) is a new type of array antenna based on time modulation technology. By introducing "time" as the fourth dimensional design freedom into the design of conventional array antennas in three-dimensional space, the array antenna has time modulation characteristics, which better controls the radiation characteristics of the array antenna and achieves the best far-field radiation pattern synthesis. This paper designs a Time-modulated linear array (TMLA) with low sidelobe level (SLL) and low sideband level (SBL) based on the chaotic exchange nonlinear dandelion optimization (CENDO) algorithm. Three optimization methods are studied: firstly, determining the optimal on-time (τnn) for each array element; The second is to determine the optimal on-time (τnn) and optimal uniform array element spacing (d) for each array element; The third is to determine the optimal opening time (ton), closing time (toff), and optimal uniform array element spacing (d) for each array element. To achieve simultaneous reduction of sidelobe level and suppression of harmonic interference. The same array model contains different harmonic frequency radiation. In this article, we only considered two harmonic frequencies, namely the first sideband frequency and the second sideband frequency. Because the harmonic of other sideband frequencies has a very small impact on the radiation of the fundamental wave, it can be ignored. To demonstrate the stronger ability of the CENDO algorithm in optimizing Time-modulated array antennas, and in line with the principle of fairness and impartiality, this paper also simulates different Time-modulated array models and compares the results of the CENDO algorithm with other published literature. It is concluded that this study shows lower SLL and lower SBL in different models. This provides a more scientific and accurate explanation of the superiority of the CENDO algorithm compared to other algorithms in the field of antenna optimization in electromagnetics. At the same time, this also provides great research value and fundamental support for designing high-performance Time-modulated array antennas in subsequent engineering applications.

Nonlinear Optical Response of Au/CsPbI3 Quantum Dots and Its Laser Modulation Characteristics at 2.7 μm.

A passively Q-switched Er:YAP laser of 2.7 µm, utilizing Au-doped CsPbI3 quantum dots (QDs) as a saturable absorber (SA), was realized. It was operated stably with a minimum pulse width of 185 ns and a maximum repetition rate of 480 kHz. The maximum pulse energy and the maximum peak power were 0.6 μJ and 2.9 W, respectively, in the Q-switched operation. The results show that the CsPbI3 QDs SA exhibits remarkable laser modulation properties at ~3 μm.

The nonlinear optical property of bandgap-tunable TMDs-PdSe2: Toward a generation mode for near-infrared ultrashort laser pulses

Two-dimensional (2D) transition metal chalcogenides (TMDs) materials have been more and more important in various research fields such as nanoelectronics, spintronics, ultrafast photonics, etc. Optical materials with compositive functions have always been desired. This work successfully verified that 2D PdSe2 nanosheets have adjustable layers and tunable bandgaps. Besides, by using the 2D PdSe2 nanosheets as saturable absorption devices in a 2 μm solid-state laser, it is discovered that the 2D PdSe2 shows obvious nonlinear saturable absorption characteristics. Moreover, in the 2 μm Q-switched mode-locked laser, an ultrashort pulse laser output of 486.5 ps was achieved, proving the excellent ultrafast modulation characteristics of PdSe2. To insight into the relationship between the structure and its optical performances, theoretical modeling and calculations were implemented based on the layered structure of PdSe2. All the above indicates that the 2D PdSe2 could be promising saturable absorption devices and ultrafast photonic devices, which may promote the development of ultrashort lasers.

Electrically tunable third-harmonic generation using intersubband polaritonic metasurfaces

Nonlinear intersubband polaritonic metasurfaces, which integrate giant nonlinear responses derived from intersubband transitions of multiple quantum wells (MQWs) with plasmonic nanoresonators, not only facilitate efficient frequency conversion at pump intensities on the order of few tens of kW cm-2 but also enable electrical modulation of nonlinear responses at the individual meta-atom level and dynamic beam manipulation. The electrical modulation characteristics of the magnitude and phase of the nonlinear optical response are realized through Stark tuning of the resonant intersubband nonlinearity. In this study, we report, for the first time, experimental implementations of electrical modulation characteristics of mid-infrared third-harmonic generation (THG) using an intersubband polaritonic metasurface based on MQW with electrically tunable third-order nonlinear response. Experimentally, we achieved a 450% modulation depth of the THG signal, 86% suppression of zero-order THG diffraction tuning based on local phase tuning exceeding 180 degrees, and THG beam steering using phase gradients. Our work proposes a new route for electrically tunable flat nonlinear optical elements with versatile functionalities.

Application of graphene-based metasurface plasma-induced transparency in terahertz band optical switches

In this paper, a monolayer graphene-based metasurface that can achieve plasma-induced transparency (PIT) is proposed. This metasurface consists of a horizontal strip and a pair of vertical ribbons. The simulation results of Finite-Difference Time-Domain (FDTD) method perfectly match with the theoretical results based on Coupled-mode Theory (CMT). Based on the dynamic modulation characteristics of graphene, an optical switch is studied with a vibration amplitude of 94.7%, 89.59% and 89.58%, corresponding to frequencies of 3.34 THz, 3.86 THz and 4.36 THz, respectively. The proposed graphene-based metasurface has potential applications in mid-infrared photoconducting devices, this work has a certain theoretical significance for the development of terahertz dynamic integrated photonic devices.

Photodetectors Based on MASnI3/MoS2 Hybrid-Dimensional Heterojunction Transistors: Breaking the Responsivity-Speed Trade-Off.

Hybrid-dimensional heterojunction transistor (HDHT) photodetectors (PDs) have achieved high responsivities but unfortunately are still with unacceptably slow response speeds. Here, we propose a MASnI3/MoS2 HDHT PD, which exhibits the possibility to obtain high responsivity and fast response simultaneously. By exploring the detailed photoelectric responses utilizing a precise optoelectronic coupling simulation, the electrical performance of the device is optimally manipulated and the underlying physical mechanisms are carefully clarified. Particularly, the influence and modulation characteristics of the trap effects on the carrier dynamics of the PDs are investigated. We find that the localized trap effect in perovskite, especially at its top surface, is primarily responsible for the high responsivity and long response time; moreover, it is normally hard to break such a responsivity-speed trade-off due to the inherent limitation of the trap effect. By synergistically coupling the photogating effect, trap effect, and gate regulation, we indicate that it is possible to achieve an enhancement of the responsivity-bandwidth product by about 3 orders of magnitude. This study facilitates a fine modulation of the responsivity-speed relationship of hybrid-dimensional PDs, enabling breaking the traditional responsivity-speed trade-off of many PDs.

Synthesis, electro‐optic properties, and performance of novel fluorinated polyurethaneimide

AbstractUrethane imide anhydride oligomers with terminal groups as anhydride groups were designed and synthesized using second‐order nonlinear optical chromophore molecule, bisphenol AF‐type diethylidene dianhydride, and toluene diisocyanate as monomers. Polyurethaneimide (PUI) second‐order nonlinear optical polymers with the structure of imide and amino ester chain segments were then synthesized by the polycondensation reaction between urethane imide anhydride oligomers and aromatic diamine monomers. The glass transition temperature (Tg) of PUI reached 186°C, and the 5% heat‐loss decomposition temperature was 320°C. The corona‐polarized PUI had an electro‐optic (EO) coefficient (γ33) of 82 pm/V tested by the reflection method. The loss of light transmission of the polymer waveguide prepared with PUI as electro‐optical material was 1.13 dB/cm at 1550 nm. Mach–Zehnder type polymer waveguide electro‐optical modulators have been prepared based on the properties of the electro‐optic material PUI. The fabricated polymer EO modulators had favorable electro‐optic modulation response performance for low‐frequency electrical signals. The good modulation characteristics of the manufactured electro‐optical modulators proved that the synthesized PUI was a waveguide polymer material with good comprehensive performance.Highlights Electro‐optic fluorinated polyurethaneimide was synthesized. Polyurethaneimide as core material, polymer waveguide EO modulators were fabricated. The prepared modulators had good electro‐optic modulation performance.

Variation of the metal-insulator phase transition temperature in VO2: An overview of some possible implementation methods

The great interest in VO2, which has stimulated a large number of studies and publications in recent decades, is caused by the reversible metal-insulator phase transition (MIT) that occurs at T = 68 °C and is accompanied by the transformation of a low-temperature dielectric (semiconductor) monoclinic phase into a high-temperature metallic phase with a rutile structure. Despite the ongoing discussion about the physical mechanism of this transition, the concomitant rapid change in the electrical and optical characteristics of the material by several orders of magnitude already finds numerous applications in optics, optoelectronics and sensors. At the same time, it became obvious that both the number and performance of the applications of VO2 would greatly increase, if it were possible to decrease the temperature of the phase transition without deterioration of other properties. This issue has become the subject of numerous studies. Mechanical stress and oxygen vacancies in the VO2 lattice, the concentration of free charge carriers, tuned by impurity doping or implantation, have been investigated and discussed as the main factors affecting the transition temperature. In this review, we intend to summarize and analyze the literature data on these ways, primarily those which are most efficient in influencing the transition temperature while maintaining a significant change in the modulation characteristics.

Toward accurate extraction of bearing fault modulation characteristics with novel time–frequency modulation bispectrum and modulation Gini index analysis

Rolling bearings are extremely critical rotating mechanical components, and when they fail, they can damage the equipment, causing safety threats or economic losses. Collecting and analyzing vibration signals of faulty bearings is a common fault diagnosis method. Modulation signal bispectrum (MSB) can utilize the inherent modulation characteristics of the signal to achieve fault feature recognition, but it is easily affected by strong background noise and other modulation signals, making it difficult to detect the fault feature frequency in the end. Based on this, a time–frequency modulation bispectrum (TFMB) method is proposed in this paper. The signal is first transformed into the time–frequency domain through short-time Fourier transform, retaining both time and frequency information. It reduces the amplitude of bispectral noise, highlights spectral lines related to fault information, and displays modulation information more clearly, making the demodulation results more accurate. Based on the characteristics of bispectrum, a two-dimensional singular value decomposition (2D SVD) strategy is designed to reduce the amplitude of the noise components in the bispectrum, and the relative change rate is proposed to automatically determine the number of effective singular values. At the same time, considering that the Gini index has good sparse property, the modulation Gini index (MGI) is proposed based on the Gini index, which can identify the repetitive pulses in the signal, suppress the random pulses and noise interference, and extract the modulation component. MGI can be used to evaluate the proportion of fault information contained in TFMB slices and select the optimal frequency slice. The simulation signal verifies the effectiveness of the method in fault diagnosis of rolling bearing, and the proposed method is applied to the diagnosis of rolling bearing outer ring fault, inner ring fault, and compound fault respectively. The experimental results show that the method can effectively reduce noise amplitude, enhance fault information in the bispectrum, and extract the optimal frequency slice to accurately detect bearing fault characteristic frequencies. The proposed method is compared with MSB detector, Fast Kurtogram and Autogram, which proves the superiority of TFMB method in extraction of rolling bearing fault characteristics.

A novel error modulation rotation scheme for dual-axis rotational inertial navigation system

Abstract Dual-axis rotational inertial navigation system (RINS) can effectively suppress the error accumulation of inertial navigation system, thereby improve the long-term navigation accuracy through rotating inertial measurement unit (IMU) according to corresponding rotation scheme. The navigation accuracy of RINS is predominantly contingent on the IMU rotation scheme. A reasonable rotation scheme can effectively attenuate or even obviate the navigation errors stemming from IMU errors, whereas an ill-considered scheme may lead to swift divergence of navigation errors. In this paper, the principle of IMU errors suppression is meticulously analyzed during rotation. By comprehensively evaluating the impact of individual IMU errors on navigation accuracy alongside their corresponding error modulation characteristics, a novel 32-position rotation scheme is devised. The proposed scheme demonstrates a notable capacity to minimize the adverse effects of IMU errors on navigation accuracy and to enhance error suppression efficacy within a modulation cycle. Meanwhile, the long-endurance navigation accuracy of RINS is substantially enhanced. The efficacy of the 32-position scheme posited herein is empirically substantiated through a 24 h simulation and navigation experiment.

Anti-Inflammatory Effects of Paraprobiotic Lactiplantibacillus plantarum KU15122 in LPS-Induced RAW 264.7 Cells.

Inflammation is a biodefense mechanism that provides protection against painful conditions such as inflammatory bowel disease, other gastrointestinal problems, and irritable bowel syndrome. Paraprobiotics have probiotic characteristics of intestinal modulation along with merits of safety and stability. In this study, heat-killed Lactiplantibacillus plantarum KU15122 (KU15122) was investigated for its anti-inflammatory properties. KU15122 was subjected to heat-killed treatment for enhancement of its safety, and its concentration was set at 8 log CFU/mL for conducting different experiments. Nitric oxide production was most remarkably reduced in the KU15122 group, whereas it was increased in the LPS-treated group. In RAW 264.7 cells, KU15122 inhibited the expression of inducible nitric oxide synthase, cyclooxygenase-2, interleukin (IL)-1β, IL-6, and tumor necrosis factor-α. ELISA revealed that among the tested strains, KU15122 exhibited the most significant reduction in PGE2, IL-1β, and IL-6. Moreover, KU15122 inhibited various factors involved in the nuclear factor-kappa B, activator protein-1, and mitogen-activated protein kinase pathways. In addition, KU15122 reduced the generation of reactive oxygen species. The anti-inflammatory effect of KU15122 was likely attributable to the bacterial exopolysaccharides. Conclusively, KU15122 exhibits anti-inflammatory potential against inflammatory diseases.

Ternary ReS2(1-x)Se2xalloys of different composition for Q-switched and mode-locked all-fiber laser.

This paper systematically studied the composition-controlled nonlinear optical properties and pulse modulation of ternary ReS2(1-x)Se2xalloys for the first time. The compositionally modulated characteristics of ReS2(1-x)Se2xon the band gap were simulated based on the first principles. We investigated the effect of the band gap on the saturable absorption properties. In addition, we demonstrated the modulation characteristics of different components ReS2(1-x)Se2xon 1.5μm Q-switched pulse performance. The Q-switched threshold, repetition rate, and pulse duration increase as the S(sulfur)-element composition rise. And pulse energy also was affected by the S(sulfur)-element composition. The ReS0.8Se1.2SA was selected to realize a conventional soliton with high energy in the all-fiber mode-locked laser. The pulse was centered at 1562.9 nm with a pulse duration of 2.26 ps, a repetition rate of 3.88 MHz, and maximum pulse energy of 1.95 nJ. This work suggests that ReS2(1-x)Se2xhas great potential in laser technology and nonlinear optics, and widely extends the material applications in ultrafast photonics.

Closed-loop optogenetic neuromodulation enables high-fidelity fatigue-resistant muscle control.

Closed-loop neuroprostheses show promise in restoring motion in individuals with neurological conditions. However, conventional activation strategies based on functional electrical stimulation (FES) fail to accurately modulate muscle force and exhibit rapid fatigue because of their unphysiological recruitment mechanism. Here, we present a closed-loop control framework that leverages physiological force modulation under functional optogenetic stimulation (FOS) to enable high-fidelity muscle control for extended periods of time (>60 minutes) in vivo. We first uncovered the force modulation characteristic of FOS, showing more physiological recruitment and significantly higher modulation ranges (>320%) compared with FES. Second, we developed a neuromuscular model that accurately describes the highly nonlinear dynamics of optogenetically stimulated muscle. Third, on the basis of the optogenetic model, we demonstrated real-time control of muscle force with improved performance and fatigue resistance compared with FES. This work lays the foundation for fatigue-resistant neuroprostheses and optogenetically controlled biohybrid robots with high-fidelity force modulation.

Patients' Preferences for Sphingosine-1-Phosphate Receptor Modulators in Multiple Sclerosis Based on Clinical Management Considerations: A Choice Experiment.

Several sphingosine-1-phosphate receptor (S1PR) modulators are available in the US for treating relapsing forms of multiple sclerosis (RMS). Given that these S1PR modulators have similar efficacy and safety, patients may consider the clinical management characteristics of the S1PR modulators when deciding among treatments. However, none of the S1PR modulators is clearly superior in every aspect of clinical management, and for some treatments, clinical management varies based on a patient's comorbid health conditions (e.g., heart conditions [HC]). This study aimed to determine which S1PR modulator patients with relapsing-remitting multiple sclerosis (RRMS) would prefer based on clinical management considerations, and to estimate how different clinical management considerations might drive these preferences. Preferences were explored separately for patients with and without comorbid HC. A multicriteria decision analysis was conducted on S1PR modulators approved to treat RMS: fingolimod, ozanimod, siponimod, and ponesimod. Clinical management preferences of patients with RRMS were elicited in a discrete choice experiment (DCE) in which participants repeatedly chose between hypothetical S1PR modulator profiles based on their clinical management attributes. Attributes included first-dose observations, genotyping, liver function tests, eye examinations, drug-drug interactions, interactions with antidepressants, interactions with foods high in tyramine, and immune system recovery time. Preferences were estimated separately for patients with HC and without HC (noHC). Marginal utilities were calculated from the DCE data for each attribute and level using a mixed logit model. In the multicriteria decision analysis, partial value scores were created by applying the marginal utilities for each attribute and level to the real-world profiles of S1PR modulators. Partial value scores were summed to determine an overall clinical management value score for each S1PR modulator. Four hundred patients with RRMS completed the DCE. Ponesimod had the highest overall value score for patients both without (n=341) and with (n=59) HC (noHC: 5.1; HC: 4.0), followed by siponimod (noHC: 4.9; HC: 3.3), fingolimod (noHC: 3.4; HC: 2.8), and ozanimod (noHC: 0.9; HC: 0.8). Overall, immune system recovery time contributed the highest partial value scores (noHC: up to 1.9 points; HC: up to 1.2 points), followed by the number of drug-drug interactions (noHC: up to 1.2 points; HC: up to 1.7 points). When considering the clinical management of S1PR modulators, the average patient with RRMS is expected to choose a treatment with shorter immune system recovery time and fewer interactions with other drugs. Patients both with and without heart conditions are likely to prefer the clinical management profile of ponesimod over those of siponimod, fingolimod, and ozanimod. This information can help inform recommendations for treating RRMS and facilitate shared decision making between patients and their doctors.