As the ride-sourcing market expands, ride-sourcing fleets have increased urban traffic congestion, and in turn, road congestion is affecting ride-sourcing operations. It is crucial to incorporate this interaction mechanism into the operational decision of ride-sourcing systems. This mechanism can be described in detail by simulation models. Applying simulation-based optimization methods to the real-time operation of ride-sourcing systems is challenging due to the limitations of simulation efficiency. To tackle this issue, this study first proposes a modular simulation model combining time-driven and event-driven mechanisms. The simulation model comprises two layers: the traffic flow module at the bottom, defined by trip-based and multi-region macroscopic fundamental diagrams and cell transmission models, and the ride-sourcing operation module at the top, which considers the interaction between the traffic congestion and ride-sourcing operation and models the random behavior of passengers and drivers. We verify the efficiency and accuracy of the simulation model. The simulation model is utilized as an evaluator of the objective functions and performance measures. Then, we integrate the Bayesian optimization, parallel sampling, and rolling horizon approaches to develop an efficient and effective simulation-based optimization framework for the dynamic joint decision-making of matching radius, matching intervals, and threshold relocation strategies. Six groups of experiments for the traffic scenario in Berlin reveal some interesting findings. (1) The matching rate first increases and then decreases with the matching radius (a concave function), while the closest study does not think so. (2) As the fleet size grows, passenger waiting time reaches its minimum and then rises because of the increased endogenous congestion generated by ride-sourcing fleets. (3) The optimal operation strategy considering endogenous congestion not only leads to an increase in the system revenue and efficiency but also leads to congestion relief, even though the latter was not our initial objective. This benefit is the most pronounced when the fleet size and background traffic are moderate.
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