Aim: To compare the complications regarding modified Duhamel procedure in male to female children for Hirschsprung’s disease (HSCR).
 Methodology: This comparative retrospective study was done at pediatric surgery department PUMHSW Nawabshah during Jun 2019-Aug 2020. Sample size was selected as 70 patients and divided it into two groups. Group A contain 45 male children while group B also consists of 25 female children. The children between the age of 2-15 year, both sexes and confirm Hirschsprung’s disease was included in this study while the children below 2 years. The study was approved by ethical review board PUMHSW Nawabshah. Written informed consent was obtained from parents or guardians of the participants. 
 Results: There were 64.28% (n=45) male and 35.72% (25) female patients (Fig 1). The mean weight of patients in male was 17.8 ± 7.6 kg while in female was 15.6±6.27 kg (Fig 2). In the distribution of patients by complications, anorectal stenosis was present in 13.33% (n=6) in male while 12% (n=3) in female children. Wound infection was present in 8.88% (n=4) in male and 8% (n=2) in female children. Intestinal obstruction was present in 11.11% (n=5) and 12% (n=3) in male and female children respectively.
 Conclusion: It was concluded that modified Duhamel Procedure for Hirschsprung’s disease has less postoperative complications in both male and females moreover there is no significant difference of postoperative complications in both sexes.
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