One of the major causes of dental anxiety in children is their first impression of the dental environment. Even minor details, such as the choice of color in a dental setting and the color of dental equipment, can positively influence a child's behavior. The aim of the study was to assess the relationship between the emotions in children and color combinations in a pediatric setting. The study involved 200 children (99 boys and 101 girls) aged between 6 and 12 years who visited the dental clinics at the College of Dentistry, Jazan University, for the first time between November 2017 and January 2018. The participants were divided into 2 groups based on age. The younger children group included participants aged from 6 to 9 years, while the older children group included participants aged from 10 to 12 years. Anxiety levels were recorded using the Modified Dental Anxiety Scale. Colored pencils and images of emoticons were provided to all children, who were instructed to color the negative and positive emoticons with their preferred colors. The analysis of anxiety levels among children in both groups revealed statistically significant differences across sexes in the younger age group, with girls being more anxious than boys (p = 0.003). Additionally, a statistically significant difference was observed in the choice of colors by children of both sexes in 2 age groups (p = 0.001). Most children were inclined towards bright colors and used them to express their emotions. The incorporation of colors in a dental setting could invoke positive emotions in children. Hence, the use of colors in the workplace has the potential to ease anxiety.