Modification Of Function Research Articles

Morphological Alterations and Oxidative Stress Induction in Danio rerio Liver After Short-Term Exposure to the Strobilurin Fungicide Dimoxystrobin

Unlike many other fungicides, strobilurins are applied several times during the growing season for prophylactic purposes, thus heightening the risk of environmental contamination. In the EU, the dimoxystrobin approval period lasted for 17 years. It has been classified as moderately toxic to birds and highly toxic to earthworms, and it is suspected to be carcinogenic to humans. However, it is still commercialized in several countries. The effects of dimoxystrobin are still largely underexplored, with only three studies reporting sublethal alterations in fish. Here, we evaluated for the first time the effects of dimoxystrobin on zebrafish liver after short-term exposure (96 h) to two sublethal and environmentally relevant concentrations (6.56 and 13.13 μg/L), providing evidence of morphological, functional, and ultrastructural modifications. We revealed severe alterations encompassing three reaction patterns: circulatory disturbance, regressive and progressive changes, which also showed a dose-dependent trend. Furthermore, we revealed that dimoxystrobin induced a significant increase in lipid content, a decrease in glycogen granules and affected the defensive response against oxidative stress through a significant downregulation of SOD and CAT. The information presented here demonstrates that the hazardous properties of dimoxystrobin may result from several pathological events involving multiple targets. Our results also emphasize the importance of the combined use of morphological, ultrastructural and functional investigation in ecotoxicological studies.

Design and Study of Azobenzene‐Modified AESO Photopolymerization Coating for Information Reversible Storage Performance

ABSTRACTThe photo‐induced cis‐trans isomerization of azobenzene molecules, known for their significant color changes, is extensively utilized in the functional modification of polymeric materials. However, the research on the functionalization of biomass‐based polyesters with azobenzene is limited. A key raw material for biomass‐based coatings possess reactive double bonds and excellent film‐forming capabilities, offering significant advantages for azobenzene functionalization in biomass‐based polyester applications. In this study, AESO served as the polyester matrix and acrylate azobenzene derivatives as the functional molecules. Under ultraviolet radiation, AESO underwent a carbon–carbon crosslinking reaction with the azobenzene derivatives to synthesize a novel resin. The coating of this resin on a PET substrate exhibited excellent pencil hardness (3B), adhesion (5B), and solvent resistance. By alternating exposure to ultraviolet and blue light, the coating displayed reversible switching between cis and trans isomers, enabling reversible writing and erasing of patterns. Even after 20 cycles of writing and erasing, high‐resolution patterns could still be observed (clearly visible under a 12x microscope). Furthermore, the image could be retained for up to 2 h under sunlight irradiation. This study presents a new method for functionalizing biobased polyesters.

Cold plasma reengineers peanut protein isolate: Unveiling changes in functionality, rheology, and structure.

This study investigates the effects of cold plasma (CP) treatment on peanut protein isolate (PPI), focusing on functionality, rheology, and structural modifications across various treatment times (0, 90, 180, 270, 360, and 450 s) and voltages (120, 140, and 160 kV). Key findings include a significant increase in solubility from 9.99 mg/mL to 15.98 mg/mL, as well as 161.07 % enhanced water-holding capacity (WHC) and 448.45 % oil-holding capacity (OHC). CP treatment also improved foaming capacity (FC) to 186.46 % and increased emulsion capacity (EC) and emulsion stability (ES) by 185.90 % at 160 kV. Rheological analysis showed shear-thinning behaviour, with viscosity decreasing as the shear rate increased-higher voltages (140 kV and 160 kV) further reduced viscosity, indicating lower resistance to flow. Additionally, CP-treated PPI exhibited viscoelasticity, with increased storage and loss moduli at higher frequencies, indicating greater stiffness. Spectroscopic studies demonstrated shifts in the protein's secondary structure, altering the balance among alpha-helix, beta-sheet, and random coil components, which highlights CP's role in reengineering PPI. FTIR-ATR spectra revealed reductions in the 3200-3400 cm-1 range, suggesting changes in protein backbone vibrations and hydrogen bonding. Particle size analysis showed significant increases, especially at higher voltages and longer treatment times, stabilizing after 270 s. Zeta potential assays indicated a gradual decrease in negative surface charge, suggesting enhanced protein aggregation. Overall, CP treatment significantly improves the functional and rheological properties of PPI while inducing structural changes, making it more suitable for applications in the food and pharmaceutical industries.

Evolution of natural polymer nerve conduit technology in peripheral nerve repair: a narrative review

Peripheral nerve injury is a worldwide challenge in the clinic. Although autologous nerve is considered the gold standard for bridging large nerve defects (> 5 mm), donor-site morbidity, limited sources of donor nerves and other potential side effects restrict its application in nerve regeneration. Nerve guidance conduits have become increasingly popular as a promising alternative to autologous nerve repair and regeneration. The evolution of nerve guidance conduits from nondegradable materials to various biodegradable materials subsequently results in enhanced properties, such as superior biodegradability, a mimetic extracellular matrix and an optimal structure. This review describes current therapies for nerve repair and the mechanism and evolution of nerve guidance conduits with advantages and limitations; proposes the detailed requirements of ideal nerve guidance conduits; and emphasizes the applications of natural polymers, including collagen, chitosan, alginate, gelatin, silk fibroin and hyaluronic acid, in nerve regeneration with the incorporation of various functional materials, chemical modifications and feasible techniques to promote cell proliferation and axon regeneration. Compared with natural polymers, advanced nerve guidance conduits have considerable potential for nerve regeneration in the clinic.

Unveiling the ecological dominance of button mangrove (Conocarpus erectus L.) through microstructural and functional traits modifications across heterogenic environmental conditions

BackgroundThe button mangrove (Conocarpus erectus L.) is regarded as a peripheral species within mangrove communities. This particular species has the ability to thrive in regions that are arid or semiarid, where there is limited availability of nutrients. This study provides evidence of the ecological dominance of Conocarpus erectus across various habitats, highlighting its adaptability and success throughout the country of Pakistan. We collected twelve populations from four distinct ecological regions, including artificial forest plantations, agricultural fields, roadsides, and wastelands, offering a comprehensive assessment of C. erectus adaptability across diverse environmental contexts.ResultsForest plantation populations exhibited impressive shoot growth and moderate root lengths, with plants generally tall and well-weighted. Physiologically, they had moderate chlorophyll content and low carotenoid levels, with a balanced chlorophyll a/b ratio, indicating stable photosynthetic activity. Anatomically, these populations had thicker epidermal and cortical root layers but smaller vascular bundles and phloem regions. Stem and leaf structures were generally moderate in size, with thicker midribs and cortical layers in the leaves. Agricultural field populations showed robust shoot and root systems with balanced fresh and dry biomass. They exhibited high chlorophyll and carotenoid levels, indicating strong photosynthetic capacity. Root and stem anatomy revealed larger root areas, thicker cortex, and wide vascular bundles, reflecting enhanced structural development. Leaves from these populations had moderate midrib and cortical thickness, with larger stomatal areas, promoting efficient gas exchange. Roadside populations displayed deeper roots and reduced biomass production. These populations adapted to environmental stress through leaf expansion, with high leaf numbers and areas. Physiologically, populations had high chlorophyll content, with a high chlorophyll a/b ratio. Root and stem anatomy showed compact structures with smaller vascular bundles, indicating adaptation to harsher conditions. Leaf anatomy was moderate, with smaller vascular bundles and reduced water transport capacity. Wasteland populations exhibited poor growth and high shoot biomass despite small leaves. Physiologically, these populations had the highest total soluble protein and proline contents, reflecting stress adaptation. Anatomically, root and stem structures were variable, with some populations showing reduced cortical cell areas and smaller vascular bundles, indicating limited resource transport. Leaf structures had thicker lamina, thinner epidermal layers, and lower stomatal densities, reflecting adaptation to nutrient-poor soils.ConclusionThis study reveals the adaptability and thriving potential of Conocarpus erectus across varied habitats, providing key insights into its resilience and survival strategies. Understanding these adaptive traits can support habitat restoration, conservation planning, and improve species management in diverse environmental conditions, especially in response to climate change and habitat degradation.

Combination Using Magnetic Iron Oxide Nanoparticles and Magnetic Field for Cancer Therapy.

Iron oxide nanoparticles (MNPs) demonstrate notable benefits in magnetic induction, attributed to their distinctive physical and chemical attributes. Emerging cancer treatment utilizing magnetic fields have also gathered increasing attention in the biomedical field. However, the defects of difficult dispersion and poor biocompatibility of MNPs seriously hinder their application. In order to overcome its inherent defects and maximize the therapeutic potential of MNPs, various functionalized MNPs have been developed, and numerous combined treatment methods based on MNPs have been widely studied. In this review, we compare and analyze the common nanoparticles based on MNPs with different sizes, shapes, and functional modifications. Additionally, we introduced the therapeutic mechanisms of the strategies, such as magnetically controlled targeting, magnetic hyperthermia, and magneto-mechanical effect, which based on the unique magnetic induction capabilities of MNPs. Finally, main challenges of MNPs as smart nanomaterials were also discussed. This review seeks to offer a thorough overview of MNPs in biomedicine and a new sight for their application in tumor treatment.

Measurement of beauty production via non-prompt charm hadrons in p–Pb collisions at sNN = 5.02 TeV

The production cross sections of D0, D+, and Λc+ hadrons originating from beauty-hadron decays (i.e. non-prompt) were measured for the first time at midrapidity in proton–lead (p–Pb) collisions at the center-of-mass energy per nucleon pair of sNN = 5.02 TeV. Nuclear modification factors (RpPb) of non-prompt D0, D+, and Λc+ are calculated as a function of the transverse momentum (pT) to investigate the modification of the momentum spectra measured in p–Pb collisions with respect to those measured in proton–proton (pp) collisions at the same energy. The RpPb measurements are compatible with unity and with the measurements in the prompt charm sector, and do not show a significant pT dependence. The pT-integrated cross sections and pT-integrated RpPb of non-prompt D0 and D+ mesons are also computed by extrapolating the visible cross sections down to pT = 0. The non-prompt D-meson RpPb integrated over pT is compatible with unity and with model calculations implementing modification of the parton distribution functions of nucleons bound in nuclei with respect to free nucleons. The non-prompt Λc+/D0 and D+/D0 production ratios are computed to investigate hadronisation mechanisms of beauty quarks into mesons and baryons. The measured ratios as a function of pT display a similar trend to that measured for charm hadrons in the same collision system.

Recent Approaches to Modify the Interaction between Cement-based Materials and Electromagnetic Waves: Effectiveness of Functional Fillers and Structural Modifications

Recent Approaches to Modify the Interaction between Cement-based Materials and Electromagnetic Waves: Effectiveness of Functional Fillers and Structural Modifications

Development of the design and synthesis of metal-organic frameworks (MOFs) - from large scale attempts, functional oriented modifications, to artificial intelligence (AI) predictions.

Owing to the exceptional porous properties of metal-organic frameworks (MOFs), there has recently been a surge of interest, evidenced by a plethora of research into their design, synthesis, properties, and applications. This expanding research landscape has driven significant advancements in the precise regulation of MOF design and synthesis. Initially dominated by large-scale synthesis approaches, this field has evolved towards more targeted functional modifications. Recently, the integration of computational science, particularly through artificial intelligence predictions, has ushered in a new era of innovation, enabling more precise and efficient MOF design and synthesis methodologies. The objective of this review is to provide readers with an extensive overview of the development process of MOF design and synthesis, and to present visions for future developments.

Exploration of modified Polymers of Intrinsic Microporosity (PIM) for extracorporeal membrane oxygenator (ECMO)

Extracorporeal Membrane Oxygenation (ECMO) is the most important supporting therapy to rescue patients with respiratory distress syndrome (ARDS), for which the membrane oxygenator offers a place for CO2 and O2 exchange. Although Poly (4-methyl-1-pentene) (PMP) has been extensively used as ECMO material, the problems of protein adsorption fouling and the need for anticoagulation remain challenging for clinical applications. Additionally, the challenges associated with the functional modification of PMP material underscore the importance of finding a new material with excellent gas permeability and blood compatibility. On the other hand, Polymers of Intrinsic Microporosity (PIM) has been extensively studied in the field of gas separation due to their unique twisted helical structure and high free volume. However, its hydrophobic nature also raises concerns about its anti-fouling ability and hemocompatibility, which restricts the exploration of PIM in ECMO applications. Herein, we modify the PIM-1 membrane and study the hemocompatibility of PIM-1, carboxylated-PIM-1, and amidoxime-functionalized-PIM-1, and explore their gas permeability by molecular dynamics simulation and experimental verification. The modified PIM membranes exhibit remarkable comprehensive performance, including effective anti-protein adhesion and hemocompatibility, high oxygen permeability, and CO2 removal rate. Blood oxygenation tests also reveal that the modified membranes prepared in this work fully meet practical requirements, exhibiting great application potential.

In Vitro and In Vivo Antitumor Activities of Isothiourea and Cinnamic Acid Derivative with NOS/MCT Inhibitory Effect.

This work presents the method of synthesis and physicochemical characterization of isothiourea and cinnamic acid original derivative α-cyano-4-hydroxycinnamate 1-cyclohexanoy-l-2-ethylisothiourea (T1114). In studies of the cytotoxic and antitumor activity of T1114, it has been found that the combination in one molecular structure of NOS-inhibitory fragment (1-cyclohexanoyl-2-ethylisothiourea) and a fragment inhibiting monocarboxylate lactate transporters (MCT) (α-cyano-4-hydroxycinnamic acid) does not modify the cytotoxic activity of bifunctional NOS/MCT-inhibitor T1114 in vitro. But in vivo inhibition of NOS and MCT is able to realize effects on the tumor microenvironment and hypoxic tumor cells. Such structural and functional modification has significantly extended the antitumor activity of the new NOS/MCT inhibitor. The bifunctional compound not only realized a more pronounced antitumor effect, but also prevented the development of hypoxic adaptation in solid Ehrlich carcinoma and acquired the ability to overcome the resistance of mouse cervical cancer (RShM-5). Therefore, the combination of NOS-inhibitory, anti-vasculogenic and hypoxia-oriented toxic effects can create new opportunities in antiangiogenic therapy of malignant neoplasms.

Evaluation of the clinical course of hypertensive disorders against the background of subclinical hypothyroidism in pregnant women

Background. Hypertensive disorders during pregnancy, such as gestational hypertension and preeclampsia, pose significant health risks. They require a personalized treatment approach due to their multifactorial nature. The presence of subclinical hypothyroidism may exacerbate these risks, making thyroid function monitoring before and during pregnancy particularly important.The aim. To investigate the clinical features and severity of hypertension in newly diagnosed subclinical hypothyroidism among women in Andijan.Methods. A case-control study conducted from November 2022 to April 2023 included 272 pregnant women aged 18 to 40 years without chronic diseases. The main group comprised 88 women diagnosed with hypertension after the 20th week of pregnancy. The control group consisted of 184 women without hypertension. The study excluded HIV-positive women, as well as those with congenital anomalies or who had undergone surgical interventions on the genitourinary and cardiovascular systems. Socio-demographic and lifestyle characteristics of the participants were studied. The analysis revealed significant differences in age, activity level, place of residence, employment, and education, as well as a correlation between body mass index, health status, and hypertension severity.Results. The findings underscored the importance of thyroid function monitoring during pregnancy, linking hypertension to age, activity level, and obesity. This confirms the necessity for a comprehensive approach to pregnancy management, including thyroid function and lifestyle modifications.

Rheological behavior and release dynamics of pregelatinized pink potato starch modified by stearic acid.

The effects of stearic acid (5 %, 10 %, and 15 % w/w) and pregelatinized pink potato starch (20, 25, and 30 min) on complex formation, physicochemical properties, rheology, and release characteristics were investigated. Moisture content decreased from 14.26 % in pregelatinized starch to 13.25 %, 12.85 %, and 11.45 % in complexes with 5 %, 10 %, and 15 % stearic acid, respectively. Water-holding capacity dropped from 268.68 % to 128.26 %, 95.05 %, and 50.63 %, with increasing stearic acid concentrations. Swelling and solubility power also decreased, with swelling power reducing from 5.57 % to 3.45 % and solubility from 12.75 % to 10.34 %. Micromeritic evaluations showed improved flowability in starch-stearic acid complexes. X-ray diffraction revealed a V-type crystalline complex with characteristic peaks at 7°, 21°, 22°, and 24°, and additional peaks at 7° and 41°. FTIR spectra indicated complex formation with bands around 2917 and 1700 cm−1. FESEM imaging showed intact granules with irregular shapes and protruding amylose fragments. Rheological assessments indicated reduced viscosity and altered viscoelastic properties in the complexes. In-vitro release studies demonstrated controlled drug release, suggesting potential applications for targeted pharmaceutical delivery. This study emphasizes the functional modifications induced by stearic acid in pregelatinized starch, enhancing material properties for industrial and biomedical applications.

A Lightweight Barcode Detection Algorithm Based on Deep Learning

For existing situations of missed detections, false detections, and repeated detections in barcode detection algorithms in real-world scenarios, a barcode detection algorithm based on improved YOLOv8 is proposed. The EfficientViT block based on a linear self-attention mechanism is introduced into the backbone of the original model to enhance the model’s attention to barcode features. In the model’s neck, linear mapping and grouped convolution are used to improve the C2f module, and the ADown convolution block is utilized to modify the model’s downsampling, which reduces the model’s parameters and computational cost while improving the efficiency of model feature fusion. Finally, the reconstruction of the model’s detection head and the modification of the loss function are implemented to enhance the model’s training quality and reduce the model’s error in barcode detection. Experimental results indicate that the improved model exhibits an increase of 1.8% in recall rate and 1.9% in mAP50:95 for barcode localization and classification. The FPS is improved by 40 frames per second. The model’s parameter count is reduced by 74.2%, and FLOPs are decreased by 79.6%. Furthermore, the proposed model outperforms other models in terms of model size and barcode detection accuracy.

Abstract 4136614: The design of novel therapeutics that target the L-type calcium channel to prevent hypertrophic cardiomyopathy

Background: Hypertrophic cardiomyopathy (HCM) is an inherited autosomal dominant disease of the sarcomere. Pathogenic features include ventricular hypertrophy, increased myofilament calcium sensitivity, myocardial fibrosis, and diastolic dysfunction. At the level of the myocyte there is cytoskeletal disarray, hypercontractility and altered mitochondrial function. Mitochondrial dysfunction is considered to be a key driver in HCM pathology. Research question: We previously demonstrated that the L-type Ca 2+ channel plays a role in the development of HCM facilitated by a structural-functional communication with mitochondria that can be regulated via the alpha interaction domain (AID) of the channel. In search of a preventative HCM therapy, we explored the efficacy of amino acid peptide variants that correspond to the AID of the cardiac L-type Ca 2+ channel. Methods and Results: Consistent with in silico predictions , competition binding assays confirmed that 4 variant peptides bound with higher affinity to the beta subunit than the AID peptide. In vitro studies confirmed that 3 of the 4 peptides could decrease the characteristic hypermetabolic state in myocytes isolated from a murine model of human HCM ( cTnI-G203S ). In vivo treatment of cTnI-G203S mice with peptide variants prevented the development of HCM and the development of fibrosis, in the absence of alterations in blood pressure, or kidney and liver function or changes in behaviour. Of note, the peptide variants also significantly improved contractile function. Similar effects were measured in αMHC 403/+ mice expressing the MYH6 mutation. Conclusions: Here we describe a first in class therapy that uniquely targets the L-type Ca 2+ channel to modify mitochondrial function and prevent hypertrophic cardiomyopathy. The peptides may be effective for treatment of HCM broadly because the mechanism of action involves the modification of mitochondrial function and impaired energy metabolism that is a common characteristic and driver of the pathology.

Development of 3D-printed braces protocol for juvenile idiopathic scoliosis: From the torso measurement and mechanical properties to preliminary experience on fitting

Background: There has been no standard for a rapid prototyping process in manufacturing of the 3D-printed brace with respect to its design, biomechanical properties, procedures, and brace adjustment and fitting. Objective: Objective of this study was to develop the 3D-printed brace protocol for juvenile idiopathic scoliosis. Methods: With the help of the Torso Measurement Frame, the child stands still and is positioned with 1 of 2 manipulation techniques by the physician. Although the patient is in the corrected position, a hand-held scanner registers the three-dimentional (3D) torso, and then the brace is designed using computer aided design (CAD) model. Finite element analysis is used to determine the minimum required thickness of the brace. Acrylonitrile Butadiene Styrene (ABS) material (thermoplastic polymers) and DuraForm PA plastic (Nylon) material were printed by 2 different systems, respectively, and were tested using standard tensile test procedures. Results: The minimum thickness of the brace should be 2 mm to maintain a standard structural factor of safety twice that of the material failure strength. The strain in elongation was less for the ABS compared to the 3D-printed Nylon (6% vs. 14%), and the tensile strength was reduced more for ABS as compared to Nylon (42% vs. 14%). The ABS brace could not withstand changes in tension and cracked when drilled into, heat flared, or donned tightly. However, the Nylon brace improved strength and eliminated the vulnerable aspects. Conclusions: The Nylon material for the 3D-printed brace improved ease of adjustments in trimming, drilling, and heat modifications for better fit and function.

Construction of a genome-editing system for the thermophilic actinomycete streptomyces thermodiastaticus K5 strain.

Thermophilic actinomycetes significantly contribute to the terrestrial carbon cycle via the rapid degradation of lignocellulosic polysaccharides in composts. In this study, a genome-editing system was constructed for the thermophilic actinomycetes Streptomyces thermodiastaticus K5 strain, which was isolated from compost. The genome-editing plasmid (pGEK5) harboring niccase Cas9 was derived from the high-copy plasmid pL99 and used for the K5 strain. It was found that pGEK5 could easily be lost from the transformed clone through cultivation on apramycin-free medium and spore formation, enabling its reuse for subsequent genome-editing cycles. With the aid of this plasmid, mutations were sequentially introduced to two uracil-DNA glycosylase genes (Udg1 and Udg2) and one β-glucosidase gene (Bgl1). Thus, the genome-editing system using pGEK5 enables us to start the functional modification of this thermophilic actinomycete, especially for improved conversion of lignocellulosic biomass.

Investigating Molecular Junctions Based on Mixed Self-Assembled Monolayers to Understand the Impact of Intermolecular Interactions on Transport.

To interrogate the importance of intermolecular interactions on charge transport at the nanoscale, we investigate molecular tunnel junctions based on mixed self-assembled monolayers (SAMs) of 1-alkyl (CnT) thiols and their fluorinated counterparts (F-CnT) that have substantially different tunneling conductances. Experiments on mixed CnT1-x:F-CnTx SAMs between Au contacts reveal a strongly nonlinear (exponential) dependence of the tunneling conductance G on composition x, a behavior that is tempting to assign to the strong impact of intra-SAM intermolecular interactions. However, analysis suggests that the exponential dependence of G on x does not arise from intra-SAM intermolecular interactions, but instead emerges from the work function modification of the Au electrode which varies linearly with x.

Indole N-Linked Hydroperoxyl Adduct of Protein-Derived Cofactor Modulating Catalase-Peroxidase Functions.

Bifunctional catalase-peroxidase (KatG) features a posttranslational methionine-tyrosine-tryptophan (MYW) crosslinked cofactor crucial for its catalase function, enabling pathogens to neutralize hydrogen peroxide during infection. We discovered the presence of indole nitrogen-linked hydroperoxyl adduct (MYW-OOH) in Mycobacterium tuberculosis KatG in the solution state under ambient conditions, suggesting its natural occurrence. By isolating predominantly MYW-OOH-containing KatG protein, we investigated the chemical stability and functional impact of MYW-OOH. We discovered that MYW-OOH inhibits catalase activity, presenting a unique temporary lock. Exposure to peroxide or increased temperature removes the hydroperoxyl adduct from the protein cofactor, converting MYW-OOH to MYW and restoring the detoxifying ability of the enzyme against hydrogen peroxide. Thus, the N-linked hydroperoxyl group is releasable. KatG with MYW-OOH represents a catalase dormant, but primed, state of the enzyme. These findings provide insight into chemical strategies targeting the bifunctional enzyme KatG in pathogens, highlighting the role of N-linked hydroperoxyl modifications in enzymatic function.

Highly efficient iodine capture from vapor and water using UiO-66-X: Effects of functional group modifications

Radioactive iodine waste from the nuclear industry poses a critical threat to human health, and its effective capture has become an important research topic. In this study, modified UiO-66-X adsorbents (where X is ATA, BTA, or STA) were used to investigate the effects of the free functional groups in the UiO-66 skeleton on iodine capture in the vapor and solution states. The adsorption behavior revealed that the capture efficiency of UiO-66-ATA was substantially higher than that of UiO-66-BTA and UiO-66-STA because the electron-donating amino groups could enhance the I − I···π halogen bond interactions compared with the electron-withdrawing carboxyl and sulfonic acid groups. In addition, the pore volume of UiO-66-ATA was significantly higher than those of UiO-66-BTA and UiO-66-STA. In particular, the removal uptakes of UiO-66-ATA were 1108.1 mg/g (vapor phase) and 3601.9 mg/g (aqueous solution). This study is the first to investigate the effects of functional groups on the adsorption uptake of UiO-66 toward iodine. This efficient functional group modification strategy holds significant promise for the development of novel metal–organic framework adsorbents.