Mode Structure Research Articles

Coordinated Optimization and Management of Oxygen Content and Cathode Pressure for PEMFC based on Hybrid Nonlinear Robust Control

Cathode inlet and exhaust management remains a significant challenge in proton exchange fuel cell (PEMFC). Achieving optimal oxygen content in real-time through precise control of the inlet gas is crucial for maintaining optimal output. Additionally, coordinating the air inlet and exhaust to ensure consistent cathode and anode pressures is essential for balancing the internal stack pressure and preventing nitrogen penetration, thereby enhancing PEMFC’s stability and lifespan. This paper addresses these challenges by introducing a mixed control strategy based on a fifth-order nonlinear mathematical model of the PEMFC stack cathode. Two non-singular fast terminal sliding mode structure controllers are combined as control system to optimize oxygen content and pressure control under dynamic loading conditions. The non-singular terminal sliding mode structure ensures finite-time convergence while mitigating potential singularity issues associated with traditional terminal sliding modes. The results showcase the robustness and effectiveness of the proposed control method in managing load variations, external disturbances, and PEMFC uncertainties.

Dynamic characteristic of transonic aeroelasticity affected by fluid mode in pre-buffet flow

Transonic aeroelasticity remains a significant challenge in aerospace. The coupling mechanism of aeroelastic problems involving the coexistence of fluid modes and multiple structural modes still needs further investigation. For this purpose, we analysed the dynamic characteristic of a two-degree-of-freedom (2DOF) NACA0012 airfoil in pre-buffet flow. First, we constructed an aeroelastic reduced-order model, which can represent near-unstable transonic flow using the dominant fluid mode. Then, the flutter mechanism was investigated by studying the main eigenvalues of the model that vary with the natural pitching frequency. The results revealed that the existence of the fluid mode transitions the transonic flutter type from coupled-mode flutter to single-DOF (SDOF) flutter, which leads to a reduction in the flutter boundary. Under the effect of the fluid mode, the system produces six aeroelastic phenomena at different structural natural frequencies, including SDOF heaving/pitching flutter, heaving/pitching instability within coupled-mode flutter, forced vibration and stable state. Moreover, we identified two types of SDOF flutter in the 2DOF system. The first type corresponds to the traditional SDOF flutter, where the coupling of other modes has a small impact on the system's stability in most cases. However, within specific ranges of natural frequencies, this type of SDOF flutter may disappear due to coupling with other modes. The second type of SDOF flutter is characterized by strong coupling dominated by the unstable mode. It arises from the interaction among the flow, heaving and pitching modes, and does not manifest in the absence of any of these modes.

Impact of General Wellbeing, Working Conditions, Job and Career Satisfaction, Control at Work and Stress at Work on Burnout among Nurses of Pakistan

Purpose: The aim of this research is to focus on the Quality of work life of Nurses and see its impact on burn outs of Nurses especially during the course of Novel Covid -19 Pandemic in Pakistan. Design/Methodology/Approach: There were 257 nurses in the sample (female 149 and 108 male). Replicability is another factor that is taken into consideration for the credibility of this research to gain confidence through research of the same type that has been conducted. The purposive sampling is utilized to ensure that nurses have the necessary specialised knowledge, as well as the desire and potential to take part in the study and an awareness of the issues. Smart PLS version 4.0 for the structural equation mode has been utilized in the study. Findings: This study's findings corroborate that the quality of work life scales discussed here have an impact on the burnout of Pakistani nurses. These findings show that Pakistani nurses take stress at work positively influence their burnout while control at work and job and career satisfaction influence burnout negatively among them. Moreover, other findings reveal that working conditions and general wellbeing doesn’t affect burnout in Pakistani nurses which may be due to nature of their job or they got use to of these working conditions during Covid-19 by using Covid-19 preventive measures. Implications/Originality/Value: Nurse burnout and its psychological and social consequences are a major problem for all health care systems around the world. If we care about the stress at work due to their extra job responsibilities and give them empowerment at work as well as give them more incentives at jobs they will be more than happy to serve patients.

Experimental and numerical investigation of failure modes in RC frame structures designed using the equivalent linearization method

The codes of many countries currently employ the column-to-beam flexural strength ratio (CBFSR) based on frequent earthquake internal forces to achieve the expected strong-column-weak-beam (SCWB) ductile failure mode. However, real earthquake damage indicates a general failure to achieve SCWB. The design method based on frequent earthquake internal forces struggles to consider factors such as internal force redistribution and variable axial forces under rare earthquakes. Therefore, developing a seismic design method directly based on rare earthquake internal forces is crucial. The equivalent linearization method is a practical approach for obtaining the internal forces of RC frame structures under strong earthquakes without extensive nonlinear computations. In this paper, nonlinear finite element analyses of RC frame structures with expected SCWB failure modes under various structural parameters were conducted to obtain ductility coefficients under rare earthquakes. Using the equivalent linearization method based on secant stiffness, the equivalent stiffness and damping of beams and columns were calculated. Simplified parameters were determined for engineering applications to facilitate seismic design based on rare earthquake internal forces. Two RC frame structures were designed using both the equivalent linearization method and the CBFSR code method, and then subjected to pseudo-static low-cycle reciprocating loading tests. The study investigated failure modes and hysteretic energy dissipation, as well as overall stiffness and bearing capacity under earthquake conditions. Results showed that the equivalent linearization method can effectively direct RC frame structures to achieve the expected strong earthquake failure mode.The dynamic time history analysis was performed on finite element models of different heights, and the results indicated that the equivalent linearization method significantly reduced plastic hinge occurrences and ductility coefficients of column ends, resulting in improved seismic performance compared to the CBFSR code method.

Method for Constructing a Compact Component Mode Synthesis Model for Analyzing Nonlinear Normal Modes of Structures with Localized Nonlinearities

Abstract Nonlinear dynamics analysis is a crucial topic in mechanical and aerospace engineering. The analysis of nonlinear normal modes (NNMs) provides an effective mathematical tool for interpreting complex nonlinear vibration phenomena. Unlike the invariant normal modes of linear systems, NNMs often exhibit frequency-energy dependence and cannot be computed using the traditional eigen-decomposition method. Calculating NNMs relies on numerical methods that involve expensive iterative computations, especially for systems with numerous degrees-of-freedom. To relieve computational costs, this paper proposes a mode selection method for the component mode synthesis (CMS) technique to enable compact reduced-order modeling of structures with localized nonlinearities. The reduced-order model is then combined with a numerical continuation scheme to establish a low-cost NNM analysis framework. This framework can efficiently predict the NNMs of high-dimensional finite element models. The proposed framework is demonstrated on an I-shaped cantilever beam with localized nonlinear stiffness. The results show that the proposed approach can identify the key modes in the CMS modeling procedure. The NNMs of the nonlinear I-shaped beam structure can then be analyzed with a significant reduction in computational costs.

Numerical study of turbulent eddy self-interaction in tokamaks with low magnetic shear. Part I: Linear simulations

Abstract This study examines the impact of low and zero magnetic shear, along with rational values of safety factor, on linear mode behavior in tokamak plasmas. We focus on how magnetic field line topology and parallel domain length influence linear mode structures and growth rates as magnetic shear decreases. Our results
show that as magnetic shear is reduced to low values, linear modes can transition between different branches, significantly affecting their characteristics. At zero magnetic shear, accurate modeling requires precisely capturing magnetic topology, as small deviations near rational surfaces can greatly impact growth rates. These findings are extended to nonlinear simulations in a companion paper (Volčokas, 2024), revealing that long turbulent eddies and magnetic field line topology play a crucial role in turbulence self-interaction and plasma transport.

Efficacy of modal curvature damage detection in various pre-damage data assumptions and modal identification techniques

The efficacy of modal curvature approach for damage localization is discussed in the paper in the context of input data. Three modal identification methods, i.e., Eigensystem Realization Algorithm (ERA), Natural Excitation Technique with ERA (NExT-ERA) and Covariance Driven Stochastic Subspace Identification (SSI-Cov), and four methods of determining baseline data, i.e., real measurement of the undamaged state, analytical function, Finite Element (FE) model and approximation of current experimental mode shape, are considered. Practical conclusions are formulated based on analysis of two cases. The first is a laboratory beam with a notch and the second is a stonemasonry historic lighthouse with modern restoration in its upper part. The analysis shows that NExT-ERA and SSI-Cov in combination with approximation of current mode shape provide high efficacy in damage localization alongside relatively straightforward determination of baseline data. It proves that the construction of advanced FE models of a structure can be replaced with a much simpler method of baseline data acquisition. Furthermore, the research shows the structural mode shapes identified with ERA may not always indicate the presence of damage.

Hierarchical Intercalation of Solvated Tetrafluoroborate Anions into Graphite Electrodes: The Case Studies of Methyl Acetate and γ-Butyrolactone Solutions.

Intercalation of anions unlocks graphite as a positive material in energy storage devices, and the performance could be affected by solvents in solutions. In this context, it is vital to investigate the role of solvents in anion intercalation. Herein, a hierarchical intercalation phenomenon, in which different graphite intercalation compounds are generated in the same solution, is studied in lithium tetrafluoroborate (LiBF4) solutions of carboxylate ester solvents γ-butyrolactone (GBL) and methyl acetate (MA). The evolution modes of the graphite cathode structure during electrochemical intercalation and deintercalation are discussed via in situ X-ray diffraction (XRD) measurements. Based on this, the relationship between GICs and potentials, together with concentrations, is compared in detail. Furthermore, various graphite materials with different surface properties are applied to adjust the anions' solvation status inside graphite sheets.

Experimental investigation of the relation between operating conditions and offshore wind turbine drivetrain dynamics

Abstract This study investigates the impact of operating and environmental conditions on the vibration induced on an offshore wind turbine drivetrain. Furthermore, it explores the role of the dynamic response of the global wind turbine structure to vibration on the drivetrain. A prolonged experimental campaign dedicated to condition monitoring the drivetrain provides experimental vibration signals. These vibration signals are acquired under varying operating conditions across multiple locations of an offshore wind turbine drivetrain of a Belgian Offshore Wind farm and serve as the basis for analysis. The signals’ statistics facilitate establishing connections between dynamic behaviour and operational variables, such as active power, rotor speed, blade pitch angle, and turbulence intensity, sampled at every second and provided by Fast-SCADA. The initial phase of the analysis involves a comprehensive examination of various statistical properties of the vibration signals to link the drivetrain’s dynamic response to operational conditions. This exploration includes both active and standstill periods of the wind turbine. A comprehensive summary that relates the global vibration characteristics with the operating conditions is formed by scrutinizing the overall vibration signals. In the study’s second phase, a detailed investigation is conducted on the vibration signals recorded during standstill conditions. Investigation of standstill data ensures that the structural modes’ spectral content does not interfere with the machines’ kinematic content. The analysis of standstill data proceeds from determining the most energetic resonance frequencies through the average power spectral density of the vibration signals. These identified frequency bands enable a thorough exploration, revealing the interlink between the offshore wind turbine drivetrain’s dynamic response and the operating/environmental conditions.

Experimental study on acoustic and flame responses in an annular combustor under azimuthal force

This study investigates the flame dynamics of an annular combustor under various azimuthal acoustic forces. The experimental platform was applied to external azimuthal acoustic force through four loudspeakers installed on the wall outside the plenum. Experiments were conducted with an equivalence ratio of Ф = 0.71 and a combustion power of P = 9.5 kW. Therein, four loudspeakers were used to precisely control the acoustic pressure amplitude, spinning ratio, and spinning direction, which stimulated the first-order standing mode, spinning modes, and second-order standing mode acoustic mode of the plenum, respectively. Our analysis of flame dynamics and acoustic response characteristics was based on different azimuthal modes, combined with dynamic mode decomposition (DMD) of the flame image sequence and acoustic pressure signal. The results corroborate the consistency between the acoustic field quaternion analysis and the flame image sequence DMD results despite varied external forcing conditions. Specifically, the characteristics of the flame vary by the applied forces. Moreover, DMD results indicate that the flame structure of the eigenfrequency mode is asymmetrical in spinning modes and tilts in the direction of the pressure gradient.

Strain mode measurement of asphalt pavements using distributed fibre optic sensor data

This paper proposes a method for measuring strain modes in asphalt pavements using distributed fibre optic strain sensor data. A processing algorithm based on cross power spectral density (CPSD) was developed to utilize high spatial resolution strain data to determine the CPSD peak frequency and corresponding relative amplitude. The proposed method was applied in both laboratory and field settings, comparing the results of distributed fibre optic cables with those of accelerometers or theoretical solutions to validate accuracy. Local heating of asphalt structures was used to test the sensitivity of the measured strain modes to changes in material properties. The results demonstrate that different fibre optic cables can provide peak frequencies comparable to traditional accelerometers (±0.6 Hz). Additionally, they offer relative amplitude with a resolution of 1 cm, achieving a modal assurance criterion exceeding 0.95 when compared to theoretical strain mode shapes. The method also sensitively reflects material property changes at different positions within the asphalt structure. This indicates that the proposed approach can effectively measure strain modes in asphalt structures, offering a more detailed understanding of the distribution of structural properties compared to traditional methods.

Influence of isochronal heat treatment on spray-deposited mixed phase tin based thin films for ammonia gas sensor applications

The current work applied the spray pyrolysis (SP) approach to coat mixed-phase SnS thin films at 3500C, and then air annealed at 400,450,5000C for use in sensor and solar cells applications. A variety of methods were employed to evaluate the structural, morphological, compositional, optical, and electrical characteristics of synthesized mixed-phase films. Films annealed at 5000C are reported to have bigger crystal sizes, and all deposited SnS films exhibit the orthorhombic phase in addition to tetragonal phase of SnO2, with other visible secondary phases like SnS2,Sn2S3. Fourier transform infrared spectroscopy and Raman analyses verified the molecular structure and vibrational mode of SnS films. The Scanning electron microscopy tests reveal a consistent, size-varying two-dimensional flake like grain structure, while the optical studies show a variation in optical direct band-gap from 1.79-2.75eV. The Hall-effect shows that films subsequently annealed at 4000C have improved electrical properties. An efficient metal oxide semiconductor gas sensor was developed by applying mixed-SnS film on the conducting side of an indium tin oxide coated glass plate. To examine the sensor selectivity at room temperature, a variety of test gases, such as NO2, H2S, C2H5OH, NH3, were purged at different concentrations. The optimum working temperature and concentration for NH3 selective gas have been determined to be 3500C and 5ppm. The sensor sensitivity is found to be maximum at operating temperature of 2000C towards NH3 gas. An inexpensive, fabricated MOS-gas sensor based on mixed-phase SnS can be easily mass produced and may find potential applications in industrial and environmental monitoring.

Aerodynamic investigation of an S-shaped intake employing sweeping jet actuators based on proper orthogonal decomposition

The central curvature change of the S-shaped intake exacerbates the three-dimensional flow separation, resulting in total pressure and swirl distortions at the outlet. In this paper, an efficient active flow control technique, the sweeping jet actuator, was applied to control flow separation. The instantaneous characteristics of the flow field inside and outside the actuator were revealed by using validated numerical simulation methods. In addition, the effect of the sweeping jet on the aerodynamic performance of the S-shaped intake was investigated. Proper orthogonal decomposition (POD), an analysis method used to extract the main feature components of data, was applied to decompose the flow field structure at the S-shaped intake outlet in this study. The results highlight the external flow field characteristics of the actuator, with a jet sweeping range of up to ±40° and a sweeping frequency of 1 500 Hz, corresponding to a Strouhal number of 0.018. When the jet momentum coefficient is only 0.116%, the total pressure loss coefficient and pressure distortion index are reduced by 5.6% and 24.76%, respectively. This study demonstrates the critical role of momentum injection and discretization in inhibiting flow separation in the channel. The POD-based analysis indicates that a sweeping jet with high momentum can significantly enhance the energy in the flow passage and reduce the vorticity intensity of the first three modes. The stable mode structures exist near the outlet, exhibiting excitation frequency and frequency-doubling properties. The findings of this research provide essential input conditions for subsequent distortion studies.

Mechanism of airfoil stall flutter: New insights from global linear stability analysis

Stall flutter is a self-excited aeroelastic vibration phenomenon that occurs in lifting systems near the stall angle of attack, characterized by the distinct single-degree-of-freedom behavior. Despite its significance, this phenomenon remains not fully understood and is often vaguely attributed to nonlinear effects. To address this gap, the present study aims to reveal the underlying fluid–structure interaction mechanisms of stall flutter through global linear stability analysis (LSA). For this purpose, a reduced-order model (ROM)-based aeroelastic stability analysis framework is established using the autoregressive with exogenous input method. The ROM-based aeroelastic model provides a low-order representation of the coupled dynamics near the equilibrium steady state and can accurately capture the stability characteristics of the fluid-elastic system. It is found that as the angle of attack approaches the static stall angle, a low-frequency weakly stable fluid mode emerges, whose frequency is sufficiently lower than that of the von Kármán vortex shedding. The interaction between this fluid mode and the structure mode ultimately leads to the instability of the aeroelastic system at high reduced velocities, which is the fundamental cause of stall flutter. Moreover, dynamic mode decomposition is employed to successfully extract the spatial coherent structures and frequency characteristics of this low-frequency fluid mode, thereby confirming the validity of the LSA results. Further analysis indicates that, as the angle of attack decreases, this low-frequency fluid mode gradually weakens and eventually degenerates into more stable non-oscillatory fluid modes, resulting in structural stabilization and the cessation of stall flutter. Overall, the linear dynamic model accurately predicts the onset of instability and the vibration frequency of the airfoil, which challenges the traditional nonlinear perspectives and supports the feasibility of using linear control theory for stall flutter suppression in future research.

Prediction of fishbone linear instability in tokamaks with machine learning methods

Abstract A machine learning based surrogate model for fishbone linear instability in tokamaks is constructed. Hybrid simulations with the kinetic-magnetohydrodynamic (MHD) code M3D-K is used to generate the database of fishbone linear instability, through scanning the four key parameters which are thought to determine the fishbone physics. The four key parameters include (1) central total beta of both thermal plasma and fast ions, (2) the fast ion pressure fraction, (3) central value of safety factor q and (4) the radius of q = 1 surface. Four machine learning methods including linear regression, support vector machines (SVM) with linear kernel, SVM with nonlinear kernel and multilayer perceptron are used to predict the fishbone instability, growth rate and real frequency, mode structure respectively. Among the four methods, SVM with nonlinear kernel performs very well to predict the linear instability with accuracy ≈ 95%, growth rate and real frequency with R2 ≈ 98%, mode structure with R2 ≈ 98%.

On how finite β and three-dimensional magnetic perturbations affect the instability of toroidal ion temperature gradient mode

Abstract The effects of finite β (the ratio of plasma kinetic pressure to magnetic pressure) and three-dimensional (3D) magnetic perturbations (MPs) on the instability of toroidal ion temperature gradient (ITG) mode are studied in this work. The expression of ion magnetic drift frequency ω_di modified by the effects from both finite β and 3D MPs is firstly derived based on the local 3D equilibrium model. Then, under the assumptions of adiabatic electrons and localized mode structure around the outboard mid-plane (ϑ_p=0), the dispersion equation of the long wavelength toroidal ITG mode with considering the parallel ion dynamics is derived and solved. The results show that the distribution of ω_di around the outboard mid-plane, including both ω_(di,0)=├ ω_di ┤|_(ϑ_p=0) and ω_(di,0)^''≡├ (d^2 ω_di \/dϑ_p^2 )┤|_(ϑ_p=0) (twist parameter quantifying the degree of concave or convex of ω_di), is the key for affecting the toroidal ITG mode instability. The diamagnetic effects from finite β and the effects from 3D MPs can suppress the instability by reducing |ω_(di,0) |. Via reducing |ω_(di,0)^'' | under the prerequisite of unchanged sign of ω_(di,0)^'', there also exist stabilization effects on the instability from 3D MPs and the modification of local magnetic shear by finite β effects. In addition, the stabilization effects induced by reducing |ω_(di,0)^'' | are closely associated with the global magnetic shear. The mechanisms for the effects of finite β and 3D MPs on the instability of toroidal ITG mode revealed in this work are helpful to the comprehensive understanding of the relationship between internal kink mode induced non-axisymmetric flux surface distortion and internal transport barrier physics in tokamak plasmas.

In silico analysis of R2R3-MYB transcription factors in the basal eudicot model, Aquilegia coerulea

R2R3-MYBs are an important group of transcription factors that regulate crucial developmental processes across the plant kingdom; yet no comprehensive analysis of the R2R3-MYBs in the early-diverging eudicot clade of Ranunculaceae has been conducted so far. In the present study, Aquilegia coerulea is chosen to understand the extent of conservation and divergence of R2R3-MYBs as a representative of the family by analysing the genomic distribution, organization, gene structure, physiochemical properties, protein architecture, evolution and possible mode of expansion. Genome-wide analysis showed the presence of 82 putative homologues classified into 21 subgroups, based on phylogenetic analysis of full-length protein sequences. The domain has remained largely conserved across all homologues with few differences from the characterized Arabidopsis thaliana R2R3-MYBs. The topology of the phylogenetic tree remains the same when full-length protein sequences are used, indicating that the evolution of R2R3-MYBs is driven by the domain region only. This is supported by the presence of similar structures of exon–intron and conserved motifs within the same subgroup. Furthermore, comparisons of the AqcoeR2R3-MYB members with monocots and core-eudicots revealed the evolutionary expansion of a few functional clades, such as A. thaliana R2R3-MYB subgroup 6 (SG6), the upstream regulatory factors of floral pigment biosynthesis and floral color. The reconstructed evolutionary history of SG6-like genes across angiosperms highlights the occurrence of independent duplication events in the genus Aquilegia. AqcoeR2R3-MYB genes are present in all seven chromosomes of A. coerulea, most of which result from local and segmental duplications. Selection analysis of these duplicated gene pairs indicates purifying selection except one, and the physiochemical analyses of R2R3-MYBs reveal differences among the MYBs signifying their functional diversification. This study paves the way for further investigation of paralogous copies and their probable role in the evolution of different floral traits in A. coerulea. It lays the foundation for functional genomic studies of R2R3-MYBs in the basal eudicots and facilitates comparative studies among angiosperms. The work also provides a framework for deciphering novel genetic regulatory pathways that govern the diversity of floral morphology.

Test and simulation of high temperature resistant polyamide composite with single lap single bolt connection

The advancement of next-generation aerospace vehicles has presented new requirements and challenges for ensuring the structural integrity of aircraft components in extreme environments. Consequently, the utilization of high temperature resistant polyamide composite materials has become pivotal in the manufacturing of aerospace vehicle parts that operate under high temperatures (250 °C). As a critical connection technology for these materials, the mechanical behavior of bolted connection structures under high temperatures requires further investigation. In this paper, a combination of experimental and numerical simulation is used to investigate the load carrying capacity and failure mechanism of T700/BMP316 composite bolted joints at room temperature and 250 °C. The experimental results show that the ultimate load carrying capacity of the structure at 250 °C is only 13.1 % lower than that of the room temperature environment, indicating that the temperature softening effect of such composites is not significant. Scanning electron microscope (SEM) and computed tomography (CT) results indicate that the structural damage modes were the crushing of the hole edge fibers and matrix due to the extrusion by the bolts, as well as the interlaminar delamination damage. Temperature effects were taken into account for the composite principal structure and finite element modeling was performed using a combination of Pinho criterion and Cohesive model. Numerical simulations allow accurate prediction of the load-displacement response and damage pattern throughout the damage evolution phase. The high temperature test results and the developed finite element model involved in this study can support the design of new-generation aerospace vehicles.

Dynamic Responses and Damage of a Model Ship in Multi-Rock Grounding

Ship grounding onto multiple rocks is one of the scenarios where a ship may suffer severe hull damage, thus leading to some serious consequences, such as casualties, oil spill pollution, and property damage. Ship bottom raking is the most common and severe damage type in grounding caused by sharp rocks moving against the bottom plate. This paper investigates the dynamic responses of ship grounding onto multiple sharp rocks, which has rarely been studied in the literature. Nine ship grounding in-tank model tests were conducted to provide experimental data for ship grounding onto a single rock or multiple rocks. A simplified scaled ship model with replaceable bottom plating was designed and used in the model test. Some artificial cone rock models with a 1 mm tip radius and a 15° semi-apex angle were assumed. The damage modes of the bottom plating and motions during ship grounding onto multiple rocks were obtained and recorded in the model tests, as well as the longitudinal grounding resistances. The effects of the initial relative height of each rock and the size of rock distribution on the structural damage mode and dynamic response of a ship model in multi-rock ship grounding were investigated. In addition, the results obtained from single-rock and multi-rock ship grounding model tests are compared.

Investigating the Impact of the Parkinson’s-Associated GBA1 E326K Mutation on β-Glucocerebrosidase Dimerization and Interactome Dynamics Through an In Silico Approach

Heterozygous mutations or genetic variants in the GBA1 gene, which encodes for the β-glucocerebrosidase (GCase), a lysosomal hydrolase enzyme, may increase the risk of Parkinson’s disease (PD) onset. The heterozygous E326K form is one of the most common genetic risk factors for PD worldwide, but, to date, the underlying molecular mechanisms remain unclear. Here, we investigate the effect of the E326K on the structure, stability, dimerization process, and interaction mode with some proteins of the interactome of GCase using multiple molecular dynamics (MD) simulations at pH 5.5 and pH 7.0 to mimic the lysosomal and endoplasmic reticulum environments, respectively. The analysis of the MD trajectories highlights that the E326K mutation did not significantly alter the structural conformation of the catalytic dyad but significantly makes the structure of the dimeric complexes unstable, especially at lysosomal pH, potentially impacting the organization of the quaternary structure. Furthermore, the E326K mutation significantly impacts protein interactions by altering the binding mode with the activator Saposin C (SapC), reducing the binding affinity with the inhibitor α-Synuclein (α-Syn), and increasing the affinity for the Lysosomal integral membrane protein-2 (LIMP-2) transporter.