Transitioning from both the direct and indirect use of fossil fuels to the renewable and sustainable resources of the near future demands a focal shift in catalysis research - from investigating catalytic reactions in isolation to developing coupled reactions for modern chemical value chains. In this Perspective, we discuss the status and emerging prospects of coupled catalytic reactions across various scales and provide key examples. Besides being a sustainable and essential alternative to current fossil-based processes, the coupling of catalytic reactions offers novel and scalable pathways to value-added chemicals. By emphasizing the specific requirements and challenges arising from coupled reactions, we aim to identify and underscore research needs that are critical to expedite their development and to fully unlock their potential for chemical and fuel production.