One of the most expected manifestations of globalization has become a noticeable intensification of regionalization trends, which are characterized by the dominance of locally oriented values and priorities. The purpose of the article is the analysis of methodological approaches to the study of the modern stage of the development of globalization transformations in the world, which was called "global regionalization", the representation of conceptual guidelines for its study in the context of modern spatial paradigms, the rethinking of the categories of territoriality and regionalism, tracing the influence of global regionalization trends on the development of modern security strategies. The research hypothesis is focused on defending the priority role of global regionalization in the processes of forming the axial coordinates of the new system of structuring of the global world, creating mechanisms of geopolitical balance and security, determining the main trends and factors of fragmentation of the geopolitical space. It has been proven that the ruptures in regional structures caused by neo-turbulence are accompanied by an intense but not problem-free "superstructure" of the global level over the system of international relations. Significant acceleration of the pace of transformational changes under the influence of military conflicts and confrontations conditions the perception of the world system as a global-regional dynamic object and rethinking of existing theories of security development. The study of the content and forms of territorialization using the methodological tools of global regionalism will make it possible to integrate both theoretical approaches to the understanding of the modern stage of the development of globalization processes, and to actualize regional practices related to the safety of human life in the modern global-regional space.