Significant Moderate Correlation Research Articles

Humeral retroversion, shoulder range of motion, and functional mobility in striking martial arts athletes

The aim of the study was to evaluate humeral retroversion, shoulder range of motion, and functional mobility in karatekas, boxers, kickboxers, and mixed martial arts fighters. This study investigated adaptive alterations in striking martial arts. Forty young healthy participants took part in the study. 20 people who professionally trained in boxing, kickboxing, karate, and Mixed Martial Arts (MMA) fighters (age: 23.5 ± 7.1, age of participation 11.8 ± 3.65, sports experience 9.55 ± 5.13, body weight 79.2 ± 13 kg, BMI 24.4 ± 3.3) were qualified for the group of athletes. 20 people (age: 27 ± 5.5, body weight 79.4 ± 7.4, BMI 24.5 ± 1.2) were included in the control group, who had no previous experience with striking combat sports. An ultrasound device and a digital inclinometer were used for the examination of the humeral retroversion angle. The mobility of the shoulder was also tested using the Functional Movement Screen (FMS). There was a significant (p < 0.001, r = 0.92) asymmetry between the dominant and non-dominant limb in the humeral retroversion angle in the athlete group. A statistically significant moderate correlation (p < 0.05) was found between the value of the retroversion angle and the range of motion of passive and active internal rotation, and external rotation, and the shoulder mobility in the FMS test. However, there were no statistically significant differences (p > 0.05) in the humeral retroversion angles between groups. The striking martial arts athletes do not exhibit significant differences in humeral retroversion compared to non-athletes, however they display notable asymmetry between limbs, with higher values in the non-dominant arm. Additionally, the observed correlation between humeral retroversion and shoulder rotation range of motion highlights the potential impact of humeral retroversion on upper limb performance and injury risk.

Changes in Immunoglobulins G and A in the Saliva and Serum of Horses with Equine Gastric Ulcer Syndrome (EGUS) and Their Relationship with Other Immune and Redox Status Biomarkers

Equine Gastric Ulcer Syndrome (EGUS) is a widespread disease with a very high prevalence and importance in horses. It includes two conditions: Equine squamous gastric disease (ESGD), linked to acid disturbances, and Equine Glandular Gastric Disease (EGGD), associated with inflammation and immune system issues. In saliva, increased levels of immunological markers have been observed in this disease, indicating immune system involvement. In addition, changes in biomarkers of oxidative stress have been described. In horses, IgG and IgA are proteins that appear in saliva and serum and are considered to be the major proteins in specific immunity; however, their levels in horses with EGUS have not been previously studied. This report aims to evaluate IgG and IgA concentrations in the saliva and serum of horses with EGUS, measured by automated assays, and compare them with other biomarkers of the immune and oxidative stress system. This work validated the IgG and IgA assays in saliva and showed that IgA significantly increased in the saliva of horses with EGUS. When the correlation between IgG and IgA and other biomarkers of immune system issues and oxidative stress such as ADA, S100 A8-A9 (calprotectin), S100 A12 (calgranulin), uric acid, FRAS, and AOPP was studied, IgA in saliva showed a significant moderate correlation with adenosine deaminase, indicating its possible involvement in the immune reaction occurring in EGUS.

Relationship between Knowledge and Self-Efficacy of Type 2 Diabetes Mellitus Patients

Background: Diabetes Mellitus (DM) poses a significant threat to global health. According to the International Diabetes Federation (IDF) in the 10th edition of the Diabetes Atlas, DM has become one of the most rapidly escalating global health emergencies. In 2021, 537 million people in the world were living with DM. This number is projected to reach 643 million by 2030, and 783 million by 2045. Indonesia is in the top 10 countries with the most DM patients, reaching 10 million people. Self-efficacy in DM patients, shows the results that there are still many patients who have low efficacy. Objective: This study aims to investigate the relationship between knowledge and self-efficacy in patients with Type 2 Diabetes Mellitus. Methods: This quantitative research utilized a cross-sectional design involving 165 patients diagnosed with Type 2 Diabetes Mellitus undergoing outpatient treatment. A purposive sampling technique was applied, and data were analyzed using bivariate analysis to assess the relationship between knowledge and self-efficacy. The sample in this study amounted to 165 people with purposive sampling technique . The analysis method used was bivariate analysis to see the relationship between the independent variable and the dependent variable. Data were analyzed using SPSS software. Results: The results showed that a significant relationship with a positive direction, namely, the higher the value of knowledge the higher the value of self-efficacy, and the strength of the moderate correlation between knowledge and self-efficacy. With moderate correlation strength. The coefficient of determination is 0.228, which means that the knowledge variable affects self-efficacy by 22.8% for patients with type 2 diabetes mellitus. Conclusion: There is a significant relationship, positive direction and moderate correlation strength between knowledge and self-efficacy in patients with Type 2 Diabetes Mellitus. In this regard, nursing can provide a preventive effort on cognitive aspects such as providing education on the importance of self-efficacy.

Effect of cognitive training on selected gait parameters in patients with stroke

Background. Not only may early cognitive rehabilitation help stroke patients with their cognitive impairment, but it can also help patients restore their capabilities to do everyday activities. There isn’t much data on how cognitive training affects spatiotemporal gait variables in stroke survivors. Objective. To examine the impact of cognitive training on selected gait parameters in stroke patients. Subjects and Methods. Forty male and female patients with mild ischemic chronic stroke, ranging in age from 45 to 60 years, were recruited and distributed into two equal groups at random (G1 and G2). The Montreal Cognitive Assessment Scale (MOCA) and the Rehacom system were utilized to evaluate the patient’s cognitive function. The Biodex gait trainer device was utilized to measure several gait variables for all patients. Rehacom cognitive training and a selected physiotherapy program were administered to the study group (G1). The similar selected physiotherapy program utilized for the G1 was applied to the control group (G2). For eight weeks, the treatment was administrated three sessions each week, day after day. All variables were evaluated before- and after-intervention. Results. The step length and walking speed, as well as the MOCA scale score of G1, were significantly higher after treatment than those of G2 (p = 0.001). The correlation between step length and median reaction time (MRT) was moderate negative significant correlation (r = – 0.698, p = 0.001). Conclusion. Cognitive training has a beneficial impact on improving the selected spatiotemporal gait parameters in stroke patients.

Correlation of Diabetic Symptoms with Severity of Diabetes Mellitus in Middle-Aged Population

Purpose: To investigate the correlation of symptoms of Diabetes with the severity of Diabetes Mellitus (DM) in Middle-aged subjects with diabetes. Participants: 68 subjects with diagnosed diabetes mellitus between the ages of 40 and 60 with/without symptoms of neuropathy were included. Participants with neurological disease, recent surgical procedures or injuries to feet, vascular disease, and cognitive impairment were excluded. Method: In a cross-sectional observational study, a total of 68 middle-aged diabetic subjects were interviewed in terms of demographic data, Fasting Blood Sugar (FBS), Post-Prandial Blood Sugar (PPBS), HBA1c, duration of diabetes, and associated medical conditions. All participants were examined by the Michigan Neuropathy Screening Instrument (MNSI). MNSI consists of 2 parts. 1) questionnaire 2) clinical examination. Analysis: Statistical analysis was done by SPSS 20 &amp; Spearman correlation test was applied. Results: In mild diabetes, hba1c has a weak positive correlation (r=0.232) with MNSI-1 and a very weak positive (0.016) correlation with MNSI-2. In moderate diabetes, hba1c has significant(p=0.003) strong positive correlation (r=0.703) with MNSI-1 and significant (p=0.019) moderate positive correlation (r=0.0596) with MNSI-2. In severe diabetes, hba1c has significant (p=0.028) moderate positive correlation (r=0.532) with MNSI-1 and significant (p=0.034) moderate positive (0.515) correlation with MNSI-2 Conclusion: Diabetic symptoms are moderately correlated with moderate &amp; severe levels of Diabetes based on hba1c in the middle-aged population. Keywords: Diabetes Mellitus, Middle age, Diabetic symptoms, Michigan Neuropathy Screening Instrument.

Achieving theorical cardiorespiratory fitness is associated with high-volumen training in a phase II cardiac rehabilitation program

Abstract Background and Puropose Cardiac Rehabilitation (CR) is an interdisciplinary therapeutic program with demonstrated success rates in reducing cardiovascular outcomes. To obtain these benefits, it is important to achieve a level of cardiorespiratory fitness (CRFIt) that should be close to the ideal according to age and gender (theorical). The best way to measure it, is through VO2p, or with its surrogate value in METs-load. In our Phase II CR program, both aerobic and strength training is supervised 3 times per week, but emphasis is placed on weekly aerobic training volume (TVol) for a sufficient dose, in order to guarantee outcomes. Our hypothesis is that with adequate TVol, CRFit will be achieved at ideal levels (theorical). The aim of the study is to evaluate the safety and achievement in CRFit measured by METs-load in patients with heart disease during a high-volume Phase II CR program. Methods Quasi-experimental study of a comprehensive Phase II CR program in which patients were evaluated by initial and final exercise testing. Depending on the result, they were assigned for 4-6 weeks (4 to those patients with &amp;gt;5METs and 6 to those with &amp;lt;5METs) to 3 weekly concurrent training sessions (30 mins of aerobic at 70-85% of their heart rate reserve plus strength training), in addition to the corresponding educational, nutritional and psychological intervention. TVol was calculated by METs/week (METs-minute obtained by ergo or treadmill multiplied by 90 minutes). Progressions were made to achieve a weekly program average TVol&amp;gt;500 METs/week according to guidelines recomendations. An adverse event was defined as malignant ventricular arrhythmias, cardiorespiratory arrest, or death. Results A population of 522 patients was analyzed, 72% men, average age of 58.8 years (+-0.59), with coronary ischemic disease, heart failure and cardiomyopathies as the most common heart diseases. Regarding the average theorical METs (8.23, +-0.6), our patients achieved final average METs of 10.2 (+-0.26) and 90.02% (+-0.53) of attendace (Figure 1). The average of TVol were 637.4 (+-37.35) METs/week. The differential between the initial and final METs (Delta1) was correlated by Spearman with the differential between the final METs and its theorical (Delta2) and a significant moderate correlation was found (r=0.32 Spearman, p &amp;lt;0.001). TVol and Delta2 shows a strong and significant correlation (r=0.72 Spearman, p&amp;lt;0.001) (Figure 2). No adverse events were reported in any of the training sessions. Conclusion The Phase II CR program with concurrent training only 3 times per week but with TVol&amp;gt;600 METs/week is safe and guarantees a CRFit above the ideal level (theorical). We recommend to measure and fullfill training volume as a strategy to achieve promising results in exercise tolerance and functional capacity in patients with heart disease.

Early detection of cardiac dysfunction using shear wave imaging: insights into reduced cardiorespiratory fitness in childhood cancer survivors

Abstract Background Diastolic dysfunction is thought to be the earliest cardiotoxic sequel after cancer therapy among childhood cancer survivors. Despite many survivors do exhibit reduced cardiorespiratory fitness (CRF) potentially due to cardiotoxicity, current echocardiographic parameters fail to detect hidden diastolic dysfunction early after therapy (1). High frame rate (HFR) shear wave imaging (SWI) is a novel tool that could give insights about myocardial stiffness, which is a key determining factor of diastolic function. Purpose We aimed at testing the ability of SWI to detect early alterations in myocardial stiffness among childhood cancer survivors and its relation with the reduced CRF. Methods Fifty childhood cancer survivors (mean 20 ±3 years) who received chemo-and/or- radiotherapy (mean time after treatment: 4 ±3 years) and thirty-two matched healthy volunteers (HV) were recruited. Conventional as well as HFR echocardiographic images (ca. 1200 frames/second) were acquired at rest using a modified commercial echocardiography machine. All participants underwent an incremental, symptom-limited cardiopulmonary exercise test on a treadmill measuring peak oxygen consumption (VO2 peak). HFR data were analysed offline. An anatomical M mode was drawn along the ventricular septum, and tissue Doppler acceleration maps were extracted to measure SW velocities after mitral valve closure (MVC) (Figure 1). Results Among cancer survivors, left ventricular ejection fraction (LVEF) and global longitudinal strain were significantly lower compared to HV (56 % ±4 vs 59 % ±4, and 17.6 % ±1.6 vs 19.1 % ±1.2, respectively; p &amp;lt;0.001). However, both LVEF and GLS were within the normal range and none of them correlated with the peak VO2 (Figure 2A&amp;B). None of the echocardiographic diastolic parameters (e.g. mitral E, E/e’, left atrial volume or TR jet velocity) showed significant difference between both groups (P &amp;gt; 0.05). The mean SW velocities were significantly higher in cancer survivors compared to HV (3.9 ±0.6 m/s vs 3.2 ±0.3 m/s respectively; p &amp;lt;0.001). Interestingly, SW velocities among cancer survivors showed moderate significant negative correlation with the VO2 peak (r= -0.590, p &amp;lt;0.001) indicating increasing myocardial stiffness as the cardiorespiratory fitness declined (Figure 2C). Conclusions Our data indicate that myocardial stiffness in cancer survivors is significantly increased. We hypothesize that this increased stiffness may at least in part explain the significantly reduced cardiorespiratory fitness in this population. Echocardiographic shear wave elastography appears as a promising non-invasive tool for early detection of diastolic dysfunction in follow-up of childhood cancer survivors.Figure 1.Figure 2.

The Correlation Between Students’ Performance in Mathematics and Physics in Form Six National Examinations 2023 in Selected Schools in Tanzania

This study investigates the correlation between student performance in Mathematics and Physics in Form Six National Examinations in Tanzania. The research adopts a correlational design using a quantitative approach, focusing on ten advanced public secondary schools, with a sample of 100 students who took both subjects in 2023. Regression analysis assessed the relationship between the subjects, with examination results serving as the primary data source. Grades were coded using a standardized scale (A = 1, B = 2, C = 3, D = 4, E = 5), and the analysis revealed a statistically significant moderate positive correlation (r = 0.717) between Mathematics and Physics performance, suggesting that proficiency in Mathematics contributes to success in Physics. The study’s findings align with previous research, highlighting the importance of mathematical skills in understanding Physics concepts. Given the statistically significant results, the study recommends integrating teaching strategies that reinforce the connection between Mathematics and Physics, continuous teacher professional development, and improved resource allocation to enhance student outcomes. While limitations such as the small sample size and reliance on exam results were noted, the research provides valuable insights for educators and policymakers, suggesting that strengthening mathematical competencies can positively impact Physics performance, with implications for improving academic outcomes in science education in Tanzania.

Foot Kinematics of Elite Female 59 kg Weightlifters in the 2018–2021 World Championships

Background/Objectives: Research on elite weightlifting performance is crucial for understanding the underlying attributes of efficient techniques. This study aimed to analyze the foot characteristics of elite female weightlifters in the 59 kg category during the snatch. Methods: Publicly available videos from the International Weightlifting Federation World Weightlifting Championships (2018–2021) were analyzed. Excluding the 2020 competition due to the COVID-19 pandemic and more unsuccessful attempts, a total of 20 videos were selected for kinematic analysis using Kenova video analysis software. Variables included the horizontal foot distance in the start and catch phases, horizontal displacement of sideway leg separation, and maximum vertical heel height of each foot. Results: The results revealed small to moderate significant negative correlations between snatch performance and maximum heel height (right: r = −0.28, p &lt; 0.05; left: r = −0.332 p &lt; 0.01). Snatch performance also demonstrated a small to moderate negative correlation with sideway leg separation and foot distance in the catch phase (r = −0.275, p &lt; 0.01; r = −0.467, p &lt; 0.01, respectively). Maximum heel height exhibited a very strong positive correlation between feet (r = 0.853, p &lt; 0.01). Conclusions: A relatively narrower stance was found to be more beneficial for elite weightlifter performance. Strong coordination suggests advanced movement strategies in this complex lift. These findings contribute to the existing knowledge on weightlifting techniques and offer valuable insights for athletes and coaches seeking to improve performance in competitive environments.

A Novel Screening Tool for Severe Obstructive Sleep Apnea.

Purpose: Obstructive sleep apnea (OSA) is a prevalent condition with long waiting lists for the gold standard polysomnography (PSG) test. Screening tests are essential to identify and prioritize patients with severe OSA. Current questionnaires do not accurately detect severe cases. This study aims to develop an alternative screening tool based on anthropometric and morphological characteristics to determine the severity of OSA. Methods: The study included 149 patients with sleep apnea symptoms who did not have additional diseases. The obstructive sleep apnea morphologic scale (OSAMS) was created using 5 parameters: 3 internal parameters related to the upper respiratory tract (tonsil size, oropharyngeal passage, and hypopharyngeal-laryngeal examination) and 2 external parameters (neck circumference and body mass index). Each parameter was scored, and the total scores were correlated with the apnea-hypopnea index (AHI) of PSG to determine the severity of OSA. Results: A statistically significant moderate positive correlation was found between AHI and OSAMS scores (rho = .491; P < .001). A grand total score >4 provided 80.3% sensitivity and 53.9% specificity to identify patients with severe OSA. OSAMS demonstrated superior results compared to existing questionnaires for OSA screening in our study group. Conclusions: OSAMS is a potential alternative to existing questionnaires to screen patients with severe OSA, offering a practical approach based on morphology during physical examinations.

Unveiling the Aggressiveness of Cholesteatoma: Associating MERI with miRNA-21 & IL-6 Expression.

Cholesteatoma, a destructive middle ear condition, poses challenges due to its variable clinical presentation and propensity for recurrence. Understanding its molecular underpinnings could enhance prognostication and guide therapeutic interventions. This study investigates the association between cholesteatoma aggressiveness, as assessed by the Middle Ear Risk Index (MERI), and the expression of miRNA-21 and IL-6 genes. A cross-sectional observational study involving 30 patients with cholesteatoma undergoing tympanomastoid exploration was conducted. MERI scores were calculated preoperatively, and cholesteatoma tissue was analyzed for miRNA-21 and IL-6 gene expression using RT-PCR. Statistical analysis was performed to correlate MERI scores with gene expression levels. The majority (80%) of patients exhibited severe MERI scores, correlating with extensive middle ear pathology and necessitating canal wall-down (CWD) mastoidectomy. Higher miRNA-21 and IL-6 gene expression levels were observed in cholesteatoma tissues, indicating local aggressiveness and inflammatory activity. Significant moderate correlations were found between MERI scores and miRNA-21 (Pearson correlation = 0.579, p = 0.001) and IL-6 gene expression (Pearson correlation = 0.388, p = 0.034). Patients with severe MERI scores had elevated miRNA-21 and IL-6 levels, suggesting a more aggressive disease phenotype. MERI scores demonstrated utility in predicting cholesteatoma aggressiveness, with higher scores correlating with elevated miRNA-21 and IL-6 expression. These findings suggest a potential role for MERI in guiding surgical decision-making and prognostication. Future research on targeted therapies based on molecular mechanisms holds promise for improving cholesteatoma management. 3 Laryngoscope, 2024.

Exploring the Impact of Medical Complexity on Nursing Complexity of Care in Paediatric Patients: A Retrospective Observational Study.

To explore the impact of medical complexity, defined by the number of chronic conditions, on the complexity of care, as described by the frequency of nursing diagnoses (NDs) and nursing actions (NAs), in paediatric patients. Retrospective observational study. This study was conducted in an Italian university hospital and involved the analysis of electronic health records for neonatal and paediatric patients who were consecutively admitted from January to December 2022. The sample was classified into three categories-non-chronic, single chronic and multimorbid patients-according to their clinical profiles. NDs recorded within the first 24 h from patient hospital admission and NAs performed throughout the hospital stay were counted for each group. Distinct variations in the prevalence and patterns of NDs and NAs were observed across different levels of medical complexity. A significant moderate positive correlation between the number of NDs and NAs was found. However, the frequency of NDs did not directly correlate with the number of chronic conditions. Conversely, a weak but significant negative correlation was identified between the quantity of NAs and the number of chronic conditions. While the frequency of NDs showed a stable but decreasing trend as the number of chronic conditions increased, a higher number of chronic conditions were associated with a lower quantity of NAs. We discovered a notable variation in the complexity of care across varying levels of medical complexity in paediatric patients. Our findings suggest that the complexity of care does not necessarily correspond to the degree of medical complexity. The observed negative relationship between the number of chronic conditions and the quantity of NAs underscores the need for further research to explore this unexpected finding and its implications for clinical practice. Without the adoption of standardised nursing terminologies, such as nursing diagnoses (NDs) and nursing actions (NAs), assessing the complexity of care in paediatric settings can be challenging. Integrating clinical nursing information systems that incorporate standardised NDs and NAs into electronic health records is crucial for accurately documenting and analysing the complexity of care and its relationship with medical complexity. In paediatric patients, the frequency of nursing diagnoses (NDs) at hospital admission is significantly associated with the quantity of nursing actions (NAs) delivered during hospitalisation. However, there is no correlation between the frequency of NDs and medical complexity, as defined by the number of chronic disorders. Specifically, the frequency of NDs decreases with increasing medical complexity, while the quantity of NAs is negatively associated with the number of chronic disorders. This indicates that the complexity of care cannot be inferred solely from medical complexity, and additional factors need to be explored. These findings enhance understanding of how complexity of care relates to medical complexity in paediatric patients. Insights into the prevalence and patterns of NDs and NAs can benefit nurses, managers, researchers and policymakers by informing clinical and organisational decision-making to ensure high-quality care. The study adhered to the RECORD Statement. Patients, service users, caregivers or public members were not directly involved in the design, conduct, analysis and interpretation of data or in writing this paper. Patients contributed only to data collection.

High-Throughput Transcriptomics Identifies Chemoresistance-Associated Gene Expression Signatures in Human Angiosarcoma

Angiosarcomas, clinically aggressive cancers of endothelial origin, are a rare subtype of soft-tissue sarcomas characterized by resistance to chemotherapy and dismal prognosis. In this study, we aim to identify the transcriptomic biomarkers of chemoresistance in angiosarcoma. We examined 72 cases of Asian angiosarcomas, including 35 cases treated with palliative chemotherapy, integrating information from NanoString gene expression profiling, whole transcriptome profiling (RNA-seq), immunohistochemistry, cell line assays, and clinicopathological data. In the chemoresistant cohort (defined as stable disease or progression), we observed the significant overexpression of genes, including SPP1 (log2foldchange 3.49, adj. p = 0.0112), CXCL13, CD48, and CLEC5A, accompanied by the significant enrichment of myeloid compartment and cytokine and chemokine signaling pathways, as well as neutrophils and macrophages. RNA-seq data revealed higher SPP1 expression (p = 0.0008) in tumor tissues over adjacent normal compartments. Immunohistochemistry showed a significant moderate positive correlation between SPP1 protein and gene expression (r = 0.7016; p &lt; 0.00110), while higher SPP1 protein expression correlated with lower chemotherapeutic sensitivity in patient-derived angiosarcoma cell lines MOLAS and ISOHAS. In addition, SPP1 mRNA overexpression positively correlated with epithelioid histology (p = 0.007), higher tumor grade (p = 0.0023), non-head and neck location (p = 0.0576), and poorer overall survival outcomes (HR 1.84, 95% CI 1.07–3.18, p = 0.0288). There was no association with tumor mutational burden, tumor inflammation signature, the presence of human herpesvirus-7, ultraviolet exposure signature, and metastatic state at diagnosis. In conclusion, SPP1 overexpression may be a biomarker of chemoresistance and poor prognosis in angiosarcoma. Further investigation is needed to uncover the precise roles and underlying mechanisms of SPP1.

Possible Role of Platelet-Rich Plasma in the Treatment of Patients with Postherpetic Neuralgia: A Prospective, Single-Arm, Open-Label Clinical Study

Abstract Background: Currently, no treatment can fully and finally treat postherpetic neuralgia (PHN). Objectives: This study aimed to evaluate the possible efficacy of autologous intralesional platelet-rich plasma (PRP) injection in treating patients with PHN. Materials and Methods: A prospective, single-arm, open-label clinical study was conducted on 45 patients with PHN attending the Dermatology Outpatient Clinics of Sohag University Hospital, Egypt, between November 2019 and November 2021. Patients were subjected to full clinical general and dermatologic examinations. Patient’s assessment included; severity of pain through visual analogue scale (VAS), numerical rating scale (NRS), and verbal rating scale (VRS), in addition to Medical Outcomes Study 36 Item Short-Form (SF-36). Patients were treated by autologous PRP injection every 2 weeks for 2 months (4 sessions). Patients were evaluated before every session and 3- months after the last session. Results: There was a significantly decreased VAS, NRS, VRS, and SF-36 questionnaire values in the last session and three months after the last session. There was a highly significant moderate correlation between both scales (VAS and VRS) and patient’s age in years and who have aggravating factors. Likewise, there was a significant moderate positive correlation between scales (VAS and VRS) and the disease duration, medical co-morbidities, and associated myalgia. Limitations: These findings require further confirmations on more inclusive large-sized multicenter, randomized, placebo-controlled, clinical trials with longer follow-up. Conclusion: This clinical pilot study concluded that autologous intralesional PRP injection was an effective therapeutic option for patients with PHN.

Impact of asprosin, interleukin-6, and adiponectin on exocrine pancreatic insufficiency in patients with type 2 diabetes mellitus and chronic pancreatitis

Exocrine pancreatic insufficiency (EPI) is a clinical condition often associated with chronic pancreatitis (CP) and type 2 diabetes mellitus (T2DM) leads to malabsorption and nutritional deficiencies, severely impacting patients’ quality of life. It has been identified that asprosin, a glucogenic protein, is a key player in carbohydrate metabolism and chronic inflammation. Elevated levels of asprosin, along with changes in interleukin‑6 (IL‑6) and adiponectin, may contribute to the pathophysiology of EPI in patients with T2DM and CP. Objective — to investigate the levels of asprosin, IL‑6, and adiponectin and their correlation with exocrine pancreatic function in patients with T2DM and CP. Materials and methods. The study included 100 patients treated at Kharkiv Regional Clinical Hospital from 2020 to 2022. Patients were divided into two groups: Group 1 (n=70) with comorbid T2DM and CP, and Group 2 (n=30) with T2DM alone. The control group included 20 healthy individuals. Blood levels of asprosin, IL‑6, and adiponectin were measured using immunoassays. Fecal elastase‑1 (FE‑1) levels were used to assess exocrine pancreatic function. Pearson’s correlation coefficient was calculated to determine the relationships between these markers. Results. Asprosin levels were significantly higher in Group 1 compared to Group 2 and the control group, with the highest levels observed in patients with comorbid T2DM and CP (10.06±3.56 ng/ml). IL‑6 levels were also elevated in Group 1 (64.44±4.35 pg/ ml), indicating heightened inflammation. Adiponectin levels were lower in Group 1 (2.80±0.38 ng/ml), correlating with worse metabolic profiles. FE‑1 levels were markedly reduced in Group 1 (142.2±6.3 mg/ g), confirming severe EPI. Significant correlations were found between asprosin levels and IL‑6 (positive correlation, r=0.49, p&lt;0.01), as well as between asprosin levels and FE‑1 (negative correlation, r=–0.52, p&lt;0.01). In the group of patients with isolated T2DM, significant moderate negative correlations were found between asprosin levels and adiponectin (r=–0.47, p&lt;0.05) and FE‑1 (r=–0.44, p&lt;0.05). The study also demonstrated a strong negative correlation between adiponectin and IL‑6 (r=–0.61, p&lt;0.01) in patients with comorbid T2DM and CP. Conclusions. Elevated asprosin levels in patients with T2DM and CP are associated with increased inflammation and reduced exocrine pancreatic function. The significant correlations between asprosin, IL‑6, and FE‑1 suggest that asprosin could serve as a clinically valuable biomarker for assessing metabolic and inflammatory status in these patients. The findings highlight the complex interaction between metabolic and inflammatory pathways in the development of EPI.

Influence of the consumatory behavior onto the risk of obesity and its complications in primary school children

Objective. To identify the relationship of eating behavior and clinical and metabolic status of 6–11-year-old children in order to develop effective methods for prevention and treatment of obesity and its complications. Materials and methods. 94 children aged 6 to 11 participated in the research. They formed 2 groups: group I (n = 64) – obese children (standard deviation score (SDS) of body mass index (BMI) ≥ +2.0), group II (n = 30) – children with normal body weight (SDS BMI –1.0 … +1.0). Clinical and laboratory parameters were studied and eating behavior was assessed using the Child Eating Behavior Questionnaire. Results. As a result of the study, it was determined that average values of triglycerides (TG), uric acid (UA), thyroid-stimulating hormone (TSH), fasting glycemia (FG), p = 0.001, p = 0.002, p 0.001, p 0.001 were higher in obese children. The following features of the eating behavior in obese children have been revealed: a more active reaction to food and emotional overeating, p = 0.016, p = 0.004 Statistically significant direct moderate correlations between SDS BMI and the level of TG, UA, TSH and FG under the influence of eating behavior according to the “eating approach” type were established. Conclusions. An association between the pattern of eating behavior in obese children aged 6–11 and their clinical and metabolic status, which determines the risk of atherosclerosis and cardiovascular diseases in the future was revealed. The results obtained are a justification for identifying the nature of children`s eating behavior in order to prevent the development of obesity and associated complications, as well as to increase the effectiveness of therapy.

Effect of evidence-based nursing practices on individualised care: A cross-sectional descriptive study.

This study was conducted to determine the effect of nurses' attitudes towards evidence-based practices on individualised nursing care. This study is a cross-sectional descriptive trial. The descriptive analysis included 200 clinical nurses working in a private hospital between April and September 2022. Data were collected with a personal information form, Individualised Care Scale (A-Nurse Version), and Evidence-Based Nursing Attitude Questionnaire. The relationship between the scales and effect was examined by Pearson correlation and linear regression analyses. T-test, one-way analysis of variance (ANOVA), and post hoc (Tukey, LSD) analysis were used in the statistical analysis of nurses according to their descriptive characteristics. This study has adhered to the STROBE checklist for reporting. They had high mean scores on Individualised Care Scale total (3.68 ± 1.25) and from Clinical Situation (3.78 ± 1.30) and Decisional Control (3.82 ± 1.35) subscales and average score from the Personal Life (3.32 ± 1.29) subscale. Their mean score from the Evidence-Based Nursing Attitude Questionnaire was average (47.64 ± 10.99). There was a positive moderate (r = 0.50, p = 0.000 < 0.05) significant correlation between the scales. Positive attitude towards evidence-based nursing practices positively affects individualised care. Variables such as professional experience positively affect nurses' attitudes towards evidence-based nursing. A positive and significant relationship was found between nurses' attitudes towards evidence-based practice and their attitudes towards individualised care.

The 1-minute sit-to-stand test to evaluate fibrotic interstitial lung disease

IntroductionFibrotic interstitial lung diseases (ILD) are a heterogeneous group of conditions. Progression criteria include clinical, imaging, and/or lung functional decline. Currently, the 6-minute walk test (6MWT) is considered the gold standard for assessing exercise-induced desaturation. The 1-minute sit-to-stand test (1STST) has the advantage of being easy to perform, making it feasible for use during clinical consultations. The aim of this study was to compare the 1STST with the 6MWT in patients with fibrotic ILD to detect exercise-induced desaturation. MethodsA multicenter cross-sectional involved patients with fibrotic ILDs from two centers. The 6MWT and 1STST were performed with a 30-minute rest period between the tests. The modified Borg scale was used to assess dyspnea and lower limb fatigue and continuous SpO2 and heart rate were monitored. Desaturation was defined as SpO2 < 90% or decline >3%. ResultsNinety patients were included. The median walking distance in the 6MWT was 432 meters and the median number of repetitions in the 1STST was 22, with a significant correlation (p<0.001, ρ=0.383). In addition, the minimum SpO2 and the desaturation levels recorded during the tests exhibited a moderate significant correlation (p<0.001, ρ=0.502 and p<0.001, ρ=0.537, respectively). There was a strong association between the increase in Borg score for dyspnea and a moderate association between the increase in Borg score for lower limb fatigue after both tests (p<0.001, ρ=0.706 and p<0.001, ρ=0.656, respectively). ConclusionsThis study demonstrates a significant correlation between the 6MWT and the 1STST in detecting exercise-induced desaturation.

The Impact of Succession Planning on Enhancing Organizational Citizenship Behavior: A Field Study at Tikrit University

The study aims to determine the extent to which succession planning contributes to enhancing organizational citizenship behavior at Tikrit University. The research hypotheses were the availability of the dimensions of succession planning and the dimensions of organizational citizenship in the university under study, and the existence of significant correlations and influence between each succession planning and organizational citizenship behavior. The research community was identified with the teaching and administrative staff of Tikrit University, consisting of (280) people, and a survey was conducted on a random sample of them, numbering (158) individuals. All distributed questionnaires were retrieved with a recovery rate of 100%, while the questionnaires suitable for analysis were (120), representing (75.9%) of the total questionnaires returned. The data were analyzed and hypotheses were tested using the statistical analysis program SPSS V.26. The study reached a number of results, most notably: There is a high level of application of both succession planning and organizational citizenship behavior at Tikrit University. The results also showed that there is a positive and moderate significant correlation between succession planning and organizational citizenship behavior at the university under study. The results also showed a statistically significant effect of succession planning methods combined in enhancing organizational citizenship behavior at Tikrit University, which explains 29.5% of the changes in the dependent variable. In addition, there was a statistically significant positive effect for all dimensions of succession planning in enhancing organizational citizenship behavior at Tikrit University, where promotion was the most influential on organizational citizenship behavior, followed by job rotation, training, and finally job transfer.

Comparative immunohistochemical expression of Beta catenin and CD163 between dysplastic / non-dysplastic oral lichen planus and lichenoid lesions (EX-VIVO STUDY)

BackgroundOral lichen planus is a well-known chronic inflammatory mucocutaneous disorder, which has clinical and histological presentation that mimics oral lichenoid reaction. According to the fifth edition of WHO, both conditions are considered as oral potentially malignant disorders. Recent studies on oral potential disorders documented deregulation of some signaling molecules related to the Wnt/β-catenin pathway. Therefore this study aimed to compare the immune expression of β-catenin & CD163 in dysplastic /non-dysplastic cases of Oral lichen planus & oral lichenoid lesion. In addition, a statistical correlation between both immune markers was done regardless of the type of the study group.MethodsFour study groups were designated as 2 groups of Oral lichen planus (one dysplastic & one non –dysplastic) and the other 2 groups were oral lichenoid lesions (one dysplastic & one non –dysplastic). Ten cases in each group were collected and investigated by immunohistochemistry. The area percent of beta catenin and also counting of m2 macrophages expressing + CD163 marker was calculated in the study groups.ResultsThe Statistical analysis highlighted a statistically significant difference between the studied groups. Moreover, Pearson correlation test reported a significant moderate positive correlation between beta catenin & CD163 expression in the studied cases.ConclusionOur findings supported new perceptions of the mechanism by which tumor associated macrophage specific β-catenin signaling promotes the aggressive behavior of oral potential malignant disorders.Clinical relevanceEvidence of the relationship between beta catenin and M2 macrophages (+ CD163) may enhance the development of macrophage-based strategies for treatment and improve the prognosis of such cases.