Moderate Magnetic Field Research Articles

Thermal gradient-induced critical current degradation in mesoscopic superconducting thin film

Abstract Superconducting materials inevitably suffer from the sudden change of temperature in localized areas in practical applications, and the concomitant thermal gradient may be detrimental to their performance. Critical current density is a key factor affecting the performance of superconductors. However, the effect of thermal gradient on the critical current density has not been identified. Here, by combining the time-dependent Ginzburg–Landau equations and the heat transfer equation, the thermal gradient and magnetic field dependence of the critical current density are systematically investigated and rationalized by exploring the behavior of vortex and magnetization. For lower magnetic fields, it is found that the thermal gradients strongly reduce the local surface barriers, which inhibits vortex entry and movement, leading to a rapid deterioration of the current-carrying capability. Under moderate magnetic fields, the critical current density corresponding to higher thermal gradients decreases more slowly with increasing magnetic field, which results from the thermal gradient-induced entry and moving of vortices along the current direction. As the magnetic field continues to increase, the variation of the critical current density transitions into a platform period and even slightly rises. The enhanced critical current is primarily attributed to the excess entry of vortices, which increases the surface barrier of the sample. With the further increase in the magnetic field, the critical current density continues to decrease due to increased magnetic field penetration. These results unveil the fundamental interplay between thermal gradients, external magnetic field, vortex, magnetization and critical current density, and provide a theoretical basis for understanding the heat-induced quenching of mesoscopic superconducting thin films in practical applications.

Giant magnetocaloric effect in a rare-earth-free layered coordination polymer at liquid hydrogen temperatures

Magnetic refrigeration, which utilizes the magnetocaloric effect, can provide a viable alternative to the ubiquitous vapor compression or Joule-Thompson expansion methods of refrigeration. For applications such as hydrogen gas liquefaction, the development of magnetocaloric materials that perform well in moderate magnetic fields without using rare-earth elements is highly desirable. Here we present a thorough investigation of the structural and magnetocaloric properties of a novel layered organic-inorganic hybrid coordination polymer Co4(OH)6(SO4)2[enH2] (enH2 = ethylenediammonium). Heat capacity, magnetometry and direct adiabatic temperature change measurements using pulsed magnetic fields reveal a field-dependent ferromagnetic second-order phase transition at 10 K <TC\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$${T}_{C}$$\\end{document} < 15 K. Near the hydrogen liquefaction temperature and in a magnetic field change of 1 T, a large maximum value of the magnetic entropy change, ΔSMPk\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$\\Delta {S}_{M}^{{Pk}}$$\\end{document} = − 6.31 J kg−1 K−1, and an adiabatic temperature change, ΔTad\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$\\Delta {T}_{{{\\rm{ad}}}}$$\\end{document} = 1.98 K, are observed. These values are exceptional for rare-earth-free materials and competitive with many rare-earth-containing alloys that have been proposed for magnetic cooling around the hydrogen liquefaction range.

Precise Calorimetry of Small Metal Samples Using Noise Thermometry

AbstractWe describe a compact calorimeter that opens ultra-low-temperature heat capacity studies of small metal crystals in moderate magnetic fields. The performance is demonstrated on the canonical heavy fermion metal YbRh$$_{2}$$ 2 Si$$_{2}$$ 2 . Thermometry is provided by a fast current sensing noise thermometer. This single thermometer enables us to cover a wide temperature range of interest from 175 µK to 90 mK with temperature-independent relative precision. Temperatures are tied to the international temperature scale with a single-point calibration. A superconducting solenoid surrounding the cell provides the sample field for tuning its properties and operates a superconducting heat switch. Both adiabatic and relaxation calorimetry techniques, as well as magnetic field sweeps, are employed. The design of the calorimeter results in an addendum heat capacity which is negligible for the study reported. The keys to sample and thermometer thermalisation are the lack of dissipation in the temperature measurement and the steps taken to reduce the parasitic heat leak into the cell to the tens of fW level.

Broadband nonreciprocal thermal emissivity and absorptivity

A body that violates Kirchhoff’s law of thermal radiation exhibits an inequality in its spectral directional absorptivity and emissivity. Achieving such an inequality is of fundamental interest as well as a prerequisite for achieving thermodynamic limits in photonic energy conversion1 and radiative cooling2. Thus far, inequalities in the spectral directional emissivity and absorptivity have been limited to narrow spectral resonances3, or wavelengths well beyond the infrared regime4. Bridging the gap from basic demonstrations to practical applications requires control over a broad spectral range of the unequal spectral directional absorptivity and emissivity. In this work, we demonstrate broadband nonreciprocal thermal emissivity and absorptivity by measuring the thermal emissivity and absorptivity of gradient epsilon-near-zero InAs layers of subwavelength thicknesses (50 nm and 150 nm) with an external magnetic field. The effect occurs in a spectral range (12.5–16 μm) that overlaps with the infrared transparency window and is observed at moderate (1 T) magnetic fields.

Energy extraction via magnetic reconnection in magnetized black holes

The Comisso-Asenjo mechanism is a novel mechanism proposed recently to extract energy from black holes through magnetic reconnection of the surrounding charged plasma, in which the magnetic field plays a crucial role. In this work, we revisit this process by taking into account the backreaction of the magnetic field on the black hole's geometry. We employ the Kerr-Melvin metric to describe the local near-horizon geometry of the magnetized black hole. By analyzing the circular orbits in the equatorial plane, energy extraction conditions, power and efficiency of the energy extraction, we found that while a stronger magnetic field can enhance plasma magnetization and aid energy extraction, its backreaction on the spacetime may hinder the process, with a larger magnetic field posing a greater obstacle. Balancing these effects, an optimal moderate magnetic field strength is found to be most conducive to energy extraction. Moreover, there is a maximum limit to the magnetic field strength associated with the black hole's spin, beyond which circular orbits in the equatorial plane are prohibited, thereby impeding energy extraction in the current scenario.

High mobility graphene field effect transistors on flexible EVA/PET foils

Monolayer graphene is a promising material for a wide range of applications, including sensors, optoelectronics, antennas, EMR shielding, flexible electronics, and conducting electrodes. Chemical vapor deposition (CVD) of carbon atoms on a metal catalyst is the most scalable and cost-efficient method for synthesizing high-quality, large-area monolayer graphene. The usual method of transferring the CVD graphene from the catalyst to a target substrate involves a polymer carrier which is dissolved after the transfer process is completed. Due to often unavoidable damage to graphene, as well as contamination and residues, carrier mobilities are typically 1000–3000 cm2(Vs)−1 , unless complex and elaborate measures are taken. Here, we report on a simple scalable fabrication method for flexible graphene field-effect transistors that eliminates the polymer interim carrier, by laminating the graphene directly onto office lamination foils, removing the catalyst, and depositing Parylene N as a gate dielectric and encapsulation layer. The fabricated transistors show field- and Hall-effect mobilities of 7000–10 000 cm2(Vs)−1 with a residual charge-carrier density of 2×1011 1 cm−2 at room temperature. We further validate the material quality by terahertz time-domain spectroscopy and observation of the quantum Hall effect at low temperatures in a moderate magnetic field of ∼5 T. The Parylene encapsulation provides long-term stability and protection against additional lithography steps, enabling vertical device integration in multilayer electronics on a flexible platform.

Large anomalous Hall effect in spin fluctuating devil’s staircase

Electrons in metals can show a giant anomalous Hall effect (AHE) when interacting with characteristic spin texture. The AHE has been discussed in terms of scalar-spin-chirality (SSC) in long-range-ordered noncollinear spin textures typified by Skyrmion. The SSC becomes effective even in the paramagnetic state with thermal fluctuations, but the resultant AHE has been limited to be very small. Here, we report the observation of large AHE caused by the spin fluctuation near the devil’s staircase transition in a collinear antiferromagnetic metal SrCo6O11. The AHE is prominent near and above the transition temperature at moderate magnetic fields, where the anomalous Hall angle becomes the highest level among known oxide collinear ferromagnets/antiferromagnets (>2%). Furthermore, the anomalous Hall conductivity is quadratically scaled to the conductivity. These results imply that the thermally induced solitonic spin defects inherent to the devil’s staircase transition promote SSC-induced skew scattering.

Giant Faraday rotation in atomically thin semiconductors

Faraday rotation is a fundamental effect in the magneto-optical response of solids, liquids and gases. Materials with a large Verdet constant find applications in optical modulators, sensors and non-reciprocal devices, such as optical isolators. Here, we demonstrate that the plane of polarization of light exhibits a giant Faraday rotation of several degrees around the A exciton transition in hBN-encapsulated monolayers of WSe2 and MoSe2 under moderate magnetic fields. This results in the highest known Verdet constant of -1.9 × 107 deg T−1 cm−1 for any material in the visible regime. Additionally, interlayer excitons in hBN-encapsulated bilayer MoS2 exhibit a large Verdet constant (VIL ≈ +2 × 105 deg T−1 cm−2) of opposite sign compared to A excitons in monolayers. The giant Faraday rotation is due to the giant oscillator strength and high g-factor of the excitons in atomically thin semiconducting transition metal dichalcogenides. We deduce the complete in-plane complex dielectric tensor of hBN-encapsulated WSe2 and MoSe2 monolayers, which is vital for the prediction of Kerr, Faraday and magneto-circular dichroism spectra of 2D heterostructures. Our results pose a crucial advance in the potential usage of two-dimensional materials in ultrathin optical polarization devices.

Effect of Moderate Static Magnetic Fields on Mice Oocyte Vitrification: Calcium-Related Genes Expression.

The ability to cryopreserve oocytes without ultrastructural injury has been a concern in the development and use of methods to preserve female reproduction. The stability of the cell membrane must be preserved to reduce the damage caused by ice crystals during vitrification. One approach that has been explored is the use of static magnetic fields (SMFs), which are believed to influence cell membrane stability. In this study, the in vitro effects of SMF that range between 20-80 mT on the vitrification of mice germinal vesicle (GV) oocytes were studied. The viability and mitochondrial (Mt) membrane potential of both vitrified and nonvitrified oocytes were assessed using Trypan blue and JC1 staining. The high in vitro maturation (IVM) rate and high Mt membrane potential in metaphase II (MII) oocytes were taken into account to determine the optimal magnetic field intensity, that is, 20 mT. None of the SMF conditions resulted in intact spindles in MII oocytes. The study also explored the expression of store-operated calcium entry (Stim1, Orai1, and Ip3r) and meiosis resumption (Ccnb, Cdk) genes in GV and MII oocytes of both vitrified and control groups. The results show that the expressions of Orai1 and Ccnb genes in Vit-MII-SMF oocytes were considerably increased. However, no significant difference in Stim1 expression was observed between the groups. The Vit-MII-SMF group exhibited a significantly higher Ccnb expression compared to other groups. In vitro fertilization (IVF) was performed to evaluate the 2 pronuclear (2PN) rates. The findings demonstrated that using 20 mT SMF improved 2PN rates compared to the nonvitrified groups. This study provides a deeper understanding of the effects of moderate SMF and vitrification on the expression of calcium channel genes in GV and MII oocytes. The results suggest that applying a 20 mT SMF can help prevent cryoinjury and enhance the characteristics of vitrified-warmed oocytes.

Unsteady Mixed Convection Flows in a Rectangular Duct and Dynamical Behaviors of Flow Channel Insert

Buoyancy-assisted upward MHD flows and dynamical behaviors of flow channel insert (FCI) in the dual-coolant lead-lithium (DCLL) blanket are studied numerically. Based on our internally developed and validated solver, the dynamical behaviors of magneto-thermo-fluid-structure coupled multiphysical field are investigated. A large amplitude, low frequency, and quasiperiodic unsteady reverse flow at high Re (31000), high Gr (3.5×1011), and moderate magnetic field (0.7~1.7T) is found in the DCLL blanket. This intricate phenomenon has been discovered for the first time, representing a combination of separate experimental results from Melnikov et al. (2016) and Khanal and Lei (2012). In our study of this large amplitude, low frequency, and quasiperiodic unsteady reverse flows, the importance of the cold helium gas to the instability of fluid flow in the bulk region and the thermal conductivity of the FCI to convection structure and instability are first found and recognized. Additionally, we take into account the effects of the temperature field and flow field on structural deformation and mechanical behavior of FCI, and we have discovered several intriguing phenomena, such as (1) the stability of fluid flow in the bulk region depends on the strength of the heat source, the magnitude of the magnetic field, and thermal conductivity of FCI; (2) the instability and periodicity of the fluid flow are primarily related to the unsteady reverse flow, which rises up and falls down periodically in the bulk region; (3) the physical mechanism of unsteady flow influenced by reverse flow, pressure drop, and Lorentz force has been concluded. It has been discovered that the breakdown of a reverse flow vortex causes a rapid reduction in pressure drop. (4) To avoid this phenomenon in engineering, a phase map of unsteady and steady flows in the DCLL blanket has been created. (5) The quasiperiodic characteristics of solid (flow channel insert) affected by flow are found and analyzed.

Large Anomalous Hall Effect at Room Temperature in a Fermi‐Level‐Tuned Kagome Antiferromagnet

AbstractThe recent discoveries of surprisingly large anomalous Hall effect (AHE) in antiferromagnets have attracted much attention due to their promising use in spintronics devices. However, such AHE‐hosting antiferromagnetic materials are rare in nature. Herein, it is demonstrated that Mn2.4Ga, a Fermi‐level‐tuned kagome antiferromagnet, has a large anomalous Hall conductivity of ≈150 Ω−1 cm−1 at room temperature that surpasses the usual high values (i.e., 20–50 Ω−1 cm−1) observed so far in two outstanding kagome antiferromagnets, Mn3Sn and Mn3Ge. Although the triangular spin structure of Mn2.4Ga shows a weak net magnetic moment of ≈0.05 µB per formula unit, it guarantees a nonzero Berry curvature in the kagome plane. Moreover, the anomalous Hall conductivity exhibits a sign reversal with the rotation of a small magnetic field that can be ascribed to the field‐controlled chirality of the spin triangular structure. This theoretical calculations further suggest that the large AHE in Mn2.4Ga originates from a significantly enhanced Berry curvature associated with the tuning of the Fermi level close to the Weyl points. These properties, together with the ability to manipulate moment orientations using a moderate external magnetic field, make Mn2.4Ga extremely exciting for future antiferromagnetic spintronics.

Strain‐controlled dynamics of transverse domain walls in hybrid piezoelectric–magnetostrictive heterostructures: An asymptotic approach

AbstractThe present work deals with an analytical study of the statical and dynamical behavior of transverse magnetic domain walls in hybrid bilayer piezoelectric/magnetostrictive heterostructures under the combined influence of spin‐polarized electric currents, transverse, and axial applied magnetic fields. The magnetostrictive material is considered to be isotropic and linearly elastic. We perform the investigation within the framework of the one‐dimensional Landau–Lifshitz–Gilbert equation. By employing the regular perturbation asymptotic expansion approach, we derive the explicit analytical expression of the most significant dynamic features, namely, traveling wave profile, DW velocity, and displacement under the influence of small and moderate transverse magnetic fields. Finally, we illustrate numerically the analytical results and delineate the domain wall motion for metallic and semiconductor ferromagnets.

Influence of thickness and domain structure on the vortex instability of superconducting/ferromagnetic bilayers

We report on the vortex instability in superconducting/ferromagnetic (FM) bilayers. Samples consisting of a 23 nm thick Mo2N superconducting layer with a capping layer of Co, Fe20Ni80, or FePt ferromagnets were grown by sputtering at room temperature on silicon (100). Our study reveals that the critical vortex velocity in these superconducting bilayers is significantly influenced by the thickness of the FM layers rather than the specific magnetic domain structure. When comparing samples with FM layers of 10 nm and 50 nm thickness, we observe a notable increase in vortex velocities at low magnetic fields, with speeds rising from approximately 3.5 km s−1 to around 6 km s−1 as the thickness increases. This trend extends to moderate and high magnetic fields. Furthermore, we establish a direct correlation between vortex velocities and the thermal conductance of the FM layers. These findings provide valuable insights for the interplay of magnetic and thermal properties within these hybrid systems, with potential implications for the design of future devices and applications.

Effects of horizontal magnetic fields on turbulent Rayleigh–Bénard convection in a cuboid vessel with aspect ratio Γ = 5

Direct numerical simulations have been conducted to investigate turbulent Rayleigh– Bénard convection (RBC) of liquid metal in a cuboid vessel with aspect ratio $\varGamma =5$ under an imposed horizontal magnetic field. Flows with Prandtl number $Pr=0.033$ , Rayleigh numbers ranging up to $Ra\leq 10^{7}$ , and Chandrasekhar numbers up to $Q\leq 9 \times 10^6$ are considered. For weak magnetic fields, our findings reveal that a previously undiscovered decreasing region precedes the enhancement of heat transfer and kinetic energy. For moderate magnetic fields, we have reproduced the reversals of the large-scale flow, which are considered a reorganization process of the roll-like structures that were reported experimentally by Yanagisawa et al. (Phys. Rev. E, vol. 83, 2011, 036307). Nevertheless, the proposed approach of skewed-varicose instability has been substantiated as insufficient to elucidate fundamentally the phenomenon of flow reversal, an occurrence bearing a striking resemblance to the large-scale intermittency observed in magnetic channel flows. As we increase the magnetic field strength further, we observe that the energy dissipation of the system comes primarily from the viscous dissipation within the boundary layer. Consequently, the dependence of Reynolds number $Re$ on $Q$ approaches a scaling as $Re\,Pr/Ra^{2/3} \sim Q^{-1/3}$ . At the same time, we find the law for the cutoff frequency that separates large quasi-two-dimensional scales from small three-dimensional ones in RBC flow, which scales with the interaction parameter as ${\sim }N^{1/3}$ .

Potential and performance of anisotropic 19F NMR for the enantiomeric analysis of fluorinated chiral active pharmaceutical ingredients.

Controlling the enantiomeric purity of chiral drugs is of paramount importance in pharmaceutical chemistry. Isotropic 1H NMR spectroscopy involving chiral agents is a widely used method for discriminating enantiomers and quantifying their relative proportions. However, the relatively weak spectral separation of enantiomers (1H Δδiso(R, S)) in frequency units at low and moderate magnetic fields, as well as the lack of versatility of a majority of those agents with respect to different chemical functions, may limit the general use of this approach. In this article, we investigate the analytical potential of 19F NMR in anisotropic chiral media for the enantiomeric analysis of fluorinated active pharmaceutical ingredients (API) via two residual anisotropic NMR interactions: the chemical shift anisotropy (19F-RCSA) and dipolar coupling ((19F-19F)-RDC). Lyotropic chiral liquid crystals (CLC) based on poly-γ-benzyl-L-glutamate (PBLG) show an interesting versatility and adaptability to enantiodiscrimination as illustrated for two chiral drugs, Flurbiprofen® (FLU) and Efavirenz® (EFA), which have very different chemical functions. The approach has been tested on a routine 300 MHz NMR spectrometer equipped with a standard probe (5 mm BBFO probe) in a high-throughput context (i.e., ≈10 s of NMR experiments) while the performance for enantiomeric excess (ee) measurement is evaluated in terms of trueness and precision. The limits of detection (LOD) determined were 0.17 and 0.16 μmol ml-1 for FLU and EFA, respectively, allow working in dilute conditions even with such a short experimental duration. The enantiodiscrimination capabilities are also discussed with respect to experimental features such as CLC composition and temperature.

Acetaminophen overdose-induced acute liver injury can be alleviated by static magnetic field.

Acetaminophen (APAP), the most frequently used mild analgesic and antipyretic drug worldwide, is implicated in causing 46% of all acute liver failures in the USA and between 40% and 70% in Europe. The predominant pharmacological intervention approved for mitigating such overdose is the antioxidant N-acetylcysteine (NAC); however, its efficacy is limited in cases of advanced liver injury or when administered at a late stage. In the current study, we discovered that treatment with a moderate intensity static magnetic field (SMF) notably reduced the mortality rate in mice subjected to high-dose APAP from 40% to 0%, proving effective at both the initial liver injury stage and the subsequent recovery stage. During the early phase of liver injury, SMF markedly reduced APAP-induced oxidative stress, free radicals, and liver damage, resulting in a reduction in multiple oxidative stress markers and an increase in the antioxidant glutathione (GSH). During the later stage of liver recovery, application of vertically downward SMF increased DNA synthesis and hepatocyte proliferation. Moreover, the combination of NAC and SMF significantly mitigated liver damage induced by high-dose APAP and increased liver recovery, even 24 h post overdose, when the effectiveness of NAC alone substantially declines. Overall, this study provides a non-invasive non-pharmaceutical tool that offers dual benefits in the injury and repair stages following APAP overdose. Of note, this tool can work as an alternative to or in combination with NAC to prevent or minimize liver damage induced by APAP, and potentially other toxic overdoses.

Leveraging the Snap Buckling of Bistable Magnetic Shells to Design a Refreshable Braille Dot

AbstractA design concept is proposed for the building block, a dot, of programmable braille readers utilizing bistable shell buckling, magnetic actuation, and pneumatic loading. The design process is guided by Finite Element simulations, which are initially validated through precision experiments conducted on a scaled‐up, single‐shell model system. Then, the simulations are leveraged to systematically explore the design space, adhering to the standardized geometric and physical specifications of braille systems. The findings demonstrate the feasibility of selecting design parameters that satisfy both geometric requirements and blocking forces under moderate magnetic fields, facilitated by pneumatic loading to switch between the two stable states. While the study is focused on experimentally validated numerical simulations, it is also identify several manufacturing challenges that need to be resolved for future physical implementations .

The Anomalous Photo‐Nernst Effect of Massive Dirac Fermions In HfTe5

AbstractThe quantum geometric Berry curvature results in an anomalous correction to the band velocity of crystal electrons with a corresponding transverse (thermo)electric conductivity. However, time‐reversal symmetry typically constrains the direct observation and exploitation of anomalous transport to magnetic compounds. Here, it is demonstrated the anomalous Hall and Nernst conductivities are essential for describing the optoelectronic transport in thin films of the non‐magnetic, weakly gapped semimetal HfTe5 subject to an external magnetic field. A focused photoexcitation adresses the symmetries of the local Nernst conductivity, which unveils a hitherto hidden, anomalous photo‐Nernst effect of three‐dimensional (3D) massive Dirac fermions. The experimental temperature and density dependencies are compared with a semiclassical Boltzmann transport model. For HfTe5 thin films with the Fermi level close to the gap, the model suggests that the anomalous photo‐Nernst currents originate from an intrinsic Berry curvature mechanism, where the Zeeman interaction effectively breaks time‐reversal symmetry of the massive Dirac fermions already at moderate external magnetic fields.

Vectorial characterization of surface wave via one-dimensional photonic-atomic structure

Quantitative assessment of polarization properties of waves opens up the way for effective exploitation of them in many amazing applications. Tamm surface waves (TSW) that propagate on the interface of periodic dielectric media are proposed for many applications in numerous reports. The polarization state of TSW is not simply intuitive and would not be extracted from reflection spectra. Here considering orientation sensitive nature of the interaction between polarized electromagnetic wave and atom, we try to quantitatively characterize the polarization state of TSWs, excited on the surface of the 1D photonic crystal. To do this we performed direct contact between TSW and rubidium atomic gas by fabrication of a one-dimensional photonic crystal-atomic vapor cell and applied a moderate external magnetic field to create geometrical meaning and a sense of directionality to dark lines in reflection intensity. Our experimental results indicate that transition lines in the reflection spectrum of our hybrid system modify dependent on the orientation of the applied magnetic field and the transverse spin of TSW. We have used these changes to redefine the geometry of Voigt and Faraday for evanescent waves, especially Tamm surface waves. In the end, we performed simple mathematical operations on absorption spectra and extract the ratio of longitudinal and transverse electric field components of the polarization vector of TSW equal to 25\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$\\frac{2}{5}$$\\end{document}.

Rapid and Simple 13C-Hyperpolarization by 1H Dissolution Dynamic Nuclear Polarization Followed by an Inline Magnetic Field Inversion.

Dissolution dynamic nuclear polarization (dDNP) is a method of choice for preparing hyperpolarized 13C metabolites such as 1-13C-pyruvate used for in vivo applications, including the real-time monitoring of cancer cell metabolism in human patients. The approach consists of transferring the high polarization of electron spins to nuclear spins via microwave irradiation at low temperatures (1.0-1.5 K) and moderate magnetic fields (3.3-7 T). The solid sample is then dissolved and transferred to an NMR spectrometer or MRI scanner for detection in the liquid state. Common dDNP protocols use direct hyperpolarization of 13C spins reaching polarizations of >50% in ∼1-2 h. Alternatively, 1H spins are polarized before transferring their polarization to 13C spins using cross-polarization, reaching polarization levels similar to those of direct DNP in only ∼20 min. However, it relies on more complex instrumentation, requiring highly skilled personnel. Here, we explore an alternative route using 1H dDNP followed by inline adiabatic magnetic field inversion in the liquid state during the transfer. 1H polarizations of >70% in the solid state are obtained in ∼5-10 min. As the hyperpolarized sample travels from the dDNP polarizer to the NMR spectrometer, it goes through a field inversion chamber, which causes the 1H → 13C polarization transfer. This transfer is made possible by the J-coupling between the heteronuclei, which mixes the Zeeman states at zero-field and causes an antilevel crossing. We report liquid-state 13C polarization up to ∼17% for 3-13C-pyruvate and 13C-formate. The instrumentation needed to perform this experiment in addition to a conventional dDNP polarizer is simple and readily assembled.