Aim: This study investigates the dissolution of tantalite mineral from granitic pegmatite in Okpella, Northern Edo State, Nigeria. Study Design: Elemental and mineral composition analysis of tantalite ore sample from Okpella was carried out using X-ray fluorescence and X-ray diffraction. Response Surface Methodology (RSM) and the shrinking core model were used in designing the study while the effects of temperature, stirring speed, particle diameter, and mixed acids concentrations were investigated in the dissolution rates of the mineral. Duration of Study: 50 experimental runs were designed using RSM Central Composite Design (CCD) to optimize variables including HF concentration (1-8 M), H2SO4 concentration (0.5-3 M), temperature (32-82°C), stirring speed (0-500 rpm), and particle size (0.1-0.3 mm), with a constant contact time of 240 minutes. Methodology: Pulverized tantalite samples (0.1-0.3 mm) were reacted with varying concentrations of hydrofluoric and sulphuric acids (1-8 M and 0.5-3.0 M, respectively) for 240 minutes, with stirring speeds between 0-500 rpm and temperatures from 32 to 82°C. The mixture was stirred in a water bath with 50 ml of mixed acids solution and 2 g of ore. After the reaction, the solution was decanted, and the residual ore was washed, dried at 60 °C, and weighed. The difference between the initial and final weights indicated the amount of undissolved tantalite ore. Results: Ore characterization results revealed high concentration of tantalum (34.17%), iron (12.55%), niobium (8.38%), and titanium (6.01%), with other elements present in smaller amounts. Optimal conditions were found to be 8 M HF, 0.5 M H2SO4, 82°C, 500 rpm stirring speed, and 0.1 mm particle size, resulting in 97.28% dissolution of tantalite ore. Regression analysis demonstrated model robustness with an F-value of 16.70 and a P-value of 0.0001, indicating HF concentration and stirring speed as the most impactful factors. The model’s R² value of 0.9201 and adjusted R² of 0.8650 confirm its predictive accuracy. Analysis using the shrinking sphere model showed that film diffusion control is the primary limiting step with t/τ=0.999, while reaction control resulted in slightly lower conversion with t/τ=0.973, highlighting film diffusion as the main constraint but with high conversion efficiency. Conclusion: The findings from this investigation not only reveal the dissolution of tantalite ore through a detailed experimental approach, identifying optimal conditions -8 M HF, 0.5 M H2SO4, 82 oC, 500 rpm stirring speed and 0.1 mm particle size- that achieve a 97.28% dissolution, but they also enhance our understanding of mineral processing. These understanding are crucial for mineral dissolution up scaling technologies in industrial applications, which will potentially leads to a more efficient extraction method that could significantly reduce costs and environmental impacts in the mining sector. This research could drive advancements in sustainable resource recovery and contribute to sourcing of critical minerals.