With the integration of large-scale wind power into the power grid, the impact on system stability, especially the issue of low-frequency oscillations caused by small disturbances, is becoming increasingly prominent. Therefore, this paper proposes a damping quantitative analysis method for regional interconnected power systems incorporating large-scale wind power. Using the cross-entropy particle swarm optimization (CE-PSO) algorithm, the control parameters of wind turbines are optimized to suppress low-frequency oscillations in interconnected systems. The method begins with the state equation of the interconnected power system in two regions; it deduces the characteristic polynomial of the interconnected system, including wind farms, and takes into account the influence of wind power integration on the electrical connectivity of the system. Subsequently, the influence of wind turbine control parameters on the system is quantified, and a quantitative analysis model of the impact of wind power integration on system damping characteristics is constructed. Based on this, an optimization model for wind turbine control parameters is established, and the CE-PSO algorithm is utilized to achieve suppression of low-frequency oscillations in interconnected power grids with wind power integration. Finally, the accuracy and effectiveness of the proposed method are verified through a typical electromagnetic transient simulation model of the two-region interconnected power system.