In this article, Caputo and Prabhakar fractional derivatives are used to analyze the influence of heat flux on fractionalized second grade flow. The fluid model is generalized by Fick’s and Fourier’s laws. Moreover, radiation and slip effects are also taken into account additionally. Fractional governing models are solved semi-analytically by using Caputo and Prabhakar fractional derivatives. The method of Laplace method is applied to solve the dimensional model for temperature, velocity, and concentration profiles. The results are contrasted visually. A variety of graphs are used to illustrate the impacts of several parameters, including the heat absorption Q, fractional parameter, magnetic parameter M, and chemical reaction R. It is evident from the figure that the velocity distribution is affected less by chemical and magnetic field, while the fluid velocity is affected more by diffusion-thermodynamics and mass Grashoff number. Furthermore, comparisons among classical and fractional fluid models are made to check the validity of the result. It is noted that the classical approach is less convenient as compared to the fractional approach.