Objective: The objective of this research is to carry out a comprehensive literature review, focusing on the period from 1988 to 2022, to systematically analyze the main anthropogenic activities responsible for deforestation in the Brazilian Legal Amazon. Theoretical reference: The theoretical framework of this research is based on the existing literature on deforestation in the Amazon, covering concepts related to anthropogenic activities, environmental impacts and conservation policies. Methodology: The method employed consists of a thorough analysis of the main scientific publication platforms and databases to compile relevant information on deforestation in the Legal Amazon. In addition, the research uses a systemic analysis to assess the future of deforestation. Results and Conclusion: The results highlight the critical areas of deforestation in the region, identifying extensive farming and illegal mining as the predominant factors. The temporal analysis projects an increase in deforestation if these activities persist. The alternatives proposed include models of sustainable agriculture, with an emphasis on preserving agrobiodiversity. The research concludes by highlighting the urgent need for more effective public policies, especially in the illegal mining sector. Research Implications: The implications of this research address the urgency of measures to tackle deforestation in the Legal Amazon, including the promotion of sustainable agricultural practices. It also highlights the need for more effective public policies, especially in relation to illegal mining, which is recognized as a high-impact activity. Originality/Value: The originality of this research lies in its comprehensive approach, integrating a literature review with a temporal analysis, and proposing sustainable solutions. It contributes to understanding the challenges faced in the Legal Amazon, presenting viable directions for conservation and sustainable management, emphasizing the importance of comprehensive and effective public policies.