Topological indices ( ) are a class of graph-based descriptors widely used in chemiformatics and Quantitative Structure-Activity Relationship (QSAR) studies. TIs capture key structural features of molecules by encoding graph-theoretic information, offering a quantitative representation of molecular topology. Each mathematical network is associated with a specific numerical value determined by a function. Among the Zagreb connection indices have been extensively researched. This study delves into the Cartesian product of cycle graphs with path graphs, elucidating the comprehensive implications of . These indices encompass the first , second , and third . Furthermore, comprehensive results of the modified first , modified second , and modified third are presented, along with the first multiplicative ZCI second multiplicative ZCI (SMZCI), and third multiplicative ZCI Moreover, modified first multiplicative ZCI ), modified second multiplicative ZCI and modified third multiplicative ZCI ( are also calculated. To provide precision, both the graphical and numerical analyses of the computed findings are aligned for the two Cartesian products. The foundation for mathematically modeling complex networks and chemical structures lies in graph theory. Topological indices ( ) are a class of graph-based descriptors widely used in chemiformatics and quantitative structure-activity relationship (QSAR) studies. TIs capture key structural features of molecules by encoding graph-theoretic information, offering a quantitative representation of molecular topology. Each mathematical network is associated with a specific numerical value determined by a topological index function. Among these the Zagreb connection indices are extensively researched TIs. This article delves into the Cartesian product of cycle graphs with path graphs, elucidating the comprehensive implications of . These indices encompass the first, Second and third. Furthermore, we present the comprehensive results of the modified , modified and modified , and also present the first multiplicative Zagreb connection index , and , along with their modified counterparts like modified first multiplicative Zagreb connection index , and . These analysis encompass two distinct types of graphs: cycle graphs and path graphs. To provide further precision, we align both the graphical and numerical analysis of our computed findings for these two Cartesian products.