Abstract Hybrid cellular automaton (HCA) method is a topology optimization method with high convergence efficiency. Harmonic response topology optimization problem has been widely researched and common frequency-domain methods have been applied to solve this problem. Despite this, little work has so far been undertaken to utilize HCA method to improve the calculation efficiency of harmonic response topology optimization. In this paper we present a methodology which applies HCA method to solve harmonic response topology optimization problem. Mode displacement method (MDM), mode acceleration method (MAM) and full method (FM) are common frequency-domain methods which are respectively utilized as harmonic response analysis methods in this study. The examples under rotating loads demonstrate that the feasibility of this methodology at one specific frequency excitation and multiple frequencies excitation. This paper presents and implements a high convergence efficiency method for harmonic response topology optimization, this method can converge in 20–30 iterations. This method can extend the application range of HCA method and improve the optimization efficiency of harmonic response topology optimization.