Ascent Modes Research Articles

Diurnally Varying Ekman Layer in a Rossby Wave

Abstract Weak but persistent synoptic-scale ascent may play a role in the initiation or maintenance of nocturnal convection over the central United States. An analytical model is used to explore the nocturnal low-level jets (NLLJ) and ascent that develop in an idealized diurnally varying frictional (Ekman) boundary layer in a neutrally stratified barotropic environment when the flow aloft is a zonally propagating Rossby wave. Steady-periodic solutions are obtained of the linearized Reynolds-averaged Boussinesq-approximated equations of motion on a beta plane with an eddy viscosity that is specified to increase abruptly at sunrise and decrease abruptly at sunset. Rayleigh damping terms are used to parameterize momentum loss due to radiation of inertia–gravity waves. The model-predicted vertical velocity is (approximately) proportional to the wavenumber and wave amplitude. There are two main modes of ascent in midlatitudes, an afternoon mode and a nocturnal mode. The latter arises as a gentle but persistent surge induced by the decrease of turbulence at sunset, the same mechanism that triggers inertial oscillations in the Blackadar theory of NLLJs. If the Rayleigh damping terms are omitted, the boundary layer depth becomes infinite at three critical latitudes, and the vertical velocity becomes infinite far above the ground at two of those latitudes. With the damping terms retained, the solution is well behaved. Peak daytime ascent in the model occurs progressively later in the afternoon at more southern locations (in the Northern Hemisphere) until the first (most northern) critical latitude is reached; south of that latitude the nocturnal mode is dominant.

Efficacy of Acetazolamide for the Prophylaxis of Acute Mountain Sickness: A Systematic Review, Meta-Analysis and Trial Sequential Analysis of Randomized Clinical Trials

BackgroundAcute mountain sickness (AMS) is a benign and self-limiting syndrome but can progress to life-threatening conditions if leave untreated. This study aimed to assess the efficacy of acetazolamide for the prophylaxis of AMS and disclose potential factors that affect the treatment effect of acetazolamide. Materials and MethodsRandomized controlled trials comparing the use of acetazolamide versus placebo for the prevention of AMS were included. The incidence of AMS was the primary endpoint. Meta-regression analysis was conducted to explore potential factors associated with acetazolamide efficacy. Trial sequential analysis (TSA) was conducted to estimate the statistical power of the available data. ResultsA total of 22 trials were included. Acetazolamide at 125, 250, and 375 mg/ twice daily (bid) significantly reduced incidence of AMS compared to placebo. TAS indicated that the current evidence was adequate confirming the efficacy of acetazolamide at 125, 250, and 375 mg/bid in lowering incidence of AMS. There was no evidence of an association between efficacy and dose of acetazolamide, timing at start of acetazolamide treatment, mode of ascent, AMS assessment score, timing of AMS assessment, baseline altitude, and endpoint altitude. ConclusionAcetazolamide is effective prophylaxis for the prevention of AMS in doses of 125, 250, and 375 mg/bid. Future investigations should focus on personal characteristics, disclosing the correlation between acetazolamide efficacy and body mass, height, degree of prior acclimatization, individual inborn susceptibility, and history of AMS.

Efficacy of acetazolamide for the prophylaxis of acute mountain sickness: A systematic review, meta-analysis, and trial sequential analysis of randomized clinical trials.

BACKGROUND:Acute mountain sickness (AMS) is a benign and self-limiting syndrome, but can progress to life-threatening conditions if leave untreated. This study aimed to assess the efficacy of acetazolamide for the prophylaxis of AMS, and disclose factors that affect the treatment effect of acetazolamide.METHODS:Randomized controlled trials comparing the use of acetazolamide versus placebo for the prevention of AMS were included. The incidence of AMS was our primary endpoint. Meta-regression analysis was conducted to explore factors that associated with acetazolamide efficacy. Trial sequential analyses were conducted to estimate the statistical power of the available data.RESULTS:A total of 22 trials were included. Acetazolamide at 125, 250, and 375 mg/bid significantly reduced incidence of AMS compared to placebo. TAS indicated that the current evidence was adequate confirming the efficacy of acetazolamide at 125, 250, and 375 mg/bid in lowering incidence of AMS. There was no evidence of an association between efficacy and dose of acetazolamide, timing at start of acetazolamide treatment, mode of ascent, AMS assessment score, timing of AMS assessment, baseline altitude, and endpoint altitude.CONCLUSION:Acetazolamide is effective prophylaxis for the prevention of AMS at 125, 250, and 375 mg/bid. Future investigation should focus on personal characteristics, disclosing the correlation between acetazolamide efficacy and body mass, height, degree of prior acclimatization, individual inborn susceptibility, and history of AMS.

Association between acute mountain sickness (AMS) and age: a meta-analysis

BackgroundAcute mountain sickness (AMS) is a potentially lethal condition caused by acute hypoxia after ascending to altitudes higher than 2500 m in a short time. The main symptom of AMS is headache. Numerous risk factors of AMS have been examined, including gender, obesity, ascent rate, age and individual susceptibility. In previous studies, age was considered a predisposing factor for AMS. However, different opinions have been raised in recent years. To clarify the association between AMS and age, we conducted this meta-analysis.MethodsWe obtained observational studies that explored risk factors for AMS by searching PubMed, Embase, China National Knowledge Internet (CNKI), the Wanfang database and CQVIP for articles published before March 2017. The studies included were required to provide the mean age and its standard deviation for subjects with and without AMS, the maximum altitude attained and the mode of ascent. The Lake Louse Score (LLS) or the Chinese AMS score (CAS) was used to judge the severity of AMS symptoms and incidence. Studies were pooled for the analysis by using a random effects model in RevMan 5.0. Meta-regression and subgroup analyses were conducted to identify sources of heterogeneity using Stata 14.2 and RevMan 5.0.ResultsIn total, 17 studies were included, and the overall number of subjects with and without AMS was 1810 and 3014, respectively. The age ranged from 10 to 76 years. Analysis of the 17 included studies showed that age was not associated with AMS (mean difference (MD) = 0.10; 95% CI: -0.38-0.58; P = 0.69).ConclusionThis meta-analysis suggests that there is no association between age and the risk of AMS. Race, age, and ascent mode are common sources of heterogeneity, which may provide an analytical orientation for future heterogeneity analyses.

Diapir versus along-channel ascent of crustal material during plate convergence: Constrained by the thermal structure of subduction zones

Subduction channel processes are crucial for understanding the material and energy exchange between the Earth’s crust and mantle. Crustal rocks can be subducted to mantle depths, interact with the mantle wedge, and then exhume to the crustal depth again, which is generally considered as the mechanism for the formation of ultrahigh-pressure metamorphic rocks in nature. In addition, the crustal rocks generally undergo dehydration and melting at subarc depths, giving rise to fluids that metasomatize and weaken the overlying mantle wedge. There are generally two ways for the material ascent from subarc depths: one is along subduction channels; the other is through the mantle wedge by diapir. In order to study the conditions and dynamics of these contrasting material ascent modes, systematic petrological-thermo-mechanical numerical models are constructed with variable thicknesses of the overriding and subducting continental plates, ages of the subducting oceanic plate, as well as the plate convergence rates. The model results suggest that the thermal structures of subduction zones control the thermal condition and fluid/melt activity at the slab-mantle interface in subcontinental subduction channels, which further strongly affect the material transportation and ascent mode. The thick overriding continental plate and the low-angle subduction style induced by young subducting oceanic plate both contribute to the formation of relatively cold subduction channels with strong overriding mantle wedge, where the along-channel exhumation occurs exclusively to result in the exhumation of HP-UHP metamorphic rocks. In contrast, the thin overriding lithosphere and the steep subduction style induced by old subducting oceanic plate are the favorable conditions for hot subduction channels, which lead to significant hydration and metasomatism, melting and weakening of the overriding mantle wedge and thus cause the ascent of mantle wedge-derived melts by diapir through the mantle wedge. This may correspond to the origination of continental arc volcanism from mafic to ultramafic metasomatites in the bottom of the mantle wedge. In addition, the plate convergence rate can also affect the material ascent mode, e.g., diapiric extrusion versus along-channel exhumation, by changing the amount of supracrustal rocks carried into the subduction channels, which further regulate the fluid/melt activity and thermo-rheological properties.

Into the deep: the functionality of mesopelagic excursions by an oceanic apex predator.

Comprehension of ecological processes in marine animals requires information regarding dynamic vertical habitat use. While many pelagic predators primarily associate with epipelagic waters, some species routinely dive beyond the deep scattering layer. Actuation for exploiting these aphotic habitats remains largely unknown. Recent telemetry data from oceanic whitetip sharks (Carcharhinus longimanus) in the Atlantic show a strong association with warm waters (>20°C) less than 200 m. Yet, individuals regularly exhibit excursions into the meso‐ and bathypelagic zone. In order to examine deep‐diving behavior in oceanic whitetip sharks, we physically recovered 16 pop‐up satellite archival tags and analyzed the high‐resolution depth and temperature data. Diving behavior was evaluated in the context of plausible functional behavior hypotheses including interactive behaviors, energy conservation, thermoregulation, navigation, and foraging. Mesopelagic excursions (n = 610) occurred throughout the entire migratory circuit in all individuals, with no indication of site specificity. Six depth‐versus‐time descent and ascent profiles were identified. Descent profile shapes showed little association with examined environmental variables. Contrastingly, ascent profile shapes were related to environmental factors and appear to represent unique behavioral responses to abiotic conditions present at the dive apex. However, environmental conditions may not be the sole factors influencing ascents, as ascent mode may be linked to intentional behaviors. While dive functionality remains unconfirmed, our study suggests that mesopelagic excursions relate to active foraging behavior or navigation. Dive timing, prey constituents, and dive shape support foraging as the most viable hypothesis for mesopelagic excursions, indicating that the oceanic whitetip shark may regularly survey extreme environments (deep depths, low temperatures) as a foraging strategy. At the apex of these deep‐water excursions, sharks exhibit a variable behavioral response, perhaps, indicating the presence or absence of prey.

Impact of Study Design on Reported Incidences of Acute Mountain Sickness: A Systematic Review.

Published incidences of acute mountain sickness (AMS) vary widely. Reasons for this variation, and predictive factors of AMS, are not well understood. We aimed to identify predictive factors that are associated with the occurrence of AMS, and to test the hypothesis that study design is an independent predictive factor of AMS incidence. We did a systematic search (Medline, bibliographies) for relevant articles in English or French, up to April 28, 2013. Studies of any design reporting on AMS incidence in humans without prophylaxis were selected. Data on incidence and potential predictive factors were extracted by two reviewers and crosschecked by four reviewers. Associations between predictive factors and AMS incidence were sought through bivariate and multivariate analyses for different study designs separately. Association between AMS incidence and study design was assessed using multiple linear regression. We extracted data from 53,603 subjects from 34 randomized controlled trials, 44 cohort studies, and 33 cross-sectional studies. In randomized trials, the median of AMS incidences without prophylaxis was 60% (range, 16%-100%); mode of ascent and population were significantly associated with AMS incidence. In cohort studies, the median of AMS incidences was 51% (0%-100%); geographical location was significantly associated with AMS incidence. In cross-sectional studies, the median of AMS incidences was 32% (0%-68%); mode of ascent and maximum altitude were significantly associated with AMS incidence. In a multivariate analysis, study design (p=0.012), mode of ascent (p=0.003), maximum altitude (p<0.001), population (p=0.002), and geographical location (p<0.001) were significantly associated with AMS incidence. Age, sex, speed of ascent, duration of exposure, or history of AMS were inconsistently reported and therefore not further analyzed. Reported incidences and identifiable predictive factors of AMS depend on study design.

Firefighter Incident Rehabilitation: Interpreting Heart Rate Responses

The primary objective of this observational study was to document the heart rate (HR) responses of firefighters during incident rehabilitation following firefighting activity in a high-rise building with a simulated fire on the 10th floor. Additionally, the study investigated potential factors, including firefighting workload, ambient temperature, firefighter movement, and individual characteristics, that may have affected HR during recovery. Firefighters (n = 198) were assigned to perform a simulation of fire suppression, search and rescue, or material support during one of six firefighting trials that involved different crew sizes and ascent modes, and were performed in different environmental conditions. After completing the simulated firefighting activity, firefighters reported to a rehabilitation area on the 8th floor. The rehabilitation area was staffed by firefighter/paramedics. HR was monitored continuously during simulated firefighting activity and a 15-minute rehabilitation period. Average HR during rehabilitation (HRmean) was calculated and compared across trials. Simulated firefighting activity was performed in the summer in Virginia, USA, and ambient conditions varied among trials (mean ± SD: 31 ± 4°C; 46 ± 15% relative humidity; 32 ± 4°C heat index). Duration of simulated firefighting activity ranged from 12.0 to 20.3 minutes among trials (mean: 15.4 ± 5.2 minutes). Over all trials, mean peak HR during simulations was 173 ± 18 beats·min−1. Mean HR over all trials at entry into rehabilitation was 149 ± 24 beats·min−1. Following 15 minutes of recovery, mean HR over all trials was 126 ± 23 beats·min−1. Exploratory analyses revealed that higher workload during firefighting (stair trials), higher ambient temperature (≥30°C), greater movement during rehabilitation (≥0.1 g-force), higher age (≥45 years), and higher BMI (≥30.0 kg·m−2) were associated with higher HR responses during rehabilitation. During complex emergency operations, emergency medical service personnel will likely encounter considerable variability in HR responses upon initial evaluation and throughout rehabilitation. Following one bout of firefighting activity during a simulated fire scenario, HR decreased but remained elevated well above resting values following 15 minutes of rehabilitation. Based on current fire service recommendations, the majority of firefighters (88%) would not have been released from rehabilitation and eligible for reassignment after a 15-minute rehabilitation period following a brief bout of simulated firefighting activity. Key words: medical monitoring, cardiac strain, firefighting

Cardiac Strain Associated with High-rise Firefighting

Although numerous studies have reported the physiological strain associated with firefighting, cardiac responses during a large-scale fire operation have not been reported and cardiac responses have not been compared based on crew assignment. The aims of this study were (1) to characterize cardiac strain during simulated high-rise firefighting, and (2) to compare the cardiac strain associated with different work assignments (fire suppression vs. search and rescue) and different modes of vertical ascent (stairs vs. elevator). Firefighters (N = 42) completed one assignment (fire suppression, search and rescue, or material support) during one of two trials that differed by ascent mode. Assignments were divided into three phases: Ascent (ascend lobby to 8th floor), Staging (remain in holding area on 8th floor), and Work (perform primary responsibilities). When comparing assignments within the same ascent mode, mean heart rate (HRmean) was higher (p = 0.031) for fire suppression than for search and rescue during Work in the stair trial (170 ± 14 vs. 155 ± 11 beats/min). Search and rescue crews experienced greater cumulative cardiac strain (HRmean × duration) during Work than did fire suppression crews (stairs: 1978 ± 366 vs. 1502 ± 190 beats; elevator: 1755 ± 514 vs. 856 ± 232 beats; p<0.05). When comparing ascent mode, HRmean and peak heart rate (HRpeak) were higher (35–57 beats/min; p≤0.001) for both fire suppression and search and rescue during Ascent and Staging phases in the stairs vs. the elevator trial. During Work, HRmean was higher (p = 0.046) for search and rescue in the stairs vs. the elevator trial (155 ± 11 vs. 138 ± 19 beats/min). HRmean and HRpeak were 47 and 34 beats/min higher (p < 0.01), respectively, when materials were transported to the staging area using the stairs compared with the elevator. Study findings suggest that high-rise firefighting results in considerable cardiac strain and that search and rescue and material support crews experienced more cardiac strain than fire suppression crews due primarily to differences in assignment duration. Furthermore, using stairs to transport firefighters and equipment to upper floors results in significantly greater cardiac strain than using the elevator.

Density and compressibility of the molten lunar picritic glasses: Implications for the roles of Ti and Fe in the structures of silicate melts

The density and compressibility of four synthetic molten lunar picritic glasses was investigated from 0 to 10GPa and 1748 to 2473K. The picritic glasses were collected from the lunar surface during the Apollo missions, and they are hypothesized to have rapidly quenched as glass beads during pyroclastic fire fountain eruptions. The specific melt compositions investigated in the present study are the Apollo 15 green glass Type C (A15C, TiO2=0.26wt%), the Apollo 14 yellow glass (A14Y, TiO2=4.58wt%), the Apollo 17 orange glass 74220-type (A17O TiO2=9.12wt%), and the Apollo 14 black glass (A14B, TiO2=16.40wt%). These glasses are reported to represent primary unfractionated melts, making them a prime candidate for experimental studies into lunar basalt density and compressibility during partial melting of the lunar mantle. Sink–float experiments were conducted on the synthetic molten lunar glass compositions using a piston-cylinder apparatus (P<2GPa) and a Walker-style multi-anvil device (P>2.5GPa) in order to bracket the density of the melts. New sink–float data are reported for A15C, A14Y, and A17O, which are combined with previously published density and compressibility data on A15C, A17O, and A14B. Although the Ti-rich liquids are highly compressible at lower pressures, they become nearly incompressible at much higher pressures when compared to the molten low-Ti glasses. Consequently, the melts with the most TiO2 (A14B) are the least dense at higher pressures, a reversal of what is seen at lower pressures. This change in density and compressibility is attributed to changes in coordination of Ti and Fe in the silicate melt structure. As Ti4+ abundances in the silicate melt increase, predominantly [IV]Ti4+ and [IV]Fe2+ change to [VI]Ti4+ and [VI]Fe2+ in the melt structure. All of the data from the present study were used to calculate a Birch–Murnaghan equation-of-state (BM-EOS) for each melt composition. The BM-EOS model for each composition was then combined with previously published estimates for the residual mantle source mineralogy and depth of origin for each of the glasses to assess the density of the partial melt with respect to its point of origin. This information was used to determine whether or not the melt would rise or sink with respect to its source region. We determined that all melt compositions, with the exception of the A17O melt, should have been able to rise to the crust-mantle boundary as a result of buoyancy forces alone, although different mechanisms are likely required for magma ascent through the lunar crust. For the rise of A17O, other modes of ascent through the lunar mantle are required to extract this melt composition from the mantle, and volatiles are not a plausible solution on the grounds of melt density alone.

Ascent modes of jets and plumes in a stationary fluid of contrasting viscosity

Using multi-phase numerical experiments based on the Volume of fluid (VOF) methods we show the ascent behavior of a fluid injected into another immiscible fluid with higher viscosity. Our VOF models reveal that the injected fluid forms jets characterized by a large head trailing to a slender tail, which do not break up, but ascend in two principal modes, Mode 1: continuous and Mode 2: pulsating. In Mode 1, their heads grow continuously either by volume expansion, forming balloon-shaped geometry (Mode 1a) or by curling, forming mushroom-shaped geometry (Mode 1b). In contrast, Mode 2 jets ascend in pulses, forming multiple heads, leading to pinched-off geometry. In this study we show the viscosity ratio (R) between the injecting and the ambient fluids as a crucial parameter in controlling the ascent modes, and provide an estimate of critical R for the Mode 1–2 transition under varying fluid injection rates (non-dimensionalized as Reynolds number, Re). From the entrainment velocity field we explain that the transition of continuous to pulsating process results from the flow convergence at several locations along the upwelling direction. We have also discussed the effects of buoyancy on the ascent modes in case of plumes.

Reappraisal of Acetazolamide for the Prevention of Acute Mountain Sickness: A Systematic Review and Meta-Analysis

Acetazolamide is used to prevent acute mountain sickness (AMS). We assessed efficacy and harm of acetazolamide for the prevention of AMS, and tested for dose-responsiveness. We systematically searched electronic databases (until April 2011) for randomized trials comparing acetazolamide with placebo for the prevention of AMS. For each dose, risk ratios were aggregated using a Mantel-Haenszel fixed effect model. Numbers needed to treat (NNT) to benefit one subject with each dose were calculated for different baseline risks. Modes of ascent were taken as proxies of baseline risks. Twenty-four trials were included; 1011 subjects received acetazolamide 250, 500, or 750 mg day⁻¹; 854 received placebo. When climbing, median speed of ascent was 14 m/h, average AMS rate in controls was 34%, and NNT to prevent AMS with acetazolamide 250, 500, and 750 mg/day compared with placebo was 6.5, 5.9, and 5.3. When ascending by transport and subsequent climbing (speed of ascent 133 m/h) or by transport alone (491 m/h), average AMS rate in controls was 60%, and NNT with acetazolamide 250, 500, and 750 mg/day was 3.7, 3.3, and 3.0. In hypobaric chambers, median speed of ascent was 4438 m/h, average AMS rate in controls was 86%, and NNT with acetazolamide 250, 500, and 750 mg/day was 2.6, 2.3, and 2.1. The risk of paresthesia was increased with all doses. The risk of polyuria and taste disturbance was increased with 500 and 750 mg/day. The degree of efficacy of acetazolamide for the prevention of AMS is limited when the baseline risk is low, and there is some evidence of dose-responsiveness.

Four-stage building of the Cambrian Carion pluton (Madagascar)

ABSTRACTThe 532±5 Ma old Carion pluton is a dark, porphyritic ferro-potassic granitoid emplaced near the late Pan-African Angavo mega-shear zone. A rough normal zoning from tonalitic to granitic compositions can be recognised in the field. Steep magmatic foliations are evidenced by K-feldspar megacryst preferred orientations. Microstructures are either magmatic or typical of incipient solid-state deformation in near solidus conditions. Magnetic susceptibility magnitudes (K) range from 11 to 111×10−3 SI in the pluton and can be correlated to the petrography (highest K values in the tonalites; lowest K in the granites; granodiorites in between). The susceptibility magnitudes display a complex zoning pattern. Combined with the arrangement of magnetic foliation trajectories, it is possible to delineate four nested sub-units, regarded as four magmatic pulses successively emplaced from the west to the east of the pluton. The four pulses are characterised by very similar magma geochemistry, but variable magmatic differentiation. The highest degrees of magnetic susceptibility anisotropies (up to 1·6) are observed along internal contacts between sub-units and along the borders of the pluton. The magnetic lineations are also steeply plunging in some places in each sub-unit, possibly imaging the different feeder zones. Magma emplacement occurred at the end of the activity of the Angavo shear zone, hence avoiding re-orientation of the magmatic structures by the late Pan-African transcurrent tectonics. The diachronicity of the four magmatic pulses is consistent with previously determined palaeomagnetic data, because only the two older sub-units display a magnetic reversal sequence, whereas the two youngest sub-units lack any reversion. Emplacement of these four magmatic batches was responsible for a strain aureole and suggests a diapiric mode of ascent.

Maximum Exercise Responses of Men and Women Mountaineering Trainees on Induction to High Altitude (4350 m) by Trekking

Maximum aerobic capacity decreases at high altitude. This study was conducted to compare the changes in maximum aerobic capacity in men and women mountaineering trainees on induction to high altitude at 4350 m by trekking. Eight men and 8 women mountaineering trainees in a mountaineering course were selected for the study. The initial study was conducted at 2100 m (586 mm Hg) and then during 6 to 7 days of sojourn at 4350 m (435 mm Hg). Maximum oxygen consumption (VO(2max)), maximum heart rate (HR(max)), pulse arterial oxygen saturation (SaO(2)), and maximum ventilation (VE(max)) were measured. VO(2max), HR(max), duration of work (minutes), and SaO(2) saturation decreased significantly (P < .05) with increasing altitude in both sexes. Conversely, VE(max) and ventilatory equivalent (VE/VO(2)) increased significantly (P < .05). Men showed a relatively higher value of maximum exercise variables (total exercise time, exercise intensity, and VO(2)) than women trainees at both altitude locations. The decrement of VO(2max) was 13% in women and 17% in men (P < .05). The results indicate that the decrement of maximum aerobic capacity at 4350 m was less in women than in men under similar modes of ascent.

High altitude pulmonary oedema.

Altitude, speed and mode of ascent and, above all, individual susceptibility are the most important determinants for the occurrence of high altitude pulmonary oedema (HAPE). This illness usually develops only within the first 2-5 days after acute exposure to altitudes above 2500-3000 m. An excessive rise in pulmonary artery pressure preceding oedema formation is the crucial pathophysiological factor. Recent investigations using right heart catheterisation and bronchoalveolar lavage (BAL) in incipient pulmonary oedema have shown that HAPE is a hydrostatic oedema in the presence of normal left atrial pressure with non-inflammatory high permeability leakage of the alveolocapillary barrier and mild alveolar haemorrhage. An inflammatory response may develop later in more advanced cases, as has been documented by BAL. Furthermore, decreased fluid clearance from the alveoli may contribute to such non-cardiogenic pulmonary oedema. Supplemental oxygen is the primary treatment in areas with medical facilities, while the treatment of choice in remote mountain areas is immediate descent. When this is impossible and supplemental oxygen is not available, treatment with nifedipine is recommended until descent is possible. Even susceptible individuals can avoid HAPE if they ascend slowly with an average gain of altitude not exceeding 300-350 m/day above an altitude of 2500 m.

High altitude pulmonary oedema.

Altitude, speed and mode of ascent and, above all, individual susceptibility are the most important determinants for the occurrence of high altitude pulmonary oedema (HAPE). This illness usually develops only within the first 2-5 days after acute exposure to altitudes above 2500-3000 m. An excessive rise in pulmonary artery pressure preceding oedema formation is the crucial pathophysiological factor. Recent investigations using right heart catheterisation and bronchoalveolar lavage (BAL) in incipient pulmonary oedema have shown that HAPE is a hydrostatic oedema in the presence of normal left atrial pressure with non-inflammatory high permeability leakage of the alveolocapillary barrier and mild alveolar haemorrhage. An inflammatory response may develop later in more advanced cases, as has been documented by BAL. Furthermore, decreased fluid clearance from the alveoli may contribute to such non-cardiogenic pulmonary oedema. Supplemental oxygen is the primary treatment in areas with medical facilities, while the treatment of choice in remote mountain areas is immediate descent. When this is impossible and supplemental oxygen is not available, treatment with nifedipine is recommended until descent is possible. Even susceptible individuals can avoid HAPE if they ascend slowly with an average gain of altitude not exceeding 300-350 m/day above an altitude of 2500 m.

Efficacy and harm of pharmacological prevention of acute mountain sickness: quantitative systematic review

Objective: To quantify efficacy and harm of pharmacological prevention of acute mountain sickness.Data sources: Systematic search (Medline, Embase, Cochrane Library, internet, bibliographies, authors) in any language, up to October 1999.Study...

On the fate of mantle plumes at density interfaces

The motion of plumes through compositionally layered systems is investigated by laboratory experiments in order to understand the ascent modes of deep mantle plumes. Experimental plumes entrain the ambient heavier fluid and the average density of the plume head ρ P( t) increases with time. The degree of entrainment depends on the viscosity ratio of the matrix fluid μ matrix to the buoyant fluid μ buoyant, and the mass flux. Two types of plume penetration through the density interface are possible. The first, which can be characterized as a ‘pass-through mode’ (PTM), exhibits relatively little entrainment. Here the whole plume head passes directly through the interface because ρ P( t) is smaller than the density of the upper layer ρ u. In contrast, in the second type of interaction (named the ‘rebirth mode’, RBM), a large entrainment effect takes place. The plume is now greatly disturbed as it passes through the interface between the two fluid layers and entrained material remains at the density interface since ρ P( t)> ρ u. In addition, a new diapir emerges from the plume conduit and rises through the upper layer. The difference between these two types of interaction is reflected in the spatial and the temporal characteristics of geochemical data obtained from mantle plume products such as Ontong Java Plateau (OJP).

High altitude pulmonary edema.

High altitude pulmonary edema. Med. Sci. Sports Exerc., Vol. 31, No. 1 (Suppl.), pp. S23-S27, 1999. Altitude, speed and mode of ascent, and, above all, individual susceptibility are the most important determinants for the occurrence of high altitude pulmonary edema (HAPE). This illness usually occurs only 2-5 d after acute exposure to altitudes above 2500-3000 m. Chest radiographs and CT scans show a patchy predominantly peripheral distribution of edema. Wedge pressure is normal at rest, and there is an excessive rise of pulmonary artery pressure (PAP) that precedes edema formation and appears to be a crucial pathophysiologic factor for HAPE. Additional factors such as an inflammatory response and/or a decreased fluid clearance from the lung may, however, be necessary for the development of this noncardiogenic pulmonary edema. Bronchoalveolar lavage in patients with mostly advanced HAPE shows evidence of inflammatory response with increased permeability. There are, however, no prospective data to decide whether the inflammatory response is a primary cause of HAPE or a consequence of edema formation. Supplemental oxygen is the primary treatment in areas with medical facilities whereas the treatment of choice in remote mountain areas is immediate descent. When this is impossible and supplemental oxygen is not available, treatment with nifedipine is recommended until descent is possible. Even susceptible individuals can avoid HAPE when they ascend slowly with an average gain of altitude not exceeding 300-350 m.d-1 above an altitude of 2500 m.

Shape of ascending feeder dikes, and ascent modes of magma

The shape of the leading edge of an ascending feeder dike is estimated using the criterion that the direction of the movement of the edge should be perpendicular to the edge. Using this criterion it is shown that the edge can have various elliptic shapes. The ascent of magma within feeder dikes can occur in different manners. The presence of mantle derived nodules in alkalic and nephelinic magmas suggest that these magmas may ascend as a single pulse. The continuous supply to the Kilauea volcano, Hawaii suggest that the tholeiitic magma forms a 20-km high vertical column in the feeder dike, supplied from below by successive pulses of magma.