In this paper, the stability analysis and stabilization of a class of mode-dependent mean residence time-based discrete-time switching nonlinear systems are addressed. More specifically, under the mode-dependent average dwell time (MDADT) switching mode, combined with the practical problem, the nonlinear factor of nested actuator saturation (NAS) is introduced. Firstly, in order to ensure the system stability, based on the parameter-dependent discontinuous switching Lyapunov function and several basic lemmas, a state feedback controller is designed that makes the closed-loop system (CLS) achieve local exponential stability (LES) by solving the optimal problem in terms of linear matrix inequalities (LMIs). Secondly, the system considers the maximum attraction domain that can be achieved by the NAS system under the conditions. The simulation results show the effectiveness of the proposed design method. At the same time, the efficiency of the proposed method is verified via a water tank example.