In the transformative landscape of healthcare, personalized medicine emerges as a pivotal shift, harnessing genetic, environmentaland lifestyle data to tailor medical treatments for enhanced outcomes and cost efficiency. Central to its success is public engagement and consent to share health dataamidst rising data privacy concerns. To investigate European public opinion on this paradigm, we executed a comprehensive cross-sectional survey to capture the general public's views on personalized medicine and data-sharing modalities, including digital tools and electronic records. The survey was distributed in eight major European Union countries and the results aim at guiding future policymaking and trust-building measures for secure health data exchange. This articledelineates our methodological approach, whereby survey findings will be expounded in subsequent publications.