Community palliative care services are scarce in Puerto Rico (PR). Therefore, patients with advanced cancer commonly visit the emergency department (ED) at end of life. Identification of these patients and their palliative care needs can help in care coordination. Recognition of patients with limited life expectancies and palliative care needs may improve the end of life trajectory of these patients. Our objective was to characterize ED visits of advanced cancer patients at the end of life by examining, for the first time, the patterns of ED visits in PR using the PR Central Cancer Registry-Health Insurance Linkage Database (PRCCR-HILD). Data was obtained from the PRCCR-HILD, which links nearly 90% of cancer cases diagnosed in PR with insurance claims files. We included patients diagnosed between 2011 and 2016, aged ≥18 years with primary invasive cancer, that died between 2011 and 2017, with a recorded date of death, who died from cancer, and who had insurance claims during their last three months. End-of-life care indicators were ED visits, ED death, and hospice use. We used logistic regression models to examine factors associated with end-of-life care. The study cohort included 10,812 cancer patients. We found that 49% had at least one ED visit, 20% had ≥2 ED visits, and another 9.7% died in the ED. Only 9.4% of patients in the cohort were enrolled in hospice. Of those, 46% used hospice within 30 days of death and, 9% enrolled in hospice within three days of death. According to the bivariate analysis, there was an association between having ≥ 2 ED visits and the variables of age group, type of cancer, and stage at diagnosis (p-value<0.05). Likewise, there is an association with death in an ED and sex, age group, and type of cancer (p-value<0.05). In the adjusted model, patients ≥ 80 years were 44% less likely to have ≥ 2 ED visits (aOR: 0.56, 95% CI: 0.46-0.68) compared to patients aged <50 years. Patients with distant stage are more likely to have ≥2 ED visits (p-value<0.05). Also, results of the multiple logistic model showed that significant predictors of death at ED were: ages 65 to 79 (aOR, 0.71; 95% CI, 0.58 to 0.87) and ages ≥80 (aOR, 0.43; 95% CI, 0.33 to 0.56). Female patients were found to be significantly less likely to die in an ED setting. ED visits at end of life can be interpreted as a poor-quality cancer care. Awareness among ED staff of the potential of ED-initiated palliative care is needed. This study demonstrates the potential of the PRCCR-HILD as a resource to further investigate the quality of care among advanced cancer patients at the end of life. Further studies are warranted to improve the quality of care and to mitigate disparities at end-of-life care in PR. Stakeholders need to commit to palliative care as a public health priority in PR, implementing education, planning services, and mobilizing community resources.