Objective: The focus of this study was to establish a simple, robust, and validated RP-column approach to analyze Candesartan and Pioglitazone in a bilayer tablet dosage form. To broaden patient compliance in conditions such as diabetes and hypertension, a combination of drugs is often prescribed. As a result, a bilayer tablet containing a fixed-dose combination of 8 mg of Candesartan and 15 mg of Pioglitazone was developed. Both drugs were analyzed and chromatographically separated using the liquid chromatography technique. Methodology: waters 2695 with a quaternary pump and Inertsil C18 column mobile phase as buffer: acetonitrile (60:40) and flow rate of 1ml per minute and detection at 220nm was used for performing Chromatography. Results: Internal standard, Candesartan, and Pioglitazone eluted with retention times of 2.208, 2.569, and 3.553 minutes, respectively. There was no interference found between the peaks. With a correlation value of 0.999, the approach is verified across a linear range of 0.5 µg/ml – 20.0µg/ml for Candesartan and 0.08 µg/ml – 3.2 µg/ml for Pioglitazone. 6 samples at LLOQ level were analyzed for accuracy and precision and found to be in limit and all the analytes were stable at 28 °C and -80 °C in human plasma.