Background: One of the pertinent challenges the periodontists face today is the regeneration of periodontal tissue because of its complex structure. Periodontal tissue damage is characterized by bone and soft tissue loss. At present, one of the recommended materials for regeneration is PRF or platelet-rich fibrin. It is a regeneration material containing growth factors, prepared from the patient’s own blood, that can be used as a membrane.
 Objective: To see the efficacy of healing periodontal tissue using the addition of PRF.
 Method: A 31-year-old woman presented to the Department of Periodontology of Hasanuddin University Dental and Oral Hospital with the chief complaint of elongated teeth that often bled. Intraoral examination showed pocket depths of 6 mm and 5 mm in teeth 32 and 42, respectively. Radiographs showed radiolucent features in lower anterior teeth with horizontal bone loss. Chronic periodontitis of 32 and 42. Therapeutic intervention included initial therapy by scaling and root planning, followed by flap operation and regenerative therapy with PRF, membrane and bone graft.
 Results: One week post regenerative therapy with PRF, the clinical appearance seemed better and there was no complaint from the patient.
 Conclusion: The addition of PRF to periodontal surgery as a regenerative therapy can accelerate healing in the treatment of chronic periodontitis.
 Keywords: flap operation, platelet rich-fibrin, tissue regeneration