Multiple Internet of Healthcare Things (IoHT)-based devices have been utilized as sensing methodologies for human locomotion decoding to aid in applications related to e-healthcare. Different measurement conditions affect the daily routine monitoring, including the sensor type, wearing style, data retrieval method, and processing model. Currently, several models are present in this domain that include a variety of techniques for pre-processing, descriptor extraction, and reduction, along with the classification of data captured from multiple sensors. However, such models consisting of multiple subject-based data using different techniques may degrade the accuracy rate of locomotion decoding. Therefore, this study proposes a deep neural network model that not only applies the state-of-the-art Quaternion-based filtration technique for motion and ambient data along with background subtraction and skeleton modeling for video-based data, but also learns important descriptors from novel graph-based representations and Gaussian Markov random-field mechanisms. Due to the non-linear nature of data, these descriptors are further utilized to extract the codebook via the Gaussian mixture regression model. Furthermore, the codebook is provided to the recurrent neural network to classify the activities for the locomotion-decoding system. We show the validity of the proposed model across two publicly available data sampling strategies, namely, the HWU-USP and LARa datasets. The proposed model is significantly improved over previous systems, as it achieved 82.22% and 82.50% for the HWU-USP and LARa datasets, respectively. The proposed IoHT-based locomotion-decoding model is useful for unobtrusive human activity recognition over extended periods in e-healthcare facilities.