Mixing Order Research Articles

Pengaruh Urutan Pencampuran Pemlastis pada Komponding Karet Terhadap Kinetika Vulkanisasi Menggunakan Model Deng-Isayev dan Kamal-Sorour

Plasticizers play an important role in the rubber industry to facilitate the dispersion of additives into rubber. This research aims to study the effect of plasticizer mixing sequence on vulcanization kinetics. This relates to its effect on printing time and energy, as well as the cost of electricity used. Compound A was made by adding plasticizer at the mastication stage and compound B was made by adding plasticizer at the masterbatch stage. Kinetic parameters were determined using Deng-Isayev and Kamal-Sorour models. The results show that the Deng-Isayev model is closer to the experimental data than the Kamal-Sorour model. Compound A has a k value (3.0635x10-6 sec-1) and cure index (0.8403) slightly lower than compound B with a k value 3.3511x10-6 sec-1 and cure index 0.9260. However, the mixing order of the plasticizers did not significantly affect the vulcanization performance, either the reaction speed constant, reaction order, induction time, optimal vulcanization time, and cure index.

Synergistic effect of magnesium stearate and fine lactose in improving aerosolization performance of fluticasone propionate in dry powder formulation

Magnesium stearate (MgSt) and lactose fines are often used as ternary components in carrier-based dry powder inhalers (DPIs) to improve fine particle fraction (FPF), but whether they act synergistically to improve aerosolization performance of DPI formulations is currently less studied. In addition, the applicability of utilizing powder rheological parameters to predict the FPF needs to be further verified. Thus, in this study, using fluticasone propionate (FP) as a model drug, effect of lactose fines addition in 0.5% MgSt containing DPI formulations on their powder and aerodynamic properties was explored. Influence of MgSt and fines mixing order on the DPIs performance was also investigated. The results showed that addition of lactose fines (1–10%) in 0.5% MgSt containing formulations could further improve flowability and enhance adhesion of the mixtures, and they could act synergistically to improve FPF. Moreover, the presence of 0.5% MgSt can greatly reduce the amount of lactose fines required to achieve the comparable FPF. The mixing order can affect distribution of MgSt on the carrier surface, with higher FPF noted when MgSt was mixed with carrier first, followed by lactose fines. A good linear relationship between powder rheological parameters such as basic flowability energy (BFE), Permeability and FPF was disclosed. In conclusion, in FP based DPIs, MgSt and lactose fines act synergistically to enhance FPF by tuning powder characteristics. Good flowability (27.39%) and strong adhesion (72.61%) contributed to the enhanced drug deposition in the lung.

A dynamic compartment model for spatially heterogeneous reactors: Scalar and Monte-Carlo particle mixing

The coupling of multidimensional population balance models with transport equations is often necessary for the simulation of spatially heterogeneous reactors. Because of numerical intractability, a compromise on both the hydrodynamics and the population description has to be made. In this work, the Monte-Carlo method is used to calculate the local integral source term due to the dispersed phase (isodense particles) and a compartment model is used to describe the fluid motion in the reactor. The number density function n(x,t,ξ) is approximated by the number of Monte-Carlo particles per compartment and their movement in the space of compartment uses a stochastic transport algorithm adapted from existing works. The numerical tool is thoroughly and successfully validated in the context of mixing and first order reaction in a 70 L stirred tank equipped with a Rushton turbine. The dynamic method makes use of time resolved CFD simulations to built time dependent flow matrices reflecting the periodic nature of the flow field. The dynamic approach is finally compared to other usual compartment model approaches in terms of complexity, accuracy and rapidity which reveals the benefit of considering the flow unsteadiness within a compartiment model approach for stirred tanks.

Effect of Graphene Oxide Localization on Morphology Development and Rheological and Mechanical Properties of Poly(lactic acid)/ethylene vinyl Alcohol Copolymer Blend Composites: A Comprehensive Study.

This study investigates the rheological, morphological, and mechanical properties of melt-processed polylactide/ethylene vinyl alcohol (70PLA/30EVOH) blend composites containing 0.25, 0.5, and 1 wt.% of graphene oxide (GO) nanoplates. Thermodynamic-based suggested the localization of nanoparticles in EVOH, SEM studies showed that the introduction of GO to the blend increased dispersed droplet size, which was attributed to the localization of GO within EVOH, as confirmed by TEM. The rheology results indicated a decrease in the elasticity for the composite containing 0.25 wt.% of GO compared to the neat blend, which was attributed to the sliding effect of the added GO nanoplatelets. However, samples containing higher amounts of GO nanoplatelets exhibited more excellent elasticity than the neat blend. The increased elasticity was suggestively attributed to the dominance of hydrodynamic interactions, the physical network of added nanoplatelets, and polymer/GO interactions over the sliding role of the GO nanoplatelets at higher loadings. In addition, the effect of the order of mixing was investigated, and the premixing of PLA and GO exhibited a decrease in the droplet radius compared to the neat blend. It was ascribed to the localization of GO nanosheets in the PLA and interface, which was confirmed by rheological results and mechanical assessments.

UV–VIS imaging-based investigation of API concentration fluctuation caused by the sticking behaviour of pharmaceutical powder blends

Surface powder sticking in pharmaceutical mixing vessels poses a risk to the uniformity and quality of drug formulations. This study explores methods for evaluating the amount of pharmaceutical powder mixtures adhering to the metallic surfaces. Binary powder blends consisting of amlodipine and microcrystalline cellulose (MCC) were used to investigate the effect of the mixing order on the adherence to the vessel wall. Elevated API concentrations were measured on the wall and within the dislodged material from the surface, regardless of the mixing order of the components. UV imaging was used to determine the particle size and the distribution of the API on the metallic surface. The results were compared to chemical maps obtained by Raman chemical imaging. The combination of UV and VIS imaging enabled the rapid acquisition of chemical maps, covering a substantially large area representative of the analysed sample. UV imaging was also applied in tablet inspection to detect tablets that fail to meet the content uniformity criteria. The results present powder adherence as a possible source of poor content uniformity, highlighting the need for 100% inspection of pharmaceutical products to ensure product quality and safety.

Mg2+- or Ca2+-regulated aptamer adsorption on polydopamine-coated magnetic nanoparticles for fluorescence detection of ochratoxin A.

It has been observed that polyvalent metal ions can mediate the adsorption of DNA on polydopamine (PDA) surfaces. Exploiting this, we used two divalent metal ions (Mg2+ or Ca2+) to promote the adsorption of fluorescence-labelled ochratoxin A (OTA) aptamers on PDA-coated magnetic nanoparticles (Fe3O4@PDA). Based on the different adsorption affinities of free aptamers and OTA-bound aptamers, a facile assay method was established for OTA detection. The aptamers adsorbed on Fe3O4@PDA were removed via simple magnetic separation, and the remaining aptamers in the supernatant exhibited a positive correlation with the OTA concentration. The concentrations of Mg2+ and Ca2+ were finely tuned to attain the optimal adsorption affinity and sensitivity for OTA detection. In addition, other factors, including the Fe3O4@PDA dosage, pH, mixing order, and incubation time, were studied. Finally, under optimized conditions, a detection limit (3σ/s) of 1.26ng/mL was achieved for OTA. Real samples of spiked red wine were analysed with this aptamer-based method. This is the first report of regulating aptamer adsorption on the PDA surface with polyvalent metal ions for OTA detection. By changing the aptamers, the method can be easily extended to other target analytes.

Chitosan−magnesium aluminum silicate nanocomposite−based films of nicotine for buccal delivery: Mixing order effect and drug retention

Chitosan-magnesium aluminum silicate (CS-MAS) nanocomposites can be used as matrix films for buccal delivery of nicotine (NCT). The objective of this work was to prepare NCT-loaded CS-MAS films with different mixing orders of the components and varying amounts of NCT, and to investigate the characteristics of the films obtained. Blending MAS and NCT in the first step caused greater %NCT retention in the films because the NCT-MAS complexes could be formed completely, leading to a decrease in NCT volatilization during film drying. Additionally, this film provided a lower burst and total release of NCT than those prepared using other mixing orders; however, an indifference in NCT permeation across the mucosa was observed. However, all mixing orders still provided features of the nanocomposite films, as revealed by PXRD. The higher amount of added NCT caused a decrease in %NCT retention because of the limitation of the MAS amount to form complexes with NCT. The release and permeation rates of NCT increased with increasing NCT content. Furthermore, the NCT-loaded CS-MAS films still exhibited mucoadhesive properties. These findings suggest that the mixing order and amount of NCT added are important parameters for fabricating CS-MAS nanocomposite films for buccal NCT delivery.

Application technology for bioherbicides: challenges and opportunities with dry inoculum and liquid spray formulations.

Bioherbicides offer many potential benefits as part of an integrated weed management system or a totally biological or organic cropping system. A key factor for success is the selection of appropriate formulation and delivery systems for each target weed and cropping/climatic region. For dry inoculum products, we discuss direct implantation as an example for successful control of woody weeds, with benefits in control extending beyond the treated weeds to surrounding weeds. These applications do not require water and will become less labor-intensive with future robotic application platforms. Indeed, all bioherbicide applications are likely to improve and become more cost-effective with the advance of new application platforms with sensors and targeted control at lower application volume rates. Unmanned aerial vehicles, as new application platforms, are one of several such potential progressive application systems for liquid formulations, and we discuss product design to maintain optimum conditioning of the active ingredient(s) and storage stability. The delivery system must not adversely affect the products and the application volume rate must be appropriate for coverage on the target. Where applied with other products, compatibility must be ensured and appropriate mixing orders observed to assure performance and avoid precipitation or settling. Droplet size is important for allowing the active materials to be included in the spray, which may require droplets with diameter >150 μm for some larger particle biologically active agents. However, droplet size should not be too large to achieve target coverage. In some cases, that may be plant stems rather than leaves, or narrow grass weeds which tend to have highest spray collection efficiency for small droplets. Narrow droplet size spectrum nozzles may help optimize droplet size. We propose spray calculators to help optimize performance for coverage, retention and avoidance of drift losses, bounce, shatter and runoff. These include regulatory-supported, validated models. © 2023 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

Thermodynamics of compound forming CdHg liquid alloys at 600 K

The quasi-lattice model has been applied to analyze the alloying behavior of the compound forming CdHg liquid alloys at 600 K. In solid state, CdHg liquid alloys exhibit the existence of Cd2Hg and CdHg2 complexes. In present study, it is considered that Cd2Hg complex also exists in liquid state near the melting temperature. The investigative equations for the thermodynamic and structural functions have been derived for a binary molten alloy having the existence of A2B complex where A and B are constituent elements. The theoretical data for the excess Gibbs free energy of mixing, Gibbs free energy of mixing, thermodynamic activity, entropy of mixing, enthalpy (i.e. heat) of mixing, concentration fluctuations and short-range order (SRO) parameter are compared with the corresponding experimental values. A well agreement have been observed between the theory and experiment. The present study reveals that CdHg system at 600 K in molten state is a weakly interacting ordered system. Further, the order energy parameters are temperature dependent.

Water-based dual polymer ceramic-coated composite separator for high-energy-density lithium secondary batteries

A simple, eco-friendly, and effective additive-free technique for stabilizing a coating slurry, using alumina (Al2O3) inorganic particles and aqueous dual polymers—sodium carboxymethyl cellulose (CMC) and polyvinyl alcohol (PVA) is developed. The slurry preparation process is optimized by determining the polymer binders (CMC/PVA) content in the ceramic slurry and studying the interaction between the polymer binders and Al2O3 ceramic particles by changing the mixing order of the slurry components. CMC effectively controls the viscosity of the slurry to maintain a stable slurry dispersion. In contrast, PVA significantly influences the formation of a uniform ceramic coating layer on the polyethylene (PE) separator. This results in a synergistic effect to produce an optimal ceramic-coated composite separator (CCS). Compared to the bare PE separators, the prepared Al2O3 CCSs display improved physical properties, such as high adhesion strength of the ceramic coating layer, thermal stability, electrolyte wettability, and increased ionic conductivity. Moreover, the CCSs exhibit enhanced electrochemical performance. Half cells (LiMn2O4/Li metal) comprising CCSs retained 96.5% (144.8 mAh g−1) of the initial discharge capacity even after 200 cycles, while bare PE separators lose their capacity rapidly after 150 cycles, retaining only 22.62% (33.5 mAh g−1) at the 200th cycle.

Ascorbic acid nanoencapsulation using polyelectrolyte complex formation and optimization using hybrid artificial neural network‐genetic algorithm

AbstractBackgroundsThe polyelectrolyte complex (PEC) formation using chitosan (Cs) and alginate (Alg) has been employed to carry out Vitamin C (VC) nanoencapsulation because of its instability in adverse conditions. This method includes VC nanoencapsulation using physical cross‐linking. The effect of the mixing order as well as the different mass ratios of both the polymer and the VC content, were investigated on the size, pdi, zeta potential, encapsulation efficiency (EE%), and yield%. Hence, considering different mass ratios of both polymer (4:1–1:4) and VC content (10%–30% w/w of Cs) as independent variables, PECs were formed using 0.1% (w/v) of Cs and Alg solution.ResultThe result showed that, for equal mass ratio (1:1) of Cs and Alg, the addition of Alg solution to Cs solution led to lower particle size, while higher particle size was observed with reverse order of addition. However, no significant effect of polymer mass ratios was observed on particle size and NPs stability, while EE varied with VC concentration. Artificial neural network (ANN) was applied to train the experimental parameters Cs: Alg ratios (X1:X2) and VC content (X3) for the output variables. Moreover, process optimization was carried out using multi‐objective genetic algorithm (MOGA) with the goal of lowering particle size and increasing EE while increasing nanoparticle yield.ConclusionThe PEC method effectively encapsulated VC as obtained from higher EE. The Cs: Alg ratio of 4:2.1 and 18% VC content (w/w of Cs) was found optimum for nanoencapsulation. The final ANN‐GA model showed an acceptable agreement with experimental data.

Mechanical and microstructural properties of cemented marine dredged clay with pre-hydrated ground granulated blast furnace slag

Marine dredged clay (MDC) is treated with large amounts of cement before being used as construction materials due to its highly water content, leading to a strong demand of economically friendly treatment method. Ground granulated blast furnace slag (GGBS) has been used in concrete production to replace partial cement, but its application in cementing MDC is rarely been investigated. Furthermore, previous studies ignore the self-hydration capacity of GGBS, which may weaken the effectiveness or cause the overuse of GGBS. This study provides a new mixing method (MMII) in treating MDC by pre-hydrating GGBS before mixing with cement, and conducts a series of laboratory tests on the cemented MDC. The influence of GGBS and the mixing method on the mechanical and microscopic properties was examined. The results show that the recommended pre-hydration time is 16 h. The cemented MDC with GGBS obtains higher strength and lower hydraulic conductivity than that of cement-treated MDC with pure cement. Under the influence of MMII, more hydration products are generated due to the two times of hydration, the UCS is improved by up to 20%, the hydraulic conductivity is reduced by up to 17% accordingly. Meanwhile, the size of Ca(OH)2 (CH) decreases to generate calcium silicate hydrate (CSH). By only change mixing order, the engineering performance of cemented MDC with GGBS is improved significantly, showing great engineering benefits and economic values in treating MDC by pre-hydrating GGBS.

Structure and functionality of cinnamaldehyde/chitosan/gum Arabic complex particles

The work aims to study the effects of the mixing order of chitosan, gum Arabic and cinnamaldehyde and the concentration of cinnamaldehyde on the structure and functionality of complex particles. The results showed that non-covalent and Schiff base reactions occurred between cinnamaldehyde, chitosan and gum Arabic. When chitosan and gum Arabic (CS-GA-1:0.3) were mixed first, the complex particles were flat spherical and more compact and existed in aggregate state, with higher particle size, Zeta potential and wettability, and lower interfacial tension. When mixing cinnamaldehyde with chitosan or gum Arabic first (CS-CA-1:0.3 and GA-CA-1:0.3) and adding high concentration of cinnamaldehyde (CS-GA-1:0.9 and CS-GA-1:1.2), the structural compactness and morphological regularity of the complex particles got weakened, leading to the decrease in contact angle and increase in interfacial tension. All complex particles could be effectively used as Pickering emulsion stabilizers. When chitosan:cinnamaldehyde mass ratio reached 1:0.6 and below, the complex particles showed obvious antibacterial properties. The above results laid a foundation for the application of chitosan-based complex particles in the food and medical field.

Exploring the influence of magnesium stearate content and mixing modality on the rheological properties and in vitro aerosolization of dry powder inhaler

Since carrier-based dry powder inhalers (DPIs) suffer from inadequate drug deposition in the lung, an increasing number of marketed products have added magnesium stearate (MgSt) to improve the aerosolization, dispersion, and stability against moisture of DPI. However, for carrier-based DPI, there is a lack of examination of the optimal MgSt content as well as the mixing modality, and there is also a need to verify the applicability of rheological properties to predict the in vitro aerosolization of DPI formulations containing MgSt. Therefore, in this work, DPI formulations were prepared using fluticasone propionate as a model drug and commercial crystalline lactose Respitose® SV003 as a carrier within 1% MgSt content, the effect of MgSt content on the rheological and aerodynamic properties were investigated. After the optimal MgSt content was determined, the effects of mixing modality, mixing order, and carrier size on formulation properties were further investigated. Meanwhile, correlations were established between rheological parameters and in vitro drug deposition parameters, and the contribution of rheological parameters were determined using principal component analysis (PCA). The results showed that the optimal content of MgSt in DPI formulations is 0.25%-0.5% under both high-shear and low-shear, using medium-sized carriers (D50 around 70 μm) and low-shear mixing are beneficial for improving in vitro aerosolization. Good linear relationships between powder rheological parameters such as basic flow energy (BFE), specific energy (SE), Permeability and fine particle fraction (FPF) were established, PCA showed that both flowability and adhesion are key properties affecting FPF. In conclusion, both MgSt content and mixing modality can influence rheological properties of the DPI, which can be used as a screeing tool for DPI formuluation and preparation process optimization.

Negatively charged chitosan nanoparticles prepared by ionotropic gelation for encapsulation of positively charged proteins

The nanoprecipitation of hydrogel nanoparticles by complex coacervation is investigated through a systematic study of the popular chitosan-polyphosphate pair of polyelectrolytes with opposite charges at pH 4. Polyphosphates of varying molar masses and electrical charges are investigated as alternatives to the commonly used tripolyphosphate, so as to assess the influence of the strength of electrostatic interactions on the fabrication possibility, the size of hydrogel particles, and their overall charge. Sodium hexametaphosphate and sodium polyphosphate allow the manufacture of such nanoparticles with either a positive or a negative charge, depending on the chitosan/polyphosphate ratio and the order of mixing. The classical way of mixing by pouring the polyphosphate solution into the chitosan solution yields microparticles. Inverting the order of mixing by pouring the chitosan solution into the polyphosphate solution allows the precipitation of negatively charged nanoparticles with diameters in the range 100–200 nm. Such charge inversion of the chitosan into negative is not possible with the common TPP. It was achieved using sodium hexametaphosphate and sodium polyphosphate having a larger negative charge. Charge inversion of chitosan allows an efficient encapsulation of positively charged proteins with an improved encapsulation efficiency than in the usual TPP-based coacervate. The encapsulation of the bovine serum albumin at pH 4 is given as a case study of a positively charged protein.

The cocontinuous morphology induced from the graphene nanosheets percolation network structures in the immiscible high density polyethylene/polyamide 6/graphene nanosheets composites

AbstractThe addition of graphene nanosheets (GNSs) into immiscible polymer composites to induce the cocontinuous morphologies shows potential application in reinforced nanocomposites and conductive polymer nanocomposites. In this work, immiscible high density polyethylene (HDPE)/polyamide 6 (PA6)/GNS composites were prepared via melt mixing. The electrical and rheological property of HDPE/PA6 composites filled with various GNS contents according to different viscosity ratios and mixing orders were investigated to reveal the double percolation effect via percolation scaling laws, and compared with those of HDPE/GNS and PA6/GNS composites. The morphology and GNS dispersion state of HDPE/PA6/GNS composites were examined via transmission electron microscopy and scanning electron microscope. Most of the GNS were selectively located in the PA6 phase of HDPE/PA6/GNS composites. The GNS‐related network and mixing order played important roles in the cocontinuous morphology formation and performance of HDPE/PA6/GNS conductive composites. Moreover, the addition of GNS also affected the crystallization kinetics and mechanical property of HDPE/PA6/GNS composites.

Monitoring Protein Complexation with Polyphosphazene Polyelectrolyte Using Automated Dynamic Light Scattering Titration and Asymmetric Flow Field Flow Fractionation and Protein Recognition Immunoassay.

Polyphosphazenes represent a class of intrinsically flexible polyelectrolytes with potent immunoadjuvant activity, which is enabled through non-covalent self-assembly with antigenic proteins by charge complexation. The formation of supramolecular complexes between polyphosphazene adjuvant, poly[di(carboxylatophenoxy)phosphazene] (PCPP), and a model vaccine antigen, hen egg lysozyme, was studied under physiological conditions using automated dynamic light scattering titration, asymmetric flow field flow fractionation (AF4), enzyme-linked immunosorbent assay (ELISA), and fluorescent quenching methods. Three regimes of self-assembly were observed covering complexation of PCPP with lysozyme in the nano-scale range, multi-chain complexes, and larger aggregates with complexes characterized by a maximum loading of over six hundred protein molecules per PCPP chain and dissociation constant in the micromolar range (Kd = 7 × 10-6 mol/L). The antigenicity of PCPP bound lysozyme, when compared to equivalent lysozyme solutions, was largely retained for all complexes, but observed a dramatic reduction for heavily aggregated systems. Routes to control the complexation regimes with elevated NaCl or KCl salt concentrations indicate ion-specific effects, such that more smaller-size complexes are present at higher NaCl, counterintuitive with respect to PCPP solubility arguments. While the order of mixing shows a prominent effect at lower stoichiometries of mixing, higher NaCl salt reduces the effect all together.

Fabrication and performance of nitrocellulose nanoparticles reinforced environment-friendly waterborne ethyl cellulose (Surelease®) nanocomposites

In terms of eco-friendly materials, cellulose-based nanomaterials have received widespread attention as nano-functional fillers due to their lower production costs, better biodegradability, and excellent interfacial compatibility with polymers. In this paper, a nitrocellulose (NC) nano aqueous dispersion was successfully prepared using a simple, low-energy solvent displacement method. The effect of the organic: aqueous phase mixing order and kinetics, organic solvent, stirring speed, and organic: aqueous phase mixing ratio on the particle size and polydispersity index (PDI) of the nanoparticles were investigated. The obtained NC dispersion had a small particle size (Z-average particle diameter (Zave) < 100 nm), uniform size distribution (polydispersity index (PDI) < 0.2), and relatively good stability (Zeta potential is about −30 mV). And a series of Surelease® nanocomposites incorporated with various content of NC nanoparticles were fabricated via a facile solution casting/solvent evaporation method. The micromorphology, chemical structure, thermal properties, and water vapor sorption behavior of the nanocomposites were systematically investigated by Field scanning electron microscopy (SEM), Fourier-transform infrared (FTIR) spectrometer, Differential scanning calorimetry, Thermogravimetric analysis, and dynamic vapor sorption technology. The results show that the nanocomposites have good resistance to moisture absorption (<3 %) and effective thermal properties.

One-Pot Synthesis, E-/Z-Equilibrium in Solution of 3-Hetarylaminomethylidenefuran-2(3H)-ones and the Way to Selective Synthesis of the E-Enamines.

We describe a method to synthesize a new class of hetarylaminomethylidene derivatives of furan-2(3H)-ones. The method uses 5-(4-chlorophenyl)furan-2(3H)-one, triethyl orthoformate, and heterocyclic amines with different ring sizes and heteroatoms under refluxing in absolute isopropyl alcohol. The obtained enamines exist in an equilibrium of E- and Z-isomers, whose configurations relative to the double exocyclic C=C bond were confirmed with a set of NMR spectroscopy data. The E-/Z-equilibrium of the synthesized compounds is affected by the configuration of the intermediate, the volume of its substituents, the site of enolate attack, the presence of intramolecular interactions of amino components, the time of the transformation, the order of mixing of the initial reagents, and the use of polar solvents in the NMR experiment. The advantages of the method are that the reaction time is short, the product yield is high, and product purification is easy.

Biodegradable Composite Materials Based on Potato Starch and Polyvinyl Alcohol

The design and production of biodegradable composite materials that are similar to polymers from petroleum products in performance characteristics, but at the same time have a biodegradable ability, is one of the ways to solve the environmental problem associated with the polymer waste disposal. Scientists around the world are conducting research on obtaining a biodegradable composite material from organic raw materials. The composition development of composite materials includes the optimal ratio selection of fillers, plasticizer and solvent. The material preparation technology involves the raw materials preparation, the mixing order at given temperatures, and the suspension drying until a film structure is formed. The study aimed at preparing samples of biodegradable composite materials based on potato starch and polyvinyl alcohol in different ratios and to study their structure, water absorption, vapor permeability, and mechanical properties. As a result of processing the experimental data, the authors determined that sample of a biodegradable composite material with a 5:1 ratio of starch and polyvinyl alcohol had the best values for water absorption and vapor permeability. Sample 4 demonstrated the best strength characteristics values (a 4:2 ratio of starch and polyvinyl alcohol). There are microphotographs of surface samples in the work, proving the fact that for samples containing potato starch and PVA in 5:1 and 5:2 ratio, the surface is more uniform, the amount of seals is small. Decrease in the polyvinyl alcohol content leads to the increase in the surface defects number. A man can use the resulting biodegradable composite materials to the film packaging materials development to solve environmental problems with the polymer waste disposal.