Mixed Qualities Research Articles

Evaluation of N80 Carbon Steel Corrosion in 15 wt.% HCl Using Isatin-hydrazones: A Comprehensive Approach with Chemical, Electrochemical Techniques, and DFTB Calculations

The adverse effects of corrosion on industrial metals, particularly N80 carbon steel under acidic conditions, call for developing effective corrosion inhibitors. Due to their structural and electrical properties, isatine-hydrazones have emerged as possible corrosion inhibitors. This study investigates the corrosion inhibition capabilities of two specific Isatin-hydrazones, (E)-1-octyl-3-(2-(5-oxo-4,4-diphenyl)-4,5-dihydro-1H-imidazol-2-yl)hydrazono)indolin-2-one (OPHIHI) and (E)-3-(2-(5-oxo-4,4-diphenyl)-4,5-dihydro-1H-imidazol-2-yl)hydrazono)indolin-2-one (OIHIHI), on N80 carbon steel in a highly acidic medium. The study assessed the corrosion inhibition efficacy of OIHIHI and OPHIHI using both computational and experimental approaches. Weight loss measurements, potentiodynamic polarization, and electrochemical impedance spectroscopy were used in the experiments. In contrast, density functional theory (DFT), molecular dynamics (MD), and tight-binding density functional theory (DFTB) were used in the computational analyses to elucidate the interaction mechanisms between the inhibitors and metal surfaces. The experiment demonstrated that both OPHIHI and OIHIHI effectively reduce corrosion rates in a 15 wt.% HCl solution at 303 K, achieving an inhibition efficiency of 96 % and 92 %, respectively, at an optimal 5 × 10−3 mol/L concentration. These inhibitors were discovered to form protective layers on the N80 carbon steel surface, offering mixed protective qualities (cathodic and anodic protection) with a preponderance of cathodic protection against carbon steel corrosion in 15 wt.% HCl. Computational studies supported the experiment's findings by demonstrating that isatin-hydrazones' superior electronic properties enabled them to form robust covalent bonds with the Fe (110) surface. Based on these results, OPHIHI and OIHIHI could be used as corrosion inhibitors in the oil and gas industry, particularly under highly acidic conditions.

Parental stature as a risk factor for stunting in Indonesia: A systematic review and meta-analysis.

Stunting is defined by height of more than two standard deviations below the World Health Organization's (WHO) child growth standard median. It is a significant nutritional problem in developing countries, where in 2021, Indonesia recorded a stunting prevalence at 24.4%, slightly higher than the global prevalence (22%). Reducing the prevalence of stunting has been the focus of the current administration in the Indonesian government, as delineated in the 2020-2024 National Medium-Term Development Plan. Globally, many studies have addressed parental stature as a risk factor of stunting. However, systematic reviews that summarized and critically appraised the relationship between parental stature and the incidence of stunting in Indonesia was scarce. This systematic review aimed to assess parental stature as a risk factor for stunting among Indonesian toddlers. Studies were searched through PubMed (MEDLINE), Google Scholar and Mendeley. Studies on Indonesian toddlers under five years old living in Indonesia were included. The quality of the included studies was assessed using Joanna Briggs Institute (JBI) critical appraisal tool. Data were extracted using a standardized data extraction form and were analyzed using Cochrane's RevMan 5.3. Twenty-seven prospective and retrospective cohort, case-control and cross-sectional studies were included with a total 4041 children. Out of 27 included studies, eight were found to be of low, seven of moderate and twelve of high quality. The result showed that parental stature was associated with the incidence of stunting among toddlers in Indonesia, either the mother only (odds ratio (OR) 1.92; 95% confidence interval (95%CI: 1.71-2.15), the father only (OR 5.21; 95%CI: 1.71-15.86) or both parents (OR 3.01; 95%CI: 2.41-3.75). However, studies on father and both parental statures suffered from substantial heterogeneity, imprecision and mixed qualities, therefore, they should be cautiously interpreted.

High Performance of Paper Strength and Energy Savings in OCC Pulp Papermaking via MFC Addition

Fiber screen fractionation of recycled old corrugated container (OCC) pulp and subsequent targeted processing of each fraction can lead to higher fiber quality, more uniform pulp, and increased handsheet strength and surface smoothness. This pilot-scale study evaluates the benefits of fiber fractionation using a pressure screen prior to low consistency (LC) refining. A 0.81-mm smooth holed screen cylinder is utilized, and two refiner plate patterns are adopted (wide 0.99 km/rev BEL and interim 2.01 km/rev BEL). Here, LC-refined reject fractions are mixed with the created microfibrillated cellulose (MFC), and the mixed pulp and paper qualities are compared with no-MFC OCC pulps. The results indicate that the highest tensile strength of the handsheet is obtained by the addition of MFC to the fractionated refined OCC pulp compared to the unfractionated refined OCC and primary OCC pulps at a given specific energy. Furthermore, the experimental approach adopted in this study can be used to optimize recycled OCC pulping systems. Overall, the results indicate that fractionated LC refining plus MFC addition provides higher pulp and paper qualities and the potential for saving energy to reach the desired tensile strength of the OCC pulp.

Effects of Message-Sidedness on Perceived Source Bias: When Presenting Two Sides Does Versus Does Not Alleviate Concerns About Bias.

Communicators commonly present two-sided messages to avoid being perceived as biased. This approach equates bias with one-sidedness rather than divergence from the position supported by available data. Messages often concern topics with mixed qualities: a product is exceptional but expensive; a politician is inexperienced but ethical. For these topics, providing a two-sided message should reduce perceived bias according to both views of bias as one-sidedness and divergence from available data. However, if perceived bias follows divergence from available data, for topics viewed as one-sided (univalent), a two-sided message should not reduce perceived bias. Across five studies, acknowledging two sides reduced perceived bias for novel topics. In two of the studies, two-sidedness no longer reduced perceived bias for topics viewed as univalent. This work clarifies that people conceptualize bias as a divergence from available data, not simply one-sidedness. It also clarifies when and how to leverage message-sidedness to reduce perceived bias.

The Exploration of Curriculum Ideological and Political Education Based on “ Project + BOPPPS” Mode

At present, there are problems in the ideological and political education, such as insufficient awareness of all staff participation, difficulties in digging out ideological and political elements, educators with mixed qualities, single teaching mode of ideological and political courses, and lack of evaluation of ideological and political effectiveness. This paper takes the ideological and political course of “ Principles and Interface Technology of Microcontroller Unit” as an example, from the top-level design of the university, the design of professional talent training programs to specialized course design of ideological and political education. Using “Project + BOPPPS” mode, the comprehensive project “Water Level Monitoring and Display” is divided into three sub-projects. Each project has its specific knowledge, ability, accomplishment and educational goals, and the matching educational elements are selected to be organically integrated into the sub-projects. The trinity assessment method of “Knowledge + Skills + Attitude” is not only the evaluation of knowledge and ability,but also the evaluation of ideological and political effectiveness. The curriculum ideological and political implementation under this model has certain achievements and has certain reference value.

Identification and analysis of low creators in Bilibili video based on multivariate statistics

Bilibili video website has grown into a giant video platform. With the anime culture that can attract the younger generation, Bilibili has built a large-scale user creation platform. To stimulate users’ creative inspiration, Bilibili issued several plans to provide corresponding rewards for the content produced by video creators, attracting more and more people to participate in the creative party. In this context, many excellent works were born, but at the same time, there are also works with mixed qualities in the video, i.e., “low-innovation” works. "Low-innovation" works hinder personal development and have a bad impact on the production climate of the platform. First, this paper uses the principal component analysis algorithm to pre-process the user data of Bilibili to improve the efficiency of the algorithm. Based on the K-means clustering algorithm, it analyzes and identifies "low-innovation" users. According to the analysis results, it sets different incentive plans for different types of user groups and plays a positive role in the video quality of Bilibili.

Wheat-Net: An Automatic Dense Wheat Spike Segmentation Method Based on an Optimized Hybrid Task Cascade Model.

Precise segmentation of wheat spikes from a complex background is necessary for obtaining image-based phenotypic information of wheat traits such as yield estimation and spike morphology. A new instance segmentation method based on a Hybrid Task Cascade model was proposed to solve the wheat spike detection problem with improved detection results. In this study, wheat images were collected from fields where the environment varied both spatially and temporally. Res2Net50 was adopted as a backbone network, combined with multi-scale training, deformable convolutional networks, and Generic ROI Extractor for rich feature learning. The proposed methods were trained and validated, and the average precision (AP) obtained for the bounding box and mask was 0.904 and 0.907, respectively, and the accuracy for wheat spike counting was 99.29%. Comprehensive empirical analyses revealed that our method (Wheat-Net) performed well on challenging field-based datasets with mixed qualities, particularly those with various backgrounds and wheat spike adjacence/occlusion. These results provide evidence for dense wheat spike detection capabilities with masking, which is useful for not only wheat yield estimation but also spike morphology assessments.

Impact of tops and green leaves on sugarcane processing: laboratory testing

In Réunion, changes in harvesting practices have led to increased amounts of sugarcane tops and leaves delivered to factories. To anticipate the changes in sugar recovery processing, laboratory trials were undertaken. Samples with known quantities of tops or green leaves were prepared and cane processing was simulated at laboratory scale: juice extraction, clarification and evaporation with operating parameters similar to those in the factory. Juice and syrup were collected and analyzed for sugar quality parameters, as well as parameters that impact sugar recovery or processing quality: ash and reducing sugars contents were monitored to estimate the sucrose loss to molasses, while calcium, phosphate and oxalate contents were monitored to evaluate the risk of fouling in evaporator. Results highlight a degradation of juice composition with increasing quantities of tops and leaves, an increase in lime consumption, and color. An increase in residual calcium in syrup was observed thus increasing the risk of evaporator fouling. The mixed juice, clear juice and syrup qualities declined in the same proportion and the composition of the juice did not get worse with juice treatment.

Varieties of urban entrepreneurialism

We revisit the concept of urban entrepreneurialism to highlight some of its variety. In particular, the present article refocuses discussion on: processes of innovation, bringing geography into dialogue with the literature on innovation in public services; normative questions surrounding the ends to which urban entrepreneurship is turned; and the need for analysis to go beyond the territorial traps of the nation and the city to consider how urban entrepreneurialism articulates with the national state and is projected internationally. We distinguish urban managerialism from the new urban managerialism, urban diplomacy, urban intrapreneurialism and urban speculation, drawing on international examples to highlight the mixed qualities and effects of these varieties of urban entrepreneurialism. In conclusion, we note the limitations of our framework and its relationship to the related ideas of neoliberalization, financialization and accumulation by dispossession.

Dynamic accounting of greenhouse gas emissions from cascading utilisation of wood waste

Cascading utilisation of post-consumer wood waste has recently gained increasing attention in the European Union, aiming for a society in which the resource's properties are optimized through sequential uses. To date, material utilisation of wood waste has been limited to particleboard production, with additional niche alternatives being restricted by quality requirements for wood waste. In this consequential life cycle assessment focusing on post-consumer wood collected at Danish recycling centres, Global Warming Potential (GWP) impacts from quality-driven choices for cascading management of wood waste were compared with those from handling mixed wood waste qualities. GWPs were modelled by considering the dynamic profile of greenhouse gas emissions (including biogenic carbon dioxide) for two time horizons (100 and 500 years). The robustness of the results was tested by varying modelling assumptions with respect to electricity system, wood sourcing and associated rotation period, and impacts from indirect land use changes. The results demonstrated that valuing quality over quantity in wood waste management can ensure larger GWP savings, especially if recycling applications have a long lifetime and/or substitute energy-intensive products; such results were confirmed under all scenario analyses. Inclusion of land use changes credited land-intensive products. More cascade steps of the wood waste resource ensured larger savings; however, assumptions on the electricity mix, on the source of the wood alongside the choice of the time horizon for GWP greatly influenced the results on cascading management.

Is Group-Based or Individual-Based Intervention more Effective for Quality of Life Outcomes in Children with Developmental Coordination Disorder? A Systematic Review

Aims: To examine whether group-based or individual-based treatment programs are more effective for quality of life (QOL) outcomes in children with developmental coordination disorder (DCD). Methods: A systematic search of the literature was conducted, in accordance with the PRISMA guidelines. Quality of the papers was assessed using the Modified Downs and Black Checklist. Peer-reviewed clinical experimental studies of children diagnosed with DCD with any QOL related outcome measure were included, of all years, languages, and approaches of intervention. Results: Sixteen studies were identified for inclusion, of mixed methodological qualities (predominantly low). Improvement of QOL with both group-based and individual-based interventions were shown, though large degrees of heterogeneity were observed in study designs, participants, modes of interventions, durations, and outcome measures utilized. Conclusions: The effectiveness of group-based versus individual-based interventions on QOL of children with DCD is unclear. There is a pressing need for a high quality, powered trials, utilizing the randomized control trial paradigm, comparing both intervention approaches with standardized treatment approaches and outcome measures to determine and compare the effect on QOL of children with DCD.

Alpha Particles and X Rays Interact in Inducing DNA Damage in U2OS Cells.

Survivors of the atomic bombings of Hiroshima and Nagasaki are monitored for health effects within the Life Span Study (LSS). The LSS results represent the most important source of data about cancer effects from ionizing radiation exposure, which forms the foundation for the radiation protection system. One uncertainty connected to deriving universal risk factors from these results is related to the problem of mixed radiation qualities. The A-bomb explosions generated a mixed beam of the sparsely ionizing gamma radiation and densely ionizing neutrons. However, until now the possible interaction of the two radiation types of inducing biological effects has not been taken into consideration. The existence of such interaction would suggest that the application of risk factors derived from the LSS to predict cancer effects after pure gamma-ray irradiation (such as in the Fukushima prefecture) leads to an overestimation of risk. To analyze the possible interaction of radiation types, a mixed-beam exposure facility was constructed where cells can be exposed to sparsely ionizing X rays and densely ionizing alpha particles. U2OS cells were used, which are stably transfected with a plasmid coding for the DNA repair gene 53BP1 coupled to a gene coding for the green fluorescent protein (GFP). The induction and repair of DNA damage, which are known to be related to cancer induction, were analyzed. The results suggest that alpha particles and X rays interact, leading to cellular and possibly cancer effects, which cannot be accurately predicted based on assuming simple additivity of the individual mixed-beam components.

Inventing Postcolonial Elites: Race, Language, Mix, Excess

This article illustrates how semiotic processes that form and circulate ideologies about race, language, and the elite are central to questions of coloniality. Considering the historical and contemporary context of the Philippines, I examine how notions of linguistic and racial “mix” and “excess” get linked to elite social figures and how one elite figure in particular—the “conyo elite”—is reportedly heard and seen by a private school–educated listening subject that is constituted, in contrast, as “middle‐class elite.” I consider how iconizations of mixedness and excessiveness invent distinctions among Philippine elite types, producing an “elite bifurcation” that recursively constitutes colonial hierarchies: positioning conyo elites as acting as colonists whose supposedly mixed and excessive qualities are regarded as immoral, overly modern, and a national betrayal.

Mixed or merged? Integration as the real challenge for mixed methods

Purpose Giampietro Gobo called for new methods that combine qualitative and quantitative approaches in a single instrument, suggesting this was the next challenge facing social research and mixed methods in particular. The purpose of this paper is to respond to that challenge. Design/methodology/approach An overview of methods, demonstrating their inherently mixed qualities, with special emphasis on a range of methods that can be classified as merged. Findings The real challenge is not to find merged methods, but to ensure integration of the quantitative and qualitative aspects of the methods used during the analysis and writing processes. Practical implications Researchers need to be alerted to the mixed elements within their work, to learn how to better tap into these and to exploit the integrative potential of their methods during analysis and writing. Researchers need more “rounded” methods training. Originality/value This paper refocuses the challenge facing mixed methods research.

When riverine dissolved organic matter (DOM) meets labile DOM in coastal waters: changes in bacterial community activity and composition

Heterotrophic bacterial communities in marine environments are exposed to a heterogeneous mixture of dissolved organic compounds with different bioreactivity that may control both their activity and composition. The coastal environment is an example of a mixing area where recalcitrant allochthonous organic matter from rivers can encounter labile organic matter from marine phytoplanktonic blooms. The objective of this study was to explore the effects of mixed qualities of dissolved organic matter (DOM) on bacterial community activity (BCA) and bacterial community composition (BCC) and to test for a priming effect when DOM sources are added in combination. Coastal marine bacterial communities were incubated separately with a mixture of amino acids and with natural riverine DOM or with both sources together for 42 days. Addition of amino acids alone or in combination with riverine DOM led to a similar stimulation of BCA compared to control condition, whereas addition of riverine DOM alone did not modify BCA compared to the control. On the contrary, BCC analyzed by 16S rRNA gene pyrosequencing was not affected by the addition of amino acids alone, but changed dramatically with riverine DOM alone or in combination with amino acids. Our results show that changes in BCA and BCC can be driven by different types of DOM, but that these changes are not necessarily coupled. Moreover, the addition of labile DOM did not modify the microbial decomposition of riverine DOM, nor the BCC, suggesting that a priming effect did not occur under these experimental conditions.

Growth and nutritional properties of lettuce affected by mixed irradiation of white and supplemental light provided by light-emitting diode

‘Green Oak Leaf’ lettuce were hydroponically cultured for 35days under mixed light qualities of white light and a different supplemental light such as blue (B), green (G), yellow (Y), red (R), and far-red (Fr) provided by light-emitting diodes (LEDs). Effects of supplemental light qualities on the growth and nutritional properties of lettuce plants were investigated. The pure white LED (W) was used as control with a photosynthetic photon flux (PPF) value of approximately 135μmolm−2s−1, and the basal white light in each treatment was 105μmolm−2s−1 while the photon flux added by supplemental LED was approximately 30μmolm−2s−1. The results indicated that supplemental lights led to obvious morphological changes, plants with WR appeared compact and vigorous while those with WY and WFr looked sparse and twisted, dwarfed plants with large leaves were detected under WB. Compared with those grown in the white light control, the fresh weight of shoots increased by 63.2% and 21.7% with supplemental R and B respectively, while decreased by 35.9% with supplemental Fr. Chlorophyll and carotenoid contents were significantly higher with supplemental R and B than other treatments. Supplemental B and G resulted in decrease of nitrate content. Supplemental G significantly promoted soluble sugar accumulation. Supplemental Fr increased S/R ratio and ascorbic acid accumulation but resulted in lower biomass and pigment contents. However, no positive impact of supplemental Y light was observed in the research.

The histological components of the phoniatrical body-cover model in minipigs of different ages.

Pigs are models in human phoniatry. However, features of maturation and ageing have not been considered with regard to the so-called body-cover model in this species. Therefore, the glottis of “young” (2–3 months; n = 6) and “old” (4–7 years; n = 6) minipigs was investigated. Their cranial (CraF) and caudal (CauF) vocal folds were histomorphometrically and stratigraphically analysed with emphasis on their amounts of collagen structures and elastic fibres. A dense subepithelial layer (SEL) was a distinct feature of CraF and CauF of both age groups; it was spread upon the underlying loose, flexible “cover” like a fibro-elastic membrane. The “cover” was characterised by the so-called superficial layer (SL), which was distinctly loose in the “young” minipigs, but had a much denser texture in the “old” minipigs. Here, the SL was dominated by elastic fibres in the CraF, but was of mixed qualities (collagenous and elastic) in the CauF. The structural requirements for the SL’s function as a loose “cover” were thus met only in the “young” animals. A clearly demarcated intermediate layer (IL)—characterised by high amounts of elastic fibres (as in humans)—was only found in the CraF of the “young” animals. In the “old” animals, it had lost its demarcation. In the depth of the CraF of the “old” animals, many thick collagen fibre bundles were detected in a location equivalent to that of the vocal muscle in the CauF. The development of their large diameters was interpreted as part of the maturation process, thereby supporting the hypothesis of their functional importance as a component of the “body.” In the CauF, the amounts of collagen structures increased throughout the entire lamina propria, resulting in a loss of demarcated stratigraphical subdivisions in the “old” minipigs. This situation resembled that described in the vocal fold of geriatric humans.

Delft blues: the long road from university town to knowledge city

Besides their teaching and research tasks, universities are increasingly expected to valorise knowledge into innovation. This involves new products, but also transdisciplinary knowledge exchange with people, technologies, firms and markets. This relates to knowledge-based urban development through a variety of locally-specific variables and features. This paper discusses the role of knowledge capacity in the development of the Dutch City of Delft. It emphasises the role of Delft University of Technology as a main player of Delft’s knowledge capacity, the qualities of the local production and consumption milieus and the role of local knowledge city policy. It explores the role and impact of knowledge capacity in urban development in a setting with mixed advantageous and disadvantageous qualities. The results suggest that the reason for the disappointing employment creation in Delft may be found particularly in the triple helix cooperation between government, knowledge institutions and industry.

Urban or Rural? Theoretical Remarks on the Settlement Patterns in Byzantine Epirus (7th–11th Centuries)

Abstract This paper refers to habitation in the Byzantine Empire from the 7th to the 11th centuries and attempts a reappraisal of the patterns used to describe, evaluate and interpret the distribution of archaeological remains. Based on the study of a region in western Greek mainland, several contradictions between the historical and the archaeological evidence on settlement are being discussed; those reveal the prevalence of dispersed rather than nuclear patterns of habitation in the area. These patterns are further discussed within the context of medieval settlement around the Mediterranean. The physical form of Middle Byzantine Episcopal sees is sought for while the term ‘κάστρον’ is examined against the “archaeological imaginary” of 6th–11th c. Byzantine fortified settlements. It is concluded that the contextualization of archaeological and historical evidence for Middle Byzantine settlements in Southern Epiros demonstrates instead a rather flexible organization of habitation; episcopal sees do not seem to have corresponded to any clear distinct type of settlement. It is therefore suggested that during periods of rapid social change expressed through a transformation of habitation, specific forms or sizes of settlements cannot be correlated to specific functions or other political or socioeconomic activities. There should rather be more of “hybrid” settlement formations of changing nature and mixed qualities. Given the dynamic development pattern of Byzantine habitats, there is room for such “open” analytical categories in the archaeology of settlements, in order to facilitate descriptions of find distributions which do not conform to the available theoretical patterns. These new categories could further lead to an emergence of new interpretation schemes bringing out the spatial differentiation and uniqueness which seems to have been very much the case in the evolution of Byzantine provincial settlement patterns.

Neuropathic Vs. Nociceptive Pain in Adolescent Sickle Cell Disease (SCD) Evaluated by a Computer-Based Self-Assessment Pain Tool.

Abstract 2576Poster Board II-553Pain remains the most frustrating and debilitating symptom of sickle cell disease (SCD). Yet, because pain is a perception of a sensation, objective assessment of pain remains elusive. In order to achieve adequate pain control, it is imperative that the patient be able to effectively communicate with the physician regarding the extent, severity and quality of the pain, as well as the response of the pain to the therapeutic intervention. Moreover, SCD pain may have two components, nociceptive (due to organ/tissue injury) and neuropathic (due to somatosensory system lesion or disease), with differing pathophysiologies, and differing responses to pain medications. PAINReportIt® is a multi-dimensional computerized, self-assessment pain reporting tool based on the McGill Pain Questionnaire (MPQ). The MPQ has been validated for adolescents and adults. However, the PAINReportIt®, which was developed originally for the evaluation of cancer pain, has not previously been used in adolescents, nor in the study of adolescents' SCD pain. The purpose of this study was to examine the frequency with which pain experienced in various body areas by adolescents and young adults had characteristics consistent with nociceptive and neuropathic pain. Methods.Inclusion criteria included an SCD diagnosis (SS, SC or S-beta thal) and age at least 14 years. Patients attending two pediatric/adolescent comprehensive sickle cell clinics were invited to participate. Consenting subjects were first instructed and then allowed to complete the PAINReportIt® tool, in which they marked their painful sites on a graphic body outline, selected pain quality descriptors from word lists provided by the computer, and for each site they matched each site to the pain quality descriptors that represented the site. The descriptors included sensory descriptors that are known to be characteristic of either neuropathic pain or nociceptive pain. Results.PAINReportIt® tools were completed by 49 SCD subjects, whose ages ranged from 14 to 27 years (mean, 18 +/− 2.6 years). For analysis, the body was divided into nine segments, and the computer analyzed the marked painful body outline sites and identified the body segments involved. Descriptive statistics were used to determine the frequency for which each body segment included a painful site, and the frequencies for which that site was characterized as having neuropathic or nociceptive pain qualities, or both. These results are summarized in the Table below.SITE% OF SUBJECTS% Reported Pain Matched by Subjects to Descriptors Indicating:REPORTING PAINONLY NOCICEPTIVE PAINONLY NEUROPATHIC PAINNOCICEPTIVE & NEUROPATHIC PAINNEUROPATHIC PAIN INCLUSIVEHEAD16%13%13%75%88%RT ARM24%8%8%83%92%LT ARM35%24%0%76%76%CHEST29%0%0%100%100%ABDOMEN29%21%0%79%79%RT LEG41%10%0%90%90%LT LEG39%16%11%74%84%UPPER BACK41%15%0%85%85%LOWER BACK4%0%0%100%100%As the Table shows, virtually all body segments were frequently involved with pain, the upper back and legs being the most frequently reported, and the lower back the least (Column 1). For body segments reported as painful, few were reported as having only nociceptive (Column 2) or neuropathic (Column 3) pain qualities. The majority of painful sites were described by subjects as having mixed pain qualities (Column 4). As Column 5 shows, from 76% to 100% of all painful sites were characterized as having a neuropathic pain component. When the number of descriptors associated with each site was reviewed (data not shown), the right leg was matched to the largest number of neuropathic descriptors (Aching, Burning, Cold, Drilling, Flickering, Numb, Penetrating, Radiating, Shooting, Spreading, Tight, Tingling). The upper back was matched to the largest number of nociceptive descriptors (Beating, Cramping, Crushing, Gnawing, Hurting, Piercing, Pounding, Pressing, Pulsing, Sharp, Sore, Splitting, Squeezing, Tender, Throbbing). Conclusions.When utilizing a computer-based self-reporting pain tool, SCD patients overwhelmingly describe a neuropathic component to their pain as well as a nociceptive component. The high frequency of neuropathic pain has been underappreciated, and this may contribute to the difficulty in managing sickle cell pain, since this pain component is not well controlled by opioid analgesics. Disclosures:No relevant conflicts of interest to declare.