Mixed Mullerian Tumor Of Uterus Research Articles

Mixed malignant mullerian tumor: A rare case report

Malignant mixed mullerian tumour of uterus also called carcinosarcoma is a very rare and also very aggressive type of tumour involving both epithelial and mesenchymal component thus is considered as a metaplastic carcinoma. Common presentation of these patients is post-menopausal bleeding with uterine enlargement. Here we present the case of 55 year old women with post-menopausal bleeding. Total abdominal hysterectomy with good vaginal cuff with bilateral salpingo-oophrectomy with bilateral pelvic lymphadenectomy was done and a diagnosis of malignant mixed mullerian tumour with Genital Tuberculosis was made. Keywords: Mixed Malignant Mullerian Tumor.

Carcinosarcoma of the uterus: Possible sequelae of long-term tamoxifen therapy for breast cancer

Carcinosarcoma (CS) of the uterus is rare and accounts for 1–2% of all uterine malignancies, occur commonly in postmenopausal women. These are highly aggressive tumors with poor prognosis and often present at advanced stage. Tamoxifen (TAM) has been known to increase the incidence of endometrial carcinoma from 1 to 2 cases per 1000 women/year and of uterine sarcoma from 0.04 to 0.17 cases per 1000 women/year. TAM has weakly estrogenic properties that can produce endometrial cell proliferation and, consequently, TAM use increases the risk of endometrial cancer by approximately two- to three-fold. Currently, no consensus is present regarding the management of Uterine CS. However, surgery plays an important role in the management along with chemotherapy (CT) and radiotherapy as an adjuvant. We report a case of a woman who developed malignant mixed mullerian tumor of uterus after taking TAM for 6 years as adjuvant hormonal therapy for breast carcinoma.

Complex karyotypic aberrations, including i(12p), in malignant mixed mullerian tumor of uterus

We report the cytogenetic findings in a malignant mixed mullerian tumor of the uterus in a 59-year-old woman. Karyotypic analysis of short-term cultures revealed two abnormal clones of cells characterized by extensive structural and numerical rearrangements. An i(12p) maker chromosome was present in addition to other changes in both clones. This marker, characteristically associated with testicular germ cell tumors in males, has recently been reported in ovarian germ cell tumors, a mediastinal germ cell tumor and in a mixed mullerian tumor of the ovary.