Motor current signature analysis (MCSA) is a fault diagnosis method for induction machines (IMs) that has attracted wide industrial interest in recent years. It is based on the detection of the characteristic fault signatures that arise in the current spectrum of a faulty induction machine. Unfortunately, the MCSA method in its basic formulation can only be applied in steady state functioning. Nevertheless, every day increases the importance of inductions machines in applications such as wind generation, electric vehicles, or automated processes in which the machine works most of time under transient conditions. For these cases, new diagnostic methodologies have been proposed, based on the use of advanced time-frequency transforms—as, for example, the continuous wavelet transform, the Wigner Ville distribution, or the analytic function based on the Hilbert transform—which enables to track the fault components evolution along time. All these transforms have high computational costs and, furthermore, generate as results complex spectrograms, which require to be interpreted for qualified technical staff. This paper introduces a new methodology for the diagnosis of faults of IM working in transient conditions, which, unlike the methods developed up to today, analyzes the current signal in the slip-instantaneous frequency plane (s-IF), instead of the time-frequency (t-f) plane. It is shown that, in the s-IF plane, the fault components follow patterns that that are simple and unique for each type of fault, and thus does not depend on the way in which load and speed vary during the transient functioning; this characteristic makes the diagnostic task easier and more reliable. This work introduces a general scheme for the IMs diagnostic under transient conditions, through the analysis of the stator current in the s-IF plane. Another contribution of this paper is the introduction of the specific s-IF patterns associated with three different types of faults (rotor asymmetry fault, mixed eccentricity fault, and single-point bearing defects) that are theoretically justified and experimentally tested. As the calculation of the IF of the fault component is a key issue of the proposed diagnostic method, this paper also includes a comparative analysis of three different mathematical tools for calculating the IF, which are compared not only theoretically but also experimentally, comparing their performance when are applied to the tested diagnostic signals.