Mitigation Of Damages Research Articles

Evidence of gill migration in monogenean polyopisthocotylean Microcotyle sebastis larvae infesting Korean rockfish (Sebastes schlegelii)

In contrast to the well-documented motility of monopisthocotyleans within the monogenean group, the mobility of polyopisthocotyleans, such as Microcotyle sebastis, has largely been undocumented with empirical evidence. This study aimed to investigate the locomotion of the polyopisthocotylean parasite of M. sebastis, which infests Korean rockfish (Sebastes schlegelii), thereby providing tangible evidence of early behavior in polyopisthocotyleans. The oncomiracidium of M. sebastis demonstrated movement facilitated by the hamulus and bilateral cilia, aiding in directional changes and propulsion. In the gill filaments of M. sebastis larvae utilized both the hamulus and their entire body for initial movements, effectively navigating between gill filaments. The hamulus played a crucial role in the locomotion of the early larval stages before the development of three clamp pairs, after which it began to degenerate. This study presents concrete evidence of early mobility in polyopisthocotyleans like M. sebastis, offering insights that could inform aquaculture management strategies, particularly in the mitigation of parasite-induced damages.

A multifunctional carbon quantum dot overcoming the BBB for modulating amyloid aggregation and scavenging reactive oxygen species

The abnormal aggregation of β-amyloid (Aβ), the accumulation of reactive oxygen species (ROS), and the presence of the blood-brain barrier (BBB) cause the prevention and treatment of Alzheimer's disease (AD) extremely difficult. In this study, we report multifunctional carbon quantum dots (CQDs) with red emission (RCQDs) for targeting Aβ42, modulating Aβ42 aggregation, overcoming the BBB, and scavenging ROS. RCQDs demonstrate exceptional targeting affinity for Aβ42 species, and exhibit high inhibition and disaggregation efficiencies against Aβ42 aggregates. Moreover, RCQDs possess outstanding scavenging abilities against the ROS in cells, thus resulting in the mitigation of cellular oxidative damages. RCQDs also exhibited strong penetration through the BBB in both in vitro and in vivo models, highlighting their potential for brain-targeted treatment. Further investigations using primary microglial cells confirm the anti-neuroinflammation properties of RCQDs. This study unprecedently demonstrates the therapeutic potential of unmodified pure CQDs for overcoming the BBB, targeting Aβ42 species, modulating Aβ42 aggregation and scavenging ROS, offering a promising candidate for the treatment of AD.

Can sustainable supply chain strategies of company enhance for mitigation of risk damages and long-term resilience? An empirical analysis for the context of COVID-19 pandemic

This study aims to investigate the effects of sustainable supply chain management strategies of the companies on mitigation of risk damages and long-term resilience through the evaluation of stock abnormal returns of companies listed on the stock markets based on the evidence from the context of COVID-19 pandemic. The empirical analysis was conducted for 63 companies listed on Vietnamese stock market, where plays as an example for emerging stock markets. The data were collected from the quarterly official financial statements of 63 companies between January 2020 and March 2023. Various regression models, including Ordinary Least Squares, Fixed Effects Model, Random Effects Model, and Generalized Least Squares were explored. Found results indicated that the implementing sustainable supply chain management strategies might help to mitigate the negative impact on stock price volatility during the COVID-19 pandemic, but it has not been the critical tool to improve the companies’ resilience ability in post pandemic yet. JEL Codes: F65, F63, G11, G34, G38Codes of Sustainable Development Goals: SDG17, SDG12, SDG02

Composite of KLVFF-Transthyretin-Penetratin and Manganese Dioxide Nanoclusters: A Multifunctional Agent against Alzheimer's β-Amyloid Fibrillogenesis.

Design of amyloid β-protein (Aβ) inhibitors is considered an effective strategy for the prevention and treatment of Alzheimer's disease (AD). However, the limited blood-brain barrier (BBB) penetration and poor Aβ-targeting capability restricts the therapeutic efficiency of candidate drugs. Herein, we have proposed to engineer transthyretin (TTR) by fusion of the Aβ-targeting peptide KLVFF and cell-penetrating peptide Penetratin to TTR, and derived a fusion protein, KLVFF-TTR-Penetratin (KTP). Moreover, to introduce the scavenging activity for reactive oxygen species (ROS), a nanocomposite of KTP and manganese dioxide nanoclusters (KTP@MnO2) was fabricated by biomineralization. Results revealed that KTP@MnO2 demonstrated significantly enhanced inhibition on Aβ aggregation as compared to TTR. The inhibitory effect was increased from 18%, 33%, and 49% (10, 25, and 50 μg/mL TTR, respectively) to 52%, 81%, and 100% (10, 25, and 50 μg/mL KTP@MnO2). In addition, KTP@MnO2 could penetrate the BBB and target amyloid plaques. Moreover, multiple ROS, including hydroxyl radicals, superoxide radicals, hydrogen peroxide, and Aβ-induced-ROS, which cannot be scavenged by TTR, were scavenged by KTP@MnO2, thus resulting in the mitigation of cellular oxidative damages. More importantly, cell culture and in vivo experiments with AD nematodes indicated that KTP@MnO2 at 50 μg/mL increased the viability of Aβ-treated cells from 66% to more than 95%, and completely cleared amyloid plaques in AD nematodes and extended their lifespan by 7 d. Overall, despite critical aspects such as the stability, metabolic distribution, long-term biotoxicity, and immunogenicity of the nanocomposites in mammalian models remaining to be investigated, this work has demonstrated the multifunctionality of KTP@MnO2 for targeting Aβ in vivo, and provided new insights into the design of multifunctional nanocomposites of protein-metal clusters against AD.

Preliminary report of field reconnaissance on the 6 February 2023 Kahramanmaras Earthquakes in Türkiye

AbstractOn February 6, a successive rupture of major faults in the Eastern Anatolian Fault Zone and Cardak-Surgu fault triggered a strong mainshock (Mw 7.7) and a major aftershock (Mw 7.6) in Kahramanmaras. The successive earthquake sequence hit southern provinces in Türkiye and northern regions in Syria, causing severe fatality and economic loss. After the earthquakes, the International Consortium on Geo-disaster Reduction (ICGdR) organized an investigation team, involving specialists from China, Japan and Türkiye, to conduct a primary field reconnaissance on seismic damage of infrastructure and ground failures. The 10-day reconnaissance, including a mini-symposium at the Istanbul Technical University (ITU), was conducted from 25 March to 3 April and specifically focused on fault ruptures, liquefaction, landslide, rockfall and lateral spreading along the major ruptured faults from Antakya in Hatay to Goksun in Kahramanmaras, passing through provinces of Gaziantep, Adıyaman and Malatya. By this reconnaissance, a large amount of original seismic data was collected and a primary understanding was established for further steps on mitigation and reduction of seismic damages and its secondary geohazards.

Protective effects of vitamin E against acrylamide-induced hepatotoxicity and nephrotoxicity from fetal development to adulthood: Insights into Akt/NF-κB and Bcl-xL/Bax signaling pathways

Acrylamide (ACR), a toxin present in fried and baked carbohydrate-rich foods, is known to cause liver and kidney damage. This study aimed to investigate the mechanisms of oxidative stress, inflammation, and apoptosis that contribute to liver and kidney damage induced by chronic administration of ACR. Additionally, the effectiveness of vitamin E in mitigating these toxic effects was examined. The study initially involved dividing 40 pregnant rats into four groups. After lactation, the research continued with male offspring rats from each group. The offspring rats were divided into Control, Vitamin E, ACR, and ACR + Vitamin E groups. Following ACR administration, liver and kidney function tests were performed on serum samples. Biochemical analyses, evaluation of inflammation markers, histopathological examination, and assessment of protein levels of Akt/IκBα/NF-κB, Bax, Bcl-xL, and Caspase-9 were conducted on liver and kidney tissues. The analysis demonstrated that ACR adversely affected liver and kidney function, resulting in oxidative stress, increased inflammation, and elevated apoptotic markers. Conversely, administration of vitamin E positively impacted these parameters, restoring them to control levels. Based on the results, the mechanism of ACR's action on oxidative stress and inflammation-induced liver and kidney damage may be associated with the activation of apoptotic markers such as Bax and Caspase-9, as well as the Akt/IκBα/NF-κB signaling pathway. Consequently, the protective properties of vitamin E establish it as an essential vitamin for the prevention or mitigation of various ACR-induced damages.

Growth and yield of soybean plants under water deficit and application of foliar fertilizer

The objective of this work was to assess the effects of a commercial foliar fertilizer (H2 Protector; H2 Agrosciences, Orizona, Brazil) on growth and yield of soybean plants grown under water deficit. The experiment was conducted for 105 days from November 2021 to February 2022 in a greenhouse at the State University of Goiás, in Ipameri, GO, Brazil. A completely randomized design was used, with a 2×5 factorial arrangement and three replications. The first factor consisted of foliar fertilizer rates (0 and 300 mL ha-1), and the second factor consisted of water depths applied to the plants (25%, 50%, 75%, 100%, and 125% of the daily evapotranspiration). Morphological variables and agronomic components of the crop were analyzed at 60 and 90 days after emergence. Water deficit at the R5 reproduction stage limits the growth and yield of soybean plants. The important results found for vegetative and reproductive growth of plants treated with the foliar fertilizer were due to the greater number of leaves and transpiration of these plants, even under water deficit, denoting a higher photosynthetic potential. The foliar fertilizer did not mitigate water deficit effects on soybean plants grown in pots, but denoted potential for mitigation of damages in the field

Investigating the implications of technological innovations, financial inclusion, and renewable energy in diminishing ecological footprints levels in emerging economies

The correlation between technological innovation, economic growth, renewable energy, and ecological footprint carries significant policy implications for environmental sustainability. Furthermore, financial inclusion can drastically affect the technology-climate nexus across different countries and its moderating impacts have received sufficient attention. To do this, this study examined how technological innovation, financial inclusion, economic growth, and renewable energy affected emerging economies' ecological footprint from 1990 to 2019. Additionally, this study also scrutinizes the moderating role of financial inclusion with other regressors on ecological footprint. To account for structural shifts, disguised cointegration, and numerous breaks in panel regression, this study applies advanced panel estimation methods for empirical analysis. The estimated outcomes exhibit that the influence of technical innovation, climate technologies, and renewable energy significantly reduces the ecological footprint levels. Besides, economic growth and financial inclusion significantly increase the ecological footprint levels in the emerging economies. Furthermore, the integration of innovative technology and renewable energy in emerging countries mitigates the adverse effects of financial inclusion by making it easier for creative technologies and reducing ecological footprints. These results show that emerging countries' innovative technology and renewable energy sources should be integrated with financial inclusion to enable long-term mitigation of environmental damages and sustainable growth. Based on these estimated findings, the research recommends that emerging economies should hasten technological innovations along with stronger financial development to curtail ecological concerns without hindering the pace of sustainable economic growth.

The possibilities and limits of insurance as governance in insuring pandemics

Insurance can, as has clearly been indicated in the literature, play an important role in dealing with catastrophe risks, not only as a compensation mechanism but also as a mechanism to influence the behaviour of the insured. It is the concept known as ‘insurance as governance’. However, we argue that there are limited possibilities for this role as far as the insurance of pandemics is concerned. The traditional technical tools, such as risk-based pricing, are difficult to apply. In addition, there may, ab initio, be serious problems in insuring pandemics within one of the main conditions of insurability (controlling moral hazard through an effective risk differentiation). One remedy that is traditionally applied, more particularly for natural catastrophes, is mandatory coverage. Furthermore, the capacity problem might potentially be solved through a multilayered approach in which, in addition to insurance and reinsurance, the government could also take up a role as reinsurer of last resort. That would also have the major advantage of stimulating market solution (and potentially providing incentives for the mitigation of damages), which clearly fails in a model where the government simply bails out operators. Finally, one important regulatory intervention is that insurers should be better informed than was apparently the case during the last pandemic about exactly which type of risks are covered and which are not.

Magnetic water irrigation changes physiological traits and stress tolerance of Salvia virgata under saline conditions

In the present study, a pot experiment was conducted to evaluate the effect of magnetic water irrigation at different intensities and durations (non-magnetic water, 0.6 Tesla half an hour passed, 0.6 Tesla once passed, 0.3 Tesla half an hour passed and 0.3 Tesla once passed) on growth and physiological characteristics of Salvia virgata under salinity stress (0, 30, 60 and 90 mM NaCl). Accumulation of malondialdehyde, proline, soluble sugars, and total phenol as well as the antioxidant activity were increased with intensifying the salinity level. However, flavonoids, leaf water content, photosynthetic pigments, and plant growth showed a decrement trend under salt stress. Although magnetic water did not have a considerable effect on the growth and physiological traits of S. virgata under non-stress conditions irrigation of stressed plants with magnetic water especially at 0.6 T once passed was efficient in mitigation of salinity damages. Magnetic water irrigation increased the accumulation of phenolic compounds and stimulated the activity of peroxidase and polyphenol oxidase thereby limiting lipid peroxidation. Magnetic water increased the salt tolerance and water use efficiency of stressed S. virgata plants and consequently enhanced plant biomass. Generally, it can be concluded that magnetic water irrigation at 0.6 T once passed could alleviate the salinity disorders of S. virgata by improving the antioxidant capacity, especially in severe saline condition.

A case study of impacts of an extreme weather system on the Mediterranean Sea circulation features: Medicane Apollo (2021)

The attention of the scientific community, policymakers, and public opinion on the Medicanes has recently grown because of their increase in intensity and harmful potential. Although Medicanes may be influenced by pre-existing upper-ocean conditions, uncertainties remain about how such weather extremes influence ocean circulation. This work examines a condition that has been never described before in the Mediterranean, which involves the interplay between an atmospheric cyclone (Medicane Apollo—October 2021) and a cyclonic gyre located in the western Ionian Sea. During the event, the temperature in the core of the cold gyre dropped dramatically, due to a local maximum in the wind-stress curl, Ekman pumping, and relative vorticity. Cooling and vertical mixing of the surface layer combined with upwelling in the subsurface layer caused a shoaling of the Mixed Layer Depth, halocline, and nutricline. The resulting biogeochemical impacts included an increase in oxygen solubility, chlorophyll concentration, productivity at the surface, and decreases in the subsurface layer. The presence of a cold gyre along Apollo's trajectory leads to a different ocean response from that observed with previous Medicanes, endorsing the efficiency of a multi-platform observation system integrated into an operational model for future mitigation of weather-related damages.

A beteg közrehatásának vizsgálata az egészségügyi szolgáltató kárfelelőssége körében

In my study, I examine the patient’s obligation of damage control, the obligation of prevention and mitigation of damages from the perspective of the liability or contributory conduct of the patient, taking into account the liablity issues arising from the legal relationship between the health care provider and the patient. The doctrinal context on which the study is based is set out in the section 6:519 of the Civil Code. After discussing certain aspects of the special legal relationship between the health care provider and the patient, as well as the obligations of the patient, I will explain to what extent the contribution of the patient affects the liability of the health care provider under the Civil Code. I will also consider the influence of the contribution of the patient on the enforceability of the claims of relatives and whether the decision to have an unwanted child or a child with a health problem and to refuse a new medical intervention can be regarded as contributory negligence.

Ograniczenie miarkowania odszkodowania do stosunków między osobami fizycznymi (art. 440 Kodeksu cywilnego) z punktu widzenia zasady równości wobec prawa

The measure of compensation regulated by Article 440 of the Civil Code is a limitation of the principle of full compensation. This provision implies the possibility to limit the obligation to compensate for the damage if the principles of social co-existence require it. However, the application of Article 440 of the Civil Code is only possible in relations between natural persons. The provision therefore omits legal persons and “crippled” legal persons. This restriction raises questions from the point of view of the constitutional principle of equality before the law. The purpose of this article is to analyse the compatibility with the principle of equality before the law of the limitation of the mitigation of damages to relations between natural persons, to the exclusion of other private law subjects. The considerations in the article lead to the conclusion that the restriction of mitigation to relations between natural persons is unconstitutional.

The obligation to limit the damages incurred to victims according to the provisions of the French and Vietnamese law

Extra-contractual liability is an important institution recognized in the civil codes of many countries, including the French Republic and Vietnam. It is the obligation to repair the damage that one causes to a third party. Or, it can be defined as the obligation imposed on a person to repair damage suffered by another person. However, in certain cases which are provided for by law, the victim of the damage will not be compensated, for example: force majeure, the fault of the victim, the victim does not apply the necessary and reasonable measures to prevent and limit the damage, etc. This article presents and analyzes the provision relating to the obligation to limit the damages of the victim, within the extra contractual liability, which interests us, in the Vietnamese and French laws in a broad way, that is to say in s relying on the texts of laws, case law and doctrine. This is a new provision, it is derived from British law (the theory of mitigation of damages), and is recognized in the Civil Code of Vietnam since 2015. Meanwhile, in France, in addition to efforts lawyers in the recognition of this provision in French law in the program of legislative reform, this question still comes up against many contradictory points of view. Through this article, the author wishes to contribute to bringing multidimensional perspectives related to the obligation to limit the damages of the victim in extra contractual liability, and at the same time to propose some solutions concerning the types of damage for which the victim is obliged to limit, necessary and reasonable measures, the costs or damages incurred by the victim in order to minimize his damage in order to contribute to the improvement of Vietnam's legal regulations on this issue.

Investigating the Role of Information and Communication Technologies, Economic Growth, and Foreign Direct Investment in the Mitigation of Ecological Damages for Achieving Sustainable Development Goals.

At the present time, information and communication technology (ICT) has played a vital role in socio-economic development such as economic growth, literacy, life expectancy, and employment levels in societies, however, such development has come with various environmental damages perspectives. This study scrutinizes the impact of ICT, economic growth, and foreign direct investment (FDI) on carbon dioxide (CO2) emissions in the 44 One Belt and Road Initiative (OBRI) countries split into sub-region from 1991 to 2019. This study applied various econometrics approaches such as cross-sectional dependence, second-generation unit root, and Westerlund panel cointegration techniques are executed to analyze the panel data set. The full modified ordinary lease square and dynamic ordinary lease square estimators are applied to investigate the long-term influence of ICT development, GDP (economic growth), and FDI on CO2 emissions. The empirical analysis was performed at a disaggregated level to assess the possible environmental influences across the OBRI countries. Overall, the results reported that broadband and mobile development have an adverse effect on CO2 emissions. The finding further reveals that the broadband indicator negatively affects CO2 emissions in all OBRI regions except South Asia. Similarly, the mobile use indicator protects the environmental quality in all OBRI regions except MENA (Middle East and North Africa) and Central Asia. Regarding country-wise analysis, broadband has alleviated the pollution level in 21 countries, while mobile has alleviated it in 15 countries. Moreover, economic growth is responsible to increase pollution levels in all panels and regions except Europe. Besides, the results highlight that higher FDI reduces environmental pollution whereby, the pollution halo hypothesis is supported to hold for all OBRI panels and regions except MENA countries. Based on the empirical findings, the policymakers and governments of these economies should design policies to grow smarter cities, transportation systems, electrical grids, industrial processes, and energy-saving production through ICT development on a macro level.

Effects of the Protein Hydrolysate Pretreatment on Cucumber Plants Exposed to Chilling Stress

This study aimed to evaluate the effects of the protein hydrolysate Naturamin WSP on the antioxidant defense system and oxidation-related damage of young cucumber plants exposed to chilling stress. Low positive temperatures have a negative effect on plant growth and performance, and besides visible alterations, such as inhibited growth, significant changes occur at the cellular level. Plants grown at low temperature typically suffer from oxidative damage, which leads to increased lipid peroxidation. Moreover, chilling-stressed plants accumulate more proline to protect their cell membranes. The application of biostimulants such as the protein hydrolysate Naturamin WSP can alleviate some of the adverse effects caused by low temperature. Our results indicated an increased activity of guaiacol peroxidase (GPOD) in all plants treated with the biostimulant regardless of the temperature of cultivation. The mitigation of damages caused by chilling stress might be explained by an enhanced anti-oxidative defense, as demonstrated by the activity of guaiacol peroxidases and increased proline concentrations in Naturamin WSP-treated plants.

A multi-target theranostic nano-composite against Alzheimer's disease fabricated by conjugating carbon dots and triple-functionalized human serum albumin

The complex pathogenesis of Alzheimer's disease (AD) involves the aggregation and accumulation of amyloid β-protein (Aβ) as well as elevated levels of reactive oxygen species (ROS), which requires the development of comprehensive diagnostic and therapeutic interventions. In this work, a multifunctional theranostic nano-composite (HSA-BFP@CDs) is constructed by conjugating triple-functionalized human serum albumin (HSA-BFP) as a theranostic agent targeting Aβ and carbon dots (CDs) as an ROS scavenger. HSA-BFP@CDs exhibits a fluorescence “off-on” effect at 700 nm upon interaction with Aβ aggregates, showing the capability for detection of Aβ plaques and potential for early diagnosis of AD. Besides, HSA-BFP@CDs effectively inhibits the aggregation of Aβ, increasing the viability of Aβ-treated cells from 74% to over 95% at 100 µg/mL. Moreover, multiple ROS, including hydroxyl radicals, superoxide radicals, hydrogen peroxide, and Aβ-Cu2+-induced-ROS, can be scavenged by HSA-BFP@CDs, thus resulting in the mitigation of cellular oxidative damages. Experiments with the AD model of Caenorhabditis elegans further demonstrate the multifunctionality of HSA-BFP@CDs in imaging amyloid plaques, reducing Aβ deposition, and relieving oxidative stress in vivo, showing the prospect for Aβ- and ROS-targeted AD diagnosis and treatment. This work provided new insight into the design of protein-carbon dots conjugate and the development of multi-target therapy of AD. Statement of significanceAlzheimer's disease (AD) is the most common form of dementia, which currently affects over 55 million people worldwide. Due to the complex pathogenesis of AD involving amyloid β-protein (Aβ) aggregation as well as elevated levels of reactive oxygen species (ROS), it is highly desired to develop comprehensive diagnostic and therapeutic interventions. In this paper, we fabricated a multifunctional theranostic nano-composite (HSA-BFP@CDs) via the conjugation of triple-functionalized human serum albumin (HSA-BFP) and carbon dots (CDs). The multifunctionality of HSA-BFP@CDs for efficient detection of Aβ aggregates and inhibition of Aβ aggregation as well as scavenging of ROS was demonstrated, demonstrating the potential of the protein-carbon dots conjugate for the multi-target therapy of AD.

The distributional incidence of wildfire hazard in the western United States

Increases in wildfire activity in the western United States in recent years have led to significant property loss in wildland-urban interface areas, raising difficult questions for policymakers regarding mitigation of wildfire damages and how mitigation costs should be distributed. Yet in spite of increased attention to the distribution of environmental and climate-related risks across socioeconomic groups, and its relevance to current wildfire-related policy debates, the distributional incidence of wildfire hazard is not well understood. This paper fills this gap by combining property-level data on locations and values of residential properties, demographics, wildfire hazard, and historical wildfire perimeters. We find that there is substantial heterogeneity within high wildfire hazard areas, but that high wildfire hazard and impact from recent wildfires (2011–2018) have disproportionately been borne by high-income, white, and older residents, and by owners of high-value properties; properties in the tenth decile of market value by county are on average 70% more likely to be in high wildfire hazard areas than median value properties. However, because many high-value high wildfire hazard properties are concentrated in high density areas, most of the high wildfire hazard area in the western US is sparsely populated and comprises mainly relatively low-value properties.

Atmospheric pressure plasma jet-mouse skin interaction: Mitigation of damages by liquid interface and gas flow control

The possible benefits of an atmospheric pressure plasma jet skin treatment have been tested in vivo on mouse skin. Many studies have been conducted in vitro on mouse skin cells, but only a few in vivo where, due to the complexity of the biological system, plasma can cause severe damages. For this reason, we investigated how kHz plasma generated in a jet that is known to inflict skin damage interacts with mouse skin and explored how we can reduce the skin damage. First, the focus was on exploring plasma effects on skin damage formation with different plasma gases and jet inclinations. The results pointed to the perpendicular orientation of a He plasma jet as the most promising condition with the least skin damage. Then, the skin damage caused by a He plasma jet was explored, focusing on damage mitigation with different liquid interfaces applied to the treatment site, adding N2 to the gas mixture, or alternating the gas flow dynamics by elongating the jet's glass orifice with a funnel. All these mitigations proved highly efficient, but the utmost benefits for skin damage reduction were connected to skin temperature reduction, the reduction in reactive oxygen species (ROS), and the increase in reactive nitrogen species (RNS).

Mitigation of salt stress damages in Carica papaya L. seedlings through exogenous pretreatments of gibberellic acid and proline

Salinity is a serious threat for global agriculture, especially in arid and semi-arid regions where its incidence leads to considerable damages in the crop growth and production. Carica papaya L. is currently one of the most cultivated fruit crops in the tropical and subtropical areas, and generally, papaya cultivars exhibit a moderate sensitivity to salinity, although such responses may depend on the genotypes. In the present study, papaya seedlings were subjected to salt stress (100 mM NaCl) for 41 d and to exogenous gibberellic acid (GA3; 0.1 mM) and proline (10 mM) pretreatments to evaluate plant physiological variables linked to stress responses. Analysis of the data (P < 0.05) showed a general decrease of plant growth parameters induced by solely salt stress compared to control, such as stem height (47%) and thickness (33%) and plant fresh and dry mass (84% and 83%, respectively), as well as a reduction in the stomatal opening (93%), chlorophylls (40%) and carotenoids (71%) concentration. By contrast, a significant increase was found in foliar and radicular proline levels under stress (87% and 47%). Exogenous foliar GA3 or proline respectively induced a better performance of plants under salt stress by increasing stomatal conductance (444% or 350%), stem height (142% or 144%) and plant biomass (49% or 41%) regarding solely stressed plants, and leading to pigments concentrations close to those from control plants. The results suggest that exogenous gibberellic acid and proline as growth regulator and osmo-regulator solute, respectively could increase papaya seedlings adaption against salt stress.