Although Russia has approximately 200 tools to support science and innovation, the observed innovative activity of Russian organisations of 12 % is 4-6 times lower than that of most technologically developed countries. Under international sanctions, it is necessary to enhance the innovative component of the country’s technological competitiveness. The study hypothesises that improvement of innovation processes management in Russian regions requires a transition to a holistic innovation policy aimed at harmonising regional science, technology and production to ensure technological sovereignty. The article refines the methodology and mechanisms of the Russian innovation policy. The author’s approach to the implementation of the mission-oriented innovation policy considering the specificity of Russian regions is described. The use of a layered innovation strategy is substantiated. Innovative activity should first be stimulated in regions with the highest development of science and technology industries; then, other regions should be gradually involved in innovation processes. The following indicators are considered while selecting regions: the number of R&D employees, shipping volume of high – and medium-tech enterprises, number of university students, fiscal capacity. Data of the Federal State Statistics Service are analysed. The rank method is used for a preliminary selection of 10 regions most suitable for implementing the developed approach (Moscow, St. Petersburg, the Republic of Tatarstan, Nizhny Novgorod, Sverdlovsk oblasts, etc.). The study presents innovation missions for these regions aimed to overcome the technological gap and reduce import dependence (innovative import substitution, circular economy, etc.). The findings can be used to improve innovation policy at the federal and regional levels. Future studies should focus on establishing theoretical and methodological foundations of a unified scientific and technological space in Russia.
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