Minus State Research Articles

ANALISIS SALDO PRIMER POSITIF PADA TAHUN 2023 SEBAGAI INDIKATOR APBN PERTUMBUHAN EKONOMI DAN KESEJAHTERAAN

The 2023 State Revenue and Expenditure Budget (APBN) shows a positive figure of 92.2 trillion. This has been anticipated since 2012, and it has always been in a negative condition. This is an indicator of the improving health of the APBN, as a manifestation that leads to better economic conditions and the welfare of Indonesian society in general. The primary balance is state income minus state expenditure without debt interest payments. In determining the initial assumptions of the 2023 APBN Law, the primary balance is in negative condition. And, until the end of 2023, it shows a positive balance how This condition can show that the economy is developing with greater income, which will impact people's welfare.

Classification of Level of Consciousness in a Neurological ICU Using Physiological Data

BackgroundImpaired consciousness is common in intensive care unit (ICU) patients, and an individual’s degree of consciousness is crucial to determining their care and prognosis. However, there are no methods that continuously monitor consciousness and alert clinicians to changes. We investigated the use of physiological signals collected in the ICU to classify levels of consciousness in critically ill patients.MethodsWe studied 61 patients with subarachnoid hemorrhage (SAH) and 178 patients with intracerebral hemorrhage (ICH) from the neurological ICU at Columbia University Medical Center in a retrospective observational study of prospectively collected data. The level of consciousness was determined on the basis of neurological examination and mapped to comatose, vegetative state or unresponsive wakefulness syndrome (VS/UWS), minimally conscious minus state (MCS−), and command following. For each physiological signal, we extracted time-series features and performed classification using extreme gradient boosting on multiple clinically relevant tasks across subsets of physiological signals. We applied this approach independently on both SAH and ICH patient groups for three sets of variables: (1) a minimal set common to most hospital patients (e.g., heart rate), (2) variables available in most ICUs (e.g., body temperature), and (3) an extended set recorded mainly in neurological ICUs (absent for the ICH patient group; e.g., brain temperature).ResultsOn the commonly performed classification task of VS/UWS versus MCS−, we achieved an area under the receiver operating characteristic curve (AUROC) in the SAH patient group of 0.72 (sensitivity 82%, specificity 57%; 95% confidence interval [CI] 0.63–0.81) using the extended set, 0.69 (sensitivity 83%, specificity 51%; 95% CI 0.59–0.78) on the variable set available in most ICUs, and 0.69 (sensitivity 56%, specificity 78%; 95% CI 0.60–0.78) on the minimal set. In the ICH patient group, AUROC was 0.64 (sensitivity 56%, specificity 65%; 95% CI 0.55–0.74) using the minimal set and 0.61 (sensitivity 50%, specificity 80%; 95% CI 0.51–0.71) using the variables available in most ICUs.ConclusionsWe find that physiological signals can be used to classify states of consciousness for patients in the ICU. Building on this with intraday assessments and increasing sensitivity and specificity may enable alarm systems that alert physicians to changes in consciousness and frequent monitoring of consciousness throughout the day, both of which may improve patient care and outcomes.

Effect of a standardized maternal meal on fetal middle cerebral artery Doppler indices: A single-blinded crossover study.

ObjectiveMeasures of Doppler blood flow velocity profiles are an integral part of monitoring fetal well-being during pregnancy. These examinations are performed at different times of the day and at different maternal meal states. In uncomplicated pregnancies, we assessed the effect of a standardized maternal meal on middle cerebral artery (MCA) and umbilical artery (UA) Doppler blood flow velocity pulsatility indices (PIs) and MCA peak systolic velocity (PSV).MethodsIn this prospective single-blinded crossover study 25 healthy women were examined at 36 weeks of pregnancy. The first examination was performed in the morning following overnight fast, and repeated after extended fast (state A), and after a standard breakfast meal (state B).ResultsIrrespective of maternal prandial status, the MCA-PI values were lower in the 2nd compared to the 1st examination (-0.187; p = 0.071, and -0.113; p = 0.099, state A and B, respectively). Compared to the values in the 1st examination, the UA-PI values, were higher after extended fast (0.014; p = 0.436), and lower post-prandially (-0.036; p = 0.070). The difference (state B minus state A) between the meal states were not significant (0.074; p = 0.487 and -0.050; p = 0.058, for MCA-PI and UA-PI, respectively). Adjusting for the possible influence of fetal heart rate on MCA-PI and UA-PI, the differences between meal states remained non-significant (p = 0.179, p = 0.064, respectively). The MCA-PSV values increased after the meal (6.812; p = 0.035), whereas no increase was observed following extended fast (0.140; p = 0.951). The difference in MCA-PSV values between the two meal states was not significant (6.672; p = 0.055).ConclusionOur results demonstrate possible diurnal variations in MCA-PI and UA-PI, with and without adjustment for fetal heart rate, that seem to be unaffected by maternal meal intake in healthy pregnancies.

Finitary codings for gradient models and a new graphical representation for the six‐vertex model

AbstractIt is known that the Ising model on at a given temperature is a finitary factor of an i.i.d. process if and only if the temperature is at least the critical temperature. Below the critical temperature, the plus and minus states of the Ising model are distinct and differ from one another by a global flip of the spins. We show that it is only this global information which poses an obstruction to being finitary by showing that the gradient of the Ising model is a finitary factor of i.i.d. at all temperatures. As a consequence, we deduce a volume‐order large deviation estimate for the energy. Results in the same spirit are shown for the Potts model, the so‐called beach model, and the six‐vertex model. We also introduce a coupling between the six‐vertex model with and a new Edwards–Sokal type graphical representation of it, which we believe is of independent interest.

Translation-invariant Gibbs states of the Ising model: General setting

We prove that at any inverse temperature $\beta $ and on any transitive amenable graph, the automorphism-invariant Gibbs states of the ferromagnetic Ising model are convex combinations of the plus and minus states. The theorem is equivalent with the differentiability of the free energy with respect to the temperature at any temperature. This is obtained for a general class of interactions, that is automorphism-invariant and irreducible coupling constants. The proof uses the random current representation of the Ising model. The result is novel when the graph is not $\mathbb{Z}^{d}$, or when the graph is $\mathbb{Z}^{d}$ but endowed with infinite-range interactions, or even $\mathbb{Z}^{2}$ with finite-range interactions. Among the other corollaries of this result, we can list continuity of the magnetization at any noncritical temperature and the uniqueness of FK-Ising infinite-volume measures at any temperature.

Metastability of the Ising model on random regular graphs at zero temperature

We study the metastability of the ferromagnetic Ising model on a random $r$-regular graph in the zero temperature limit. We prove that in the presence of a small positive external field the time that it takes to go from the all minus state to the all plus state behaves like ${\exp(\beta (r/2+ \mathcal{O}(\sqrt{r}))n)}$ when the inverse temperature $\beta\rightarrow\infty$ and the number of vertices $n$ is large enough but fixed. The proof is based on the so-called pathwise approach and bounds on the isoperimetric number of random regular graphs.

Gibbs–non-Gibbs properties for evolving Ising models on trees

Dans cet article, nous étudions les mesures homogènes de Gibbs sur un arbre de Cayley soumises à une évolution de Glauber à une température infinie, et nous considérons leurs propriétés dites « non Gibbsiennes ». Nous montrons que l’ état de Gibbs intermédiaire (c’est à dire pour un champ magnétique nul l’état de Gibbs correspondant à la condition au bord libre) se comporte différemment des états de Gibbs « plus » et « moins ». Par exemple, lorsque le temps est assez grand, toutes les configurations sont mauvaises pour l’état intermédiaire, tandis que la configuration « plus » n’est jamais mauvaise pour l’état « plus ». De plus nous montrons que, pour chaque état, il y a deux transitions. Pour l’état intermédiaire il y a une première transition d’un régime Gibbsien à un régime non-Gibbsien, où certaines configurations mais pas toutes sont mauvaises. Après cette première transition, il y en a une seconde dans laquelle l’état intermédiaire passe à un régime où toutes les configurations sont mauvaises. Pour les états « plus » et « moins », il y a également deux transitions : une première d’un régime Gibbsien à un régime non-Gibbsien, et une deuxième d’un régime non-Gibbsien à un régime Gibbsien.

Stochastic domination: the contact process, Ising models and FKG measures

We prove for the contact process on Z d , and many other graphs, that the upper invariant measure dominates a homogeneous product measure with large density if the infection rate λ is sufficiently large. As a consequence, this measure percolates if the corresponding product measure percolates. We raise the question of whether domination holds in the symmetric case for all infinite graphs of bounded degree. We study some asymmetric examples which we feel shed some light on this question. We next obtain necessary and sufficient conditions for domination of a product measure for “downward” FKG measures. As a consequence of this general result, we show that the plus and minus states for the Ising model on Z d dominate the same set of product measures. We show that this latter fact fails completely on the homogeneous 3-ary tree. We also provide a different distinction between Z d and the homogeneous 3-ary tree concerning stochastic domination and Ising models; while it is known that the plus states for different temperatures on Z d are never stochastically ordered, on the homogeneous 3-ary tree, almost the complete opposite is the case. Next, we show that on Z d , the set of product measures which the plus state for the Ising model dominates is strictly increasing in the temperature. Finally, we obtain a necessary and sufficient condition for a finite number of variables, which are both FKG and exchangeable, to dominate a given product measure.

SV40 T/t-antigen induces premature mammary gland involution by apoptosis and selects for p53 missense mutation in mammary tumors.

We recently established transgenic animals (WAP-SV-T/t) carrying the early coding region of Simian Virus 40 (SV40) under the transcriptional control of the whey acidic milk protein promoter (WAP), which restricts the expression of the transgene to mammary gland epithelial cells (ME-cells). SV40 T/t-antigen synthesis causes premature mammary gland involution during late pregnancy by inducing apoptosis and leads to development of mammary tumors after the first lactation period in both p53 positive (WAP-SV-T/t) and p53 negative double transgenic animals (WAP-SV-T/t.p53-/-). The high apoptotic rate persists in all of the T/t-antigen positive breast tumor cells, as well as in established ME-tissue culture cell lines. ME-cells which spontaneously switch off the expression of the WAP-SV-T/t transgene do not undergo apoptosis. However, these cells again exhibit an extensive DNA fragmentation when SV40 T/t-antigen synthesis is reintroduced, which indicates that it is the expression of T/t antigen which is the critical factor for induction of apoptosis. In addition, we isolated several ME-cell lines from different breast tumors which have spontaneously lost the T/t-antigen yet remain maximally transformed. Strikingly, these cells contain a missense mutation of the p53 gene at codon 242 (p53(242)), which substitutes alanine for glycine. This mutation increases p53 stability and it reduces the transactivating function of p53, albeit without affecting the ability of the protein to interact with the DNA. This indicates that p53 missense mutations are selected for in breast tumors initially expressing T/t-antigen. Therefore, the p53(242) mutation is sufficient to maintain the transformed state after the ME-cells have switched off the WAP-SV-T/t transgene. Interestingly, the p53 minus state per se is not sufficient to induce ME-cell transformation since homozygous null mice for the p53 gene (p53-/-) fail to develop breast cancer.

Theoretical study of the valence π→π* excited states of polyacenes: Benzene and naphthalene

Multireference perturbation theory with complete active space self-consistent field (CASSCF) reference functions was applied to the study of the valence π→π* excited states of benzene and naphthalene. The eigenvectors and eigenvalues of CASSCF with valence π active orbitals satisfy pairing properties for the alternant hydrocarbons to a good approximation. The excited states of polyacenes are classified into the covalent minus states and ionic plus states with the use of the alternancy symmetry. The present theory satisfactorily describes the ordering of low-lying valence π→π* excited states. The overall accuracy of the present approach is surprisingly high. We were able to predict the valence excitation energies with an accuracy of 0.27 eV for singlet u states and of 0.52 eV or better for singlet g states of naphthalene. Our predicted triplet states spectrum provides a consistent assignment of the triplet–triplet absorption spectrum of naphthalene. For benzene we were able to predict the valence excitation energy with an accuracy of about 0.29 eV. The covalent minus states and ionic plus states exhibit different behavior as far as the electron correlation is concerned. The ionic plus states are dominated by the single excitations but covalent minus states include a large fraction of doubly excited configurations. The covalent minus states always give lower energy than the corresponding ionic plus states. This is true for triplet states. The dynamic σ–π polarization effects introduced by perturbation theory are significant for the ionic plus states while those on covalent excited states are usually of the same order as in the covalent ground state. The enlargement of the active space of the reference functions represents a great improvement of the description of the ionic states. The present approach with the pairing properties has proved to be of great value in understanding and predicting the experimental data of the alternant hydrocarbons.

Theoretical study of the excitation spectra of five-membered ring compounds: Cyclopentadiene, furan, and pyrrole

Multireference perturbation theory with complete active space self-consistent field (CASSCF) reference functions was applied to the study of the valence and Rydberg excited states in the range of 5–8 eV of five-membered ring compounds, cyclopentadiene, furan, and pyrrole. The spectra of these molecules have been studied extensively for many years but characterization is far from complete. The present approach can describe all kinds of excited states with the same accuracy. The calculated transition energies are in good agreement with corresponding experimental data. We were able to predict the valence and Rydberg excited states with an accuracy of 0.27 eV or better except for the B+2 of pyrrole. The valence excited states of five-membered ring compounds were interpreted in terms of the covalent minus states and ionic plus states of the alternate symmetry. The unobserved 1A1→A−1 transition with very weak intensity, which is hidden under the strong 1A1→B+2 transition, is also discussed. Overall, the present theory supports the assignments recently made by Serrano-Andres et al. based on the CASSCF plus second-order perturbation results. However, there remain some discrepancies in the assignment of the spectrum of pyrrole.

Tempering Dynamics and Relaxation Times in the 3D Ising Model

We discuss the tempering Monte Carlo method, and its critical slowing down in the $3d$ Ising model. We show that at $T_c$ the tempering does not change the critical slowing down exponent $z$. We also discuss the exponential slowing down for the transition from the plus to the minus state in the cold phase, and we show that tempering reduces it to a power law slowing down. We discuss the relation of the flip-flop rate to the surface tension for the local dynamical schemes.

Relation of the charge and spin correlation functions to the structures of π electron wave functions in alternant hydrocarbons

AbstractWe analyze, in the Pariser–Parr–Pople (PPP) model of alternant hydrocarbons, how the charge and spin correlation functions (CF's) are related to the structure of a CI wave function and the MO's of the systems. The analysis is based on the fact that an uncorrelated electron present in an orbital does not contribute to the linked dynamically correlated parts of the CF's. By using the fact, simple rules are deduced predicting the covalent or ionic nature of the correlation structure in a low‐lying state with two correlated electrons. The rules predict that the singlet minus and triplet plus states are covalent, while singlet plus and triplet minus states are ionic, where the plus and minus mean the alternancy symmetry. The rules also give a prediction for the unknown charge and spin correlation structures between different sites.

Stimulation of mitochondrial adenosine diphosphate uptake by thyroid hormones.

Thyroid hormone administered in vivo increased carrier-mediated (atractyloside-sensitive) ADP uptake by rat liver mitochondria. 3 Days after a single large dose of triiodothyronine (20 mug/100 g of body weight), mitochondrial uptake of ADP measured at 6 degrees was 2.35 +/- 0.17 nmol/min per mg of protein, compared with an uptake of 1.81 +/- 0.19 nmol/min per mg of protein in mitochondria from untreated rats (P < 0.025). Cyanide (1.33 mM) had no effect on ADP uptake by mitochondria from either untreated or triiodothyronine-treated animals. Uptake of ADP by mitochondria from thyroidectomized rats treated with thyroxine for 7 days was 2.89 +/- 0.40 nmol/min per mg in mitochondria from thyrotoxic rats (20 mug of thyroxine per 100 g per day) and 1.98 +/- 0.22 nmol/min per mg in mitochondria from euthyroid rats (2 mug of thyroxine per 100 g per day) (P < 0.025). Mitochondria from both untreated and thyroid hormone-treated rats displayed a highly significant linear correlation between ADP uptake and ADP-dependent (i.e., state 3 minus state 4) oxygen consumption. There was, however, no difference in respiratory control ratios between mitochondria from euthyroid and thyrotoxic animals. Administration of dinitrophenol (2 mg/100 g) also stimulated carrier-mediated ADP uptake, but respiratory control of mitochondria from dinitrophenol-treated animals was virtually abolished. Triiodothyronine in vitro, at concentrations of 100 and 0.1 nM, appeared to inhibit rather than stimulate the uptake of mitochondrial ADP. The relationship between these observations and the clinical manifestations of thyrotoxicosis is discussed from the point of view of the possible effects of increased mitochondrial ADP transport on oxidative phosphorylation and adenosyl nucleotide metabolism.