In this study, the effect of sustainable cooling and lubrication strategies such as MQL, LN2, LN2 +MQL, LN2 +hBN/GA, LN2 +GNP/GA, LN2 +hBN-GNP/GA on drilling nickel-based Hastelloy X alloy was examined. The environmental impacts and health risks of traditional petroleum-based cutting fluids used in drilling operations have led researchers to look for ecological alternatives. In this context, combinations of nanofluids enriched with minimum quantity lubrication (MQL), liquid nitrogen (LN2), and nanosized hBN and GNP particles have been tested. The experiments were carried out at cutting speeds of 20 and 30 m/min and feed rates of 0.04 and 0.06 mm/rev. Nanofluids characteristics i.e., viscosity, Ph, thermal conductivity and wettability, and drilling performance were evaluated with criteria such as cutting force, surface roughness, hole quality and tool wear. The results obtained showed that the hybrid methods combining LN2 and nanofluid-based MQL provided superior performance in terms of both cooling and lubrication, and the condition directly positively affected the processing outputs. This study contributes to the literature by revealing the potential of ecological cooling/lubrication methods in the sustainable production of difficult-to-machine materials such as Hastelloy X.