Massive multiple-input multiple-output (MIMO) systems are at the forefront of 5G technology, significantly improving energy efficiency compared to earlier wireless communication systems. This study develops an optimal model for energy-efficient massive MIMO systems, aiming to increase spectral efficiency (SE) within a multi-cell framework. Base stations (BSs) use various techniques for channel estimations during uplink (UL) transmission, including minimum mean-squared error (MMSE), Least Squares, and Element-wise MMSE (EW-MMSE) estimators. The research evaluates the SE achievable through MMSE channel estimation by applying different receive combining schemes. Additionally, it explores downlink (DL) transmission using various precoding schemes, utilizing vectors similar to those in combining schemes. Simulations show a significant improvement in SE by advancing UL and DL transmission models. The study highlights that optimized MMSE channel estimation, along with an increased number of BS antennas and the ability to serve multiple user equipment (UEs) per cell, can enhance the average SE per cell. The findings indicate that optimizing channel estimation is crucial for the development of massive MIMO systems, especially for improving SE in both UL and DL transmissions.