The experiment was conducted at Horticultural farm, Sher-e-Bangla Agricultural University, Dhaka, Bangladesh during the period of September to November 2023. The experiment was laid out with single factor experiment using a completely randomized design with three replications to study the Growth and Yield responses of Red Amaranth (Amaranthus cruentus L) to liquid manure. The treatments under this study were; T1: Control (Only Water), T2: Vermi Tea; T3: SAU- MLM, T4: SAU-NLM, T5: SAU-PLM. Significant variation of growth and yield parameters were found among the treatments. Among the treatments. The tallest plant (44.3 cm), maximum root length was (13.3cm), maximum leaf area (38.2 sq. cm), maximum leaf number (14.0), maximum fresh weight per plant (22.1g), highest weight of plants per 506.25 sq. cm (274.9 g) and highest yield per ha (54.3 ton) was found in T5 while shortest plant (25.1 cm, minimum root length (4.8cm), minimum leaf area (16.4 sq. cm), minimum leaf number (8.6), minimum weight of plants/506.25 sq.cm. (77.5 g) and the lowest yield per ha (15.6 t) was found in T1 at final harvest (30 days after showing). Considering the overall analysis, it becomes evident that T5 consistently exhibits superior outcomes when compared to the other treatments. The superior performance of T5 suggests that it could be the optimal choice for maximizing agricultural productivity while maintaining a focus on human well-being and environmental sustainability. This treatment option not only results in higher yields, indicating potential economic benefits, but it also contributes to the overall safety and health considerations for individuals involved in the agricultural processes.