Minimally Invasive Direct Coronary Artery Bypass Grafting Research Articles

Quality of life following Minimally Invasive Direct Coronary Artery Bypass Grafting (MIDCABG) versus Conventional Open-Heart Coronary Artery Bypass Grafting (CABG): A 3-year data from a single centre

Introduction: In Malaysia, MIDCABG started in 3 centers developing the technique. As the technique is gaining traction in the country, this study aims to compare the quality of life following MIDCABG compared with conventional CABG in one of the centers actively developing this technique. Methods: A retrospective cohort study was performed involving 30 post CABG patients which consists of 15 MIDCABG and 15 conventional CABG from January 2015 to May 2018. 15 from 21 post-MIDCABG patients were included and selected, based on EuroSCORE II less than 5. Modified Post-Operative Quality of Recovery Scale was used to assess and compare the quality of life following respective approaches. Data were analyzed using SPSS version software and comparison using mean rank with p 0.05. Conclusion: There is no significant difference in quality of recovery following MIDCABG compared to conventional CABG. Modified PostOPQRS system can be a useful assessment tool to evaluate the impact of an intervention in relation of quality of life.

Review of the differences in outcomes between males and females after revascularization.

This review aims to compare outcomes of males and females undergoing coronary artery bypass grafting (CABG), percutaneous coronary intervention (PCI), off-pump CABG (OPCAB), minimally invasive direct CABG (MIDCAB), and robotic total endoscopic CABG (TECAB). Females demonstrated increased rates of morbidity and mortality post PCI and CABG. In studies that performed risk adjustments, these differences were reduced. Although inferior outcomes were observed for females in some measures, generally outcomes between males and females were comparable post OPCAB, MIDCAB, and TECAB. Previous literature has demonstrated that females undergoing coronary revascularization experience inferior postoperative outcomes when compared to their male counterparts. The discrepancies between males and females narrow, but do not disappear when preoperative risks are accounted for and when considering minimally invasive approaches such as MIDCAB, OPCAB, and TECAB. Minimally invasive cardiac surgery has demonstrated numerous benefits with reduced morbidity, mortality, and shorter recovery times. In patients with increased comorbidities, minimally invasive approaches confer a greater advantage. As females often fall within this category, it is paramount that the diagnosis and referral process be optimized to account for preoperative differences to provide the most beneficial approach if the disparity between the sexes is to be addressed.

Efficacy of oxycodone combined with thoracic paravertebral block for postoperative analgesia in patients undergoing minimally invasive direct coronary artery bypass grafting

Objective To evaluate the efficacy of oxycodone combined with thoracic paravertebral block (TPVB) for postoperative analgesia in patients undergoing minimally invasive direct coronary artery bypass grafting (MIDCABG). Methods Thirty-two American Society of Anesthesiologists physical status Ⅱ or Ⅲ patients of both sexes, aged 60-75 yr, weighing 50-85 kg, scheduled for elective MIDCABG under general anesthesia, were divided into 2 groups (n=16 each) using a random number table method: morphine plus TPVB group (group MT) and oxycodone plus TPVB group (group OT). Paravertebral catheter was placed at T4, 5 before induction of anesthesia to perform left thoracic paravertebral puncture, patients were tracheally intubated, and 0.375% ropivacaine 15 ml was injected followed by continuous infusion of 0.375% ropivacaine 5 ml/h until 0.5 h before the end of surgery.Both groups received patient-controlled analgesia (PCA) after surgery.The PCA solution contained 1 mg/ml morphine 60 ml in group MT or 1 mg/ml oxycodone 60 ml in group OT, and the PCA pump was set up to deliver a 1 mg bolus dose with a 10-min lockout interval and background infusion at 1 ml/h after a loading dose of 2 mg, with the maximum dose of 20 mg every 4 h. Pethidine 50 mg was intravenously injected as a rescue analgesic to maintain visual analog scale≤4.The intraoperative consumption of fentanyl, consumption of analgesics for PCA within 48 h after surgery, ratio of total to effective pressing times of PCA, consumption of analgesics for rescue analgesia, requirement for rescue analgesia, score of satisfactory analgesia, extubation time, duration of intensive care unit stay and length of hospital stay were recorded.The development of nausea and vomiting, pruritus, respiratory depression, atelectasis and somnolence was recorded within 72 h after surgery. Results Compared with group MT, the intraoperative consumption of fentanyl, consumption of analgesics for PCA, consumption of analgesics for rescue analgesia, requirement for rescue analgesia and ratio of total to effective pressing times of PCA were significantly decreased, the score of satisfactory analgesia was increased, the extubation time and duration of intensive care unit stay were shortened, and the incidence of nausea and vomiting, pruritus, respiratory depression and somnolence was decreased in group OT (P<0.05). Conclusion Oxycodone combined with TPVB provides safe and effective efficacy for postoperative analgesia in patients undergoing MIDCABG. Key words: Oxycodone; Analgesia, patient-controlled; Nerve block; Coronary artery bypass, off-pump

Minimally invasive direct coronary artery bypass grafting (MIDCABG) - our experience in Olomouc, Czech Republic

Results Between 2008-2013 (June) a total of 2316 CABGs were performed at our department, out of which 149 (6,4%) were MIDCABs. The mean age of pts was 67 years (±12), male/female ratio 89/60. Indications were as follows isolated LAD stenosis 64, hybrid procedure (combination with PCI) 27, in-stent restenosis 4, palliative single vessel procedure 30, redo after previous cardiac surgery 9, different malignancy 8. Intraoperative conversion to full sternotomy 2 (1,3%), re-exploration for bleeding 2 (1,3%), 30-day mortality 2 (1,3 %).

Anesthetic and Technical Considerations in Redo Coronary Artery Bypass Surgery Using Sternal-Sparing Approaches

REOPERATIVE CORONARY ARTERY bypass grafting (CABG) has decreased significantly in the previous 20 ears, likely because of the increased availability of percutaeous coronary intervention (PCI).1 Reoperative surgery using he classic trans-sternal approach is more technically challengng than primary surgery and is associated with an increased isk of major complications and death.2,3 There is an increased isk of injury to patent bypass grafts, the great vessels, and right entricle during sternal re-entry. Manipulation of the aorta or iseased bypass grafts can precipitate embolization and cause troke or myocardial infarction.2,4,5 Reoperative sternotomy also is associated with prolonged cardiopulmonary bypass (CPB) time, an increased risk of sternal wound infections, and postoperative mediastinitis.2,5 Patients undergoing reoperative sternotomy often have regional ischemia with patent grafts or native vessels to other territories. Although sternotomy provides the best exposure for global access to the myocardium, when only regional access is required, limited-access nonsternotomy approaches are an attractive option. Collectively, these are known as minimally invasive direct CABG (MIDCAB). In addition to the standard monitoring, there are specific anesthetic considerations for nonsternotomy approaches in reoperative coronary surgery. These include the possible use of lung separation techniques and the need for external defibrillator pads. In addition, it is imperative to be prepared for catastrophic events and longer surgical times. An avoidance of CPB affords the benefit of avoiding the coagulopathic derangements that occur on CPB, including platelet, fibrinogen, and coagulation factor dysfunction and dilution. Another common coagulopathic consequence of CPB is fibrinolysis. During off-pump CABG, the use of fibrinolytics usually is not needed. The authors present 3 patients who underwent nonsternotomy approaches to CABG. The surgical approach for each patient was chosen based on vessel involvement.

Is there an optimal minimally invasive technique for left anterior descending coronary artery bypass?

BackgroundThe aim of this retrospective study was to evaluate the clinical outcome of three different minimally invasive surgical techniques for left anterior descending (LAD) coronary artery bypass grafting (CABG): Port-Access surgery (PA-CABG), minimally invasive direct CABG (MIDCAB) and off-pump totally endoscopic CABG (TECAB).MethodsOver a decade, 160 eligible patients for elective LAD bypass were referred to one of the three techniques: 48 PA-CABG, 53 MIDCAB and 59 TECAB. In MIDCAB group, Euroscore was higher and target vessel quality was worse. In TECAB group, early patency was systematically evaluated using coronary CT scan. During follow-up (mean 2.7 ± 0.1 years, cumulated 438 years) symptom-based angiography was performed.ResultsThere was no conversion from off-pump to on-pump procedure or to sternotomy approach. In TECAB group, there was one hospital cardiac death (1.7%), reoperation for bleeding was higher (8.5% vs 3.7% in MIDCAB and 2% in PA-CABG) and 3-month LAD reintervention was significantly higher (10% vs 1.8% in MIDCAB and 0% in PA-CABG). There was no difference between MIDCAB and PA-CABG groups. During follow-up, symptom-based angiography (n = 12) demonstrated a good patency of LAD bypass in all groups and 4 patients underwent a no LAD reintervention. At 3 years, there was no difference in survival; 3-year angina-free survival and reintervention-free survival were significantly lower in TECAB group (TECAB, 85 ± 12%, 88 ± 8%; MIDCAB, 100%, 98 ± 5%; PA-CABG, 94 ± 8%, 100%; respectively).ConclusionsOur study confirmed that minimally invasive LAD grafting was safe and effective. TECAB is associated with a higher rate of early bypass failure and reintervention. MIDCAB is still the most reliable surgical technique for isolated LAD grafting and the least cost effective.

Combined Transapical Aortic Valve Replacement and Minimally Invasive Direct Coronary Bypass Grafting�A New Concept for Selected High-Risk Patients

Transcatheter aortic valve implantation and minimally invasive direct coronary artery bypass (MIDCAB) procedures are both off-pump treatment options for a subset of higher-risk patients. We present a new, minimally invasive surgical concept involving combining the procedures and performing them through the same thoracic access in a patient with a vascular disorder. We report on a 78-year-old patient with symptomatic calcified aortic stenosis and a critical lesion of the left anterior descending coronary artery. In addition, Rendu-Osler-Weber disease was diagnosed. He was successfully treated with combined off-pump transapical, transcatheter aortic valve implantation and MIDCAB grafting. The initial postoperative recovery was good; however, the patient died 3 months postoperatively from septic complications. This combined procedure performed through the same anterolateral incision was technically feasible and may be a promising, minimally invasive approach for selected patients.

Robot Assisted Left Internal Thoracic Artery Harvesting in Minimally Invasive Direct Coronary Artery Bypass: Report of a Case

Coronary artery bypass grafting (CABG) is usually performed through a sternotomy. Minimally invasive direct coronary artery bypass grafting (MIDCABG) has been used recently in a select group of patients with severe lesions of the left anterior descending (LAD) coronary artery. CABG has been proven difficult to adapt to a totally endoscopic approach because of the inability to perform a precision microvascular-sutured coronary anastomosis with conventional endoscopic instrumentation. The Da Vinci telemanipulation system has six degrees of freedom and allows free orientation in space and a remote, tremor-free, three-dimensional visual image. We report hereby a 76-year-old male who suffered from substernal chest pain that radiated to the left shoulder for one day. Coronary angiography confirmed coronary artery disease with 90% occlusion of the LAD coronary artery. The patient volunteered to receive the operation. Robotically assisted left internal thoracic artery (LITA) harvesting and direct off-pump anastomosis to the LAD through small thoracotomy incisions were performed safely. The patient improved clinically and was free of angina at the six-month follow-up. We describe an alternative procedure for one-vessel disease using robotic takedown of the LITA and off-pump anastomosis to the LAD artery through small incisions. This procedure is associated with minimal blood loss and ventilatory requirements, and short stays in the intensive care unit and hospital.

Gastroepiploic Artery Minimally Invasive Grafting in Reoperative Patients With Patent Mammaries

Patients with patent grafted bilateral internal thoracic arteries may require repeat myocardial revascularization because of either progression of disease in a nongrafted native vessel or failure of a saphenous vein graft. In order to avoid extensive dissection and possible damage of the internal thoracic arteries, we elected to proceed with an off-pump minimally invasive direct coronary artery bypass grafting (MIDCABG) approach using the pedicled right gastroepiploic artery. This paper summarizes our midterm angiographic results. From 1996 to 2003, 15 patients were reoperated on using this approach in our department. Internal thoracic artery grafts always revascularized the anterior and lateral territories and were angiographically patent. Indications for repeated surgery were: (1) coronary disease progression in 8 patients; (2) occlusion of the saphenous vein graft in 6 patients; and (3) anastomotic stenosis of a pedicled right gastroepiploic artery in 1 patient. Off-pump grafting of the pedicled right gastroepiploic artery was targeted at the posterior descending artery in 14 patients, and at the left anterior descending artery in 1 patient. Thirty-day mortality was 6.5% (1 of 15 patients). With a mean follow-up of 56 +/- 20 months, angina-free survival was 79%. At angiographic control (mean, 38 months), the pedicled right gastroepiploic artery was patent in 13 patients. One patient had an occluded right gastroepiploic artery graft at 23 months and another patient showed progression of disease distal to the right gastroepiploic artery anastomosis at 28 months. Off-pump MIDCABG repeat revascularization with a pedicled right gastroepiploic artery is an effective method of revascularization for patients with patent bilateral internal thoracic arteries.

Port access video-assisted proximal anastomosis with the symmetry aortic connector in MIDCABG procedure

We present an alternative way to create a video-assisted port access proximal anastomosis in the ascending aorta with the Symmetry Bypass System Aortic Connector (St. Jude Medical ATG, St. Paul, MN). This technique was successfully used in a patient undergoing urgent minimally invasive direct coronary artery bypass grafting (MIDCABG), in whom the left internal mammary artery was not harvested owing to subtotal occlusion of the left subclavian artery. Port access use of mechanical anastomotic devices may increase the indications for minimally invasive coronary artery surgery.

Different CABG methods in patients with chronic obstructive pulmonary disease

Background. Pulmonary dysfunction is still a major problem in coronary artery bypass grafting (CABG). The purpose of this randomized study was to determine the effect of different CABG techniques on pulmonary function. Methods. Fifty eight patients with severe obstructive pulmonary disease had elective isolated coronary surgery. The surgical methods for the patients with chronic obstructive pulmonary disease (COPD) were standard CABG in 18 patients (group 1), beating heart surgery in 19 patients (group 2), and minimally invasive direct coronary artery bypass grafting (MIDCABG) in 21 patients (group 3). Results. The earliest extubation time was from group 3 ( p < 0.001). The average stay in the intensive care unit was significantly longer in group 1 (2.6 ± 1.5 days) than in groups 2 (1.4 ± 0.8 days) and 3 (1.1 ± 0.8 days) ( p < 0.05). The most prevalent respiratory morbidity was atelectasis that developed in 6 patients from group 1, in 2 patients from group 2, and in 3 patients from group 3. Forced expiratory volumes in 1 second (FEV 1) obtained in the second postoperative month were significantly lower than preoperative values only in group 1 ( p < 0.05). Forced vital capacity (FVC) values were significantly lower than the preoperative values in all three groups ( p < 0.05). Conclusions. Off-pump bypass surgical procedures are more advantageous than on-pump methods for patients with COPD. These patients can be operated on using the beating heart technique or by using MIDCABG to prevent side effects of CPB on pulmonary function and effects of sternotomy.

Markers of myocardial ischemia after minimally invasive and conventional coronary operation

Background. The purpose of this study was to evaluate the course of serum markers of myocardial tissue damage after two different types of minimally invasive coronary surgical procedures (MICS) as compared with conventional coronary artery bypass grafting (CABG). Methods. We enrolled 87 patients with one- or two- vessel disease scheduled for one of the three procedures: minimally invasive direct coronary artery bypass grafting (MIDCABG) by lateral thoracotomy (n = 29), the OCTOPUS method by median sternotomy (n = 27), and CABG (n = 31). Creatine kinase activity (CK), creatine kinase MB activity (CK-MB act), creatine kinase MB mass concentration (CK-MB mass), myoglobin concentration (MG), and cardiac troponin I concentration (cTnI) were measured perioperatively until the second postoperative day. Results. Creatine kinase-MB, CK-MB mass, and cTnI were significantly higher after CABG and were nearly maintained within the normal range in MICS. Creatine kinase and MG were significantly lower in the OCTOPUS group than in the MIDCABG or CABG groups. Conclusions. Minimally invasive coronary surgical procedures cause less myocardial injury than CABG as indicated by specific serum markers. However, higher CK and MG reflect more substantial skeletal muscle trauma during MIDCABG operation compared with Octopus procedures.

Minimally invasive direct coronary artery bypass grafting: intermediate-term results

Background. Intermediate- and long-term clinical outcome and graft patency in minimally invasive direct coronary artery bypass grafting (MIDCABG) procedures remain a concern. Methods. Over a 13-month period, 66 MIDCABG procedures were performed utilizing robotic-assisted internal mammary artery (IMA) harvesting and direct CABG through a 5-cm thoracotomy without cardiopulmonary bypass. Clinical follow-up was obtained on all patients. Graft patency was assessed in 61 of 66 consecutive patients 6 months (range 2 to 15 months) postoperatively. Group I consisted of 45 patients who underwent IMA angiography and group II consisted of 16 patients who underwent both a nuclear stress test and transthoracic Doppler examination. All group II patients had abnormal preoperative nuclear stress tests for comparison. Results. To date, all 66 patients are alive. Graft patency rates in the two groups were 97.8% (45 of 46 grafts in 45 patients) in group I and 100% (15 of 15 grafts), with one indeterminate study, in group II. The overall patency rate for the entire study group was 98.3% (60 of 61 grafts). Sixty-two of 66 (93.9%) patients were able to return to their normal level of activity within 3 weeks. Conclusions. This study demonstrates that the MIDCABG with thoracoscopic IMA harvesting can achieve effective intermediate-term revascularization and an acceptable clinical outcome.

Minimally invasive direct coronary artery bypass grafting: midterm results and quality of life

Background. There is increasing interest in minimally invasive direct coronary artery bypass grafting (MIDCABG); however, there is still little information about midterm results and postoperative quality of life. Methods. From March 1995 to March 1998, 64 patients underwent MIDCABG at our hospital. Their mean age was 60 ± 9.5 years; 22 (34.4%) had unstable angina. All patients were followed-up by both direct visit and questionnaire to assess the postoperative quality of life. Results. There were no perioperative deaths nor conversions to sternotomy; the perioperative myocardial infarction rate was 1/64 (1.6%). Predischarge angiography showed overall and unobstructed patency rates of 96.8% (62 of 64) and 93.8% (60 of 64), respectively. At follow-up (25 ± 11.4 months) actuarial survival was 100%, and survival free of myocardial infarction was 98.4% ± 1.6% at 3 years. Both the Physical Activity Score and the Psychological General Well-being Index improved significantly after the operation, with percentage improvements of 31% and 23%, respectively, at 12 months postoperatively. Conclusions. In selected patients MIDCABG can be a reliable and safe option. Patients who undergo this procedure are free of major complications and enjoy a good quality of life after surgery.

Human cytokine responses to coronary artery bypass grafting with and without cardiopulmonary bypass

Background. Coronary artery bypass grafting (CABG) is associated with a systemic inflammatory response. This has been attributed to cytokine release caused by extracorporeal circulation and myocardial ischemia. This study compares the inflammatory response after CABG with cardiopulmonary bypass and after minimally invasive direct coronary artery bypass grafting (MIDCABG) without cardiopulmonary bypass. Methods. Cytokine release and complement activation (interleukin-6 and interleukin-8, soluble tumor necrosis factor receptors 1 and 2, complement factor C3a, and C1 esterase inhibitor) were determined in 24 patients before and after CABG or MIDCABG. The maximum body temperature, chest drainage, and fluid balance were recorded for 24 hours after operation. Results. Release of interleukin-6, interleukin-8, and tumor necrosis factor receptors 1 and 2 was significantly higher ( p ≤ 0.005) in the CABG group than the MIDCABG group just after operation. After 24 hours, a significant increase in interleukin-6 was also found in the MIDCABG group ( p = 0.001) compared with preoperative value. Body temperature and fluid balance were significantly higher after CABG ( p ≤ 0.001). Conclusions. Minimally invasive direct coronary artery bypass grafting represents a less traumatizing technique of surgical revascularization. The reduction in the inflammatory response may be advantageous for patients with a high degree of comorbidity.

Hybrid technique for myocardial revascularization: value of combined minimal invasive bypass technique (MIDCAB) with interventional therapy (PTCA)

Minimally invasive direct coronary artery bypass (MIDCAB) grafting without cardiopulmonary bypass (CPB) through an anterolateral minithoracotomy has become a promising therapeutical option especially in multimorbid, elderly and reoperative patients with single vessel disease. However, this procedure precludes complete revascularization in multivessel disease because the minithoracotomy limits the surgical access either to anterior or lateral or posterior vessels of the beating heart. To expand the benefits of the MIDCAB concept to patients with multivessel disease, new interdisciplinary approaches have recently been introduced. Since December 1996, 26 patients (21 male, 5 female, mean age 56.6 +/- 18.8 years) underwent a "hybrid" revascularization performed as a primary MIDCAB procedure for grafting of the left anterior descending artery (LAD) with the left internal mammary artery (LIMA) followed by staged angioplasty and stenting of additional coronary lesions. After MIDCAB grafting, the postoperative course was uneventful in all patients. Coronary re-angiography after a median of 7 days revealed patent and functioning LIMA grafts in all patients. Applying subsequent percutaneous transluminal coronary angioplasty (PTCA) and occasional stenting (n = 8), a total of 31 lesions were treated successfully. Procedure related complications did not occur. All patients remained angina-free and no stress electrocardiographic changes were recorded. Our preliminary results of a "hybrid" approach to myocardial revascularization suggest that this concept is a safe and effective approach of complete revascularization for selected patients with multivessel involvement. Especially elderly and reoperative patients with significant comorbidity may benefit from hybrid procedures avoiding cardiopulmonary bypass and midsternotomy.

Minimally invasive direct coronary bypass versus cardiopulmonary technique: angiographic comparison

Background. Studies comparing minimally invasive direct coronary artery bypass grafting (MIDCABG) with techniques using cardiopulmonary bypass (CPB) are needed. Methods. Sixteen patients underwent single-vessel left internal thoracic artery–left anterior descending (LITA-LAD) MIDCABG through a left anterior thoracotomy, and 10 underwent multivessel bypass grafting that included a LITA-LAD, using CPB. Intraoperative completion angiography was performed on all LITA-LAD bypasses, and graded. One point each was given for: anastomotic patency, pedicle patency, intercostal obliteration, proper placement into the correct native coronary artery, and Thrombosis In Myocardial Ischemia grade III flow. Results. There were no intraoperative deaths or morbidities. LITA takedown averaged 49 ± 18.6 minutes for MIDCABG and 16 ± 2.0 minutes for CPB CABG ( p < 0.05). LITA length did not differ between groups (15.3 ± 1.2 cm for MIDCABG, 14.3 ± 1.08 cm for CPB CABG). Ischemic arrest time was significantly less for the CPB group (13.3 ± 8.3 minutes versus 24.5 ± 9.6 minutes; p < 0.05). Average grade for MIDCABG LITA-LAD was 4.06 ± 0.98 points versus 4.77 ± 0.98 points for CPB LITA-LAD bypass ( p = not significant). Conclusions. Intraoperative completion angiography is feasible and, when combined with a grading system, may facilitate the comparison of MIDCABG with standard techniques.

Morbidity, cost, and six-month outcome of minimally invasive direct coronary artery bypass grafting

Background. Minimally invasive direct coronary artery bypass grafting (MIDCABG) promises to reduce the morbidity of coronary bypass, but this has not been proved. Methods. This retrospective study compares the morbidity, mortality, cost, and 6-month outcome of patients less than 80 years old undergoing elective left internal mammary artery to left anterior descending artery bypass grafting via MIDCABG (n = 60) or sternotomy (n = 55) between January 1995 and December 1996. There were no differences between the groups in mean age, sex distribution, or preoperative risk level. The left internal mammary artery was mobilized from the fifth costal cartilage to the subclavian artery in all patients. The anastomoses were done with a beating heart in the MIDCABG group and with cardioplegic arrest in the sternotomy group. Results. There were no operative deaths in either group. The MIDCABG patients had a lower transfusion incidence (10/60 [17%] versus 22/55 [40%]; p ≤ 0.02) and a shorter postoperative intubation time (2.1 ± 4.2 versus 12.6 ± 9 hours; p ≤ 0.0001). One patient in each group was reexplored for bleeding. Three sternotomy patients (3/55, 5%) required ventilatory support for greater than 48 hours, but no MIDCABG patient was ventilated for more than 24 hours. Median postoperative length of stay was 4 days for MIDCABG and 7 days for sternotomy. Estimated hospital costs were $11,200 ± 3100 for MIDCABG and $15,600 ± 4200 for CABG ( p < 0.001). The reduced morbidity and cost of MIDCABG was found mostly in high-risk patients. At 6-month follow-up, 5 MIDCABG patients (5/60, 8%) had evidence of recurrent ischemia involving the left anterior descending artery, primarily the result of anastomotic stricture. Conclusions. This analysis shows that MIDCABG reduces the initial morbidity and cost of coronary bypass, but some patients require subsequent reintervention. Long-term follow-up is needed before MIDCABG can be judged better than traditional bypass, but the initial results are promising, especially in high-risk patients.

The expanded role of minimally invasive coronary grafting.

The evolution of minimally invasive direct coronary artery bypass (MIDCAB) grafting has extended the role of this approach for limited coronary revascularization. MIDCAB techniques can now be used to address isolated stenoses in the inferior and lateral coronary distributions. MIDCAB techniques are increasingly being used in the reoperative setting, and multiple vessels can be bypassed during a single operation. This article reviews the expanded role of MIDCAB grafting in the treatment of coronary artery disease.

Reoperative MIDCAB grafting: 3-year clinical experience.

Minimally invasive direct coronary artery bypass (MIDCAB) is performed under direct vision without sternotomy or cardiopulmonary bypass. The technique is used in reoperative patients through various incisions to revascularize one or two areas of the heart. The internal mammary artery, gastroepiploic artery, radial artery, or saphenous vein are used as graft conduits. Anterior coronary targets are grafted with the internal mammary artery via a small anterior thoracotomy. Inferior coronary targets are grafted with the gastroepiploic artery via a small midline epigastric incision. Lateral coronary targets are grafted with radial artery or saphenous vein via a posterior thoracotomy. After partial heparinization, the anastomosis is facilitated by local coronary occlusion and stabilization. Graft follow-up consists of outpatient Doppler examination and selective recatheterization. Between January 1994 and August 1997, 81 patients underwent reoperative MIDCAB grafting. Twenty-one patients (25.9%) had internal mammary grafting, 39 (48.2%) had gastroepiploic grafting, and 21 (25.9%) had lateral grafting with radial artery or saphenous vein. There were nine early deaths (four cardiac, five non-cardiac), five late deaths (three cardiac, two non-cardiac), and nine myocardial infarctions in remaining patients. Sixteen patients underwent recatheterization; there were one graft occlusion, two graft stenoses, and eight anastomotic stenoses. Mean postoperative length of stay was 3.8 days. Ninety percent (55/61) of patients are free of symptoms at a mean follow-up of 7.8 months (range 0-39). Reoperative MIDCAB grafting avoids the risks of resternotomy, aortic manipulation, and cardiopulmonary bypass. The techniques yield an early patency rate of 94%, which includes eight patients who had postoperative catheter-based interventions. Reoperative MIDCAB grafting had lower rates of supraventricular arrhythmia and transfusion when compared with conventional coronary artery bypass grafting, but did not offer an advantage for mortality, stroke or myocardial infarction. This 3-year experience suggests that while reoperative MIDCAB grafting can effectively revascularize focal areas of the heart, patients should be carefully selected to minimize operative risk.