Abstract Background Obesity is a potent risk factor for the development and progression of type 2 diabetes, and weight loss is a key component of diabetes management. Bariatric surgery results in significant weight loss and remission of diabetes in most patients. After surgery, glycemic control is restored by a combination of enforced caloric restriction, enhanced insulin sensitivity, and increased insulin secretion. Aim and Objectives to review the currently available evidence for the effect of laparoscopic mini gastric bypass in obese patients on remission of diabetes type 2. Subjects and Methods This was a systematic review, including all available studies meeting the eligible criteria: well conducted descriptive studies, case reports and series, cohort, articles, accepted manuscripts, clinical trials, analytic studies and literature of reviews. Excluding other systematic reviews, technical notes, letters, and comment. Intervention done in all the studies concerning this subject including laparoscopic mini gastric bypass. Result Mean number of Improved, % (no.) [HbA1c <7%] were 64%, mean Partial remission, % (no.) [HbA1c <6.5%] was 77% and mean Complete remission, % (no.) [HbA1c <6.0%, glucose <110 mg/dl] was 50.5%. Conclusion GB surgery is an effective treatment strategy for diabetes remission and control of metabolic syndrome. Duodenum exclusion plays a role in the mechanism of diabetes mellitus remission.