Burnout among medical students is depressingly common. Studies estimate the prevalence of burnout to be anywhere from 40 to 76%. More distressingly, a recent study reported that 9.4% of fourth-year medical students and interns admitted to having suicidal thoughts during the previous two weeks. These findings have prompted a small number of medical schools to create targeted wellness programs for their students. The most promising interventions focus on a concept known as mindfulness training. In particular, students planning a career in emergency medicine may benefit from mindfulness, as the emergency department is often a crowded, chaotic, and uniquely high-stress environment in which to practice. Described here is an innovative wellness curriculum integrated into a four-week emergency medicine clerkship for senior medical students that uses mindfulness techniques to reduce their risk of burnout. After participation in this curriculum, learners will be able to: (1) explain foundational wellness concepts; (2) practice a regular schedule of meditation; (3) create a wellness plan using mindfulness strategies to address their individual risk factors for developing burnout. This curriculum uses self-directed learning theory to build relatedness, competence, and autonomy to cultivate mindfulness. Students have readings and short written assignments prior to each of the four weekly 60-minute classroom sessions. Each session includes techniques to encourage active participation and collaboration, such as icebreakers to create community; brainstorming on current stressors; brief didactics; role-play to foster value; and meditation exercises to promote efficacy. To create the value and skills required for sustained behavioral change, the students also practice a regular schedule of meditation and track their progress via an online journal. Their final assignment is to develop a long-term individual wellness plan using mindfulness techniques. Evaluation takes place on multiple levels. Following completion of the curriculum, learners fill out reaction scales for content, methods, and quality of teaching. Students also complete pre- and post-curriculum forms that include a burnout scale, multiple-choice knowledge questions, and a self-assessment of attitudes and behaviors related to wellness and mindfulness. Six months later, students complete the post-curriculum form again, as well as participate in semi-structured interviews and email correspondence to assess for any sustained changes in knowledge, skills, attitudes, or behavior. This curriculum provides a uniquely flexible and targeted method to address burnout in medical students. It can be adapted for any third- or fourth-year clinical rotation to help all students manage stress, not just those planning a career in emergency medicine. In this way, we can potentially give all of our future physicians the tools to combat burnout during the early years of residency and beyond.