Background: Adaptability is a requisite and indispensable trait for future global leaders. Remaining adaptable through times of change is a mechanism through which leaders can be best prepared to navigate evolving environments and ever-changing circumstances. Objectives: The authors aim to explore the relationships between global leadership mindset and adaptability by applying servant leadership and cultural humility perspectives. Approach: Leadership theories and approaches to leadership and adaptability will be discussed relative to leadership traits, skills, and knowledge and their potential relation to the degree of leadership adaptability. A global leader with cultural humility develops cultural awareness and tends to interact and adapt effectively with people of different cultures. By combining servant leadership and cultural humility, mindsets will enhance the development of global leadership adaptability. Being adaptable as a leader allows for creativity and innovation while navigating cultural disparities. Conclusion: Global leaders must be resilient, relevant, and vigilant. They must be prepared to address crises while simultaneously fostering stability and progress for the survival of humanity. Their transformative actions should inspire effective change. The proposed conceptual framework integrates servant leadership and cultural humility perspectives and fosters a global leadership mindset. This mindset enhances leadership adaptability to address contemporary challenges.