On one hand, to bring down the vehicular pollution levels, the Indian government implemented BS-VI emission standards from April 2020. On the other hand, future regulatory requirements for in-use compliance of large sources like heavy-duty vehicles (HDV) are monitored using Portable Emissions Measurement Systems (PEMS). Henceforth, to meet these regulatory emissions requirements, the advancement in catalyst technologies is progressing rapidly to meet the ever-tightening control on tailpipe emissions. It is also imperative to ensure no significant catalyst performance deterioration throughout the useful emission life of the vehicle. However, for such catalyst technology, performance durability validation is important based on vehicle market and duty cycle applications. Moreover, the durability of the selected catalyst is validated for emission performance after accelerated regeneration conditions to understand the thermal stability and the sintering effect of catalyst behaviour in an engine rig. Based on this, the significance of catalyst technology selection for commercial vehicle applications as well as catalyst validations for the Indian market are discussed in this paper. Related to in-use performance, the catalyst performance behaviour after a vehicle mileage accumulation of 160,0000 km and the exhaust emissions under real-world conditions using PEMS are also conversed.