Middle East Research Articles

Quantification of Contributions from Different Dust Sources to the Distribution and the Variation of Spring Dust over the Tibetan Plateau and Corresponding Mechanisms since 2000

Abstract Dust is the predominant type of aerosol over the Tibetan Plateau (TP) due to the existence of surrounding significant dust sources. However, the contributions of different dust sources to the distribution and variation of dust over the TP and corresponding mechanisms are still being explored. By separating emissions from different dust sources in a numerical model, this study detected that dust originating from East Asia, the Middle East, and North Africa are the main contributors to spring dust over the TP, accounting for 42%–68%, 13%–27%, and 9%–25% of the total dust concentration, respectively. East Asian dust primarily affects the dust over the central and northern parts of the TP, whereas Middle Eastern and North African dust mainly contributes to the dust over the western and southern parts of the TP. Additionally, the variation in dust over the TP is related to East Asian and North African dust, which contribute 58% and 35% of the total variation, respectively. The mechanism underlying this association is attributable to the SST over the northern North Atlantic and updrafts over the northern slope of the TP: the increased SST enhances westerlies from North Africa to East Asia and northwesterly winds over the northern slope of the TP and combines with the stronger westerlies to promote the transport of East Asian and North African dust to the TP. Consequently, it is necessary to focus on the impact of multiple dust sources on the dust over the TP.

International attitudes towards medical and planned oocyte cryopreservation.

This study aims to better understand the knowledge and attitudes of men and women internationally towards oocyte cryopreservation (OC). An online 25-question survey was distributed internationally via email and social media. Knowledge and attitudes towards OC among different regions and genders were assessed. The study population consisted of adults from North America (NA, 15.7%), Southeastern and Eastern Europe (SE, 34.7%), Central and Western Europe (CWE, 12.7%), Asia (12.7%), and Middle East (ME, 8.9%). A total of 496 respondents initiated the survey and the completion rate was 80.2%. The mean (SD) age was 35.2 (12.1) years. Over 70% were aware of OC, but only 4.8% had previously undergone the procedure. Most considered ages 26-31 as optimal for OC and correctly identified conditions that could impact the chance of spontaneous conception. Significant differences were observed regarding etiologies that would render OC acceptable. Only in NA and ME did solid majorities strongly agree that it is acceptable to proceed with OC to allow more time to find the right partner or for professional opportunities. More similar opinions were observed between genders. When medical conditions existed, large majorities across all nationalities and genders strongly agreed that OC is acceptable. In NA, SE, and ME most respondents would consider or recommend OC for any reason, whereas most respondents in CWE and Asia would do that only for certain social reasons or medical necessity. A good understanding of OC was observed. Nationality appeared to impact opinions on appropriate indications for this procedure, though overall positive attitudes were documented.

Understanding Pediatric Physical Therapists' Experiences With Middle Eastern Patients and Arabic Interpreters: A Qualitative Study.

The purpose of this study was to explore pediatric physical therapists' (PTs') experiences including successes, challenges, and barriers with cross-cultural communication with Arabic-speaking Middle Eastern children and their families who require interpreter services. Eight PTs consented to participate in qualitative dyadic interviews. Transcription and interviews were conducted virtually in Microsoft Teams. Quality criteria included member checking for validity and trustworthiness and bracketing to minimize investigator bias. Inductive thematic analysis was used to identify meaning units and major themes. The 6 themes that emerged were: fostering therapeutic relationships, practicing culturally sensitive care, communicating intentionally, experiencing successes, recognizing challenges, and tailoring a physical therapy plan of care. Representative quotations support each theme. Therapists perceive their experiences with Arabic-speaking children, families, and interpreters positively despite challenges related to cultural and language barriers. In sharing their experiences, therapists demonstrated self-reflection, openness to learning, and desire to build strong therapeutic alliances.

Distribution of pathogenic variants in the CFTR gene in a representative cohort of people with cystic fibrosis in the Kingdom of Bahrain

BackgroundCystic fibrosis (CF) is a rare multi-systemic recessive disorder. The spectrum and the frequencies of CFTR mutations causing CF vary amongst different populations in Europe and the Middle East. In this study, we characterised the distribution of CF-causing mutations (i.e. pathogenic variants in the CFTR gene) in a representative CF cohort from the Kingdom of Bahrain based on a three-decade-long analysis at a single tertiary centre. We aim to improve CF genetic diagnostics, introduce of CF neonatal screening and provide CFTR modulator therapy (CFTRm).MethodsCFTR genotyping and associated clinical information were drawn from a longitudinal cohort. We sequenced 56 people with CF (pwCF) that had one or both CFTR mutations unidentified and carried out comprehensive bioinformatic- and family-based segregation analyses of detected variants, including genotype–phenotype correlations and disease incidence estimates. The study methodology could serve as a basis for other non-European CF populations with a high degree of consanguinity.ResultsAltogether 18 CF-causing mutations were identified, 15 of which were not previously detected in Bahrain, accounting for close to 100% of all population-specific alleles. The most common alleles comprise c.1911delG [2043delG; 22.8%], c.2988+1G > A [3120+1G>A; 16.3%], c.2989-1G>A [3121-1G>A; 14.1%], c.3909C>G [N1303K; 13.0%], and c.1521_1523delCTT [p.PheF508del; 7.6%]. Although the proportion of 1st cousin marriages has decreased to 50%, the frequency of homozygosity in our pwCF is 67.4%, thereby indicating that CF still occurs in large, often related, families. pwCF in Bahrain present with faltering growth, pancreatic insufficiency and classical sino-pulmonary manifestations. Interestingly, two pwCF also suffer from sickle cell disease. The estimated incidence of CF in Bahrain based on data from the last three decades is 1 in 9,880 live births.ConclusionThe most commonCF-causing mutations in Bahraini pwCF were identified, enabling more precise diagnosis, introduction of two-tier neonatal screening and fostering administration of CFTRm.

999 telephone triage: a comparison of UK ambulance nurse and paramedic case mix, outcomes and audit compliance

PurposeMost UK ambulance services undertake remote assessments of 999 calls with nurses and paramedics to manage demand and reduce inappropriate hospital admissions. However, little is known about the differences in the types of cases managed by the two professions comparatively, their clinical outcomes, and the quality and safety they offer.Design/methodology/approachThe retrospective descriptive study analysed data collected at Welsh Ambulance Services University NHS Trust (WAST) from prioritisation, triage, and audit tools between the 17th May 2022 to 8th November 2022. A total of 21,076 cases and 728 audits were included for review.FindingsThere was little difference in the type and frequency of the presenting complaints assessed, and clinical outcomes reached in percentage terms. Whilst paramedics had more highly compliant call audits and fewer non-compliant call audits, there was, again, little difference in percentage terms between the two, indicating positive levels of safety across the two professional groups.Research limitations/implicationsThere continues to be a substantial difference between UK paramedics to those in the Middle East, the United States, and some African nations, which may limit the applicability of findings. This study also looked at a six-month window from only one UK service using one type of prioritisation and triage tool. Future research could explore longer periods from multiple services using various tools. It is important to note that this study did not link outcome data with primary, secondary or tertiary care settings. Thus, it is impossible to determine if the level of care aligned closely with the final diagnosis.Practical implicationsThe practical implications of this work include better workforce planning for agencies who have perhaps only employed one type of clinician or a reaffirmation to those who have employed both. The authors suggest that the training and education of both sets of clinicians could remain general in nature, with no overt requirement for specificity based on professional registration alone. Commissioners and stakeholders in the wider health economy should consider ensuring equitable access to alternative pathways for patients assessed by both nurses and paramedics.Social implicationsIt has been posited that UK nurses and paramedics are, by virtue of their consistency in education, skill set, licensure, and general experience, both able to achieve safe and effective remote outcomes in 999 settings. This study provides evidence to support that hypothesis. These results say more about the two professions' ability to work together rather than just the professions themselves. The multidisciplinary team approach is well-established in acute care settings, and is broadly considered to improve communication, coordination decision making, adherence to up-to-date treatment recommendations, and be positive for shared learning and development for younger colleagues.Originality/valueMost UK services use a mix of nurses and paramedics; however, little is known about the differences in the types of cases managed by the two professions comparatively, their clinical outcomes, and the quality and safety they each offer. The most recent studies of this nature were published in 2003 and 2004 and looked only at low-acuity 999 calls when remote assessment was not even an established role for UK paramedics. This study updates the literature, identifies areas for future research, and applies to the international setting for the most part.

A Systematic Review of Knowledge, Attitudes, and Factors Influencing HPV Vaccine Acceptance Among Adolescents, Parents, Teachers, and Healthcare Professionals in the Middle East and North Africa (MENA) Region

A Systematic Review of Knowledge, Attitudes, and Factors Influencing HPV Vaccine Acceptance Among Adolescents, Parents, Teachers, and Healthcare Professionals in the Middle East and North Africa (MENA) Region

Prognostic impact of chronic lymphocytic leukemia comorbidity index in a young population: a real-world evidence study of a national gulf region cohort

In chronic lymphocytic leukaemia (CLL), comorbidities assessed by the CLL comorbidity index (CLL-CI) have been associated with outcomes in Western cohorts. We conducted a retrospective analysis of an unselected Middle Eastern cohort of newly diagnosed CLL patients seen at the Kuwait Cancer Control Center (n = 300). Compared to Western studies, these Middle Eastern patients were diagnosed at a younger age (median of 59) and had a higher comorbidity burden (69% non-low risk CLL-CI). A higher CLL-CI score was independently associated with significantly shorter event-free survival and greater risk of death. Our analysis demonstrates that CLL-CI is a valuable tool for comorbidity assessment and prognostic influence in (relatively young) Middle Eastern CLL patients.

Forensic Geochemistry Reveals International Ship Dumping as a Source of New Oil Spill in Brazil's Coastline (Bahia) in Late 2023.

In the present study, we applied forensic geochemistry to investigate the origin and fate of spilled oils like tarballs stranded at the beaches of Bahia, in northeastern Brazil, in September 2023, based on their fingerprints. Saturated and aromatic compounds were assessed by gas chromatography, and the oceanic surface circulation patterns were deciphered to determine the geographic origin of the spill. Contamination by petroleum represents an enormous threat to the unique, species-rich ecosystems of the study area. The geochemical fingerprint of the oil spilled in 2023 did not correlate with those of previous events, including the one in 2019, the one in early 2022 in Ceará, and an extensive spill across the Brazilian Northeast in late 2022. However, the fingerprint did correlate with crude oils produced by Middle Eastern countries, most likely Kuwait. The oil of the 2023 spill had a carbonate marine origin from early mature source rocks. These findings, together with the moderate weathering of the 2023 tarballs and the ocean circulation patterns at the time of the event, indicate that the oil was discharged close to the shore of Brazil, to the east or southeast of Salvador, by a tanker on an international route in the South Atlantic.

Risk perception and use of personal care products by race and ethnicity among a diverse population

Personal care products can contain phthalates, parabens and other endocrine-disrupting chemicals. However, information on perception of risks from personal care product use and how use varies by race and ethnicity is limited. We evaluated differences in personal care product use and risk perception in a diverse sample of participants recruited from a US college campus and online. A self-administered questionnaire captured information on sociodemographic factors, personal care product use trends and perception of risk associated with them. Pearson’s chi-square and Fisher’s exact tests were used to determine differences in personal care product use and risk perception by race and ethnicity. Ordered logistic regressions were performed to measure associations between personal care product use frequency across racial/ethnic categories. Participant (n = 770) mean age was 22.8 years [standard deviation ± 6.0]. Daily use of make-up (eye = 29.3%; other = 38.0%; all = 33.7%) and skincare products (55%) was most frequently reported among Middle Eastern and North African participants. Non-Hispanic Black participants reported the highest daily use of hairstyling products (52%) and lotion (78%). Daily make-up use was more frequently reported among females (41%) than males (24.6%). Levels of agreement were similar across racial and ethnic groups, that personal care product manufacturers should be required to list all ingredients (≥87%). There were significant associations between the frequency of use of some personal care products and racial/ethnic categories when the use frequencies of participants from other racial/ethnic categories were compared to the use frequency of non-Hispanic White participants. There were significant differences in daily use frequency, levels of trust, perception of safety and health risks associated with personal care products by race and ethnicity, underscoring that there may be different sources of exposure to chemicals in personal care products by race and ethnicity.

The De-Europeanization of the Kurdish Question in Turkey and the EU

ABSTRACT Using an in-depth interview method, this study examined HDP deputies’ thoughts concerning Turkey–EU relations, its effect on Kurdish issues, and the HDP’s expectations of the EU, showing that the high expectations of the EU during the 1990s and early 2000s have faded and that the EU accession process no longer generates enthusiasm among the HDP deputies interviewed. The most notable finding of the interviews was the consensus that the EU has now lost its role as the driving force for Turkey’s democratization and, moreover, that the EU has ignored Turkey’s authoritarianism by remaining silent on AKP’s disobedience of the Copenhagen criteria and non-compliance with international agreements. The interviewees believed that the EU has become an accomplice of the AKP regime by indirectly supporting Erdoğan’s authoritarianism. Both the EU and Turkey’s loss of faith in Turkey’s full membership have caused the EU to lose its transformative power, encouraging the AKP government to more confidently jettison the values of democracy and human rights. Moreover, the recent developments in the Middle East, particularly the emergence of a Kurdish entity in Syria and Iraq, have resulted in a redirection of Kurdish attention towards the Middle East.

Trend of pharmaceuticals 3D printing in the Middle East and North Africa (MENA) region: An overview, regulatory perspective and future outlook

The traditional method of producing medicine using the “one-size fits all” model is becoming a major issue for pharmaceutical manufacturers due to its inability to produce customizable medicines for individuals’ needs. Three-dimensional (3D) printing is a new disruptive technology that offers many benefits to the pharmaceutical industry by revolutionizing the way pharmaceuticals are developed and manufactured. 3D printing technology enables the on-demand production of personalized medicine with tailored dosage, shape and release characteristics. Despite the lack of clear regulatory guidance, there is substantial interest in adopting 3D printing technology in the large-scale manufacturing of medicine. This review aims to evaluate the research efforts of 3D printing technology in the Middle East and North Africa (MENA) region, with a particular emphasis on pharmaceutical research and development. Our analysis indicates an upsurge in the overall research activity of 3D printing technology but there is limited progress in pharmaceuticals research and development. While the MENA region still lags, there is evidence of the regional interest in expanding the 3D printing technology applications in different sectors including pharmaceuticals. 3D printing holds great promise for pharmaceutical development within the MENA region and its advancement will require a strong collaboration between academic researchers and industry partners in parallel with drafting detailed guidelines from regulatory authorities.

An Advanced Quality Assessment and Monitoring of ESA Sentinel-1 SAR Products via the CyCLOPS Infrastructure in the Southeastern Mediterranean Region

The Cyprus Continuously Operating Natural Hazards Monitoring and Prevention System, abbreviated CyCLOPS, is a national strategic research infrastructure devoted to systematically studying geohazards in Cyprus and the Eastern Mediterranean, Middle East, and North Africa (EMMENA) region. Amongst others, CyCLOPS comprises six permanent sites, each housing a Tier-1 GNSS reference station co-located with two calibration-grade corner reflectors (CRs). The latter are strategically positioned to account for both the ascending and descending tracks of SAR satellite missions, including the ESA’s Sentinel-1. As of June 2021, CyCLOPS has reached full operational capacity and plays a crucial role in monitoring the geodynamic regime within the southeastern Mediterranean area. Additionally, it actively tracks landslides occurring in the western part of Cyprus. Although CyCLOPS primarily concentrates on geohazard monitoring, its infrastructure is also configured to facilitate the radiometric calibration and geometric validation of Synthetic Aperture Radar (SAR) imagery. Consequently, this study evaluates the performance of Sentinel-1A SAR by exploiting the CyCLOPS network to determine key parameters including spatial resolution, sidelobe levels, Radar Cross-Section (RCS), Signal-to-Clutter Ratio (SCR), phase stability, and localization accuracy, through Point Target Analysis (PTA). The findings reveal the effectiveness of the CyCLOPS infrastructure to maintain high-quality radiometric parameters in SAR imagery, with consistent spatial resolution, controlled sidelobe levels, and reliable RCS and SCR values that closely adhere to theoretical expectations. With over two years of operational data, these findings enhance the understanding of Sentinel-1 SAR product quality and affirm CyCLOPS infrastructure’s reliability.

UN General Assembly Resolution 76/262 as a strengthening of the collective response to the use of the veto right in the UN Security Council

The article describes the legal nature of United Nations General Assembly Resolution 76/262 (A/76/L.52) entitled "Standing mandate for a General Assembly debate when a veto is cast in the Security Council", adopted on April 26, 2022. We have analyzed this topic due to its relevance and the emergence of a new procedure of the United Nations General Assembly, aimed at increasing of the transparency and accountability of the United Nations Security Council, as a result of the ineffective activity of the Security Council in crisis in which our world finds itself today, in particular due to armed conflicts in Ukraine and the Middle East, which have led to complex humanitarian consequences. Many states and scientists have been expressing their interest in the issue of Security Council reform for a long time. We deeply researched the Resolution which is the first in a long time and a significant legal instrument that changes the existing mechanism of the functioning of the United Nations and has revived the discussions on the need for a complete reform of the Security Council in accordance with Resolution 62/557 of December 15, 2008. The purpose of the article is an overview of the new Resolution 76/262, namely the reasons and expediency of its adoption, cases of application and its effectiveness in modern conditions. The methodological basis of the study are the following general scientific and special methods of cognition of legal phenomena: the method of the philosophical level – the dialectical method; empirical methods – comparative, observation and description methods; general logical methods – analysis, synthesis; specially-legal method. The article analyzes the main provisions of Resolution 76/262, the reasons for its adoption, examines cases of its application, and draws conclusions about the effectiveness of this resolution. We have differentiated the procedures provided for by Resolution 76/262 "Standing mandate for a General Assembly debate when a veto is cast in the Security Council" and Resolution 377 (V) "Uniting for Peace". We have reviewed the international legal conceptual foundations of the need to apply the resolution. The topic of reforming the United Nations against the backdrop of the current world security crisis is very important and relevant for further research by domestic scientists in order to formulate their own proposals, approaches and scientific justifications in the modern Ukrainian science of international public law, as well as for the scientific enlightenment of society in this of knowledge.

Empowering engagement: unveiling motivational drivers for social media adoption: a Facebook case study

IntroductionSocial networking websites and applications are increasingly becoming significant cultural phenomena. However, the motivation driving individuals to utilize these platforms, particularly in the Middle East, remains unclear. While numerous studies have explored technology adoption, limited research has investigated social media usage in the UAE. Therefore, this study proposes and empirically analyzes a framework based on a modified version of the Technology Acceptance Model to understand the factors influencing users’ opinions, objectives, and actual usage of social media platforms, focusing on Facebook.MethodsTo investigate these factors, we employed structural equation modeling and smart PLS techniques on a sample of 540 participants. We aimed to identify predictors such as perceived usefulness, perceived ease of use, as well as a hedonic dimension encompassing perceived enjoyment, curiosity, and perceived connectedness, in shaping users’ attitudes towards Facebook usage. Additionally, we examined the relationship between social presence and users’ intentions to use Facebook.ResultsOur analysis revealed that perceived usefulness and perceived ease of use are significant predictors of users’ attitudes towards utilizing Facebook. Furthermore, the hedonic dimension, comprising perceived enjoyment, curiosity, and perceived connectedness, also plays a crucial role in shaping users’ attitudes. Moreover, social presence was found to have a significant association with users’ intentions to use Facebook.DiscussionThese findings contribute to our understanding of the factors influencing the adoption and usage of social media platforms, particularly in the context of the UAE. By highlighting the importance of both utilitarian and hedonic aspects, this research provides insights into the complex motivations behind individuals’ acceptance of dynamic applications like Facebook. Furthermore, our empirical model lays the groundwork for exploring additional factors that may influence the uptake of information systems and social media utilities, thereby advancing attitude-behavior theories in this domain.

Governing summer in Mount Lebanon: Istiyaf, tourism, and mobility in the interwar Arab East

ABSTRACT This article examines the lattice of dynamics, networks, and perceptions underpinning the blanket label of ‘tourism’ in Lebanon and the broader Arab East during the interwar (mandate) era. It analyses guidebooks, pamphlets, government correspondence and travelogues published in the Middle East and Europe. Hoteliers, tour operators, merchants, and journalists distinguished between siyaha (tourism) and istiyaf (‘summering’) to create different tourist publics – one western, the other regional Arab. Separate guidebooks were written for each, pinpointing different sites of interest, cuisines, and leisure destinations, based on assumed cultural attributes, travel practices, and desires. While historiography argues that Europeans created mass tourism as an industry, istiyaf was rooted in a legacy of indigenous travel practices and economies. By drawing Arab travellers to Mount Lebanon’s village resorts, istiyaf enabled residents to produce, narrate, and exhibit Lebanon–not just aesthetically or geographically, but also climatologically and gastronomically. Different classes and genders could claim ownership of this new Lebanon. Making interwar Lebanon a regional leisure destination cemented its connection to new neighbours while simultaneously distinguishing it from them. This research thus reveals how tourism, leisure, and mobility both undergirded and undermined nation and state-building efforts in these germinal postwar decades of the Middle East.

Predicting drug-Protein interaction with deep learning framework for molecular graphs and sequences: Potential candidates against SAR-CoV-2.

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the COVID-19 disease, which represents a new life-threatening disaster. Regarding viral infection, many therapeutics have been investigated to alleviate the epidemiology such as vaccines and receptor decoys. However, the continuous mutating coronavirus, especially the variants of Delta and Omicron, are tended to invalidate the therapeutic biological product. Thus, it is necessary to develop molecular entities as broad-spectrum antiviral drugs. Coronavirus replication is controlled by the viral 3-chymotrypsin-like cysteine protease (3CLpro) enzyme, which is required for the virus's life cycle. In the cases of severe acute respiratory syndrome coronavirus (SARS-CoV) and middle east respiratory syndrome coronavirus (MERS-CoV), 3CLpro has been shown to be a promising therapeutic development target. Here we proposed an attention-based deep learning framework for molecular graphs and sequences, training from the BindingDB 3CLpro dataset (114,555 compounds). After construction of such model, we conducted large-scale screening the in vivo/vitro dataset (276,003 compounds) from Zinc Database and visualize the candidate compounds with attention score. geometric-based affinity prediction was employed for validation. Finally, we established a 3CLpro-specific deep learning framework, namely GraphDPI-3CL (AUROC: 0.958) achieved superior performance beyond the existing state of the art model and discovered 10 molecules with a high binding affinity of 3CLpro and superior binding mode.

Beijing Winter Olympics and China’s Middle East Diplomacy in the Xi Era

ABSTRACT Sports diplomacy, host diplomacy and pandemic diplomacy intertwined in the Beijing Winter Olympics and jointly served China’s overall diplomacy. The Middle East region has a long history of participation in the Winter Olympics. A total of seven Middle East countries, including Turkey, Cyprus, Israel, Lebanon, Saudi Arabia, Morocco and Iran, participated in Beijing Winter Olympics, while Israel and Iran participated in the Beijing Paralympic Winter Games. Middle East countries generally help China break the politicization of the Winter Olympics from other countries. Thanks to the Beijing Winter Olympics, Chinese president and leaders of Middle East countries met offline for the first time since the outbreak of the COVID-19 pandemic, which is also conducive to the new development of relations between China and the Middle East in the post-pandemic era. The leaders of Egypt, the UAE and Qatar also took the opportunity of attending the opening ceremony of the Beijing Winter Olympics to hold their own meetings, which is conducive to the further repair of the relations among these countries since the Qatar diplomatic crisis. The Beijing Winter Olympics objectively set up a platform to promote the easing of crisis issues in the Middle East.

Assessing Lidar Ratio Impact on CALIPSO Retrievals Utilized for the Estimation of Aerosol SW Radiative Effects across North Africa, the Middle East, and Europe

North Africa, the Middle East, and Europe (NAMEE domain) host a variety of suspended particles characterized by different optical and microphysical properties. In the current study, we investigate the importance of the lidar ratio (LR) on Cloud-Aerosol Lidar with Orthogonal Polarization–Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observations (CALIOP-CALIPSO) aerosol retrievals towards assessing aerosols’ impact on the Earth-atmosphere radiation budget. A holistic approach has been adopted involving collocated Aerosol Robotic Network (AERONET) observations, Radiative Transfer Model (RTM) simulations, as well as reference radiation measurements acquired using spaceborne (Clouds and the Earth’s Radiant Energy System-CERES) and ground-based (Baseline Surface Radiation Network-BSRN) instruments. We are assessing the clear-sky shortwave (SW) direct radiative effects (DREs) on 550 atmospheric scenes, identified within the 2007–2020 period, in which the primary tropospheric aerosol species (dust, marine, polluted continental/smoke, elevated smoke, and clean continental) are probed using CALIPSO. RTM runs have been performed relying on CALIOP retrievals in which the default and the DeLiAn (Depolarization ratio, Lidar ratio, and Ångström exponent)-based aerosol-speciated LRs are considered. The simulated fields from both configurations are compared against those produced when AERONET AODs are applied. Overall, the DeLiAn LRs leads to better results mainly when mineral particles are either solely recorded or coexist with other aerosol species (e.g., sea-salt). In quantitative terms, the errors in DREs are reduced by ~26–27% at the surface (from 5.3 to 3.9 W/m2) and within the atmosphere (from −3.3 to −2.4 W/m2). The improvements become more significant (reaching up to ~35%) for moderate-to-high aerosol loads (AOD ≥ 0.2).

The challenge of interviewing Middle East leaders: A first-hand story of my encounters with dictators and dissidents

ABSTRACT In the course of almost four decades of journalistic work in the greater Middle East the author has interviewed some of its most charismatic leaders, from the Iranian Presidents Ahmadinejad and Khatami to Saudi King Abdullah, Taliban ministers, dissidents, rebels, and warlords. Some of them were popular. Others were not. Only a few were elected. Such is the predicament in the region. All were convinced of their own legitimacy. But is the interview by a mainstream western media journalist a confirmation of this, ora way to highlight their shortcomings? This article argues that the answer lies in the eye of readers and their complicity with an interviewer who is bound both by the journalistic mandate to unveil the truth and by being the interviewee’s guest. When leaders agrees to an interview, they either have a message to sell to the public, or they are convinced of projecting an ideal image.

Genetic background of primary and familial HLH in Qatar: registry data and population study

BackgroundFamilial hemophagocytic lymphohistiocytosis (FHLH) is an inherited life-threatening disease. Five types are identified, with the addition of congenital immunodeficiency syndromes in which HLH is a typical manifestation. The literature on this disease is very scarce in the Middle East, with only a few scattered reports.MethodsWe report detailed demographic, clinical, and genomic data from 28 patients diagnosed with primary and familial HLH over the last decade in Qatar. An evaluation was performed of allele frequencies of deleterious variants from 12 primary and familial HLH causative genes on the Qatar Genome Programme (QGP) cohort of 14,669 Qatari individuals.ResultsThe genetic diagnosis was obtained in 15 patients, and four novel mutations in Perforin 1 (PRF1), UNC13D, LYST, and RAB27A genes were found. We identified 22,945 low/high/moderate/modifier impact variants significantly enriched in the QGP in those 12 genes. The variants rs1271079313 in PRF1 and rs753966933 in RAB27A found in our patient cohort were significantly more prevalent in the QGP compared to the Genome Aggregation Database (gnomAD) database, with a high carrier frequency in the Qatari population.ConclusionsWe established the first primary and familial HLH Registry in the Gulf Region and identified novel possibly pathogenic variants present at higher frequency in the Qatari population, which could be used for screening purposes. Raising awareness about primary and familial HLH and implementing screening activities in the Qatari highly inbred population could stem into more comprehensive premarital and prenatal evaluations and faster diagnosis.