Sardinia has an important heritage of autochthonous grape varieties, most of which are not widely known or cultivated. The aromatic profile of 19 wines (free and glycoconjugate fractions), obtained from different minor varieties, was investigated to contribute to their oenological characterisation. From a genetic point of view, most of the studied varieties are identical to certain Mediterranean grapes, while a few have been recognised as a native of the Corso-Sardinian area. All wines analyzed were produced from grapes harvested in 2014 following the same protocol and under microvinification conditions. Both instrumental data and sensorial analysis highlighted a significant contribution of varietal compounds linked to an unusual aromatic profile in the wines produced from certain native Sardinian varieties namely, Giro di Gonnos, Amansosu Triei, Gregu Nieddu and Nera di Bosa. In the context of an increasingly globalized market, the aromatic originality of these wines could be appreciated for commercial success.