The objective of this study was to investigate the mechanical degradation of AISI 316 austenite stainless steel as light-water reactor pressure vessel materials in the primary system of nuclear power plants. The influences of long-term aging on the microstructural and mechanical characteristics were studied. The long-term aging tests were interrupted at various stages to obtain different levels of degraded specimens. The test specimens were heat-treated and exposed to an acceleration heat-treatment at 600°C for up to 10,000 hours. AISI 316 steel showed polygonalshaped grains with many annealing twins, and these tended to become gradually more circularshaped grains during long-term aging. In the initial material degradation, twins were distributed uniformly within most grains, but they all recovered and disappeared after a prolonged 10,000-hour aging time. Delta ferrite along austenitic grain boundaries transformed into sigma phases and Cr23C6 precipitates during long-term aging, and the area fraction on the grain boundary increased. The peak strength appeared at a 100-hour aging time and then decreased up to 1000 hours. With further aging time, the strength increased to a higher level than the initial state. However, the elongation and toughness decreased continuously, demonstrating the material embrittlement during long-term thermal aging.