Microstructural Damage Research Articles

Cortical microstructural associations with CSF amyloid and pTau

Diffusion MRI (dMRI) can be used to probe microstructural properties of brain tissue and holds great promise as a means to non-invasively map Alzheimer’s disease (AD) pathology. Few studies have evaluated multi-shell dMRI models such as neurite orientation dispersion and density imaging (NODDI) and mean apparent propagator (MAP)-MRI in cortical gray matter where many of the earliest histopathological changes occur in AD. Here, we investigated the relationship between CSF pTau181 and Aβ1–42 burden and regional cortical NODDI and MAP-MRI indices in 46 cognitively unimpaired individuals, 18 with mild cognitive impairment, and two with dementia (mean age: 71.8 ± 6.2 years) from the Alzheimer’s Disease Neuroimaging Initiative. We compared findings to more conventional cortical thickness measures. Lower CSF Aβ1–42 and higher pTau181 were associated with cortical dMRI measures reflecting less hindered or restricted diffusion and greater diffusivity. Cortical dMRI measures, but not cortical thickness measures, were more widely associated with Aβ1–42 than pTau181 and better distinguished Aβ+ from Aβ- participants than pTau+ from pTau- participants. dMRI associations mediated the relationship between CSF markers and delayed logical memory performance, commonly impaired in early AD. dMRI metrics sensitive to early AD pathogenesis and microstructural damage may be better measures of subtle neurodegeneration in comparison to standard cortical thickness and help to elucidate mechanisms underlying cognitive decline.

Assessment of Cerebral White Matter Involvement in Amyotrophic Lateral Sclerosis Patients With Disease Progression and Cognitive Impairment by Fixel-Based Analysis and Neurite Orientation Dispersion and Density Imaging.

Previous studies using emerging diffusion MRI techniques have revealed damage to the white matter (WM) microstructure in amyotrophic lateral sclerosis (ALS), particularly the influence of crossed fibers, but there is a lack of subgroup analyses. To detect WM microstructural changes in ALS patients using fixel-based analysis (FBA) and neurite orientation dispersion and density imaging (NODDI) MRI. Prospective. Thirty-six ALS patients (aged 60.50 ± 9.5 years) and 25 healthy controls (HCs) (aged 58.90 ± 8.1 years). 3 T; NODDI and FBA (b-values = 0, 1000, and 2500 seconds/mm2). Subgroups were performed according to progression rate and cognition, including fast and slow progression (FP/SP), ALS with and without cognitive impairment (ALS-ci/ALS-nci). Fiber density (FD), fiber-bundle cross-section (FC), combined fiber density and cross-section (FDC), neurite density index (NDI), orientation dispersion index (ODI), isotropic volume fraction (ISO), and fractional anisotropy (FA) were calculated and their correlation with clinical variables examined. Chi-square test, Mann-Whitney U test, two-sample t test, partial correlation analysis, and false discovery rate (FDR) corrected. A P-value <0.05 was considered significant. ALS patients had lower FD and FDC values predominantly in the corticospinal tract (CST) and corpus callosum (CC) regions, as well as lower NDI value in the CC, radial crown, and internal capsule compared to HCs. Subgroup analysis based on progression rate and cognitive function showed significant differences in FBA results. The FC in the right CST region was significantly lower in the FP than SP, and the FD in the CC region was significantly lower in the ALS-ci than ALS-nci. Furthermore, a negative correlation was found between the mean FC value and the rate of progression in ALS patients (r = -0.408). FBA is a powerful tool for detecting complex cerebral WM microstructural damage for evaluating ALS cognition and disease progression.

Experimental and finite element analysis for evaluating influence of contact pressure on fretting fatigue mechanisms of A319‐T6 cast aluminum alloy

AbstractThis paper evaluates the influence of contact pressure on the surface contact state, fretting damage degradation mechanism, crack initiation and propagation characteristics, and fretting fatigue life of A319‐T6 cast aluminum alloy in fretting fatigue test using bridge‐type fretting pad. For a certain range of contact pressure, the fretting fatigue life exhibits a trend of increasing and subsequently decreasing with increasing contact pressure. With finite element analysis, the fretting contact region can be divided into two characteristic zones according to the dynamic evolution of the contact status within one fatigue cycle. The contact pressure affects both the distribution of the two characteristic zones as well as the relative slip range, which results in distinct fretting damage mechanisms. The nucleation characteristics and propagation paths of fatigue cracks under three typical contact pressures were analyzed considering the effects of fretting damage and heterogeneous microstructures of the alloy, accounting for the contact pressure dependency of the fretting fatigue life.

Diffusion-sensitized magnetic resonance imaging highlights placental microstructural damage in patients with previous SARS-CoV-2 pregnancy infection

IntroductionSevere acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has been a major global health problem since December 2019. This work aimed to investigate whether pregnant women's mild and moderate SARS-CoV-2 infection was associated with microstructural and vascular changes in the placenta observable in vivo by Intravoxel Incoherent Motion (IVIM) at different gestational ages (GA). MethodsThis was a retrospective, nested case-control of pregnant women during the SARS-CoV-2 pandemic (COVID-19 group, n = 14) compared to pre-pandemic healthy controls (n = 19). MRI IVIM protocol at 1.5T was constituted of diffusion-weighted (DW) images with TR/TE = 3100/76 ms and 10 b-values (0,10,30,50,75,100,200,400,700,1000s/mm2). Differences between IVIM parameters D (diffusion), and f (fractional perfusion) quantified in the two groups were evaluated using the ANOVA test with Bonferroni correction and linear correlation between IVIM metrics and GA, COVID-19 duration, the delay time between a positive SARS-CoV-2 test and MRI examination (delay-time exam+) was studied by Pearson-test. ResultsD was significantly higher in the COVID-19 placentas compared to that of the age-matched healthy group (p < 0.04 in fetal and p < 0.007 in maternal site). No significant difference between f values was found in the two groups suggesting no-specific microstructural damage with no perfusion alteration (potentially quantified by f) in mild/moderate SARS-Cov-2 placentas. A significant negative correlation was found between D and GA in the COVID-19 placentas whereas no significant correlation was found in the control placentas reflecting a possible accelerated senescence process due to COVID-19. DiscussionWe report impaired microstructural placental development during pregnancy and the absence of perfusion-IVIM parameter changes that may indicate no perfusion changing through microvessels and microvilli in the placentas of pregnancies with mild/moderate SARS-Cov-2 after reaching negativity.

Failure behavior of dielectric films for peaking capacitor subjected to surface flashover under nanosecond pulses

The flashover failure and damage of polypropylene (PP) and polyester (PET) films under nanosecond current pulses were experimentally investigated. A nanosecond pulse current test platform was established to study the flashover characteristics, performance degradation, and structural damage of dielectric films under repeated nanosecond current pulses. The accumulation and emission of surface charge influenced by field distortion and trap distribution were analyzed to clarify the mechanism by which the flashover voltage increases linearly with gas pressure at low pressure and saturates at high pressure. The significant effects of pulse energy, gas pressure, and discharge gap on film damage behavior were investigated. The damage pattern of PP and PET films includes surface deformation, reduced flash-voltage tolerance, molecular chain breakage, and group shedding. The damage of PP films is manifested as fine furrows, while PET corresponds to mountainous bumps. With the increasing number of discharges, the breakdown voltage of PP films decreased significantly, while the flash tolerance performance of PET films was more stable. Under the conditions of high pulse current amplitude, small discharge gap, and low air pressure, the damage degree of the film intensifies, which is characterized by severe destruction to the molecular structure and a significant decrease in flashover withstand voltage. Polymer films, flashover, nanosecond current pulses; performance degradation; microstructural damage.

Detecting cortical microstructural alterations secondary to white matter hyperintensity in amyloid positive cognitively normal subjects

AbstractBackgroundPrevious research showed that cortical diffusivity is sensitive to primary cortical microstructural changes due to amyloid deposition (1). The present study aimed to investigate the cortical microstructural alterations secondary to white matter damage in cognitively normal participants, amyloid positive and negative.MethodThree hundred and thirty‐five cognitively normal (MMSE &gt; 24) participants with baseline CSF Aß42 and MRI scans were obtained from the European Prevention of Alzheimer’s Dementia (EPAD) cohort. Participants were classified as Aß42‐ (N = 231) or Aß42+ (N = 104), based on a published cut‐off (2). The Fazekas scale deep white matter (FSDWM) score was used to further classify participants as LOW (0 and 1; N = 281) or HIGH (2 and 3; N = 54) FSDWM. Structural and diffusion MRI (dMRI) were used to calculate whole brain cortical volume fraction, cortical thickness and three neuropathology‐inspired cortical diffusivity measures: the angle between the radial minicolumnar direction and the principal diffusion direction (AngleR); the principal diffusion component parallel with the minicolumns (ParlPD), and the diffusion components perpendicular to the minicolumns (PerpPD+). Group differences in structural and diffusion metrics were tested using GLM adjusting for scanner manufacturer, number of dMRI volumes, age and sex, with Bonferroni’s correction (p&lt;0.05/5).ResultThe interaction between Aß42 status and FSDWM revealed significant differences in cortical microstructural measures (GLM: AngleR F17,317 = 7.065, p = 0.008; PerpPD+ F17,317 = 7.976, p = 0.005). The pairwise comparisons showed significantly lower AngleR values in Aß42‐ HIGH compared to Aß42‐ LOW and significantly higher PerpPD+ values in Aß42+ HIGH compared to Aß42+ LOW (Figure). No significant differences in structural measures (thickness or volume) were detected.ConclusionCortical diffusivity measures can detect differences in cortical microstructure of amyloid positive and negative participants with different WM damage severity. The reduced AngleR value in Aß42‐ HIGH participants was potentially due to neuroinflammatory processes, consistent with previous findings(1). The higher PerpPD+ values in Aß42+ HIGH may indicate the secondary cortical microstructural damage.

Simulation of the compression test of the Zr1Nb fuel cladding ring

Fuel cladding is a first protective barrier against the loss of fission products that must withstand extreme conditions, from normal operation to final and interim dry storage. This hostile environment results in mechanical and microstructural damage of cladding caused by different stress levels, temperature, corrosion, hydrogen pick up and other degradation processes further enhanced by radiation. For this reason, the integrity of the cladding is a critical issue. The aim of this work is to simulate a ring compression test to evaluate the stress-strain behavior and hoop fracture properties of a zirconium-based alloy with niobium, which was chosen because it is widely used as fuel cladding in light water nuclear reactors.

Detecting cortical microstructural alterations secondary to white matter hyperintensity in amyloid positive cognitively normal subjects

AbstractBackgroundPrevious research showed that cortical diffusivity is sensitive to primary cortical microstructural changes due to amyloid deposition (1). The present study aimed to investigate the cortical microstructural alterations secondary to white matter damage in cognitively normal participants, amyloid positive and negative.MethodThree hundred and thirty‐five cognitively normal (MMSE &gt; 24) participants with baseline CSF Aβ42 and MRI scans were obtained from the European Prevention of Alzheimer’s Dementia (EPAD) cohort. Participants were classified as Aβ42‐ (N = 231) or Aβ42+ (N = 104), based on a published cut‐off (2). The Fazekas scale deep white matter (FSDWM) score was used to further classify participants as LOW (0 and 1; N = 281) or HIGH (2 and 3; N = 54) FSDWM.Structural and diffusion MRI (dMRI) were used to calculate whole brain cortical volume fraction, cortical thickness and three neuropathology‐inspired cortical diffusivity measures: the angle between the radial minicolumnar direction and the principal diffusion direction (AngleR); the principal diffusion component parallel with the minicolumns (ParlPD), and the diffusion components perpendicular to the minicolumns (PerpPD+).Group differences in structural and diffusion metrics were tested using GLM adjusting for scanner manufacturer, number of dMRI volumes, age and sex, with Bonferroni’s correction (p&lt;0.05/5).ResultThe interaction between Aβ42 status and FSDWM revealed significant differences in cortical microstructural measures (GLM: AngleR F17,317 = 7.065, p = 0.008; PerpPD+ F17,317 = 7.976, p = 0.005). The pairwise comparisons showed significantly lower AngleR values in Aβ42‐ HIGH compared to Aβ42‐ LOW and significantly higher PerpPD+ values in Aβ42+ HIGH compared to Aβ42+ LOW (Figure). No significant differences in structural measures (thickness or volume) were detected.ConclusionCortical diffusivity measures can detect differences in cortical microstructure of amyloid positive and negative participants with different WM damage severity. The reduced AngleR value in Aβ42‐ HIGH participants was potentially due to neuroinflammatory processes, consistent with previous findings(1). The higher PerpPD+ values in Aβ42+ HIGH may indicate the secondary cortical microstructural damage.

혈관 및 대사 건강 증진을 위한 기능의학적 임상영양의 활용

Blood pressure, blood sugar, and lipid health are easily overlooked in their twenties or thirties. Still, if blood pressure is high in the normal range or metabolic abnormalities persist, microstructure damage could accumulate little by little in all organs receiving blood supply, with changes in vascular endothelial cells. Daily vascular health care can be very important for overall health throughout life, and cardiometabolic health management is necessary for anyone, whether early or late. Understanding and utilizing clinical nutrition via functional medicine can also be an essential starting point for cardiovascular and metabolic health management. Furthermore, harmonious management through functional medicine's care and conventional medicine's control can have additional health benefits from a preventive perspective.

The evolution mechanism of anti-abrasive UHPC microstructure under impact and erosion

In the mudslide prone areas of western China, concrete piers were severely damaged by washing.In our previous research, the anti-abrasive UHPC prepared with saturated prewet high titanium heavy slag sand (ST-UHPC) is proposed to prevent such damage. And we studied the effect of grinding and erosion on the performance of ST-UHPC before, but the mechanism has not been studied in depth In order to study the microstructure evolution of ST-UHPC cement by the grinding and erosion, we use XRD, SEM, 27Al NMR, 29Si NMR test methods in this paper. By this way, we studied the effects of shock and salt erosion on hydration products composition, migration and transformation of Al-containing hydration products, hydration degree of cement and C-A-S-H gel microstructure. The results showed that the impact of bedload damaged the microstructure of UHPC. Then the damage of UHPC microstructure accelerates the transport of aggressive ions. Next, SO42- erodes from the site of damage and produces expansive erosion products such as gypsum and calcareous vanadite. The erosion of SO42- and Mg2+ resulted in the dealuminization and decalcification of C-A-S-H gel in UHPC cement and mechanical properties degradation. Thus, the expansion damage of UHPC and the impact damage of UHPC structure are aggravated. So the microstructure damage of UHPC was further aggravated. Under the action of impact, the water impacting material forms various chemical bonds with the C-A-S-H substrate. The chemical bonds results in the evolution of C-A-S-H microstructure. In conclusion, the structure of C-A-S-H substrate deteriorates obviously under the coupling effect of scouring and erosion. And the impact resistance of C-A-S-H substrate decreases significantly.

Cerebellar peduncle damage in Langerhans cell histiocytosis-associated neurodegenerative disease revealed by diffusion tensor imaging.

To confirm the hypothesis that brain white matter damage is involved in the pathogenesis and disease progression of Langerhans cell histiocytosis (LCH)-associated neurodegenerative disease (ND), we aimed to analyze pediatric patients with LCH using diffusion tensor imaging (DTI). We enrolled 33 patients with LCH and obtained 33 DTI datasets. Using DTI-based tractography, fractional anisotropy (FA), apparent diffusion coefficient (ADC), axial diffusivity (AD), and radial diffusivity (RD) were measured in the cerebral and cerebellar white matter tracts. The participants were divided into three groups-non-ND, ND without clinical symptoms (r-ND), and ND with clinical symptoms (c-ND)-according to their clinical status during the examination with DTI. We compared the DTI parameters in white matter tracts were compared among the three groups. In the order of non-ND, r-ND, and c-ND groups, the FA in superior cerebellar peduncle (SCP) and middle cerebellar peduncle (MCP) significantly decreased, the ADC, AD, and RD of MCP, and the RD of SCP were significantly elevated (FA-SCP; p < 0.001, FA-MCP; p = 0.026, ADC-MCP; p < 0.001, AD-MCP; p = 0.002, RD-MCP; p = 0.003, and RD-SCP; p = 0.018). Furthermore, in the simple linear regression analysis, the FA, ADC, AD, and RD values in the MCP and the FA value in the SCP were significantly influenced by the presence of neurological symptoms and ND findings on MRI (all p < 0.001). In LCH-ND, we identified microstructural damage in the SCP and MCP. DTI parameters in these tracts may help monitor LCH-ND; therefore, future studies are required to validate these results in a large cohort.

Networks of microstructural damage predict disability in multiple sclerosis

BackgroundNetwork-based measures are emerging MRI markers in multiple sclerosis (MS). We aimed to identify networks of white (WM) and grey matter (GM) damage that predict disability progression and cognitive worsening...

Grinding subsurface damage mechanism of nickel-based single crystal superalloy based on stress-strain

This study investigates the microstructure damage mechanism of the difficult-to-machine material nickel-base single crystal superalloy DD5 by analyzing the working condition load and crystal deformation. The complexity of the macroscopic and microscopic deformation phenomena during the machining process makes it challenging to study the damage mechanism of the workpiece. Hence, crystal kinematics equation is established using true stress-true strain theory, and the internal force balance and constitutive model of the crystal are analyzed. The proposed theory is applied to finite element processing and experimental analysis of the workpiece, and the subsurface deformation behavior is studied from a mechanistic perspective.The stress model is employed to explore the plastic flow phenomenon of the material during the machining process, and the influence of stress and shear force on the subsurface of the workpiece is discussed. The theoretical analysis of crystal deformation, based on the principles of materials science and mechanics, uncovers the relationship between subsurface deformation curvature and stress. The study delves into the effects of the grinding process on subsurface damage and deformation by analyzing the phenomena of plastic flow, plastic slip, and plastic winding in the subsurface microstructure. The results indicate that at grinding speed vs = 25 m/s and grinding depth ap = 60 μm, the damage to the subsurface deformation layer is minimal. The grinding process considerably impacts the stress exerted on the workpiece, with an amplitude ranging from 1.255 × 103 to 1.286 × 103. Conversely, the strain on the workpiece is relatively less affected by the grinding process, exhibiting an amplitude of 2.366–3.568. Moreover, when the normal stress and shear force of the abrasive particles form 45° angle, the subsurface deformation of DD5 manifests a distinct slip distortion at an approximate 45° curvature.

Evaluation of the aortic wall structural alteration following cryopreservation in 1 year follow-up period

Vascular graft infection is still a life-threatening complication of reconstructive surgery. Among other options, application of cryopreserved homografts can eventuate favorable outcome, if graft replacement is necessary. The preparation and storage of these allografts need special infrastructure and deep subzero (− 80 °C) temperature. However, the longer storage time can lead to inferior results after implantation, based upon clinicians’ experiences. The goal of our investigation was to circumscribe the optimal storage time interval with differential scanning calorimetry (DSC) and histological evaluation, using porcine aorta. All samples were deep-freezed using − 80 °C. Cryopreservated grafts were melted after 4, 6, 12, 16, 20, 24, 28 and 52 weeks; then, DSC and different types of histology were performed. Light microscopy analysis showed significant changes in the connective tissue fibers’ structure from the 16th week; while, DSC measurements confirmed systematic decrease in the thermal stability from the same week during the follow-up period. Our investigation suggested that cryopreservation can lead to significant and increasing microstructural damage of the fibers following the 12th week; thus, the homograft implantation can result in higher success rate inside this timeframe.

Quantitative T1 brain mapping in early relapsing-remitting multiple sclerosis: longitudinal changes, lesion heterogeneity and disability

ObjectivesTo quantify brain microstructural changes in recently diagnosed relapsing-remitting multiple sclerosis (RRMS) using longitudinal T1 measures, and determine their associations with clinical disability.MethodsSeventy-nine people with recently diagnosed (< 6 months) RRMS were recruited from a single-centre cohort sub-study, and underwent baseline and 1-year brain MRI, including variable flip angle T1 mapping. Median T1 was measured in white matter lesions (WML), normal-appearing white matter (NAWM), cortical/deep grey matter (GM), thalami, basal ganglia and medial temporal regions. Prolonged T1 (≥ 2.00 s) and supramedian T1 (relative to cohort WML values) WML voxel counts were also measured. Longitudinal change was assessed with paired t-tests and compared with Bland-Altman limits of agreement from healthy control test-retest data. Regression analyses determined relationships with Expanded Disability Status Scale (EDSS) score and dichotomised EDSS outcomes (worsening or stable/improving).ResultsSixty-two people with RRMS (mean age 37.2 ± 10.9 [standard deviation], 48 female) and 11 healthy controls (age 44 ± 11, 7 female) contributed data. Prolonged and supramedian T1 WML components increased longitudinally (176 and 463 voxels, respectively; p < .001), and were associated with EDSS score at baseline (p < .05) and follow-up (supramedian: p < .01; prolonged: p < .05). No cohort-wide median T1 changes were found; however, increasing T1 in WML, NAWM, cortical/deep GM, basal ganglia and thalami was positively associated with EDSS worsening (p < .05).ConclusionT1 is sensitive to brain microstructure changes in early RRMS. Prolonged WML T1 components and subtle changes in NAWM and GM structures are associated with disability.Clinical relevance statementMRI T1 brain mapping quantifies disability-associated white matter lesion heterogeneity and subtle microstructural damage in normal-appearing brain parenchyma in recently diagnosed RRMS, and shows promise for early objective disease characterisation and stratification.Key Points• Quantitative T1 mapping detects brain microstructural damage and lesion heterogeneity in recently diagnosed relapsing-remitting multiple sclerosis.• T1 increases in lesions and normal-appearing parenchyma, indicating microstructural damage, are associated with worsening disability.• Brain T1 measures are objective markers of disability-relevant pathology in early multiple sclerosis.Graphical abstract

Unified thermomechanical model of Ti-6Al-4V titanium alloy considering microstructure evolution and damage fracture under different stress state

Unified thermomechanical model of Ti-6Al-4V titanium alloy considering microstructure evolution and damage fracture under different stress state

Progressive microstructural evolution characteristics and weakening mechanism of coal exposed to acid mine drainage (AMD)

This study aims to analyze the extent of softening structural deterioration of coal pillars over time when exposed to acid mine drainage (AMD) from abandoned pits. The research involves using microscopic recognition techniques on coal samples and hydrochemistry tests in solution to identify changes in mineral compositions and microstructure parameters quantitatively. The study examines the micro-scale changes in microstructural hydro-chemical damage processes in coal samples. Based on the findings, the decrease in pH of the acidic pit effluent leads to degradation in the physical microstructural characteristics of the coal. Specifically, there is a 6.90% increase in the fractal dimension and a 23.33% rise in the area porosity. Similarly, the chemical parameters of the coal also undergo significant changes. The thickness of the aromatic layer in the coal decreases significantly, while the average diameter of the aromatic layer increases by 16.9%. The aromaticity of the coal increases, indicating noticeable deterioration of the matrix layer, particularly fragmentation. Moreover, the solution characteristics reflect the progressive coal deterioration, including increased metal ions in the soaking solution, the transformation of divalent iron to trivalent iron, and a continuous rise in sulfate content. These results have implications for assessing and maintaining load-bearing structures in underground abandoned pits subjected to long-term immersion.

Mismatch of MRI White Matter Hyperintensities and Gait Function in Patients With Cerebral Small Vessel Disease.

Cerebral small vessel disease (CSVD) is closely related to gait disorders. Previous studies have found a negative correlation between the severity of MRI white matter hyperintensities (WMH) and gait speed. However, not every individual with WMH experiences a gait disorder. To investigate the mechanisms underlying the mismatch between the severity of MRI WMH and gait impairment, in particular in subjects with severe WMH (Fazekas 3, scale 0-3) resulting from vascular disease. Cohort. 54 subjects with severe WMH and gait disorder (WMH-GD; 29 males) and 114 subjects with severe WMH with no gait disorder (WMH-nGD; 60 males). 3T/diffusion tensor imaging (DTI), and T1-weighted, T2-weighted, FLAIR, DWI, SWI. Trace-based spatial statistics analysis (TBSS) approach (fractional anisotropy, FA; mean diffusivity; radial diffusivity; axial diffusivity); Cognitive assessment; Conventional MRI markers of CSVD (WMH, enlarged perivascular spaces, lacunae, and cerebral microbleeds); Gait parameters (gait speed; cadence; stride length; gait cycle duration; step duration; time-up-and-go test, TUG). Gait disorder was defined as a TUG time exceeding 12 sec. The t-tests, Mann-Whitney U tests, Chi-square tests, and partial correlation analysis (Pearson or Spearman) were used. P < 0.05 with threshold-free cluster enhancement corrected was considered statistically significant for TBSS. After adjusting for age, sex, height, and other conventional MRI markers of CSVD, the WMH-nGD group showed significantly decreased FA values in the corpus callosum, bilateral superior longitudinal fasciculus, left corona radiata, and left posterior thalamic radiation. There was a significant association between FA values and TUG time, gait speed, and stride length in multiple WM tracts, independent of other conventional CSVD markers. This study provides evidence for microstructural damage of specific fibers in WMH-GD subjects compared to WMH-nGD subjects. This may explain the mismatch between WMH and gait impairment in subjects with severe WMH. 1 TECHNICAL EFFICACY: Stage 3.

Influence of surface treatment on the bonding quality of wood for load-bearing purposes

ABSTRACT This study investigates the influence of different machining processes on the tensile shear strength of glued lumber, focusing on optimizing the tool geometry of face milling. The data obtained were analyzed using statistical methods. The roughness of the surface produced by the machining process and the damage to the microstructure under the cutting edge are identified as important factors influencing the quality of the bond. The results show that the optimized process (low roughness and microstructure damage) leads to more effective gluing.

Cerebral Microstructural and Microvascular Changes in Non-Neuropsychiatric Systemic Lupus Erythematosus: A Study Using Diffusion Kurtosis Imaging and 3D Pseudo-Continuous Arterial Spin Labeling.

The purpose of this study was to observe cerebral microstructure and microcirculation features, as well as changes in white matter (WM) and gray matter (GM) among patients with non-neuropsychiatric systemic lupus erythematosus (non-NPSLE). We compared 36 female patients with non-NPSLE and 20 age- and gender-matched healthy controls (HCs) who underwent 3.0T MRI imaging with diffusion kurtosis imaging (DKI) and 3D pseudo-continuous Arterial Spin Labeling (pCASL). Mean kurtosis (MK), mean kurtosis tensor (MKT), and cerebral blood flow (CBF) values were obtained from 25 brain regions, including WM and GM. We analyzed the correlation between imaging indicators and clinical data. When compared with HCs, patients with non-NPSLE had reduced MK and MKT values in regional WM, deep GM, and the left frontal lobe cortical GM, and increased CBF in the right parietal lobe WM and right semioval center (SOC). The MK and MKT values were weakly correlated with CBF in some regions, including WM and GM. Complement 3 (C3) and Complement 4 (C4) showed a weak positive correlation with MK and MKT in some regions, including WM and deep GM, while platelet (PLT) was positively correlated with MKT in the left frontal lobe WM; dsDNA antibody was correlated negatively with MK in the right occipital lobe WM; and erythrocyte sedimentation rate (ESR) was correlated negatively with CBF in the left SOC. Our findings revealed the presence of brain microstructural and microvascular abnormalities in non-NPSLE patients, indicating microstructural damage in the cortical GM, which was less commonly reported. We found DKI and pCASL useful in detecting early brain lesions, and MK was a more sensitive and beneficial indicator.