Micronutrient Powder Supplementation Research Articles

Evaluating Interventions With Special Fortified Products and Complementary Feeding Recommendations to Best Achieve the Nutrient Adequacy in Filipino Complementary Diets

ObjectivesThe objective of this study was to predict the intervention scenarios that best fulfil the nutrient adequacy in Filipino complementary diets in rural settings using linear programming (LP) analyses of special fortified foods, alone or in combination with complementary feeding recommendations (CFRs). MethodsA cross-sectional survey was conducted in the municipality of Mercedes, Camarines Norte Province. Dietary intakes of breastfed children 6–8, 9–11 and 12–23 months of age (n = 297) were assessed using a multi-pass 24-hour recall method with 7-day food consumption frequency. Optifood, an LP tool was used to formulate age-specific CFRs and determine the extent to which special fortified foods, namely micronutrient powder (MNP), small-quantity lipid-based nutrient supplements (LNS-SQ) and fortified blended food with micronutrient powder (FBF + MNP), can contribute towards nutrient adequacy in complementary diets. ResultsLP analyses show that for 6–8 and 9–11-month-old infants, requirements for iron will be difficult to meet even with four serves of MNP per week, while for 9–11 and 12–23-month-old young children, calcium adequacy would remain a challenge even with daily serves of LNS-SQ per week. Adequacy for 11 modelled micronutrients could only be achieved if CFRs that modify current dietary patterns were fully adopted along with supplementation of LNS-SQ 5–7 times per week. ConclusionsAdoption of food-based CFRs with special fortified products is necessary to best fulfil the gaps of essential micronutrients in the diets of rural Filipino children aged 6–23 months. The findings provide insight into the current program in the Philippines. The MNP supplementation with the usual ration of MNP 3 to 4 times per week would not be sufficient to ensure adequacy for iron in 6–8 and 9–11-month-old infants unless the frequency is increased to 5 times per week. Empirical intervention studies are needed to confirm the LP simulations and feasibility of the CFRs. Funding SourcesThe authors received no funding for this work.

Effect of low-iron micronutrient powder (MNP) on the composition of gut microbiota of Bangladeshi children in a high-iron groundwater setting: a randomized controlled trial

PurposeAdverse effects of iron fortification/supplements such as Micronutrient Powder (MNP) on gut microbiota have previously been found in infection-prone African settings. This study examined the adversaries of a low-iron MNP compared with the standard MNP on the composition of gut microbiota in Bangladeshi children exposed to a high concentration of iron from potable groundwater.MethodsA randomized controlled trial was conducted in 2- to 5-year-old children, drinking groundwater with a high concentration of iron (≥ 2 mg/L). Children were randomized to receive one sachet per day of either standard MNP (12.5 mg iron) or low-iron MNP (5 mg iron), for 2 months. A sub-sample of 53 children was considered for paired assessment of the gut microbiome by 16S rRNA amplicon sequencing.ResultsAt baseline, the gut microbiota consisted of Bifidobacteriaceae (15.6%), Prevotellaceae (12.2%), Lactobacillaceae (3.6%), Clostridiaceae (4.1%) and Enterobacteriaceae (2.8%). Overall, there was no significant treatment effect of the low-iron MNP compared to the standard MNP. However, an apparent treatment effect was observed in children with a relative adult-like microbiota, with a higher relative abundance of potentially pathogenic Enterobacteriaceae after receiving the standard MNP compared to the low-iron MNP. This effect, however, was statistically non-significant (p = 0.07).ConclusionIn Bangladeshi children drinking iron-rich groundwater, a low-iron MNP supplementation did not have a significant impact on their gut microbiota profile/composition compared to the standard MNP.The trial registration number is ISRCTN60058115; Date of registration 03/07/2019; retrospectively registered.

Impact of iron fortification on anaemia and iron deficiency among pre-school children living in Rural Ghana.

Anaemia in young sub-Saharan African children may be due to the double burden of malaria and iron deficiency. Primary analysis of a double-blind, cluster randomized trial of iron containing micronutrient powder supplementation in Ghanaian children aged 6 to 35 months found no difference in malaria risk between intervention and placebo groups. Here, we performed a secondary analysis of the trial data to assess the impact of long-term prophylactic iron fortificant on the risk of iron deficiency and anaemia in trial subjects. This population-based randomized-cluster trial involved 1958 children aged between 6 to 35 months, identified at home and able to eat semi-solid foods. The intervention group (n = 967) received a daily dose containing 12.5 mg elemental iron (as ferrous fumarate), vitamin A (400 μg), ascorbic acid (30 mg) and zinc (5 mg). The placebo group (n = 991) received a similar micronutrient powder but without iron. Micronutrient powder was provided daily to both groups for 5 months. At baseline and endline, health assessment questionnaires were administered and blood samples collected for analysis. The two groups had similar baseline anthropometry, anaemia, iron status, demographic characteristics, and dietary intakes (p > 0.05). Of the 1904 (97.2%) children who remained at the end of the intervention, the intervention group had significantly higher haemoglobin (p = 0.0001) and serum ferritin (p = 0.0002) levels than the placebo group. Soluble transferrin receptor levels were more saturated among children from the iron group compared to non-iron group (p = 0.012). Anaemia status in the iron group improved compared to the placebo group (p = 0.03). Continued long-term routine use of micronutrient powder containing prophylactic iron reduced anaemia, iron deficiency and iron deficiency anaemia among pre-school children living in rural Ghana's malaria endemic area.

Multiple micronutrient supplementation improves growth and reduces the risk of anemia among infants in Gaza Strip, Palestine: a prospective randomized community trial

BackgroundInfants and young children 6–24 months of age are the most nutritionally vulnerable groups, as their needs for vitamins and minerals are high relative to the amount of food they consume. This study determines the effect of Micronutrient Powder Supplementation (MNP) on growth and hemoglobin of infants in Gaza Strip, Palestine.MethodThis was a two-arm parallel-group randomized controlled trial conducted in two health care clinics of the United Nations Relief and Work Agency (UNRWA) at the Middle Area governorate of Gaza Strip, Palestine. A total of 200 healthy infants aged 6-month-old were recruited and randomized to receive 3 sachets/week of MNP for 12 months alongside with the National Micronutrient Supplement (NMS) (n = 100) or NMS alone (n = 100). Weight, length, blood hemoglobin, and dietary intakes were measured at 6, 9, 12, 15, 18, and 21 (3 months after the end of intervention) months of age. Analysis was by intention to treat.ResultsThe experimental group had a higher concentration of hemoglobin at 12 and 15 months than did the control group, and a significant difference (p < 0.05) was observed at 15 months only. Significantly greater weight, length, weight-for-age, length-for-age, and weight-for-length z-scores were observed in the experimental group than that in the control group at 12 and 15 months (p < 0.05). The prevalence of anemia (18% vs. 52%) and stunting (1% vs. 11%) were higher in the control than the experimental group, respectively. After controlling for sex, similar findings were reported.ConclusionsAddition of MNP to the existing NMS program improved the nutritional status of young children. The potential benefits of MNP supplementation on physical growth and hemoglobin should be considered in the existing NMS program.Trial registrationISRCTN57594793; Date of registration: 20-03-2018 (Retrospectively registered).

Multiple Micronutrient Powder Reduces Vitamin E Deficiency in Brazilian Children: A Pragmatic, Controlled Clinical Trial.

Multiple micronutrient powder supplementation is a health promotion strategy, but data on its effectiveness regarding vitamin E are rare. The objective was to evaluate the impact of home fortification with powdered micronutrients on α-tocopherol concentrations, growth, and inflammation in Brazilian children aged 6–15 months. This is a pragmatic, controlled clinical trial, in which the intervention group received micronutrient powder sachets for up to 3 months. Vitamin E deficiency was considered when α-tocopherol was less than 11.6 µmol/L. The Poisson regression model was used to estimate adjusted values for prevalence ratios (PR) for the outcome variable. A total of 224 children participated in the study. The intervention group had a higher median α-tocopherol level (17.2 versus 3.6 µmol/L; p < 0.001) and an 82.0% reduction in the prevalence of vitamin deficiency (PR = 0.18; 95% CI 0.11–0.30) when compared with the control group. Consumption of multiple micronutrients in powder increases serum α-tocopherol concentrations, promotes better linear growth, and reduces morbidity in children.

Impact of micronutrient powder on anemia in children aged 10-35 months in Apurimac, Peru

Objective. To assess the impact of micronutrient powder supplementation (MNP) in reducing anemia in children aged 10 to 35 months in Apurimac, Peru. A secondary analysis of the database of the Evaluation of supplementation with MNP in the Apurímac region, conducted by the National Food and Nutrition Center (CENAN, in Spanish) between 2009 and 2010, was conducted. The intervention group was defined as children who consumed 60 or more packets of MNP; to generate the controls (children who did not consume MNP), we applied a propensity score matching (PSM); and, to estimate the impact of the MNP, we compared the prevalence of anemia in each study group, weighted by the probability of participation, applying three matching algorithms: nearest neighbor, kernel and local linear regression. All calculations were performed in the Stata 14 SE statistical program. The prevalence of anemia was significantly lower by up to 11 percentage points in the intervention group compared to controls (p=0.001), and mean hemoglobin increased by 0.3 g/dL in the same group (p<0.001). MNP supplementation showed impact in reducing anemia and increasing hemoglobin level in children who consumed 60 or more packets of MNP over a six-month period. Efforts to reduce anemia by using MNP to prevent this nutritional deficiency should continue.

Barriers and Facilitators of Micronutrient Powder Supplementation: Maternal Perceptions and Dynamics of Health Services

To explore the barriers and facilitators of micronutrient powder (MNP) supplementation to mothers of children aged 6 to 35 months living in the Peruvian cities of Tacna, Loreto, Puno, and Lima. This qualitative exploratory study with a grounded theory approach was conducted in the Peruvian cities of Lima, Tacna, Loreto, and Puno in 2014. In-depth interviews were conducted with mothers of children younger than 3 years, and observations in health care facilities (HCFs) were made to determine the barriers and facilitators of MNP supplementation. The barriers identified at the health care level were limited access to HCFs, negative rumors regarding the MNP in the clinics, and poor care by health personnel. The barrier at the product (MNP) level was the lack of knowledge about the supplement, including taste and side effects. The barrier at the maternal level was lack of time, neglect, difficulties in preparing the MNP, and opposition to the use of the MNP by the husband. The main facilitators were receiving information from health personnel regarding child improvement, mother's perception of child's improvement, and positive testimonies about the effectiveness of the MNP from relatives and neighbors. Barriers regarding MNP use at the health care system level and those associated with the behavior mothers and family/community, which prevent children from consuming the MNP supplement daily, need to be addressed through the development of strategies. Strategies must be developed to overcome the barriers related to the health care system, the MNP, and the behavior of children, mothers, and family/community because these barriers prevent children from consuming the MNP daily.

Recommendations for Interventions with Iron Supplements: Lessons Learned in a Community Trial in Four Regions of Peru

Iron supplementation programs, despite evidence of their effectiveness in controlled conditions, are not effective as largescale interventions in health services because of the necessary involvement during execution of a series of processes that, when not fulfilled, limit the implementation of the program. In many cases, the lack of impact of interventions to provide iron supplements is the result of failures or deviations from execution rather than flaws in the intervention design (theory of change) or intervention strategy. The objective of this study was to share the lessons learned in the execution of a community trial in 2015 to improve adherence to micronutrient powder supplementation in children younger than 3 years in four regions of Peru, as well as to provide recommendations on iron supplementation in children to help close gaps in the design and execution of public policies.

Effect of micronutrient powder supplementation for two and four months on hemoglobin level of children 6–23 months old in a slum in Dhaka: a community based observational study

Anemia is pervasive among children under the age of two years in Bangladesh. This study aimed to assess the effect of daily supplementation of multiple micronutrient powder (MNP) for 2 months and 4 months primarily on hemoglobin status of children aged 6–23 months living in a slum of Dhaka, Bangladesh. It was a community-based observational study where a total of 402 children and 578 children were enrolled for 2 months and 4 months MNP supplementation respectively. Venous blood was collected at enrollment and 5 months later. Hemoglobin level was measured and morbidity episodes recorded from twice weekly home visits. At enrollment, hemoglobin levels were 10.57 ± 1.28 g/dl and 10.78 ± 1.35 g/dl across 2 months and 4 months MNP supplementation groups respectively, compared to 10.65 ± 1.36 g/dl and 11.14 ± 1.11 g/dl at the end-line after MNP supplementation. Plasma hemoglobin increased only after 4 months supplementation in difference-in-difference analysis and this was significantly more in younger children after adjusting the confounding variables (p = 0.03). Prevalence of anemia had improved for both at 2 months (p = 0.015) and 4 months (p = 0.004) of MNP supplementation. Incidence rate ratios (IRR) for diarrhea, cough and fever were comparable across the groups during the supplementation periods and IRR for acute lower respiratory tract infection was significantly lower in 4 months supplementation group with a IRR of 0.30 (95 % CI; 0.22, 0.42). Four months MNP supplementation was relatively more effective in improving hemoglobin level in children 6–24 months.

Delivering Sprinkles Plus through the Integrated Child Development Services (ICDS) to Reduce Anemia in Pre-School Children in India: Correspondence

To the Editor: We read with great interest article entitled “Delivering sprinkles plus through the Integrated Child Development Services (ICDS) to reduce anemia in preschool children in India” [1]. The authors have concluded that following micronutrient powder supplementation; a reduction in anemia by 50– 30 % was achieved in children. It would have been more scientifically informative if the authors could have mentioned the increase in hemoglobin (Hb) amongst the children at different levels of Hb. Generally children with mild anemia show improvement in Hb and they become non anemic. This is reported as success of intervention in reduction of anemia. The authors have not mentioned the side effects associated with micronutrient powder. A recent largest intervention trial carried out till date on supplementation of micronutrient powder with zinc (10 mg) and without zinc has reported a strong evidence of an increase in proportion of days with diarrhea (p=0.001), increase in incidence of bloody diarrhea (p= 0.003) and increase in rates of lower respiratory tract infection or pneumonia. The study also documented the compliance rate was 50 %. The lead investigator who is author of Lancet Nutrition series 2013 has requested for a detailed scientific review and discussion on benefits and potential harm of micronutrient powder supplementation [2]. The readers of Indian Journal of Pediatrics (IJP) would have been benefited if authors had provided more data on i) compliance, ii) respiratory infection and iii) bloody diarrhea associated with micronutrient powder use in their study population. The validity of the results reported on reduction of anemia is questionable. As the method utilized for hemoglobin estimation i.e., HemoCue does not provide correct estimation of hemoglobin [3–5]. The cost effectiveness of micronutrient supplementation vs. Iron Folic Acid syrup is an important issue for consideration. Comments from the authors would help the policy makers in India to make an objective decision on inclusion of micronutrient powder for combating anemia.

Delivering Sprinkles Plus through the Integrated Child Development Services (ICDS) to Reduce Anemia in Pre-school Children in India

To assess the effectiveness of micronutrient powder (MNP) supplementation in reducing anemia levels in children aged 6 mo to 6 y in India. Sixty sachets of MNP (Sprinkles Plus) were administered flexibly over a 4 mo period to 17,124 children at anganwadi centers or at home through Integrated Child Development Services (ICDS). Compliance was monitored using compliance cards and an assessment of mother's recall at post-intervention survey. Hemoglobin was measured in separate random samples of 1,786 children before and 1,782 children after MNP supplementation. Mean compliance rate was estimated at 56.4 % (based on mother's recall) and 91.7 % (based on compliance cards) for children who received MNP at home. Mean compliance was 96.9 % (based on compliance cards) for children who received MNP at anganwadis. A significant reduction in anemia (50 % to 33 % in boys; p-value <.000; 47.4 % to 34.2 % in girls) was seen following MNP supplementation. Integration of a flexibly administered MNP supplementation into the ICDS is effective in reducing and treating anemia in children 6 mo to 6 y age.

Combined intensive nutrition education and micronutrient powder supplementation improved nutritional status of mildly wasted children on Nias Island, Indonesia.

To assess the impact of intensive nutrition education (INE) with or without the provision of micronutrient powder (MNP) on the nutritional status of mildly wasted children in Nias, Indonesia, two groups of mildly wasted (>=-1.5 to <-1.0 WHZ) children aged >=6 to <60 months in the Church World Service (CWS) project areas were assigned by village randomization to receive INE (n=64) or INE+MNP (n=51) in a weekly program. Another two groups of mildly wasted children who were living at a clear distance from INE and INE+MNP villages were selected to receive a monthly non-intensive nutrition education program (NNE) with or without MNP (n=50 both respectively). WHZ, weight, height, haemoglobin (Hb) level, and morbidity data were assessed at admission, during the study, and at individual discharge. Children's weight gain (g/kg body weight/day) was highest in INE+MNP group (2.2±2.1), followed by INE (1.1±0.9), NNE+MNP (0.3±0.5) and NNE (0.3±0.4) group. In both MNP intervention groups (INE+MNP, NNE+MNP), supplements significantly increased Hb value (g/L) of respective children (10.0±10.0; p<0.001 and 3.0±8.0; p<0.05 respectively). Proportion of children who reached discharge criterion was highest among the INE+MNP (70.6%; n=36), followed by INE (64.1%; n=41), NNE+MNP (26.0%; n=13), and NNE (20.0%; n=10) groups (p<0.001). Shortest length of stay until recovery was observed among children in the INE+MNP group (29.9 days), followed by INE (40.0 days), NNE+MNP (80.6 days), and NNE (86.2 days) respectively (p<0.001). Weekly intensive nutrition education supported by MNP supplementation produced the best results regarding weight gain and haemoglobin status of mildly wasted children.