Efficient control of flow separation holds significant economic promise. This study investigates flow separation mitigation using an experimental platform featuring a combination of passive and active actuators arranged in a matrix configuration. The platform consists of 5 × 6 hybrid actuator units, each integrating a height-adjustable vortex generator and a micro-jet actuator. Inspired by the distributed pattern of V-shaped scales on shark skin, these actuator units are strategically deployed in a matrix configuration to reduce flow separation on a backward-facing ramp. Distributed pressure taps encircling the hybrid actuators monitor the flow state. Parametric analyses examine the effect of different control strategies. By adopting appropriate passive and active actuation patterns, effective pressure recovery on the ramp surface can be achieved. The most significant flow control outcome occurs when the actuators operate under combined active and passive excitation, harnessing the benefits of both control strategies. Particle image velocimetry (PIV) results confirm a notable reduction in flow separation under the best-controlled case. These findings suggest a promising future for flow control devices employing combined passive and active actuation in matrix-like configurations.